CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
GLO1	2739	Glyoxalase I	6	GLYI; GLOD1

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
20812987	2010	Cell line : - Source : Nanfang Hospital tumour tissue bank. Sample Type : CRC tumor and Normal tissue No. of Sample : 150 Stage : TNM Stage I-IV	2-D Gel electrophoresis, and mass spectrometry,Western blot analysis, Immunohistochemistry	Up-regulation	-	This gene differentially expressed in between normal colorectal tissue and colorectal cancer tissue experiment done by 2-D Gel eclectrophotesis.

Gene Details

Chromosome: 6; NC_000006.11 (38643701..38670952, complement)
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Gene Type	protein coding
Gene Family	-
Description	The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. [provided by RefSeq, Jul 2008]
Chromosome	6
Location	6p21.3-p21
Start	38675925
End	38703176
Strand	-
Gene Sequence	>gi\|568815592:c38703176-38675925 Homo sapiens chromosome 6, GRCh38.p2 Primary Assembly AGCGGTCTCCCGCCCGCGGCGCCATCGCGCCATTCCTAGTTAAGGCGGCACAGGGCCGAGGCGTAGTGTG GGTGACTCCTCCGTTCCTTGGGTCCCGTCGTCTGTGATACTGCAGCGCAGCCATGGCAGAACCGCAGCCC CCGTCCGGCGGCCTCACGGACGAGGCCGCCCTCAGTTGCTGCTCCGACGCGGACCCCAGTACCAAGGTGG GCACAGGACCGAAGGGAACGGCTCCCCCAGCTCCGCTGGGCCGGGACCGGGCCGCATTCTATCCAACCCC ATCCCGCCGCCGCTGCAGGTCCGCCGGCCTCGGGCGGACGGGAGTGTGATGGGAAGAGGGATAATGGTGT TTGATGGGGCGATCGTGGGGCCCGCGAAGTGTGGAGGGGATCTGTTGCCTCAGCTAGTTTCAAAGACTGC GACCCTGTTTTGAATTGGCTTGTTTATGTTGCGACGGTGGCTGGAAGCCAGGCCAACCCAGGGTCAGCTT TCCCAAATCAGTCGCCAAGGCCCACGAGAACAGTAGTTTCAGAACTCCCAGAAATAGGTTCAAAGATGCC TGTCCTGTACCAGTCCTGCCCAGCCTCGTTTTTCCTTACCACCCTGACTGCAGTCTTAACTCCTGCAAAC TAATTTGATCGCTCTAAGTTTAACCGCGCCCAGAATTTCACTTTTGCTTGCTTGGCCTTTGCTGTGGGTC ACAACAGCCCTTCTTGCCTTCCTCATCTTCGTGGGGCCCAGGAGAGATTACAGAATCATAGAGTTTGGAT CTGAAAGGAATCTTAGAAATTCCTTCTCTTACCCTCTCGTTTTACAGTAATGACCCAGTAAGAGAAATGA CCTGTTGCATACAAAGGCTTTCACTTACCGAACATGTCTTTACTGGGTAAGAATCAGTGTAACTCACTCA GGTGTGGTGTTTCGGTTGCCTTGTTAAGATCAGACACAGTTGGCGGGCGCGGTGGCTCACGCCTGTAATC CCAGCACTTTGGGAGGCCAAGGCGGGCGGATCACGAGGTCAAGAGGTAGAGACCATCCTAACACGGTGAA ACCCCGTCTCTACTAAAAATACAAAAAAATGAGCTGGGCGTGGTGGCGGGTGCCTGTAGTCCCAGCTACT CGGGAGGCTGAGGCAGGAGAATGGCATGAACCCGGGAGGCGGAGCTTGCAGTGAGCTGAGATCGTGCCAC TGCACTCCAGCCTGGGCGACAGAGTGAGACTCTGTCTAAAAAAAAAAAAAAAAAAAAATTCAGGCACAGT AACCGCTGTTTATTCCAGTGAAGTCATCAGTGTCTGTAAACACCTTTGTATTTATTTATTTGACTACATC ATTTGTAAATTCCTTGAAGATTGAATATGTGCTTCGTGCAGACCTTTAAAAGGGGTAGATAAGTGGTCCA TGACTCTGGTCCCTGCTTGTTCTTTACCTTCAGGGCAAAGAGTCAGACACATCTCATTGCTAAAACTTTT GACTAGCACCTGGTACTTGGCTTAGGAAAAATGTTAGTCATTGCAAAATTAAGGGGGAAGGTAAAAAAAT TCCGTCATGCCCATCTCACTTGTATATCCCTTAATATTAATACCTGGTTTTTTCATATAATGTAAATTGA GTCACTCAGTGTAAAGTATTTTCCCAGATAACTAGGGGTTTTATGTAATGGGGTTTTCAAATAAAAAGGA TTCCAGGGATATCTTTATAAAATATACTAAGTAAATGTCCTTGCAGCTTAATTTACATTCCACAGTATCT AAATTTCTCTTGATGATTCGGAGTAATTAATTTTGAGATCAGTAATTTTTGGCCATGGGAGACATAAAAT GGAATACATAATAATAGCTGGTATATATTGAGTGTGCCAGGCCCTGGCTTGGTATTTTAAGTACATTGTT TAATTTAATCCTAACAACAACCCTATGAAGAAGGCATAATTATGATCTTCATTTTACAAATAAGGACACT CAGGCACATAGAGGTGTTGAGTGATTTGCCCAGGGAGGACCCCACACTTCCAACCTCCACCCTGTTCTGC TTCTGGGGTGCTGACTCCAGCAGTAATTTTGGAATTTGCCATAAAGGAAAATAAAAAACCTCAATGAAGG CTGGGTGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGAGCGAGGTGGGCAGATCACCTGAGGTT AGCAGTTCGAGACCAGCCTGGCCAACATGGCAAAACTCTGCTCTACTAAAAATACAAAAATTAGCTGGGC ATGGTGGCGGGCACCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAAAATCACTTGAACCCATGAGG TGGAGGTTGCAGGGAGCCGAGATCATGCCACTGCATTCCAGCTTGGGTGACAGAGTGAGACTTTGTCCAA AAAAAAAAAAAAACCCTCAATGAATTAAATTCAGTTTGATCACTTGATACATTTATGCTATATGTAAAGA AGATGGTAAGTACTTTGGGGATACTGGGATAAACAAGATGAGGTTCCCTCCCTTCACCAACTTATATCAA CTCTAATATACAATGGACCTGGGGTTAGTGTGCTATTGAAATATAAATCACCCTGAGAGCACCCTGGGAG GTAGAGGTTTTTAAAGGTAGCATTAGTGGAATGGGGTATGCACAGGGTATTTGGAGCCTGAAGACCTGCA TTTGAATCCCCACTTCTGTTGTTGGCTGCAGTGACCTTGCCAGGGCACTTGGGCTCAGTTTGTAGAAGGA GCATAAAGATATCTCAGAGAGCTGCTATGAGGATAAAATGACATGTATTATGTTCTCTAAACTATGAAGA GTGATACAATTCAAGGTTGTATTTCAGCTGTGGGGATCAGGGCACACATCAAAAAGATGGTGGTGATGGG CCTATGCCTTGATAGATTGGGTAGGATTCCAGCAGAGTACATGGGAAGGCATTCTGATGAAGGAAACATC TTAGCAAAAATGTGTTTTGATACGGGGGGAACCCACCCCAATATTTCAACGTAGGTTCTTTCTATTTTCC ATAAGTATTGGCCAGCTGAGAAATAAAGAGTACAAAGAGAGGAATTTTACAGCTGGGCTGCCGGGGGGTG ACATCACATATCAGTAGGACTGTGATGCCCACCTGAGTCTTAGACCAGCAAGTTTTTATTAAGGGTTTCA AAAGGGGAGGGGGTGTAAGAACAGGGAGTAGGTACAAAGATCACATGCTTCAAAGGGCAAAAAGCAGAAC TACTAATAAGGGTCTAACAAAGATCACAAGGCAAAGGGCAAAAGCAGAACTACTGATAAGGGTCCAACAA AGATCACAAGGCAAAGGGCAAAAGCAGAACTACTGATAAGGGTCTATGTTCAGCAGTGCACGTATTGTCT TGATAAACATCTTAAACAACAGAAAACAGGGTTCGAGAGCAGAGAAGCGGTCTGACCACAAATTTACTAG GGTGAAGTTTTTTCCCCACCCTAGTAAGCCTGAGGGTACTGCAGGAGACGAGGGCGTATCTCAGTCCTTA TCTCAACCTCATAAGACAGACATTCCCAGAGCGGGCGTTTATAGACCTCCCCCCAGGAATGCGTTCCTTT CCCAGGGTATTAATATTAATATTCCTTGCTAGGAAAATAATTTAGCAATATCTCTCCTACTTGCACGTCC GTTTATAGGCTCTCTGCAAGAAGAAAAATATGGCTCTTTTTGTCCGACCCCTCAGGCAGTCAGACCTTAT GGTTGTCTTCCCTTGTTCCCTAAAATCGCTGTTTTTCTGTTGTTTTTCAAGGTGCGCCGATTTCATATTG TTCAAACACAGTTTTACAATCAATTTGTACAGTTAACACAATTATCTCAGTGGTCCTGAGGTGATGTACA TCCTCAGCTTACGAAGATAACAGGATTAAGAGATTAAAGACAGGCATAAGAAATTATAAAAGTATTATTT GGGAACTGATAAATGTCCATATTAAAATGAAATCTTCACAATTTATGTTCCTCTGCCACAGCTCCAGCTG GTCCCTCCATTCGGGGTCCCTGACTTCCCACAACAGTTTTAGGATGGTAGAATTGCAATGCAGGGCAGGT ACTGGAGAGTTAGTTAAATGTTATTGGTTGCAGTTCAGGTTATCTAAGCAGTGGTGGAAGAGGCTAACAT GGTAGGTTGGGGCCAGATTGTGGAGACAGCTTTGAGTGTCACATCTAAGGAAGTTAGATTTTATATACAT AGTGGGGAATGAGTCAGGGTTTTGAAGTATTCTATAAAGTAGATTGGAGGGATCCAAGTCTGGAGGTGAT TAGGCCACTTAAAAAGCTCTTCCAGAAGGTGAGATAAGTGATATGAGGGTCTCGTTTGTAAAGAAGACAG CAGCAATGGCACAAAGTCGACTTGTTTTTTGATCATTTGCATCTTCATTATAAAGGAAGTCCAGAGAATG TATGGCTATGTCACATTTTGGGCAATCTCTCTGGGCTAACTTTCTTTAAAAGGTCAGATTCTCCTGGCAA CAGAGAGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAGGTCAGGTTCTCCTTCCAAGTAGTGATCTGG AGATCTTTTCTTTTTTACTATCTGTATCTGTCTCCACTAATACAGTAGACAATGTCCTCAGTGTTGCCAT TATTTCTACCACCACTGCCAATGTCCATTTTCACATCGTTCCATATATAAATATATGAATATATAAAAAT ATAAAAAATTAATATATATTAATATATAAATATATCTATAAATATATGAATATATATATATATGATGGGG TCCCTCTCCAATCAGGTAGATTGGTGGAATTGAATGCAGTAGAAAGGAGAATAGGGAATGGAAAGGAGGA AGGAAGAAGGACAATGGCCAGATAAATGGCTGACTATTCAAGGCATAGAGAATCATAATATATATAAAGG CATAATGACATCAGAGAACTGAGGCAGGGACCTACGGGTAACACAGTGAATGAAGTTATAAGCAGTGGGA CTTGAGGGAAGGGTGACCAAAACAATCATTAGGGTACTCAAAGAAAAGATGAGAATTCCCATTATATTCA TTTGTTTTTCTCACCCTGTAATGGTTGCTATTTAAGTGATAAGGGTATGAAATAGAAAATGTTTGAGATG ACCGGTTTAGGGGAGTGGTGATAACCGTTGGTGTTAGAGAAGTATGCAGCTACATATGTGGTTGCTTTTG GGACTGTCTCTCAAATGTGTTGAGGAACCACTGAAGTATTGATTTTTAAGCCAAAAATGACATGACAGGG TTTTCTTTATGGAAAGATCACTCCAAATTGCATGTAGATAAGCCTATGAAAAGCAAAGAGATAATTGTCT AGGCAGGAAGTAGTGAGGACTTCTTGCTTTCCTCAAGATACACTGAAGGCAGTTGAAAAGCTCATTTTTA AAAGTCTGGTGAAAACCACTTTGTTCACTTTTGTTTTGTGGGAGATGTGACACCTAGTAATAAAGAGTTA ACAAACCCTTTCCCCTTTTATGAAAATTTGACTTTTCGTTAACTCCCTAGTTTCCCAGAAAACAATGAAA AATTGTGTTTGTTGCTTATGGTAAAAATAACCCAATTGGTAAATTGCATCTGGAGAGGGAGAATTGTAAA TACTTGAAAGGAAGCCATAGCTTTGGACTTCCCTGATTGTAGTGACTCTTATAACTGTCCCTTGTGGAAA TTCTAGAAGTTCTGCCTATGGAGTTGCTACTAGAGATACTGGCTCCTGTGGTACATGGGGCCTTCTGCCC TAGGGTGATTCTCATTCATATCCAGTGTGAATCTTCTCCCTGTACCTGATCTGTGTCGACTCCTGTAAGG ACTCCCACTGAAGAGGAACACCTGATACTTCTTTGTTGGCAATCTGTGTTTTCCTAACAGATACCGTTTT GAGTAAACTGGCACCATGTATGGCCTATGGCTATGGTTGTCTTATAAGTCTGGATGTTTAGTTGAGCCTT AAGAAGACTTTCTGGGCCAGGCCCGGTGGCTCACGTCTGTAATCCCAGCACTTTGGGAGACCAAGGTGGG TGGATCATGAGGTCAGGAGTTCGAGACCAGCCTAACCAACATGGTGAAACCCTGTGTCTACTAAAAATAC AAAAAAATTAGCCAGACATGGTGGCGCGTGCCTGTAATCCCAGCTACTCAGGGGGCTGAGGCAGGAGAAT AGCCTGGGAGGCAGAGGTTGCAGTGAGCCGAGATCGTGCCATTGCACTCCAGCCTGGGCAACAGAGTGAG ACTCCATCTCAAAAAAAAAAAAAAAAGAAGAAGGCTTTCTGTTGGGGGCAATATAACACTTTTGAAAGTT ATTTGAGAGACAAAGTAGATAGTCTCTAAAGGGAATTGGTCTCAGTCTTATTAAGGTCGAAAGACAACAT TTTTTAAACCAGAGAAATTTTTTAATTTCTGAAAATATGGCTAATGCAAGTGTGGAACTTCTCCTTTCTG CAGACTGAGGGTAATAAAGGTGCTATGGTCTGAATGTTTGTGTCCCCTCAAAATTCATGTGTTGAAATCC TAATCCCTGAGGCAGGTATTAGGAGGTGGGGCCTTTCAGAAAGTGATTAGGTAGGTCATGAGGACAAAGT CTTCATGATTAGGATTAGCATCCTATAAAAGAGACTGTAAAGAATGATCAAGCCCTTCTGCCATGTGAGG TCACAGTGCAAAGGTACCATCTATGAGGACAGACACTAAATCTCCAAGTGCCTTGATCTTGGACTTCCTA GCCTCCAAACCTGTGAGAAATAAATGTCTGTTGTTTATAAGCCACCCAGTTTATGGAATTTTTGTTACAG CAGCCTAAATGGACTAAGATAAGAGGCAATGGAGATTTTAACTTTAAGATGTAACCTCTTACAAAGCTCT CTAGTAATACTTCTAGAGAAATAAGTATCTTCATCACTAGAAGCAAATTTGAGATTTTGTAGGGAGAAAA CACAAAGTCAAACAACGTTTTTATCATTGTTGTAGCTTTTTGACCAGTTTTGATTCATCCTGAAAATAGA CATATTGTAACCAAATACACTCATATCCCATTGTGGGAGGCAGTTGTATAAAATTCATTTAGAGACTCTG CTTCTGACAAGATGAAGTAGACATACTTTTCCTTATTCCTCCTGCTAAGTACAACTAAAAACTCTGGACA TGATATATAAGACAAACATTGGAAGACTCTGAAAGGTGGTGAGAAGAAGGTAGACTGGCTAGGGACCTTG AGACCCTAGGAACAACAAGGCAATGAGTTTCCTAAGTTTTCTTTTTGCCTCATATTGCCCAGACTTGAAG CTGAAGAAGCTAGTAACCTGGAAATGCTGATGGACACAGACCAAAAAAAAGCCTAATGAAAGCCTGCTCT CTAGCCACAGGACCTGGAAATGGGCAGCATTTCCTGGCAAGAAAGAAAACTTTTAGACAATAACTGCTCT ACTCCAACTAAACTCCATAGAGAAAACTGTGGCCTCAGTCCCACCCATGCCAGCAAAAGCTGAGTGGGGA GCCTAGATTTTCACCCAACCAGATGTAATGAGCTGCCCAGCCTTCCCCTGCCAAGGTGATGTGGGGGAAG GCTGGGTAGGGAGCCAGGACTTTCATCCTGCCAGGCTTTCCCCTCTTGCCATATCAATGGAGACACATGA GGAACCTAAAATTCCACCCCAACCCAGCAGTGGAAATATTTAAGATAATTATAAGCGGGAGAAGGTACAG GAATGTAAAGAGAGGTGAGGTTTCTGTACCTTGTTCAAACTAATAAAATGATGTCACCAAATGACTGATA AGTTATGTGTGTGTGTGTATACATATACATGGGTATATGTATATACATATATACATGTATGTCTGTATAT ATGTGTATGCGTATATGTATATATATGCCATATGTATATACATATATAGTAACACCTAGAGCCACCATTT AAAAAGCTATACAAAGAGATACATGCAAAAACACTACAGATAAATGAAAATTGAATTTTAAAAAGTTCCA GTGACCCAGAGAAAGGCAAAAAGAAGACAGAAAACATTAAAAAAGGAAGAACAAACAGAAAACAAACATG AATAAAATGGCCAACTTAAGCCCTAACATTTCAGTACTTACATTAGATACAAATACATTAAGAGACAATG ATTGATAGAATGGATTAAAAAACATGCCCCAGCTGTATGCTGTCTACATGAAACTCACTTCCAATATGAT AGAGACAAGGTAAAAGTAAAAGGGTAGAAAAGATAATTCATGCAGATATTCATCAAAAGAAAGCAGGAGT GGCTATCTTGATATCAGATAAAGTAGACTTTGGGGCAAAGAAAATTACCAGACATAAGAAGTACATTATA CAGTGATAAAAGAGTTGTGATTGACCAAGATGACACAGTAATCATAAATATATGTTACTAAACAGCAGAG CTAGGGAACACATGAAGCAAAACTGATATAACTGAAAGGAGAAATAGAAAAATCTAAAATTATAGTTGGA GACCTCAACACTGCTCTTTTTTTTTTTGAGATAGGGTGTCACTCCTGTCACCCAGGCTGGAGTGCAGTGG TGCCGTCTCAGCTCACTACAATCTCTGCTTCCCGGGTTCAAGGGCTCCTCCTACCTCAGCCTCCCAAGGA GCTGGGGCTACATGTGTACACTACCACACCCAGCTAATTTTTCTATTTTTTGTAGAAATGGGGTCTCACT ATCTTGCCTAGGCTGGTCTTGAACTCTGGGGCTCAAGCAATCCAGCCACCTCGGCCTCCCAAAGTGCTGG GATTACAAGCATGAGCCACCAAGCCCAGCCAACGCTCCTCTTTCAACAATTGATAGAACTAGACAGAAAA TTAACAAGGAAACAGAAGAACTCAGCAATACCATCAACAAATAAGATCTAATTAGTATTTATAGAATGTT CTACCGAACAACAACAGAATTCCCCTTTTTTTTTCCAAGTGTCTGTAGAAAATATACCAAAGTAGACCAT GCCCTGGGTCCTAAAGCCAACTTCAGCAAATTTAAAAGAATGGAATGATGTATTCTTCAGCAACAGTGGA ATTAAACTAGAAATCAGTAGCAGAAACATAATAAGAACATCTTCAAGCACTGGGAAAATAAACAGCACAC TTCTAAATAAATAATCCATGGATTACAAAGGAAGTCTTGGGAACTTTTTAAAAATATTTTGAGCTGAGGC CGGGTGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACGAGGTCAGG AGATCGAGACCATCCTGGCTAACATGGTGAAACCCCGTCTCTACTAAAAACACAAAAAATTAGCCAGGCG TGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAAGCAGGAGAATGGCGTGAACCCGGGAGGC GGAGCTTGCAGTGAGCCGAGATCGCTCCACTGCACTCCAGCCTGGGTGACAGAGCTAGACTCTGTCTCAA AACAAAACAAAACAAAACAAATATATATATATATATATATAGAGAGAGAGAGAGAGAGAGAGAGAGAGCT GAATGAAAATGAAAAAGGGATCATAGCTAAACAGTGCAAAGGGGGAAATGTATAGCACTGACTGCATACA TTATAAAAGAGGAAAAGTCTCAAATTAATAACGTAAGCTTCCTCCTAAGAAACTAGAAAATGAAAAGCAA AGTAAACCCAAAGGAAGCAGAAGGAAGGAATTAGAGAAGCAGAAATTAATGAAATTAAGAACAGAAAATC AGTAAAACAGAGCTGGTTCTTTGAAAAGACCAGTAGAATAGACAAACCTGTAGCAAGACTGACAATGAAA ACAAAGAAGCACAAACTACCAATATCAGGAATGAAATAGGGGATACACTACAGACCTTTCTGACATAAGA AAGATAAGGGAATACTAAAAACAACTTTGTATACATAAATTTGACAACTTGAATTGGACCAATTCCTCAT CCAATATGAACTAATATGATGAGTCCTATAACTTAAGGCAATTGAATTTATGATTAACAAACTTCCAAAG AAGATTTGTCCAGACCCAGGTGATTTCACTGGAGAATTCTGCCAAATGTAAAAGAAGAATTAACATCAAT TATACACAACCCCTTCCAGAAAACTGAAGACGGGAGAACACTTCCCAATTCATTTGATAAAGCTAATATT ACCCTGATACCAAAAACAAATGAAGACAGTACAAGAAAACTACAGACCAATATCTCCAATGAATATAAAT GTAAAAACCCTTGACAAAATGTTAGTAAACAGAATTCAACAGTATATATAGAAAGAATTATACACCTTAA CCAAGTGAGGTTTATATCTAGGATGCAAGCCTGGTTCAGTATACAAAAATCAGTCAGTATAATCCACCAT ATTAAGAGGGTAAAGAAGAATCACATGATCATATCAGTTGGTACAGAAAAGGCATTTGACAAAATTCAAC ACTCATTCATTATTTTTTTTAAGTTCAGAAAAAAATAGGAATGGGGGCATTTCTTTAACTTGATAAAGAG CTTCTCTTGAAAAGTTAGAGCTAATATTACACTCAGTGGTGATGCTTTCTCCCTAATTTTGGTAATAAGA CAAGGATGTCTGCTGTTACCACTCTTATTTGACAAAGTGCTGAAAGTTCTAGACAGTGCAGTAAAGCAAG AAAAGGAAATAAGAGACATATAGGTTGGAAAGGAAGAAATCAAACTGTCCTTATTTGAAGATGACATGAT TGTCTACATAGGGAATAATAAGTAATTTACAGAAAACTCCCAGAATTCATAAATGAGTTCAGCAAGGTTG CAGGGTACAAAATAAACATACAGAAATCAATCGCGTTTCTATATACTAGCAAAGAACACACAGGCACCAA AAATTAAAAAATACATTACCATTTACAATTGCCCAATAAAATGAAATACTTAGATATAAATCTAATAAAC ATTTACAGGACACATATGCTGAAAACAGCAATGGCGATGCAAAAAGTCATAGATCTAAATAAATGGAGAG ATTTATTGTGTTCATGATTGGAAGACTCAGCACAGTAAGGATATCAATTCTCCCCAAATCAATATACATG TTTAACACACTCCTTATCAAACTTTTTTAGACAGAGACAGGGTTATTCTAGATTGAAAGGCAAAAAAACT AGAATAACAAACCATTTTGGAAAAGAATAAAGTGGGAAGAATTTTTCTACCTGATTTTAAGACTTACATA GCTACAGTAATCACTACTCTGTGGTATTGGCAGAGAGATAGAACATTGAAACAAAATAGAGAACCCCAAA ATATACCCACACTAGTATGCCCAACAGCTTTTTGACAAAGATGAAAAAGCAGTTCACCAGAGGGAGGATA GCCTCAACAAATGGTGCTGAAGCAATTGGACATCCTTAGGTTAAAAATGAAGCTCTACTCAATTCTCATC CCTTATACCAAAAAAAAAAAAATCCATTTACTGGTGCTTAAAGGGGCCTTAATCCTTTGGTTCACATCCT TGCCTCACTTTTACAGTTTTGTAAGGATTGTATTGTAGGCAGGTAGGACATGCACTAGAAACATCCTTGA TTGTACCTTTAAAGTTTTCTTGGCGGTTGCGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGTCAA GGCGGGTGGACCACAAGTTCAGGAGTTTGAGATCAGCCTGGCCAATGTGGTGAAACCCTTTCTCTACTAA AAATATAAAAATTAGCTGGGCGTGGTGGCTGGTGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGA GAATCGCTTGAAGCTCGGGAGGCGGAGCTTGCAGTGAGCCAAGATTGCGCCACTGCACTCCAGCCTGGGT GACAGAGCGAGACTCCATCTTAAAAAAAAAAAAAGTTTTCTTACAGTAGTTTTCTTAATTAAATTTGGAG AATGACACTTCCCCTCCCCCCGAAAAAAACCTTATTATTTCTATTGTCCACCTTTTGATAAGGCACAGGA GCAAATCTTTGTCACCCAGTAGCCATCCCTGTAAAACCAAAGATAGTTTAGGCATAAAAGACACCTTATT TTTATTGTTCTAAATTTAAAGCATGATAAGGGAAAGACAAAATTAAGGACTATCAGGTGAGACAAGACAT GAGCATAGCATAAGTCTTACTTTTTAAAACAGGAGATACATGTATTTTAAACGATATTTTAGAACCATAC CAATAAAGCAATAATTTTTAGGAACTTAACTTTTTAAAACAGGAACTTTTTCTCAAGATCATGCAAGTGT TCACAAGAGGCACATGGAGTTAACAGACTATTTTGGTGATAAAAATAAAACTGTTATCTGAGCATAGAAT AACTTGATCATTTTCTTAAAAATAAGCCCTTCTTGTTTTTATATCCATTTAACAATTTGTAGCAAAGGAT TTATAAGCCTCTATTTTATCAATAAATTCACTAACGTTGAATATATCTTACTTTTTTTGCCACGTATAGA CTTTTTAAAGTGAATTTTAATATTCTTTATGTGTATGTGTTTAGGCAGATACAGTACATAGTTCTCTTAA TAATAAAGTTAAAGTCTGTAACATTAATTTTAAGATATAATTAATCTCAATAGCATATTAAGTGGTATTT GTTTTCATATGCATGTGTGTGTGTATATATATATAATGTTTTTAAAAGCTAATATACCATTTTATATATT CCCATGCCATTAGACTTAGTATACCATCTGTATATATCTCCATGCCATTTAATATACCTCGACGCAGCAT TTTAAATGTTTTTCATAATATTCTTTTATGCCTGTGTCATACTATCTAACTATTCCTTTGTTAGAGGCAG TTAGTGGTTTAAAAGCAAGGACTTTGGAATCAGATTGCTTGGGCCAGAATTTTTTCTCTGCCACTTACTT TCTCAGCAGTAAAATGGGGATGATAATAATATGTATCTCATGGGCTTGTTGTGAAGATTACATGTATTAG TTTCTTTGAATCTCTTAGAACAGCATCTGGCACATAGTTATTGTGTAAGTGTTGTGATGGATGCCTTTGT ACATAAATCTTTGTCAGAGTAATTATTTCCTTAGAATTTTAGAAAGAGAACATCTTGGTCAAAGAATATG AATTCTTAGGCCAAGGCAGGCGGATCACGAGGTCAAGAGATCGAGACCATCCTGGCCAACATGGTGAAAC TCTGTCTCTACTAAAAATACAAAAATTAGCCGGGCTGGGTGGCGGGCGCCTGTAGTCCCAGCTACTCGGG AGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCGGGTTGCAGTGAGCCAAGATCTCACTGCTGCACT CTAGCCTGGAAACAGAGGGAGACTCTATCTCAAAAAAAAAGAAAAGAATATTAATTCGTGCACCACCACT ACTGGCTGATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGATCAGTCTGTTTCTCGAGCTC CTGACCTCGTGATCCGCCCGTCTCAGCCCCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCACCTGG CCAAGAATATGAATTCTTGAGGACTCTTGATATTCCAGTTGTTTTCCAGAAAGATTGTAAGATAAGGATA TGATAGACTATGGGATAGAATAGTTAAGGTTGTCTAACTTTGGCAAGTACTTGGCATGGCATCTACAACA AAAAATACATGCTGTGCCTAAGATATATGGATTTGAGTATAGCCTGTATAGTGTGAACAGAAGTAATGAT AAAGTCGTTGGTAAAGTACCAATACTAATGTTGGTACTAGAAAGATGTTGAAGAAACAAAACATAAACAG GGTCACTACAAAGCAGATTTTAAAAGATAGTTTTTAGATTTTATCCTTTTTTAAAAAAACTGAGCAACAA ATAATGTTGGGTGCAGCTTGGTTGGAAATATATTATCTCATAATTCCATAGGCTAGAGGTCCGACTTGGG TCTGTCCCACTGTATTGACAGGACTGTGTTCCTTACTCAGAGGCTCTGGGGAAGAATCTGCATCTAAATC CATTTAGATTGTTCCCTGAATTCAGTTTCTTTCCACTGTCGGACAGGGGTCCCAGCTTCCTTGCTGGCTG TCAGGCGTGGATGGGTATGGTGGGGTGGGAGCAGAGGGCAGCTGCCTTTAACTCCTGGCACATGTGCCCC ATGTCTCAGAGCCAGCACCTGCAGGTTGGCCCCTTCTCACACTTGGAATCTGTCCCACTTCCCTTTATGC CACACTCCTCTTCTACTTTCTTTGCGCGCGCACGCTCGCTCTCTCTCTCTCCTGCTTTTAAGGTCTTGTG TGATTACATTGAATCCACCTCAGTAATCCAGGCTAATCCCATTTTAAAGTCCACTGATGAGTGACCTTAA TTTCCTCTCAGAGTCTCTCACAGCAGCACCTAGGTTAGTGTTTGAGAGAATAAGGAAGGACATCTTTAGA ATTTAGTCCTTGCTTGCACCTCCCTCCAGGGACTGCAGTGCTCCCTCCTGAGACTGAGAACCAGTGCTGG GAGGACAGATCTCCCCCATGAGGCCTGCCAGCTAAAGTCTGTGTGATTGTGTGTGGTCGGGCCTGACAGA TCATACATAAGACTTTGTCCTGCAGGTGGCTTCCTCAAGCAAACATTGTAATCAATAGAGAAGCAGCTAC CACTCATATTAGCTGGGAAAGAAGGATGTTTGTTATTTTGGTAGTGTTCATAGTGCCTTGTTTTAATGTA TACTTAGACCGGAATATGAAGTGGACATGGTCTTGCTGCTTTAAATTTTTTTTTTTTATTTTGGTATCAC ATCATGGCAGCCACAGAGTGACTTTATATATGTTCAACAGGAGAAAACCAAGGCCCAGCTGTGAGTACCA GGCCAGCACTTGGATGTGCAGAGCTACTTTTCTCTTTCTCAGCTGCTTGATAAAATCGAGACCTTTAGGA CTGTAGCATCTGACTGAGAAAAGCAACCCAAATGTTCTAGAAACATGTAACCTGCCTGGCATGTGATTAT AAGCTGCGAATAAAGAATTTAATTATTATATTTATTAAGATCAGTTTTAATAAGATAAAGTAGTTTTTAG GCTAGTTTTGTTTTAAATGAGAATTTTAATGCCTAAAAGAGTATGTTTCATTTACTTAAAATTTAGCAAA AGAGAAAAATATAATTTCCTAATGAGGCTGAATGAACTATATTTGTATTTTATATGATGTGAGTTATATA GGAGAAAGATGGCATGTGGCTCCAAAGTAAGTGGTCAGAATTTTCAGGCCTGTTTTGTCAAGCCATGGGT TTAACAGAAAAAAAAAAAAAATCTGTTAGGAAGCACCAGTGAGGTTCACAGACTTATGGTCTGGAAGGTA CATACCAATGGTAAAGGGAGACCAAAACTTAGAGGCCTTAAACAGTTAATTACTCAGTGTCAGCTTCTCA TCTACAACATGGGGTATGAATATCGACAGTAATACCATATAGAGTTATTACACCTAGTTAAGTCCTAAGT AGAATTATTAATGCTATTAATAATCTTAACTCCATGAATTTACATACCTTCTACCCTTTTCTCAGTCAAG CCTTCTGTTTCCTGATAAGTAAGTTGAATTTCCCAAAGGTGTTAGCAACAGTAACTTTTTACCCTTTTAG TTATTTAGGAGTCTAGGATCTTGTGAGTAACTCTTTGCTAATTTGCGTGGTCACCAGTAAATGGTTCTAG AAGGGCATTTATGCCTTCATTCAACAAATATTGTAGTGATCAACCTCTTTATGTGTAAAATCAGTGTCTT AGTTTGGGTAGCCCCAAAGCAGACTAGAGAGAATGGTGTGGTTTTAAGTTTTTGAGAAGTGGTCACAGAG AGCTCTGCAGAGTTAGGGAGAGAGGGTGATCATAGGTGTATACGAGTGGATTACCACTGTGGGCAACTGA GGTTCAATCCTGCTGGGGATTCTTTGAGGGACTTTGTGGTACCTGCCTCTGAATTGTCCCACCAAGGGAC AGGGATGCCAGGTTTTTTATCGACCATTGGTTGAAGGTCATTCCTGCAGTGGAAACTTTCTGACACTTTG GACTTGCATCACACAGGGGCCTGCAACCAGAAGATACCACTGAGCAGAGAGCCCTTGCAAGTTGTAGGTG GTAGGTTAACAATTGTGTTTGTATCTTGTTACAGAAAGCACAATTAATGTTGGTAATAAATGGTAAAAGT GAAAGATGTTTAATATAAATATTTTTCCATAGGATTTTCTATTGCAGCAGACCATGCTACGAGTGAAGGA TCCTAAGAAGTCACTGGATTTTTATACTAGAGTTCTTGGAATGACGTAAGTCAAGTACTTATTGGCACCT TAATGTTTAAATATATAGCTTTGCAAATCTAGAGAGTGTTTTCAGACCCATCTTAAAGTTTGTTTCAGAA GTAACAGAAGTTCTTTTGGCCAGGAGTCTGTGATTAGGCCTGGCTGGACAGGGCTTCTCTCGTAAGTTCT TTTTCTTCTCTATCCCAGCCAGCCTGAAAGGGCAAAACAAGACACAAATAGTTGCATTTTCTCCAGTCTG CCTTCTCTGAGCGCTCCCAGCTAAATCCTTAATGTGTTCAGACCCCTTTTGATGTTCTGGCCACTTTTAG CCTCTTGTTTACTTCAGAAAAGTTATAGATAATAAGAACTTACTACTCAGAAAACCAATGGGTTTACTTA AAACTGACCATCTGTTCTATTTTTCTAGGCTGTGTTTTCTTTTGCTCAACAGGTCATATCCACTGATCTT GCAATCCTAAAGCATACTTATTTTTCTAAAGCATGTTTATTTTTCTTTTTTTCTCCAGCTTTACTGAGGT ATATTGAGAAATAATTTTGTCATATTGTTGATTTGTTTCCCTAAGTTATGTGAGCATTTTGCTTTTGAGC ATATAGATACATGAATAATAAAATAATCTTTAAATTTAGTGCCTAGATAACTTCCATTCACATTGAGAGA AAAATTTAAGTAATATATGTCTATATTTAGAAAATTTGACCAGTTCAGAAAAATACAAAATGAAAAGTAA TAGCTTCCCTCCCCAAGTTCTTCTCCCCAGAGATAACTGCTGTCCAGTTTCTTGTGATTTTTTTCTAGAA AAAGGTATTATGAATATATTTATGACATATTTAAAGGACAAAATGAAAACAGATTTATTGAACACTTTTG CCAGGCACTTCAAATGTTATTTTGTTCAGTCTTCACACCAGTCTTAGGAGGTAGCTTTTATCCCCATTTC ACAGACGGAGAAACCAAAGCTTAATGAGATGAAGTTACTAGCTCCAAATCCCACAGTTGGCATATGGCAG GGCTGGAACCTGTATCCATTGTCTGATGGGCTCTAATGTAGACTTCCTGTGCAGAGCCCCCAAATAGGGT ACAAGTTGACAGTAAGCTGGAAGATTTGAACAGCTGAGAAAAGCAAGTTGCAACAGTTTCATTTCCTTCA GTCCCAACTGATTGGTCCATGAGGGTTGTGTAGTCTGCTTTAGTAGGTGCAGAGATTGTTTTTCATGATT GGAGTATTTGAGGTGTTTGATACTTTATTATAAACATGTTAGAGTAAATCTTATTTGTGATAAGTCAATG CAAGGATCTAAGTGGGCCAAGGTCTATTATATAGCAGTGATAATGAAATAAAAGATTGGAAGCAGAACTC TAGAAACTTTCCATTTGCTATATGGCAATAACAGCCATTTGCTCTTATTGATTATGAACAAAGTCATCTT TGAATAATCTAAAGAAAATCATATATGCATTCTCATGCCACCTTACTCCTTGCCAAATAATCCTATACCA TTTAAAGTCATTTAAGGTTCAGGACTTCAGTTATCTTTCTTAAAACCTCAGGATTCATAATTCATTCACT CTCTCTCCCATCAGTCTCTTCTACTGTCTCTTTCCCCTCAGAGAAGCGTAAGTCTTCTTTGTTCCAGAAT ATTTCTTGCCCTCTGCTCCTTCGCCTACCTCCCCATTGTCACTGCCATGCTTGCTACTGTTTTACCTGCT CACCTGCCATTCTCTCTCCCCAGTACAGTGTAATCCAGCTGATGCTTCCCCACTCTGCTGACATTGCTCT CATGGGACCTTTCCATATCTCATGACCTTTTCTTAGTCTTAATACTGTTTGACCTTTCTACAGTATCTGA TACTGTTAGCCACCTTACTGTTGACATTCACGTCTTCTGTGATACTAGTCTGTCCTTCCTCCTTCTTTCT TACCACCTATCCTTAATTTCCTTTCCTAGATGTTTTGGCATAGTAAGAACTCAATAAATGTGTTTATTTA ACTGAATGACATATTTATATATGTGTTTGTATGTGTGTATATATATGAAATAGCAACAAGGTTCTTTATA TTTTTCAGTACAAATAAACACAGTTCTCTTTTGGAGATAGCCGTTTCTATTTATTAACAAGTACCATAAT TTCAGCTAAATGTTACTATATTTACAGAATTGATGAATTACAGAAGTTTTCATTTTTGTATTTCAAATAT TTACAGATGCATTTTTCATGATATTTTTTCACTGATTTTTCCTCCTGCTTATTCCATTAAAATAGGCTTA CTACATATAGCTCTTCTTTTTAGTAAAACTTGAATATTAAGTTATGTTGATTATAGTATGAATTAGCCTT TCCTGTTGTTAATGATTCAGGCTTGTTGTTTTTTCATTGCAGGCTAATCCAAAAATGTGATTTTCCCATT ATGAAGTTTTCACTCTACTTCTTGGCTTATGAGGATAAAAATGACATCCCTAAAGAAAAAGATGAAAAAA TAGCCTGGGCGCTCTCCAGAAAAGCTACACTTGAGCTGACACAGTGAGTATGAGTTTCTATATTTATATA TATTATAGATTTTTTAAGGTAGTTTTTAAAAATCTTTTTTGTTTTGTTTACTGACCAGTATAATTCAAAC CAGATCTGCCTATGACTTCACATTTTTAATAATATATTGAAGTGTTTTTCATGCATCTTTTGATCTTTGT ATTGTTCTTGGGCAAATGAGATGTGTTTTTTTTAGAGACAGGCTCTCTGAAGCCTCTAACTTCTAGGTAG TCTTCCTGCCTCAGCCTCCTGAGCACCTTGGACTACACATGTGTGCCACCACACCCAGCTAGTTTTTGTT TGTTTGTTTTTGGTAGAGGCATAGAGGCAAGGTCTCACTATGTTGCCCAGGCTGGTCTCAAACTCCTGGC CTCAAGTGATCCGCCCGCCTCGGCCTCCCAGACTGCTGGGATTATAAGCATGAGCCACCACGCCTGGCCC ATTTGTCTTTTATTTTTATTTATTTATTTATTTATTTTTTGAGACAGAGTCTTGCTCTGTTGCCCAGGCT GGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCTGCCTCCCGGATTCACTCCATTCTCCTGCCTCA GCCTCCCAAGTAGCTGGGACTACAGGCGCCCGCCACTACGCCCAGCTAATTTTTTGTATTTTTTGTAGAG ACGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGTCTGCCTCGGCCGCC CAAAGTGCTGGGATTACAGGCGTGACCCACCACGCCCGGCCTCCATTTGTCTTTTAGATAAGAGAATATA AGACCCTGAAATTGTAAGATATTTGCCTGTTTGTCTCTAACTAATTTTTAGGTACTATAATTAGTCTTTC AGCATCCAAAATTTTGTTCTTTTATTATTTTGCTACATTTTGGATCCAGAAATGTGATATCATGTGTTCC TTTAAAAATTCTTCAAACCATTTTGTAATAATTAACATTCAAATTTGGTATTTTTATAACTTGAGCACTT AAAAATGTAGGCAATTTCTTTACATTGTTTATCTGCATACTTTAAAAGAGATTGATTTCAGAGTGTGTGA TTTCGTGTGTCCCTTGATTCAAAATAAAGCTTTGGAATCAGGCAGGCTTAGATATGAGTCTGTGACTCTA AACAAGTAAGTGGCAGTTTCATCAATAGAATGGAGATGTTCACACCTAGCCCATGGAGCTGTTTTAAGGG TTTAAATGAAATATAAAGTACTTAGCACAATAAATGAGCATTATTATTATTCTTATTATTGTTCTTGTCC AGTACCTGTATTTACTGTCTCTTTAGTCTCGTTAAAATCATACTTTGGCCATTTGTCCTTTCTATAGTTG AAAACTTAATATTTTTGTAGCAGGGGTTAGGCCAATTATGTAAAGTAGCATATAAACGTGGTAAGATTTC AAAGATGTTACTTGCTTTTCAGAATATCTATTCCCTAGGACATTGTAGCTATGTTTTCCTTCCTTTTGTA GCAATTGGGGCACTGAAGATGATGAGACCCAGAGTTACCACAATGGCAATTCAGACCCTCGAGGATTCGG TAAGTTTGCCTGTTTTTATGTGATATATGTAGATTTGTGTGATTTTGTATTATGTATATAATTATGATTT TAATAAACCTAAAACATTAATGTCCTAATTAAGTATGATCAATTTATTAGAGATATGATTATTTTTATTT TCCACAAATAATCTTATTTAGGAGTTGTTTAATTTCAGAGTCTCGATCTAAAATTACACTTACCATCTCA CCATGATTTACTTTTAAGTCTCAGAATTAATTTCCAGTAGACTTTTTTTTTTAAAAAAGCTGTAGTTAAT ACTAATCCCAGTTTCTGCTAGCACATACACTTCTGCCTTGATCTCCAGTCTCTCAATCAAGATGACAGTA TTGCAGGCTTCAGCTGGCTGCTATAGTCAATGCCAACCACAAACCTATTAAGTATTAGTAAATGATTACT GTTTTTTGGTGTCGATTATTCTTAACTGATTAGACTGTATATGAGCTGATATTGATTAATTTTAAATAAT TTATAATTCAAGGCAACTAATTAACTACTTATACCCAGCCCATTAGATCTATATTTGTTCTTTAATGTAT TATAGATTTTGAACCTACCTAAGTCTGTTCCCAAGTGCCTTATGTTTTGAAATAAACAAGTTTTGGAATC TACTTGTGGTACTTGGACACCCTGTTATAATTATTTCTTCCTTCTCTCTGCTTTTTTCGGGGGGTATCAC GTAAGGTCATATTGGAATTGCTGTTCCTGATGTATACAGTGCTTGTAAAAGGTTTGAAGAACTGGGAGTC AAATTTGTGAAGAAACCTGATGATGGTGAGTCTACTACTTACTGTGTTCAGGCCTGTCTTTAGTTGATAT TTACTAACCACCTACAGAGGCCACTGTTGTAGTAAAACCCTTTTGGCTACAAGTAACAGAAGTCTCCACT TCAACCAGAGTTTTAAAAAAGAGAAATGATTGGAAGAATATCTGGGTATTTTAGGGAACTGAAAGACAGC AACTAGGGTGGCTTTCCAAGGCACTAGACACAGGACCTGGACAGCCATCAAAACCCTACGCTTCCTCTCC CACTGCCCGACCCCACCACTTTCTTTCATTGGCCACCAGCTTTCACTATTTCAGTGTATATCTTTCCGCC CAAAAATAAGTTCCTTAAAGTCCATTTTATCTGATGCTCATATAATGACACCAGCTCTCTTTAGTTTATA ATCACATGGTATTTCTTTTTCATCTTTTATAACCTTTGTATGTCCTTAAGTTTTAGGTAGGTTTTTTGAA ATAGCCTACGTATGGATTTTGCTGGGTTTACATGTATTGTTATTATTTTACTTAGATCTCTTTCTGAACT ATTTCAAATTAAAATTGAAATATTAAATATTTCAGAGTCTCAATCTAAACATTTGAAATATTTCACTGTT TAATTTCAATCCTTTTTTAAAAAAATTAAAATACTTAATATCCAGTGCTGGGCGTGGTGGCTCACACCTG TCATCCCAACACTTTGGGAGGCCAAGGCGGGCGGATCACGAGGTCAGGAGATCCAGACCATCTGGGCTAA CATGGTGAAACCCTGTCTCTACCAAAAATAGAAAAAATTAGCCAGGCATGGTGGTGGGCGCCTATAGTCC GCCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGTGGAGGTTGCAGTGAGCCAAGATC GCACCACTGCACTCCAGCCTGGGCGACAGAGTGAGACTCCGTCACAAAAATATATATATATTTAATATCC AAATCTTCTCCCCAATAAGAAAGGAATTTGCTTCACTCTGTCCTCATTGTGTCACTATTACCTAGAGTGG GATAGTATTGATTTTATTTTTTAAAGATAATAATAAATATATCACGGTGTTTGATCACTTTTTCTTCATA TATCTCTTGTAGTGTCTCCTTTGAGACAGGATCTCACTCTCATCCAGGCTGGGGTGCTGCAATGGCACTG TCATAGCTCACTATAGCCTTGAAACTCCTGGGCTCAAACAATCCTCTGCCTCAGCCTCCTCCTAAGTAGC TAGGACCACAGGCACATGCCACCACACCCAGCTAATTGTTTTATTTTTTTGTAGAGATGAGTTCCTGCTA TGTTGCCCAGGTTTGTCTCAAACTCCTGAGCTCAAGCGATTCTTTCACCTTGGCCTCCCAAAGCACTGGG ATTACAGGCGTGAGCCACTATGCCCAGCCTTTTTAGCATCTTTTGGATTTTTCTGTTCTTTTATTTAAAT ACCTCAACCAAAATGGTCTTTAAAGGGGTTTTGTTTTTGTTTTTTGAGACGGAGTTTCGCTCTTGTTGCC CAGGTTGGAGTGCAATGGCACGGTCTTGGCTCACCGCAACCTCTGCCTCCTGGGTTCAAGTGATTCTCTT GCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCATGCACCACCGTGCCTGGCTAATTTTGTATTTTTAGT AGAGACGGGGTTTCTCCATGTTGGTCAGGCTGGTCTCAAAATCCCAACCTCAGGTGATCCGCCTGCCTCA GCCTCCCAAAGTGCTGGGATTACAGCTATGAGCCACCGCACCCAGCCCTTTAAAGGGTTTTTAAGGCAAA ACTTTTGAGATTCTGTGTAACTGAGGATGATGCCTTTATGTCTGAAGGACAGTTTTATGGAAAAGCCTAG GTTTAATTTCCTTCAGTCTTGAAAATACTCTTCTATTTTCTTTTTGCATATGATGTTGCTGTTGAAAAAT CTGTCAATTCATGTTCCTTTGTATATTCTTCTGTTTTATTCTAGAAGCTTTTTATATTATTTCTTTGTCA CTGCCTGCATTCTGGGAGATTTCCTCAAACTGGAATACCAATTAGCTAATTTTCTCCCAAATGTATCTGT TCTGATATTTAATTCATCTATTTTGTTCTTAAACACCTGTTATAATTTTGATCTCTAATTTTCGCTTAGT TTGCTTAATATGTTCTTGTTCTTTTTTTCATATTGGTAATATTTCATATTGTTTATTACTTTTTTTTTTT TTTGAGACAGAGTCTTGCTCTGTTGCCCAGGCTAGAGTGCAGTGGTGTGATCATAGCTCACTGCAACCTC AAACTCCTGGGATCAAACAATAATCCACCTCAGCCTCCTGAGTAGCTGGGACTACAGGCAAATGCCACCA TGTATGGCTAATTTTTTATTTTTTGTAGAGACAGGGTCTTACTATGTATCTCAGGCTGGTCTCAAACTCC TGGCCTCAAGTGATCCTTCTGCCTCAGCCTCCCAAAGTATTGGGATTACAGATGTGAACCACCACACCCG GCCGGTCATTACTTTTACATGTCTAAATAGTCCTTGGGTCTGGGCATGGTGGCTCATGCCTGTAATTGCA GCACTTTGGGAGGCCGAGGCAGAGGATTGGGAGGTTCGGGAGGATCACTTGAGGCCAGCAGTTCAAGGCT GCAGTGAGCTATGATTGTGCCATTGCATTCCAGCCTGGGTGACATAGGAAGACCTTGTTTCTACAAAAAG GTTTTTTTTTAAATTATCTGGGCATGGTGGCACATGCCTGTAGTCTGTATGCCTAGCTACTCGGGAGGCT GAGGTGGGAGGATTGCTTGGGCCCAGGAGTTGGAGGCTGCAGTGAGCTATGATCCACTGTACTTCATTTC AGTATAAACGACAGAGCAAGACCCTGTCTCCAGAAAAAAAACAAAAATAGCTCTTGGTCCATTATTCTAA TATTTCTTCTGTTTGAATCTACAGTCCATTGCTTTGGGGGTGTTTTATGGTTATGTTTCTCAAATTATTA TTTTTTGCCTCTGAGCTTTTTTCCCCTGCAACTGTTCGCTATTCTAACACATCAAGCAGTGTGAATAGGA GAATGGCCAGATCCCTGTCCTTAACAACCCACATGATCTCAGGACAATGGGCTGGATAAGCCTAGGCCAG AGATTCCTAGGCACCTAGAAATGAGACTTAAATTTATTTCACCTTCCACAAAACACCTCTTCAGGTTGGA TCTTCCCACTTCATCCCTCAGGGAAGAGTATTAGTAGGAGACACTTCCGATAGTGTTATTCCCTAGCCCT GGGCGTGGAGAGAGGGCTGGGGAGATCATTCGGCCCTACCAGTTTTTCTCAGTTTCTCACAAGCACAAGG CTCCTGCACTGCCCTTGTTTACTGGTAAGGACATCTGAACAAGCGAGAGGGCAGGTGCCGATGCACACAG CAGTGAGGGAGGAGCAAGAGCAAAACTCTGTTCTCTCGCAGCCATTATGCACTGCCTTCTGGTCCAGGCC AGAACTACCACCTCCCACACAGCCCAAGTTAAAACAGTCACCCGGCCCCATCCTCACCCATTCTCCCCAG CTGTCACCAGCCGGGTTTCTTTCTTTCTTTCCTTTTCTTTTCTTTTCTTTTCTTTTCCTTTTCTTTTCCT TCCTTCCTTCCTTCCTCTCTCTCCCTCCCTCCTTCCTTCCTTCTCTCTTTCTCTCTTTCTCTTTCTCTTT CTCTTTCTCTCTTTCTTTCTTTTTCCTGCATTTTCCATCTATGTTCCTCTAGGATTGATCTTGGAGAAAG GAGGCAGAGATAAGAGTCAAACCAATTCAACATAATGGTCCCCAAATAAATTTCTGAGGTCATATTTTTC CATTTAAGCAAACAGCTCTGACATACTAGACTCTCAATCTCAGTTTTGAATTCCTGGGAGAAAGACTCTC GCAGAGCTTGGGTTGCCTAGGATAGTATTTAAAAGGGTTTGTATGACCCAAGCATCTGGGTCTTTTGGTT GTGGGGGTAAGCCATGCTACCAGCTCCCTTCAGCACCTCCCTATTTTCTTTTTCTTCTTTAAAATAAGAC AATTTCTGTAACTACTGAACTGGTAGTGTGGTATCATGAAGGTGAGGCAAATGCCTGATACCTAAAAGAT GCAGCCAGTCCCACAGTTTATTTCAGGAGGGCTGGTATTTGCAATGTGTGCAAGATAACATTTTAGTCAT TATGAAAAGTATGACTTTTCATACTTTTCTGACAATAAGAATTTTTAAAATTTAAAACTGTAAACAAAAT AATGTACTTCATTAAAATGCAAAGTAAATCTTTAATTAATAAAAGTTTTTAAGGCCAGGTGCAGTGGTTT GTGCTTGTAATCCCACCACTTTGGGAGGCAAGGCAGGAGGATTGCTTGAGGCCAGGAGTTTGATAGCAGC CTGGGCAGTACATTGAGATCCCGCCTCTACAAAATCAAAAAATTAGCCAGGCAAGGTGGTGCGTGCCTGT CGCCCCAGCTACTTGGCAGGCTGAGCTCAGGAGGTCAAGCCTGCCTTGGGCCATGATCATCCCATGCACT CCAGCCTGACATTCAGAGCAAGACCTTGTCTCAAAGAAAGAAAAACATTTTTATGGTGTTTTCTTTTTTA GTCTTTTCAATAATGAAAATTTTCATTTTACAGGTAAAATGAAAGGCCTGGCATTTATTCAAGATCCTGA TGGCTACTGGATTGAAATTTTGAATCCTAACAAAATGGCAACCTTAATGTAGTGCTGTGAGAATTCTCCT TTGAGATTTCAGAAGAAAGGAAACAATGTGATTCAAGATATTTACATACCAGAAGCATCTAGGACTGATG GATCACTGTCCCGATTCAAATTATTCTTCAGTCCATTTCCCCTTCCTATTTCAGCTGTTCCTTTTCACCT AACTGTTCAGTCATTCTGGTTTTCAAGCAGTGCTTTATCTCATGTCCTTGAATATAGTTGTGTAACTTTA TTTTTTAGGTAATAATTAGAACAGTTCCCTTCAGAGGCTGCATTTGCCTTCTTCTGCCACCTAAATATTA CTTCCCTTCAAATCTGCCTTTGAATCATCATTTTTAAAAAAAAATTAACATGTTTTTGTTGTAGTTATCT TCTGGGGTTTCAATTCCTCAGAAACAACTTTTTTCACAACGGAAAGGAAAGAACACTAGTGTTCTTTCAG TAAAGTACAAAGTGTTTATTTTACAAAAGAGTAGGTACTCTTGAGAGCAATTCAAATCATGCTGACAAGG ATACTGATAGAAAAAGTGATTTCTTCTTATTATAAAGTACATTTAAAGTTCAAGGACTAACCTTATTTAT TTGGGAAAGGGGAGGAGGAAGGAAATGATATGGTACCCAGACACTGGGCTAGGCTGCAACTTTATCTCAT TTAATACTCCCAGCTGTCATGTGAGAAAGAAAGCAGGCTAGGCATGTGAAATCACTTTCATGGATTATTA ATGGATTTAAGAGGGCATCAATCAGCTCAACTCAAGATTTCATAATCATTTTTAGTATTTAGATTGTGCC TCAAAGTTGTAGTACCTCACAATACCTCCACTGGTTTCCTGTTGTAAAAACCTTCAGTGAGTTTGACCAT TGTGCTCTTGGCTCTTGGGCTGGAGTACCGTGGTGAGGGAGTAAACACTAGAAGTCTTTAGTACAAAACT GCTCTAGGGACACCTGGTGATTCCTACACAAGTGATGTTTATATTTCTCATAAAGAGTCTTCCCTATCCC AAGGTCTTCATGATGCCAGTAGCCATATATGATAAATTATGTTCAGTGATAACTTAGTTATCAGAAATCA GCTCAGTGGTCTTCCCCGCCATGATTCACATTTGATGAGTTTTTAAAAATCAAAGTGATTTTGAAAATCT CTAATGGCTCAGAAAATAAAAACATCCAGTTTGTGGATGACTATATTTAGATTTCTCTAGACTCTAGTGG AAGACCTTTGGAAAGGCCATGCCAACCGTGCTTGTACTGCTAGAAGCACTTTATGTTTCCTTTTTGGGTG AAATGGATTTATGTGAGTGCTTTAAACAAATAGCAATACTTATAGACTGAAATAAAATGAAACTTCAAAT AAGACTATGTTTAATTTGTAAA Download Select all
Length	27252
OMIM ID	138750
HGNC ID	HGNC:4323
Unigene ID	Hs.268849
Ensembl ID	ENSG00000124767
PharmGKB ID	-

mRNA Information

mRNA ID	NM_006708.2
Exon	join(1..206,16203..16285,18663..18803,20302..20369, 21076..21165,25794..27252)
mRNA Sequence	>2739 AGCGGTCTCCCGCCCGCGGCGCCATCGCGCCATTCCTAGTTAAGGCGGCACAGGGCCGAGGCGT AGTGTGGGTGACTCCTCCGTTCCTTGGGTCCCGTCGTCTGTGATACTGCAGCGCAGCCATGGCA GAACCGCAGCCCCCGTCCGGCGGCCTCACGGACGAGGCCGCCCTCAGTTGCTGCTCCGACGCGG ACCCCAGTACCAAGGATTTTCTATTGCAGCAGACCATGCTACGAGTGAAGGATCCTAAGAAGTC ACTGGATTTTTATACTAGAGTTCTTGGAATGACGCTAATCCAAAAATGTGATTTTCCCATTATG AAGTTTTCACTCTACTTCTTGGCTTATGAGGATAAAAATGACATCCCTAAAGAAAAAGATGAAA AAATAGCCTGGGCGCTCTCCAGAAAAGCTACACTTGAGCTGACACACAATTGGGGCACTGAAGA TGATGAGACCCAGAGTTACCACAATGGCAATTCAGACCCTCGAGGATTCGGTCATATTGGAATT GCTGTTCCTGATGTATACAGTGCTTGTAAAAGGTTTGAAGAACTGGGAGTCAAATTTGTGAAGA AACCTGATGATGGTAAAATGAAAGGCCTGGCATTTATTCAAGATCCTGATGGCTACTGGATTGA AATTTTGAATCCTAACAAAATGGCAACCTTAATGTAGTGCTGTGAGAATTCTCCTTTGAGATTT CAGAAGAAAGGAAACAATGTGATTCAAGATATTTACATACCAGAAGCATCTAGGACTGATGGAT CACTGTCCCGATTCAAATTATTCTTCAGTCCATTTCCCCTTCCTATTTCAGCTGTTCCTTTTCA CCTAACTGTTCAGTCATTCTGGTTTTCAAGCAGTGCTTTATCTCATGTCCTTGAATATAGTTGT GTAACTTTATTTTTTAGGTAATAATTAGAACAGTTCCCTTCAGAGGCTGCATTTGCCTTCTTCT GCCACCTAAATATTACTTCCCTTCAAATCTGCCTTTGAATCATCATTTTTAAAAAAAAATTAAC ATGTTTTTGTTGTAGTTATCTTCTGGGGTTTCAATTCCTCAGAAACAACTTTTTTCACAACGGA AAGGAAAGAACACTAGTGTTCTTTCAGTAAAGTACAAAGTGTTTATTTTACAAAAGAGTAGGTA CTCTTGAGAGCAATTCAAATCATGCTGACAAGGATACTGATAGAAAAAGTGATTTCTTCTTATT ATAAAGTACATTTAAAGTTCAAGGACTAACCTTATTTATTTGGGAAAGGGGAGGAGGAAGGAAA TGATATGGTACCCAGACACTGGGCTAGGCTGCAACTTTATCTCATTTAATACTCCCAGCTGTCA TGTGAGAAAGAAAGCAGGCTAGGCATGTGAAATCACTTTCATGGATTATTAATGGATTTAAGAG GGCATCAATCAGCTCAACTCAAGATTTCATAATCATTTTTAGTATTTAGATTGTGCCTCAAAGT TGTAGTACCTCACAATACCTCCACTGGTTTCCTGTTGTAAAAACCTTCAGTGAGTTTGACCATT GTGCTCTTGGCTCTTGGGCTGGAGTACCGTGGTGAGGGAGTAAACACTAGAAGTCTTTAGTACA AAACTGCTCTAGGGACACCTGGTGATTCCTACACAAGTGATGTTTATATTTCTCATAAAGAGTC TTCCCTATCCCAAGGTCTTCATGATGCCAGTAGCCATATATGATAAATTATGTTCAGTGATAAC TTAGTTATCAGAAATCAGCTCAGTGGTCTTCCCCGCCATGATTCACATTTGATGAGTTTTTAAA AATCAAAGTGATTTTGAAAATCTCTAATGGCTCAGAAAATAAAAACATCCAGTTTGTGGATGAC TATATTTAGATTTCTCTAGACTCTAGTGGAAGACCTTTGGAAAGGCCATGCCAACCGTGCTTGT ACTGCTAGAAGCACTTTATGTTTCCTTTTTGGGTGAAATGGATTTATGTGAGTGCTTTAAACAA ATAGCAATACTTATAGACTGAAATAAAATGAAACTTCAAATAAGACTATGTTTAATTTGTAAAA AAAAAAAAAAAAAAAAAAAAAAA Download Select all
Length	2071

CDS Information

Location	join(123..206,16203..16285,18663..18803,20302..20369, 21076..21165,25794..25882)
CDS Sequence	>gi\|118402585:123-677 Homo sapiens glyoxalase I (GLO1), mRNA ATGGCAGAACCGCAGCCCCCGTCCGGCGGCCTCACGGACGAGGCCGCCCTCAGTTGCTGCTCCGACGCGG ACCCCAGTACCAAGGATTTTCTATTGCAGCAGACCATGCTACGAGTGAAGGATCCTAAGAAGTCACTGGA TTTTTATACTAGAGTTCTTGGAATGACGCTAATCCAAAAATGTGATTTTCCCATTATGAAGTTTTCACTC TACTTCTTGGCTTATGAGGATAAAAATGACATCCCTAAAGAAAAAGATGAAAAAATAGCCTGGGCGCTCT CCAGAAAAGCTACACTTGAGCTGACACACAATTGGGGCACTGAAGATGATGAGACCCAGAGTTACCACAA TGGCAATTCAGACCCTCGAGGATTCGGTCATATTGGAATTGCTGTTCCTGATGTATACAGTGCTTGTAAA AGGTTTGAAGAACTGGGAGTCAAATTTGTGAAGAAACCTGATGATGGTAAAATGAAAGGCCTGGCATTTA TTCAAGATCCTGATGGCTACTGGATTGAAATTTTGAATCCTAACAAAATGGCAACCTTAATGTAG Download Select all
CCDS ID	CCDS4837.1

Protein Information

Protein ID	NP_006699.2
Protein Name	Glyoxalase I
Molecular Wt. (Da)	20647
Protein Sequence	>2739 MAEPQPPSGGLTDEAALSCCSDADPSTKDFLLQQTMLRVKDPKKSLDFYTRVLGMTLIQKCDFP IMKFSLYFLAYEDKNDIPKEKDEKIAWALSRKATLELTHNWGTEDDETQSYHNGNSDPRGFGHI GIAVPDVYSACKRFEELGVKFVKKPDDGKMKGLAFIQDPDGYWIEILNPNKMATLM Download Select all
Length	184
Uniprot ID	Q12983
Ensembl Protein ID	ENSP00000357625

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
K	Acetylation	148

Enzyme Information

EC	4.4.1.5
Name	lactoylglutathione lyase methylglyoxalase aldoketomutase ketone-aldehyde mutase glyoxylase I (R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing)
Class	Lyases; Carbon-sulfur lyases; Carbon-sulfur lyases (only sub-subclass identified to date)
Sysname	(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing; glutathione-forming)
Substrate	(R)-S-lactoylglutathione
Product	glutathione [CPD:C00051]; methylglyoxal
Reaction (IUBMB)

PPi Information

(Click to view network : Source STRING) View

No matching records from HPRD source could be found.

Pathway Information

Pathway Name	Pathway ID
Pyruvate metabolism	hsa00620

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd07233	32-175	Glyoxalase_I
cl14632	32-175	Glo_EDI_BRP_like superfamily
PLN03042	20-183	PLN03042
TIGR00068	16-184	glyox_I
pfam00903	32-174	Glyoxalase
PRK10291	36-175	PRK10291
COG0346	32-174	GloA
cd06587	34-174	Glo_EDI_BRP_like
pfam12681	37-174	Glyoxalase_2
cd07245	37-174	Glo_EDI_BRP_like_9
cd08346	37-174	PcpA_N_like
cd08348	37-174	BphC2-C3-RGP6_C_like
cd08358	37-170	Glo_EDI_BRP_like_21
cd07263	34-175	Glo_EDI_BRP_like_16
cd07264	35-177	Glo_EDI_BRP_like_15
cd08349	37-172	BLMA_like
cd07253	37-58	Glo_EDI_BRP_like_2
cd07255	37-60	Glo_EDI_BRP_like_12
cd07241	39-174	Glo_EDI_BRP_like_3
cd07261	34-169	Glo_EDI_BRP_like_11
pfam13669	33-153	Glyoxalase_4
cd07242	37-174	Glo_EDI_BRP_like_6
cd07250	46-154	HPPD_C_like
cd07254	117-174	Glo_EDI_BRP_like_20
cd07249	127-177	MMCE
TIGR03645	122-155	glyox_marine
PLN02367	21-182	PLN02367
PLN02300	38-175	PLN02300
PLN02300	3-170	PLN02300
TIGR03213	26-73	23dbph12diox
TIGR03211	37-100	catechol_2_3

Ontology Information

HPRD ID	4482
Molecular Class	Enzyme: Lyase
Molecular Function	Molecular function unknown (GO:0005554)
Biological Process	Apoptosis (GO:0006915)

SNP Information

View SNP Geneview Report

Drug Information

Uniprot ID DrugBank ID Name Type
Q04760 DB00143 Glutathione SmallMoleculeDrug
Q04760 DB00328 Indomethacin SmallMoleculeDrug

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

Uniprot ID	DrugBank ID	Name	Type
Q04760	DB00143	Glutathione	SmallMoleculeDrug
Q04760	DB00328	Indomethacin	SmallMoleculeDrug

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO