Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| AMFR | 267 | autocrine motility factor receptor, E3 ubiquitin protein ligase  | 16 | RNF45, gp78  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25852009    | 2015 | Cell line : - Source : Sample Type : CRC tumor No. of Sample : 118 Stage : - | real time RT-PCR,Univariate and multivariate analysis, Spearman's correlation | Up-regulation | - | AMFR may serve as a molecular prognosticator for colon cancer and rectal cancer. |
| 8082090    | 1994 | Cell line : - Source : - Sample Type : CRC tumor No. of Sample : 127 colon cancer, 131 rectal cancer, 47 colonic and 25 rectal corresponding lymph node metastases Stage : - | Immunohistochemistry, Multivariate analysis | Unknown | - | - |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | RING-type (C3HC4) zinc fingers |
| Description | This locus encodes a glycosylated transmembrane receptor. Its ligand, autocrine motility factor, is a tumor motility-stimulating protein secreted by tumor cells. The encoded receptor is also a member of the E3 ubiquitin ligase family of proteins. It catalyzes ubiquitination and endoplasmic reticulum-associated degradation of specific proteins. [provided by RefSeq, Feb 2012]   | Chromosome | 16 |
| Location | 16q21 |
| Start | 56395364   |
| End | 56459450   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 64087   |
| OMIM ID | 603243    |
| HGNC ID | HGNC:463    |
| Unigene ID | Hs.295137    |
| Ensembl ID | ENSG00000159461    |
| PharmGKB ID | PA24768    |
mRNA Information
| mRNA ID | NM_001144.5 |
|---|---|
| Exon | join(1..466,11195..11287,15951..16115,17423..17575, 20295..20335,20498..20630,22421..22554,23696..23806, 36164..36354,39517..39620,56212..56346,58012..58095, 61434..61618,62483..64087)   | mRNA Sequence |    Download   Select all |
| Length | 3631   |
CDS Information
| Location | 212..2143 |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS10758.1 |    
Protein Information
| Protein ID | NP_001135.3 |
|---|---|
| Protein Name | autocrine motility factor receptor, E3 ubiquitin protein ligase |
| Molecular Wt. (Da) | 72865 |
| Protein Sequence |    Download   Select all |
| Length | 643   |
| Uniprot ID | P33991 |    
| Ensembl Protein ID | ENSP00000262105   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 509 |
| S | Phosphorylation | 522 |
| S | Phosphorylation | 516 |
| S | Phosphorylation | 523 |
| S | Phosphorylation | 542 |
| S | Phosphorylation | 601 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 7322 |    UBE2D2 |    4268 |    NP_003330.1 |    in vitro;in vivo |    11724934    |
| 7327 |    UBE2G2 |    4387 |    NP_003334.2 |    in vitro;in vivo |    1   172   493   417   310   140    |
| 7415 |    VCP |    3013 |    NP_009057.1 |    in vitro;in vivo;yeast 2-hybrid |    1   533   159   816   275   660    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Protein processing in endoplasmic reticulum |    hsa04141 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd14421 | 458-498  | CUE_AMFR |
| cl21463 | 458-498  | UBA_like_SF superfamily |
| cd00162 | 340-382  | RING |
| cl17238 | 340-382  | RING superfamily |
| pfam13639 | 339-379  | zf-RING_2 |
| cd14376 | 458-494  | CUE_AUP1_AMFR_like |
| cd14420 | 460-499  | CUE_AUP1 |
| smart00184 | 341-378  | RING |
| pfam13923 | 341-378  | zf-C3HC4_2 |
| smart00546 | 456-497  | CUE |
| cd14424 | 459-494  | CUE_Cue1p_like |
| pfam00097 | 341-378  | zf-C3HC4 |
| pfam12861 | 339-386  | zf-Apc11 |
| pfam02845 | 458-497  | CUE |
| cd14422 | 457-494  | CUE_RIN3_plant |
| pfam14634 | 341-379  | zf-RING_5 |
| COG5194 | 335-386  | APC11 |
| pfam13920 | 337-381  | zf-C3HC4_3 |
| smart00744 | 340-379  | RINGv |
| pfam15227 | 341-378  | zf-C3HC4_4 |
| COG5243 | 86-382  | HRD1 |
| pfam12678 | 327-379  | zf-rbx1 |
| COG5540 | 340-382  | COG5540 |
| COG5574 | 311-379  | PEX10 |
| TIGR00599 | 341-381  | rad18 |
| COG5432 | 339-379  | RAD18 |
| COG5219 | 339-382  | COG5219 |
Ontology Information
| HPRD ID | 4075 |    
|---|---|
| Molecular Class | Ubiquitin proteasome system protein |
| Molecular Function | DNA binding (GO:0003677) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
