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General Information
- Evidence
- Gene
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- Protein
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- Enzyme
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 12147710 | 2002 | Cell line : HT29, Colo205, CaCo2 Source : Chao Family Comprehensive Cancer Center and ATCC Sample Type : CRC Tumor and adjecent normal tissue No. of Sample : 20 Stage : - | In situ hybridisation | Up-regulation | - | - |
| 25417160 | 2010 | Cell line : SNU449, SNU475, BT549, Hs578t, Calu-1, NCIH661,
HepG2 Source : ATCC Sample Type : - No. of Sample : - Stage : - | Kinetic Wound-Healing Assay | Up-regulation | - | Wnt receptor Frizzled2 (Fzd2) and its ligands Wnt5a/b are elevated in metastatic liver, lung, colon, and breast cancer cell line. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GPCR / Class F : Frizzled receptors |
| Description | This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways. [provided by RefSeq, Dec 2010] | Chromosome | 17 |
| Location | 17q21.1 |
| Start | 42634812 |
| End | 42638630 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 3819 |
| OMIM ID | 600667 |
| HGNC ID | HGNC:4040 |
| Unigene ID | Hs.142912 |
| Ensembl ID | - |
| PharmGKB ID | PA28457 |
Protein Information
| Protein ID | NP_001457.1 |
|---|---|
| Protein Name | frizzled class receptor 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 565 |
| Uniprot ID | P09455 |
| Ensembl Protein ID | ENSP00000429166 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1742 | DLG4 | 4199 | NP_001356.1 | yeast 2-hybrid | 12067714 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Basal cell carcinoma | hsa05217 |
| Hippo signaling pathway | hsa04390 |
| HTLV-I infection | hsa05166 |
| Melanogenesis | hsa04916 |
| Pathways in cancer | hsa05200 |
| Proteoglycans in cancer | hsa05205 |
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
| Wnt signaling pathway | hsa04310 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd07464 | 35-161 | CRD_FZ2 |
| cl02447 | 35-161 | CRD_FZ superfamily |
| pfam01534 | 234-558 | Frizzled |
| cl21587 | 234-558 | 7tm_2 superfamily |
| cd07466 | 35-158 | CRD_FZ7 |
| cd07458 | 37-154 | CRD_FZ1_like |
| cd07465 | 35-161 | CRD_FZ1 |
| cd07456 | 39-155 | CRD_FZ5_like |
| smart00063 | 39-152 | FRI |
| cd07460 | 39-157 | CRD_FZ5 |
| cd07461 | 39-157 | CRD_FZ8 |
| pfam01392 | 39-151 | Fz |
| cd07066 | 39-152 | CRD_FZ |
| cd07457 | 37-145 | CRD_FZ9_like |
| cd07448 | 39-158 | CRD_FZ4 |
| cd07462 | 37-142 | CRD_FZ10 |
| cd07463 | 39-151 | CRD_FZ9 |
| cd07449 | 39-142 | CRD_FZ3 |
| cd07441 | 39-142 | CRD_SFRP3 |
| cd07442 | 39-142 | CRD_SFRP4 |
| cd07450 | 39-142 | CRD_FZ6 |
| cd07446 | 39-161 | CRD_SFRP2 |
| cd07888 | 39-151 | CRD_corin_2 |
| cd07444 | 41-142 | CRD_SFRP5 |
| cd07454 | 37-142 | CRD_LIN_17 |
| cd07453 | 41-169 | CRD_crescent |
| cd07443 | 41-154 | CRD_SFRP1 |
| cd07452 | 41-142 | CRD_sizzled |
| cd07447 | 39-141 | CRD_Carboxypeptidase_Z |
| cd07455 | 41-127 | CRD_Collagen_XVIII |
| cd07445 | 39-144 | CRD_corin_1 |
| cd07451 | 39-139 | CRD_SMO |
Ontology Information
| HPRD ID | 4111 |
|---|---|
| Molecular Class | G protein coupled receptor |
| Molecular Function | Calcium ion binding (GO:0005509) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.