Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
AMFR 267 autocrine motility factor receptor, E3 ubiquitin protein ligase  16RNF45, gp78 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25852009   2015Cell line : -

Source :

Sample Type : CRC tumor

No. of Sample : 118

Stage : -

real time RT-PCR,Univariate and multivariate analysis, Spearman's correlationUp-regulation-AMFR may serve as a molecular prognosticator for colon cancer and rectal cancer.

8082090   1994Cell line : -

Source : -

Sample Type : CRC tumor

No. of Sample : 127 colon cancer, 131 rectal cancer, 47 colonic and 25 rectal corresponding lymph node metastases

Stage : -

Immunohistochemistry, Multivariate analysisUnknown--


Gene Details



NC_000016.9 (56395364..56459450, complement)

View Larger Image
   
Gene Type protein coding
Gene Family RING-type (C3HC4) zinc fingers
Description This locus encodes a glycosylated transmembrane receptor. Its ligand, autocrine motility factor, is a tumor motility-stimulating protein secreted by tumor cells. The encoded receptor is also a member of the E3 ubiquitin ligase family of proteins. It catalyzes ubiquitination and endoplasmic reticulum-associated degradation of specific proteins. [provided by RefSeq, Feb 2012]  
Chromosome 16
Location 16q21
Start 56395364  
End 56459450  
Strand -  
Gene Sequence

   Download   Select all

Length 64087  
OMIM ID 603243   
HGNC ID HGNC:463   
Unigene ID Hs.295137   
Ensembl ID ENSG00000159461   
PharmGKB ID PA24768   

mRNA Information


mRNA ID NM_001144.5
Exon join(1..466,11195..11287,15951..16115,17423..17575, 20295..20335,20498..20630,22421..22554,23696..23806, 36164..36354,39517..39620,56212..56346,58012..58095, 61434..61618,62483..64087)  
mRNA Sequence

   Download   Select all

Length 3631  



CDS Information


   
Location212..2143
CDS Sequence

   Download   Select all

CCDS ID CCDS10758.1



Protein Information


      
Protein IDNP_001135.3
Protein Nameautocrine motility factor receptor, E3 ubiquitin protein ligase
Molecular Wt. (Da)72865
Protein Sequence

   Download   Select all

Length 643  
Uniprot IDP33991
Ensembl Protein ID ENSP00000262105  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation509
SPhosphorylation522
SPhosphorylation516
SPhosphorylation523
SPhosphorylation542
SPhosphorylation601

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                             
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
7322UBE2D24268NP_003330.1in vitro;in vivo11724934   
7327UBE2G24387NP_003334.2in vitro;in vivo1   172   493   417   310   140   
7415VCP3013NP_009057.1in vitro;in vivo;yeast 2-hybrid1   533   159   816   275   660   


Pathway Information


      
Pathway Name Pathway ID
Protein processing in endoplasmic reticulum hsa04141


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd14421458-498  CUE_AMFR
cl21463458-498  UBA_like_SF superfamily
cd00162340-382  RING
cl17238340-382  RING superfamily
pfam13639339-379  zf-RING_2
cd14376458-494  CUE_AUP1_AMFR_like
cd14420460-499  CUE_AUP1
smart00184341-378  RING
pfam13923341-378  zf-C3HC4_2
smart00546456-497  CUE
cd14424459-494  CUE_Cue1p_like
pfam00097341-378  zf-C3HC4
pfam12861339-386  zf-Apc11
pfam02845458-497  CUE
cd14422457-494  CUE_RIN3_plant
pfam14634341-379  zf-RING_5
COG5194335-386  APC11
pfam13920337-381  zf-C3HC4_3
smart00744340-379  RINGv
pfam15227341-378  zf-C3HC4_4
COG524386-382  HRD1
pfam12678327-379  zf-rbx1
COG5540340-382  COG5540
COG5574311-379  PEX10
TIGR00599341-381  rad18
COG5432339-379  RAD18
COG5219339-382  COG5219


Ontology Information


   
HPRD ID4075
Molecular ClassUbiquitin proteasome system protein
Molecular FunctionDNA binding (GO:0003677)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO