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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20812987 | 2010 | Cell line : - Source : Nanfang Hospital tumour tissue bank. Sample Type : CRC tumor and Normal tissue No. of Sample : 150 Stage : TNM Stage I-IV | 2-D Gel electrophoresis, and mass spectrometry,Western blot analysis, Immunohistochemistry | Up-regulation | - | This gene differentially expressed in between normal colorectal tissue and colorectal cancer tissue experiment done by 2-D Gel eclectrophotesis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. [provided by RefSeq, Jul 2008] |
| Chromosome | 6 |
| Location | 6p21.3-p21 |
| Start | 38675925 |
| End | 38703176 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 27252 |
| OMIM ID | 138750 |
| HGNC ID | HGNC:4323 |
| Unigene ID | Hs.268849 |
| Ensembl ID | ENSG00000124767 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_006708.2 |
|---|---|
| Exon | join(1..206,16203..16285,18663..18803,20302..20369, 21076..21165,25794..27252) | mRNA Sequence | Download Select all |
| Length | 2071 |
CDS Information
| Location | join(123..206,16203..16285,18663..18803,20302..20369, 21076..21165,25794..25882) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS4837.1 |
Protein Information
| Protein ID | NP_006699.2 |
|---|---|
| Protein Name | Glyoxalase I |
| Molecular Wt. (Da) | 20647 |
| Protein Sequence | Download Select all |
| Length | 184 |
| Uniprot ID | Q12983 |
| Ensembl Protein ID | ENSP00000357625 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Acetylation | 148 |
Enzyme Information
| EC | 4.4.1.5 |
|---|---|
| Name | lactoylglutathione lyase methylglyoxalase aldoketomutase ketone-aldehyde mutase glyoxylase I (R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing) |
| Class | Lyases; Carbon-sulfur lyases; Carbon-sulfur lyases (only sub-subclass identified to date) |
| Sysname | (R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing; glutathione-forming) |
| Substrate | (R)-S-lactoylglutathione |
| Product | glutathione [CPD:C00051]; methylglyoxal |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Pyruvate metabolism | hsa00620 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd07233 | 32-175 | Glyoxalase_I |
| cl14632 | 32-175 | Glo_EDI_BRP_like superfamily |
| PLN03042 | 20-183 | PLN03042 |
| TIGR00068 | 16-184 | glyox_I |
| pfam00903 | 32-174 | Glyoxalase |
| PRK10291 | 36-175 | PRK10291 |
| COG0346 | 32-174 | GloA |
| cd06587 | 34-174 | Glo_EDI_BRP_like |
| pfam12681 | 37-174 | Glyoxalase_2 |
| cd07245 | 37-174 | Glo_EDI_BRP_like_9 |
| cd08346 | 37-174 | PcpA_N_like |
| cd08348 | 37-174 | BphC2-C3-RGP6_C_like |
| cd08358 | 37-170 | Glo_EDI_BRP_like_21 |
| cd07263 | 34-175 | Glo_EDI_BRP_like_16 |
| cd07264 | 35-177 | Glo_EDI_BRP_like_15 |
| cd08349 | 37-172 | BLMA_like |
| cd07253 | 37-58 | Glo_EDI_BRP_like_2 |
| cd07255 | 37-60 | Glo_EDI_BRP_like_12 |
| cd07241 | 39-174 | Glo_EDI_BRP_like_3 |
| cd07261 | 34-169 | Glo_EDI_BRP_like_11 |
| pfam13669 | 33-153 | Glyoxalase_4 |
| cd07242 | 37-174 | Glo_EDI_BRP_like_6 |
| cd07250 | 46-154 | HPPD_C_like |
| cd07254 | 117-174 | Glo_EDI_BRP_like_20 |
| cd07249 | 127-177 | MMCE |
| TIGR03645 | 122-155 | glyox_marine |
| PLN02367 | 21-182 | PLN02367 |
| PLN02300 | 38-175 | PLN02300 |
| PLN02300 | 3-170 | PLN02300 |
| TIGR03213 | 26-73 | 23dbph12diox |
| TIGR03211 | 37-100 | catechol_2_3 |
Ontology Information
| HPRD ID | 4482 |
|---|---|
| Molecular Class | Enzyme: Lyase |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Apoptosis (GO:0006915) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q04760 | DB00143 | Glutathione | SmallMoleculeDrug |
| Q04760 | DB00328 | Indomethacin | SmallMoleculeDrug |