Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| FLT3 | 2322 | fms-related tyrosine kinase 3 | 13 | STK1, FLK2, CD135 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 10738251 | 2000 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | real time RT-PCR | Unknown | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules, "Immunoglobulin superfamily / Immunoglobulin-like domain containing" |
| Description | This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015] |
| Chromosome | 13 |
| Location | 13q12 |
| Start | 28577411 |
| End | 28682904 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 105494 |
| OMIM ID | 136351 |
| HGNC ID | HGNC:3765 |
| Unigene ID | Hs.507590 |
| Ensembl ID | ENSG00000122025 |
| PharmGKB ID | PA28181 |
mRNA Information
| mRNA ID | NM_004119.2 |
|---|---|
| Exon | join(1..125,29981..30102,38524..38726,43131..43246, 47919..48048,50371..50498,50819..50958,51056..51209, 52150..52318,63305..63408,64550..64658,64920..65098, 66186..66292,66379..66511,66602..66706,72305..72415, 73352..73505,75650..75732,77116..77243,82004..82126, 84892..85003,85337..85436,86036..86141,96419..97319) | mRNA Sequence | Download Select all |
| Length | 3848 |
Protein Information
| Protein ID | NP_004110.2 |
|---|---|
| Protein Name | fms-related tyrosine kinase 3 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 993 |
| Uniprot ID | P49792 |
| Ensembl Protein ID | ENSP00000283195 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 589 |
| Y | Phosphorylation | 591 |
| Y | Phosphorylation | 597 |
| Y | Phosphorylation | 599 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2885 | GRB2 | 150 | NP_002077.1 | in vivo | 10080542 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Acute myeloid leukemia | hsa05221 |
| Central carbon metabolism in cancer | hsa05230 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Hematopoietic cell lineage | hsa04640 |
| Pathways in cancer | hsa05200 |
| Transcriptional misregulation in cancer | hsa05202 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05055 | 572-947 | PTKc_PDGFR |
| cl21453 | 572-947 | PKc_like superfamily |
| cd05106 | 571-947 | PTKc_CSF-1R |
| cd05104 | 572-947 | PTKc_Kit |
| cd05105 | 572-940 | PTKc_PDGFR_alpha |
| cd05107 | 572-944 | PTKc_PDGFR_beta |
| cd05054 | 602-944 | PTKc_VEGFR |
| cd00192 | 614-943 | PTKc |
| cd05102 | 602-944 | PTKc_VEGFR3 |
| cd05103 | 602-944 | PTKc_VEGFR2 |
| cd14207 | 602-944 | PTKc_VEGFR1 |
| cd05053 | 600-954 | PTKc_FGFR |
| cd05099 | 599-952 | PTKc_FGFR4 |
| cd05101 | 596-943 | PTKc_FGFR2 |
| cd05098 | 596-943 | PTKc_FGFR1 |
| cd05100 | 600-939 | PTKc_FGFR3 |
| cd05045 | 609-941 | PTKc_RET |
| cd05032 | 603-943 | PTKc_InsR_like |
| cd05039 | 603-936 | PTKc_Csk_like |
| cd05044 | 614-936 | PTKc_c-ros |
| cd05034 | 614-943 | PTKc_Src_like |
| cd05036 | 604-936 | PTKc_ALK_LTK |
| cd05057 | 604-941 | PTKc_EGFR_like |
| cd05048 | 604-944 | PTKc_Ror |
| cd05049 | 604-936 | PTKc_Trk |
| cd05059 | 610-944 | PTKc_Tec_like |
| cd05050 | 604-936 | PTKc_Musk |
| cd05047 | 615-940 | PTKc_Tie |
| cd05068 | 602-939 | PTKc_Frk_like |
| cd05089 | 608-953 | PTKc_Tie1 |
| cd05052 | 603-936 | PTKc_Abl |
| cd05051 | 604-943 | PTKc_DDR |
| cd05046 | 605-944 | PTK_CCK4 |
| cd05041 | 616-936 | PTKc_Fes_like |
| cd05060 | 616-943 | PTKc_Syk_like |
| cd05148 | 603-944 | PTKc_Srm_Brk |
| cd05082 | 603-943 | PTKc_Csk |
| cd13999 | 616-943 | STKc_MAP3K-like |
| cd05085 | 613-939 | PTKc_Fer |
| cd05061 | 603-943 | PTKc_InsR |
| cd05056 | 603-949 | PTKc_FAK |
| cd05072 | 603-956 | PTKc_Lyn |
| cd05088 | 601-949 | PTKc_Tie2 |
| cd05058 | 614-941 | PTKc_Met_Ron |
| cd05038 | 605-939 | PTKc_Jak_rpt2 |
| cd05092 | 601-943 | PTKc_TrkA |
| cd05084 | 613-944 | PTKc_Fes |
| cd05083 | 603-943 | PTKc_Chk |
| cd05067 | 602-943 | PTKc_Lck_Blk |
| cd05035 | 610-939 | PTKc_TAM |
| cd05040 | 614-943 | PTKc_Ack_like |
| cd05113 | 607-941 | PTKc_Btk_Bmx |
| cd05073 | 603-943 | PTKc_Hck |
| cd05097 | 604-943 | PTKc_DDR_like |
| cd05091 | 610-943 | PTKc_Ror2 |
| cd05062 | 603-941 | PTKc_IGF-1R |
| cd05108 | 614-982 | PTKc_EGFR |
| cd05095 | 604-943 | PTKc_DDR2 |
| cd05112 | 606-939 | PTKc_Itk |
| cd05109 | 614-941 | PTKc_HER2 |
| cd05096 | 604-943 | PTKc_DDR1 |
| cd05033 | 614-943 | PTKc_EphR |
| cd14203 | 614-943 | PTKc_Src_Fyn_like |
| cd14204 | 607-939 | PTKc_Mer |
| cd05069 | 603-956 | PTKc_Yes |
| cd05075 | 610-939 | PTKc_Axl |
| cd05093 | 607-943 | PTKc_TrkB |
| cd05094 | 607-943 | PTKc_TrkC |
| cd05071 | 603-943 | PTKc_Src |
| cd05114 | 606-939 | PTKc_Tec_Rlk |
| cd00180 | 616-943 | PKc |
| cd05070 | 603-956 | PTKc_Fyn |
| cd05074 | 606-943 | PTKc_Tyro3 |
| cd05043 | 607-943 | PTK_Ryk |
| cd05115 | 607-939 | PTKc_Zap-70 |
| cd05090 | 604-939 | PTKc_Ror1 |
| cd05111 | 605-941 | PTK_HER3 |
| cd05110 | 614-962 | PTKc_HER4 |
| cd05116 | 616-936 | PTKc_Syk |
| cd05063 | 614-943 | PTKc_EphR_A2 |
| cd14205 | 605-940 | PTKc_Jak2_rpt2 |
| cd14058 | 616-944 | STKc_TAK1 |
| cd05081 | 781-939 | PTKc_Jak3_rpt2 |
| cd05066 | 614-943 | PTKc_EphR_A |
| cd05080 | 605-943 | PTKc_Tyk2_rpt2 |
| cd05065 | 614-943 | PTKc_EphR_B |
| cd05079 | 616-939 | PTKc_Jak1_rpt2 |
| cd14059 | 616-943 | STKc_MAP3K12_13 |
| cd14061 | 615-939 | STKc_MLK |
| cd06606 | 613-935 | STKc_MAPKKK |
| cd14206 | 616-939 | PTKc_Aatyk3 |
| cd05064 | 604-943 | PTKc_EphR_A10 |
| cd05042 | 614-935 | PTKc_Aatyk |
| cd14145 | 601-939 | STKc_MLK1 |
| cd05087 | 614-935 | PTKc_Aatyk1 |
| cd14146 | 615-936 | STKc_MLK4 |
| cd05122 | 611-939 | PKc_STE |
| cd14003 | 609-935 | STKc_AMPK-like |
| cd13978 | 616-936 | STKc_RIP |
| cd14148 | 788-936 | STKc_MLK2 |
| cd14147 | 608-943 | STKc_MLK3 |
| cd14063 | 610-943 | PK_KSR |
| cd14060 | 617-943 | STKc_MLTK |
| cd14066 | 616-883 | STKc_IRAK |
| cd05086 | 616-935 | PTKc_Aatyk2 |
| cd06628 | 613-939 | STKc_Byr2_like |
| cd14014 | 614-935 | STKc_PknB_like |
| cd06627 | 609-935 | STKc_Cdc7_like |
| cd14065 | 616-943 | PKc_LIMK_like |
| cd14121 | 616-889 | STKc_ULK3 |
| cd14202 | 602-889 | STKc_ULK1 |
| cd13992 | 614-943 | PK_GC |
| cd14009 | 616-904 | STKc_ATG1_ULK_like |
| cd07833 | 608-891 | STKc_CDKL |
| cd05117 | 611-911 | STKc_CAMK |
| cd07829 | 616-875 | STKc_CDK_like |
| cd06623 | 608-935 | PKc_MAPKK_plant_like |
| cd06612 | 606-935 | STKc_MST1_2 |
| cd08215 | 614-935 | STKc_Nek |
| cd14155 | 616-943 | PKc_TESK |
| cd14008 | 616-904 | STKc_LKB1_CaMKK |
| cd13979 | 608-935 | STKc_Mos |
| cd08225 | 609-943 | STKc_Nek5 |
| cd14158 | 613-883 | STKc_IRAK4 |
| cd14007 | 611-935 | STKc_Aurora |
| cd14002 | 608-903 | STKc_STK36 |
| cd06614 | 610-935 | STKc_PAK |
| cd07840 | 616-891 | STKc_CDK9_like |
| cd14120 | 616-880 | STKc_ULK1_2-like |
| cd14062 | 792-943 | STKc_Raf |
| cd05037 | 610-936 | PTK_Jak_rpt1 |
| cd06605 | 608-940 | PKc_MAPKK |
| cd05118 | 614-935 | STKc_CMGC |
| cd13993 | 609-890 | STKc_Pat1_like |
| cd14221 | 791-943 | STKc_LIMK1 |
| cd07848 | 615-891 | STKc_CDKL5 |
| cd08217 | 611-935 | STKc_Nek2 |
| cd14080 | 612-878 | STKc_TSSK-like |
| cd05581 | 608-904 | STKc_PDK1 |
| cd14156 | 616-939 | PKc_LIMK_like_unk |
| cd14152 | 610-943 | STKc_KSR1 |
| cd06608 | 606-876 | STKc_myosinIII_N_like |
| cd14150 | 788-941 | STKc_A-Raf |
| cd06629 | 613-941 | STKc_Bck1_like |
| cd06624 | 596-939 | STKc_ASK |
| cd14201 | 603-889 | STKc_ULK2 |
| cd14151 | 603-939 | STKc_B-Raf |
| cd13996 | 607-882 | STKc_EIF2AK |
| cd14064 | 773-943 | PKc_TNNI3K |
| cd14042 | 641-943 | PK_GC-A_B |
| cd14069 | 613-878 | STKc_Chk1 |
| cd05123 | 616-933 | STKc_AGC |
| cd14079 | 613-879 | STKc_AMPK_alpha |
| cd08530 | 614-935 | STKc_CNK2-like |
| cd07830 | 614-884 | STKc_MAK_like |
| cd05570 | 614-954 | STKc_PKC |
| cd07838 | 616-884 | STKc_CDK4_6_like |
| cd06620 | 741-935 | PKc_Byr1_like |
| cd06611 | 606-881 | STKc_SLK_like |
| cd07846 | 612-979 | STKc_CDKL2_3 |
| cd14154 | 616-943 | STKc_LIMK |
| cd06631 | 613-935 | STKc_YSK4 |
| cd06621 | 792-935 | PKc_Pek1_like |
| cd14027 | 791-937 | STKc_RIP1 |
| cd06632 | 613-875 | STKc_MEKK1_plant |
| cd14222 | 779-939 | STKc_LIMK2 |
| cd14001 | 771-886 | PKc_TOPK |
| cd14044 | 764-943 | PK_GC-C |
| cd14119 | 616-904 | STKc_LKB1 |
| cd13975 | 783-934 | PKc_Dusty |
| cd07834 | 614-882 | STKc_MAPK |
| cd06610 | 611-935 | STKc_OSR1_SPAK |
| cd14090 | 613-891 | STKc_Mnk |
| cd06917 | 799-893 | STKc_NAK1_like |
| cd06622 | 786-940 | PKc_PBS2_like |
| cd14149 | 788-892 | STKc_C-Raf |
| cd14050 | 611-935 | PKc_Myt1 |
| cd13994 | 616-935 | STKc_HAL4_like |
| cd07863 | 780-882 | STKc_CDK4 |
| cd13997 | 616-935 | PKc_Wee1_like |
| cd07862 | 784-882 | STKc_CDK6 |
| cd08529 | 611-935 | STKc_FA2-like |
| cd14190 | 609-891 | STKc_MLCK2 |
| cd06616 | 792-942 | PKc_MKK4 |
| cd14054 | 780-937 | STKc_BMPR2_AMHR2 |
| cd14052 | 614-881 | PTKc_Wee1_fungi |
| cd14000 | 792-943 | STKc_LRRK |
| cd08219 | 614-941 | STKc_Nek3 |
| cd05580 | 608-906 | STKc_PKA_like |
| cd14173 | 614-891 | STKc_Mnk2 |
| cd06619 | 792-892 | PKc_MKK5 |
| cd08223 | 611-939 | STKc_Nek4 |
| cd06644 | 606-881 | STKc_STK10 |
| cd05619 | 779-913 | STKc_nPKC_theta |
| cd14186 | 608-908 | STKc_PLK4 |
| cd05078 | 610-936 | PTK_Jak2_rpt1 |
| cd06609 | 786-882 | STKc_MST3_like |
| cd14010 | 791-883 | STKc_ULK4 |
| cd14153 | 610-943 | PK_KSR2 |
| cd14099 | 613-935 | STKc_PLK |
| cd14137 | 614-875 | STKc_GSK3 |
| cd07842 | 613-910 | STKc_CDK8_like |
| cd14162 | 611-879 | STKc_TSSK4-like |
| cd07841 | 611-880 | STKc_CDK7 |
| cd05589 | 615-891 | STKc_PKN |
| cd08224 | 609-935 | STKc_Nek6_7 |
| cd08220 | 614-934 | STKc_Nek8 |
| cd08228 | 609-934 | STKc_Nek6 |
| cd14081 | 613-890 | STKc_BRSK1_2 |
| cd08229 | 794-934 | STKc_Nek7 |
| cd08218 | 614-935 | STKc_Nek1 |
| cd14192 | 614-891 | STKc_MLCK3 |
| cd06617 | 786-889 | PKc_MKK3_6 |
| cd07858 | 791-891 | STKc_TEY_MAPK |
| cd08221 | 765-935 | STKc_Nek9 |
| cd06607 | 794-935 | STKc_TAO |
| cd13998 | 780-883 | STKc_TGFbR-like |
| cd14144 | 781-938 | STKc_BMPR1 |
| cd07859 | 783-891 | STKc_TDY_MAPK |
| cd14056 | 614-881 | STKc_TGFbR_I |
| cd07847 | 641-891 | STKc_CDKL1_4 |
| cd07845 | 790-882 | STKc_CDK10 |
| cd14078 | 608-941 | STKc_MELK |
| cd14025 | 793-941 | STKc_RIP4_like |
| cd06648 | 606-889 | STKc_PAK_II |
| cd07866 | 608-882 | STKc_BUR1 |
| cd06615 | 741-890 | PKc_MEK |
| cd14208 | 610-936 | PTK_Jak3_rpt1 |
| cd06613 | 616-880 | STKc_MAP4K3_like |
| cd14047 | 793-883 | STKc_EIF2AK2_PKR |
| cd13968 | 616-831 | PKc_like |
| cd06625 | 613-942 | STKc_MEKK3_like |
| cd14167 | 607-913 | STKc_CaMKI_alpha |
| cd06649 | 741-896 | PKc_MEK2 |
| cd06650 | 741-902 | PKc_MEK1 |
| cd06636 | 606-881 | STKc_MAP4K4_6_N |
| cd05616 | 609-904 | STKc_cPKC_beta |
| cd14664 | 616-883 | STK_BAK1_like |
| cd14177 | 771-895 | STKc_RSK4_C |
| cd07843 | 790-883 | STKc_CDC2L1 |
| cd13977 | 791-879 | STKc_PDIK1L |
| cd06642 | 794-889 | STKc_STK25 |
| cd07857 | 791-888 | STKc_MPK1 |
| cd14199 | 778-889 | STKc_CaMKK2 |
| cd06641 | 794-881 | STKc_MST3 |
| cd14072 | 609-891 | STKc_MARK |
| cd05620 | 791-933 | STKc_nPKC_delta |
| cd14106 | 769-891 | STKc_DRAK |
| cd06618 | 792-939 | PKc_MKK7 |
| cd14048 | 794-885 | STKc_EIF2AK3_PERK |
| cd14175 | 771-895 | STKc_RSK1_C |
| cd07856 | 791-891 | STKc_Sty1_Hog1 |
| cd07849 | 791-883 | STKc_ERK1_2_like |
| cd14131 | 808-939 | PKc_Mps1 |
| cd05077 | 792-936 | PTK_Jak1_rpt1 |
| cd08222 | 794-935 | STKc_Nek11 |
| cd07831 | 791-891 | STKc_MOK |
| cd06640 | 794-881 | STKc_MST4 |
| cd14091 | 640-895 | STKc_RSK_C |
| cd14178 | 787-895 | STKc_RSK3_C |
| cd14176 | 771-895 | STKc_RSK2_C |
| cd14076 | 613-904 | STKc_Kin4 |
| cd06630 | 613-881 | STKc_MEKK1 |
| cd14118 | 777-879 | STKc_CAMKK |
| cd06643 | 606-881 | STKc_SLK |
| cd14084 | 614-935 | STKc_Chk2 |
| cd07851 | 597-880 | STKc_p38 |
| cd14077 | 609-879 | STKc_Kin1_2 |
| cd13987 | 792-878 | STKc_SBK1 |
| cd13985 | 614-881 | STKc_GAK_like |
| cd06633 | 797-881 | STKc_TAO3 |
| cd14026 | 793-936 | STKc_RIP2 |
| cd14075 | 612-879 | STKc_NIM1 |
| cd14006 | 616-891 | STKc_MLCK-like |
| cd07832 | 790-891 | STKc_CCRK |
| cd14043 | 797-936 | PK_GC-2D |
| cd07853 | 783-883 | STKc_NLK |
| cd06638 | 798-939 | STKc_myosinIIIA_N |
| cd06634 | 797-935 | STKc_TAO2 |
| cd14067 | 781-934 | STKc_LRRK1 |
| cd14004 | 614-889 | STKc_PASK |
| cd07855 | 783-891 | STKc_ERK5 |
| cd14174 | 614-891 | STKc_Mnk1 |
| cd14049 | 764-882 | STKc_EIF2AK1_HRI |
| cd14185 | 611-913 | STKc_DCKL3 |
| cd06637 | 606-881 | STKc_TNIK |
| cd13982 | 793-935 | STKc_IRE1 |
| cd07879 | 603-883 | STKc_p38delta |
| cd05592 | 614-913 | STKc_nPKC_theta_like |
| cd05076 | 792-936 | PTK_Tyk2_rpt1 |
| cd06655 | 797-957 | STKc_PAK2 |
| cd14055 | 781-889 | STKc_TGFbR2_like |
| cd05615 | 609-904 | STKc_cPKC_alpha |
| cd06647 | 794-889 | STKc_PAK_I |
| cd14011 | 793-903 | PK_SCY1_like |
| cd07854 | 791-881 | STKc_MAPK4_6 |
| cd14209 | 608-939 | STKc_PKA |
| cd05590 | 614-991 | STKc_nPKC_eta |
| cd06654 | 797-939 | STKc_PAK1 |
| cd13989 | 616-889 | STKc_IKK |
| cd07873 | 741-899 | STKc_PCTAIRE1 |
| cd14097 | 612-879 | STKc_STK33 |
| cd14053 | 781-883 | STKc_ACVR2 |
| cd14071 | 614-917 | STKc_SIK |
| cd14220 | 767-933 | STKc_BMPR1a |
| cd14095 | 784-879 | STKc_DCKL |
| cd14663 | 611-912 | STKc_SnRK3 |
| cd07877 | 783-891 | STKc_p38alpha |
| cd14219 | 809-938 | STKc_BMPR1b |
| cd08528 | 616-884 | STKc_Nek10 |
| cd06635 | 797-881 | STKc_TAO1 |
| cd05613 | 609-959 | STKc_MSK1_N |
| cd14012 | 791-935 | PK_eIF2AK_GCN2_rpt1 |
| cd07865 | 616-880 | STKc_CDK9 |
| cd07880 | 786-883 | STKc_p38gamma |
| cd07852 | 792-882 | STKc_MAPK15-like |
| cd07839 | 791-895 | STKc_CDK5 |
| cd07872 | 781-895 | STKc_PCTAIRE2 |
| cd14057 | 791-936 | PK_ILK |
| cd05612 | 608-889 | STKc_PRKX_like |
| cd05611 | 786-904 | STKc_Rim15_like |
| cd06639 | 606-939 | STKc_myosinIIIB_N |
| cd07871 | 781-894 | STKc_PCTAIRE3 |
| cd06659 | 770-889 | STKc_PAK6 |
| cd14197 | 794-928 | STKc_DRAK1 |
| cd05632 | 786-986 | STKc_GRK5 |
| cd14193 | 609-891 | STKc_MLCK4 |
| cd14038 | 616-889 | STKc_IKK_beta |
| cd14033 | 791-939 | STKc_WNK4 |
| cd14070 | 613-883 | STKc_HUNK |
| cd14142 | 809-881 | STKc_ACVR1_ALK1 |
| cd14104 | 755-891 | STKc_Titin |
| cd07870 | 787-892 | STKc_PFTAIRE2 |
| cd07864 | 611-883 | STKc_CDK12 |
| cd13983 | 794-907 | STKc_WNK |
| cd06656 | 797-939 | STKc_PAK3 |
| cd14191 | 777-891 | STKc_MLCK1 |
| cd14103 | 616-891 | STKc_MLCK |
| cd05578 | 791-891 | STKc_Yank1 |
| cd05630 | 791-889 | STKc_GRK6 |
| cd14165 | 613-903 | STKc_TSSK1_2-like |
| cd14184 | 784-889 | STKc_DCKL2 |
| cd06626 | 613-875 | STKc_MEKK4 |
| cd05631 | 791-889 | STKc_GRK4 |
| cd05579 | 791-905 | STKc_MAST_like |
| cd14039 | 616-889 | STKc_IKK_alpha |
| cd05582 | 614-891 | STKc_RSK_N |
| cd14143 | 767-938 | STKc_TGFbR1_ACVR1b_ACVR1c |
| cd07850 | 771-881 | STKc_JNK |
| cd05572 | 794-915 | STKc_cGK |
| cd06652 | 609-883 | STKc_MEKK2 |
| cd14187 | 733-939 | STKc_PLK1 |
| cd14116 | 608-917 | STKc_Aurora-A |
| cd06657 | 786-889 | STKc_PAK4 |
| cd07878 | 783-891 | STKc_p38beta |
| cd05608 | 791-883 | STKc_GRK1 |
| cd07836 | 791-891 | STKc_Pho85 |
| cd14159 | 616-883 | STKc_IRAK1 |
| cd05587 | 791-898 | STKc_cPKC |
| cd14036 | 610-879 | STKc_GAK |
| cd14183 | 781-891 | STKc_DCKL1 |
| cd06651 | 791-939 | STKc_MEKK3 |
| cd14094 | 794-911 | STKc_CASK |
| cd05577 | 787-889 | STKc_GRK |
| cd14164 | 794-891 | STKc_TSSK6-like |
| cd14111 | 786-889 | STKc_SPEG_rpt2 |
| cd14073 | 611-903 | STKc_NUAK |
| cd07844 | 790-892 | STKc_PCTAIRE_like |
| cd14098 | 794-935 | STKc_Rad53_Cds1 |
| cd07876 | 771-881 | STKc_JNK2 |
| cd14045 | 781-881 | PK_GC_unk |
| cd07875 | 771-891 | STKc_JNK1 |
| cd05609 | 798-902 | STKc_MAST |
| cd14083 | 607-913 | STKc_CaMKI |
| cd14166 | 607-913 | STKc_CaMKI_gamma |
| cd06653 | 791-883 | STKc_MEKK3_like_u1 |
| cd05595 | 782-881 | STKc_PKB_beta |
| cd05605 | 791-881 | STKc_GRK4_like |
| cd05585 | 799-912 | STKc_YPK1_like |
| cd14194 | 774-891 | STKc_DAPK1 |
| cd06658 | 786-893 | STKc_PAK5 |
| cd14086 | 793-889 | STKc_CaMKII |
| cd14109 | 784-892 | PK_Unc-89_rpt1 |
| cd07869 | 791-892 | STKc_PFTAIRE1 |
| cd14068 | 792-935 | STKc_LRRK2 |
| cd14096 | 616-881 | STKc_RCK1-like |
| cd14200 | 798-889 | STKc_CaMKK1 |
| cd05602 | 609-889 | STKc_SGK1 |
| cd14093 | 642-879 | STKc_PhKG |
| pfam00047 | 265-331 | ig |
| cl11960 | 265-331 | Ig superfamily |
| cd14161 | 607-891 | STKc_NUAK2 |
| cd14112 | 794-891 | STKc_Unc-89_rpt2 |
| cd14114 | 725-891 | STKc_Twitchin_like |
| cd14189 | 791-882 | STKc_PLK3 |
| cd05584 | 614-891 | STKc_p70S6K |
| cd13995 | 794-889 | STKc_MAP3K8 |
| cd14665 | 791-941 | STKc_SnRK2-3 |
| cd07874 | 768-881 | STKc_JNK3 |
| cd14198 | 794-891 | STKc_DRAK2 |
| cd07861 | 791-881 | STKc_CDK1_euk |
| cd14110 | 787-883 | STKc_obscurin_rpt2 |
| cd14168 | 607-913 | STKc_CaMKI_delta |
| cd14188 | 782-889 | STKc_PLK2 |
| cd14141 | 768-883 | STKc_ACVR2a |
| cd14113 | 783-935 | STKc_Trio_C |
| cd06645 | 599-884 | STKc_MAP4K3 |
| cd07835 | 791-895 | STKc_CDK1_CdkB_like |
| cd07837 | 791-903 | STKc_CdkB_plant |
| cd14105 | 783-891 | STKc_DAPK |
| cd14082 | 794-879 | STKc_PKD |
| cd14223 | 782-889 | STKc_GRK2 |
| cd14046 | 614-880 | STKc_EIF2AK4_GCN2_rpt2 |
| cd06646 | 794-884 | STKc_MAP4K5 |
| cd14087 | 773-889 | STKc_PSKH1 |
| cd14195 | 774-891 | STKc_DAPK3 |
| cd14140 | 781-935 | STKc_ACVR2b |
| cd14196 | 783-933 | STKc_DAPK2 |
| cd05601 | 808-880 | STKc_CRIK |
| cd14180 | 808-883 | STKc_MSK2_C |
| cd05593 | 791-881 | STKc_PKB_gamma |
| cd14101 | 790-881 | STKc_PIM2 |
| cd14108 | 794-891 | STKc_SPEG_rpt1 |
| cd14018 | 794-935 | STKc_PINK1 |
| cd05591 | 614-883 | STKc_nPKC_epsilon |
| cd13991 | 786-873 | STKc_NIK |
| cd14037 | 731-881 | STKc_NAK_like |
| cd07860 | 791-881 | STKc_CDK2_3 |
| cd07867 | 793-939 | STKc_CDC2L6 |
| cd14179 | 808-883 | STKc_MSK1_C |
| cd05614 | 609-889 | STKc_MSK2_N |
| cd14107 | 782-935 | STKc_obscurin_rpt1 |
| cd13988 | 774-891 | STKc_TBK1 |
| cd05603 | 614-933 | STKc_SGK2 |
| cd08216 | 611-889 | PK_STRAD |
| cd05586 | 799-881 | STKc_Sck1_like |
| cd05606 | 781-881 | STKc_beta_ARK |
| cd05617 | 791-889 | STKc_aPKC_zeta |
| cd14074 | 611-879 | STKc_SNRK |
| cd14662 | 791-903 | STKc_SnRK2 |
| cd14169 | 793-913 | STKc_CaMKI_beta |
| pfam13895 | 253-344 | Ig_2 |
| cd05633 | 782-889 | STKc_GRK3 |
| cd14092 | 794-883 | STKc_MSK_C |
| cd13986 | 797-943 | STKc_16 |
| cd05573 | 608-882 | STKc_ROCK_NDR_like |
| cd14020 | 792-883 | STKc_KIS |
| cd14135 | 790-883 | STKc_PRP4 |
| cd05594 | 791-881 | STKc_PKB_alpha |
| cd05604 | 791-889 | STKc_SGK3 |
| cd14133 | 791-883 | PKc_DYRK_like |
| cd14170 | 795-933 | STKc_MAPKAPK2 |
| cd13990 | 794-881 | STKc_TLK |
| cd05607 | 783-889 | STKc_GRK7 |
| cd14136 | 790-880 | STKc_SRPK |
| cd14089 | 793-905 | STKc_MAPKAPK |
| cd14005 | 808-881 | STKc_PIM |
| cd07868 | 793-883 | STKc_CDK8 |
| cd14172 | 795-889 | STKc_MAPKAPK3 |
| cd14041 | 702-889 | STKc_TLK2 |
| cd14125 | 777-850 | STKc_CK1_delta_epsilon |
| cd05618 | 754-889 | STKc_aPKC_iota |
| cd13974 | 771-881 | STKc_SHIK |
| cd14117 | 742-889 | STKc_Aurora-B_like |
| cd05588 | 754-889 | STKc_aPKC |
| cd14019 | 783-929 | STKc_Cdc7 |
| cd14013 | 808-843 | STKc_SNT7_plant |
| smart00750 | 774-880 | KIND |
| cd14040 | 702-889 | STKc_TLK1 |
| cd05598 | 808-880 | STKc_LATS |
| pfam07714 | 610-943 | Pkinase_Tyr |
| smart00221 | 610-943 | STYKc |
| smart00219 | 610-943 | TyrKc |
| smart00220 | 611-939 | S_TKc |
| pfam00069 | 610-939 | Pkinase |
| COG0515 | 609-913 | SPS1 |
| PHA03209 | 783-890 | PHA03209 |
| PLN00034 | 741-890 | PLN00034 |
| PTZ00036 | 791-903 | PTZ00036 |
| PTZ00267 | 756-891 | PTZ00267 |
| PTZ00263 | 602-889 | PTZ00263 |
| PTZ00024 | 790-883 | PTZ00024 |
| PHA03212 | 787-881 | PHA03212 |
| PHA02988 | 774-943 | PHA02988 |
| PRK13184 | 772-889 | pknD |
| PTZ00426 | 608-889 | PTZ00426 |
| PTZ00283 | 794-947 | PTZ00283 |
| PTZ00266 | 808-978 | PTZ00266 |
| PHA03211 | 792-903 | PHA03211 |
| PLN00009 | 791-901 | PLN00009 |
| smart00408 | 265-331 | IGc2 |
| PLN03224 | 775-842 | PLN03224 |
Ontology Information
| HPRD ID | 6769 |
|---|---|
| Molecular Class | Receptor tyrosine kinase |
| Molecular Function | Ligand-dependent nuclear receptor activity (GO:0004879) |
| Biological Process | Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P36888 | DB00398 | Sorafenib | SmallMoleculeDrug |
| P36888 | DB01268 | Sunitinib | SmallMoleculeDrug |
| P36888 | DB08901 | Ponatinib | SmallMoleculeDrug |
| P36888 | DB09079 | Nintedanib | SmallMoleculeDrug |