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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
FOXO3 2309 Forkhead box O3  6FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23592131   2013Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Micro-array, RT-PCR, Western Blotting, immunohistochemistryDown-regulation- Downregulation of FoxO3a may greatly contribute to tumor development, and thus FoxO3a may represent a novel therapeutic target in colorectal cancer.

23828518   2013Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Tissue microarrayDown-regulation-The FOXO3 expression is significantly reduced in CRC specimens compared with normal tissue, and progressive FOXO3 downregulation is associated with advancing pathological stage.

FOXO3 may represent a novel biomarker of nodal and distant disease spread with clinical utility in CRC.


Gene Details



Chromosome: 6; NC_000006.11 (108881026..109005971)

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Gene Type protein coding
Gene Family Forkhead boxes
Description This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]  
Chromosome 6
Location 6q21
Start 108559823  
End 108684769  
Strand +  
Gene Sequence

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Length 124947  
OMIM ID 602681   
HGNC ID HGNC:3821   
Unigene ID Hs.220950    
Ensembl ID ENSG00000118689   
PharmGKB ID -   

mRNA Information


mRNA ID NM_201559.2
Exon join(1..193,1264..2007,103633..105067,120005..124946)  
mRNA Sequence

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Length 7314  



CDS Information


   
Locationjoin(1387..2007,103633..105033)
CDS Sequence

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CCDS ID CCDS5068.1



Protein Information


      
Protein IDNP_001446.1
Protein NameForkhead box O3
Molecular Wt. (Da)71146
Protein Sequence

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Length 673  
Uniprot IDP18075
Ensembl Protein ID ENSP00000379204  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation253
SPhosphorylation315
TPhosphorylation32
SPhosphorylation253
SPhosphorylation315
TPhosphorylation32
SPhosphorylation253
TPhosphorylation32
SPhosphorylation253
TPhosphorylation32
SPhosphorylation280
SPhosphorylation284
SPhosphorylation280
SPhosphorylation284
SPhosphorylation299
SPhosphorylation299
SPhosphorylation286
SPhosphorylation286
SPhosphorylation7
SPhosphorylation12
SPhosphorylation7
SPhosphorylation12
SPhosphorylation26
SPhosphorylation26
SPhosphorylation289
SPhosphorylation289

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                          
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2033EP3004078NP_001420.2in vitro11896584   
3551IKBKB4462NP_001547.1in vitro;in vivo15084260   
4087SMAD23221NP_005892.1in vitro;in vivo15084259   
4089SMAD42995NP_005350.1in vitro;in vivo15084259   
7534YWHAZ3183NP_003397.1in vivo10102273   
23411SIRT18381NP_036370.2in vitro;in vivo;yeast 2-hybrid14976264   


Pathway Information


                                                            
Pathway Name Pathway ID
AMPK signaling pathway hsa04152
Chemokine signaling pathway hsa04062
Endometrial cancer hsa05213
FoxO signaling pathway hsa04068
Longevity regulating pathway - mammal hsa04211
Longevity regulating pathway - multiple species hsa04213
Neurotrophin signaling pathway hsa04722
Non-small cell lung cancer hsa05223
PI3K-Akt signaling pathway hsa04151
Prolactin signaling pathway hsa04917


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00059157-237  FH
cl00061157-237  FH superfamily
smart00339157-239  FH
pfam00250161-249  Fork_head
COG5025151-250  COG5025
COG5025160-239  COG5025


Ontology Information


   
HPRD ID212
Molecular ClassUnknown
Molecular FunctionReceptor binding (GO:0005102)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO