Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
FZD2 2535 frizzled class receptor 2  17- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
12147710   2002Cell line : HT29, Colo205, CaCo2

Source : Chao Family Comprehensive Cancer Center and ATCC

Sample Type : CRC Tumor and adjecent normal tissue

No. of Sample : 20

Stage : -

In situ hybridisationUp-regulation--

25417160   2010Cell line : SNU449, SNU475, BT549, Hs578t, Calu-1, NCIH661, HepG2

Source : ATCC

Sample Type : -

No. of Sample : -

Stage : -

Kinetic Wound-Healing AssayUp-regulation-Wnt receptor Frizzled2 (Fzd2) and its ligands Wnt5a/b are elevated in metastatic liver, lung, colon, and breast cancer cell line.


Gene Details



NC_000017.10 (42634812..42638630)

View Larger Image
   
Gene Type protein coding
Gene Family GPCR / Class F : Frizzled receptors
Description This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways. [provided by RefSeq, Dec 2010]  
Chromosome 17
Location 17q21.1
Start 42634812  
End 42638630  
Strand +  
Gene Sequence

   Download   Select all

Length 3819  
OMIM ID 600667   
HGNC ID HGNC:4040   
Unigene ID Hs.142912   
Ensembl ID -   
PharmGKB ID PA28457   

mRNA Information


mRNA ID NM_001466.3
Exon 1..3819  
mRNA Sequence

   Download   Select all

Length 3834  



CDS Information


   
Location246..1943
CDS Sequence

   Download   Select all

CCDS ID CCDS11484.1



Protein Information


      
Protein IDNP_001457.1
Protein Namefrizzled class receptor 2
Molecular Wt. (Da)0
Protein Sequence

   Download   Select all

Length 565  
Uniprot IDP09455
Ensembl Protein ID ENSP00000429166  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1742DLG44199NP_001356.1yeast 2-hybrid12067714   


Pathway Information


                                                
Pathway Name Pathway ID
Basal cell carcinoma hsa05217
Hippo signaling pathway hsa04390
HTLV-I infection hsa05166
Melanogenesis hsa04916
Pathways in cancer hsa05200
Proteoglycans in cancer hsa05205
Signaling pathways regulating pluripotency of stem cells hsa04550
Wnt signaling pathway hsa04310


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0746435-161  CRD_FZ2
cl0244735-161  CRD_FZ superfamily
pfam01534234-558  Frizzled
cl21587234-558  7tm_2 superfamily
cd0746635-158  CRD_FZ7
cd0745837-154  CRD_FZ1_like
cd0746535-161  CRD_FZ1
cd0745639-155  CRD_FZ5_like
smart0006339-152  FRI
cd0746039-157  CRD_FZ5
cd0746139-157  CRD_FZ8
pfam0139239-151  Fz
cd0706639-152  CRD_FZ
cd0745737-145  CRD_FZ9_like
cd0744839-158  CRD_FZ4
cd0746237-142  CRD_FZ10
cd0746339-151  CRD_FZ9
cd0744939-142  CRD_FZ3
cd0744139-142  CRD_SFRP3
cd0744239-142  CRD_SFRP4
cd0745039-142  CRD_FZ6
cd0744639-161  CRD_SFRP2
cd0788839-151  CRD_corin_2
cd0744441-142  CRD_SFRP5
cd0745437-142  CRD_LIN_17
cd0745341-169  CRD_crescent
cd0744341-154  CRD_SFRP1
cd0745241-142  CRD_sizzled
cd0744739-141  CRD_Carboxypeptidase_Z
cd0745541-127  CRD_Collagen_XVIII
cd0744539-144  CRD_corin_1
cd0745139-139  CRD_SMO


Ontology Information


   
HPRD ID4111
Molecular ClassG protein coupled receptor
Molecular FunctionCalcium ion binding (GO:0005509)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO