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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| BRD7 | 29117 | bromodomain containing 7  | 16 | CELTIX1, BP75  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23215825    | 2013 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Real time RT-PCR, Western blotting, immunohistochemistry | Down-regulation | - | BRD7 may serve as a potential prognostic biomarker of human colorectal cancer. BRD7 was down-regulated in colorectal cancer cell lines and cancerous tissues compared with that in normal colon epithelial cells and adjacent noncancerous tissue samples. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants.   |
| Chromosome | 16 |
| Location | 16q12.1 |
| Start | 50319018   |
| End | 50368966   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 49949   |
| OMIM ID |     |
| HGNC ID | HGNC:14310    |
| Unigene ID | Hs.437894    |
| Ensembl ID | ENSG00000166164    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_013263.4 |
|---|---|
| Exon | join(33..241,669..877,14045..14174,14485..14542, 18800..18944,28881..28991,34072..34256,35270..35393, 40223..40298,42576..42683,43084..43219,45269..45380, 46929..46985,48193..48304,48576..48719,48937..49080, 49701..49949)   | mRNA Sequence |    Download   Select all |
| Length | 2330   |
CDS Information
| Location | join(193..241,669..877,14045..14174,14485..14542, 18800..18944,28881..28991,34072..34256,35270..35393, 40223..40298,42576..42683,43084..43219,45269..45380, 46929..46985,48193..48304,48576..48719,48937..49080, 49701..49756) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS10742.1 |    
Protein Information
| Protein ID | NP_001167455.1 |
|---|---|
| Protein Name | bromodomain containing 7 |
| Molecular Wt. (Da) | 74136 |
| Protein Sequence |    Download   Select all |
| Length | 652   |
| Uniprot ID | P13647 |    
| Ensembl Protein ID | ENSP00000252242   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 279;- |
| S | Phosphorylation | 279;- |
| S | Phosphorylation | 622 |
| S | Phosphorylation | 621 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1855 |    DVL1 |    3220 |    NP_004412.2 |    in vitro;in vivo;yeast 2-hybrid |    12941796    |
| 4747 |    NEFL |    1206 |    NP_006149.2 |    yeast 2-hybrid |    15383276    |
| 5783 |    PTPN13 |    2602 |    NP_542416.1 |    in vivo;yeast 2-hybrid |    10526152    |
| 8290 |    HIST3H3 |    4156 |    NP_003484.1 |    in vitro |    12489984    |
| 8332 |    HIST1H2AL |    9103 |    NP_003502.1 |    in vitro |    12489984    |
| 8349 |    HIST2H2BE |    3494 |    NP_003519.1 |    in vitro |    12489984    |
| 8553 |    BHLHE40 |    16050 |    NP_003661.1 |    yeast 2-hybrid |    16169070    |
| 9001 |    HAP1 |    2972 |    NP_003940.3 |    yeast 2-hybrid |    15383276    |
| 11100 |    HNRNPUL1 |    10428 |    NP_008971.2 |    in vitro;in vivo;yeast 2-hybrid |    12489984    |
| 55183 |    RIF1 |    10603 |    NP_060621.3 |    yeast 2-hybrid |    15383276    |
Pathway Information
No matching records could be found.
Structure Information
| PDB ID | 2I7K |
|---|---|
| Resolution | |
| Method | SOLUTION NMR |
| Chains | A   |
| Molecule | Bromodomain-containing protein 7   |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05513 | 135-232  | Bromo_brd7_like |
| cl02556 | 135-232  | Bromodomain superfamily |
| pfam12024 | 286-534  | DUF3512 |
| cl13461 | 286-534  | DUF3512 superfamily |
| smart00297 | 129-235  | BROMO |
| cd04369 | 136-225  | Bromodomain |
| cd05512 | 135-232  | Bromo_brd1_like |
| cd05509 | 135-224  | Bromo_gcn5_like |
| pfam00439 | 140-223  | Bromodomain |
| cd05500 | 145-224  | Bromo_BDF1_2_I |
| cd05507 | 153-235  | Bromo_brd8_like |
| cd05511 | 140-242  | Bromo_TFIID |
| cd05504 | 139-225  | Bromo_Acf1_like |
| cd05499 | 137-224  | Bromo_BDF1_2_II |
| cd05502 | 151-224  | Bromo_tif1_like |
| cd05498 | 141-224  | Bromo_Brdt_II_like |
| cd05497 | 136-224  | Bromo_Brdt_I_like |
| cd05510 | 129-221  | Bromo_SPT7_like |
| cd05529 | 139-224  | Bromo_WDR9_I_like |
| cd05516 | 166-224  | Bromo_SNF2L2 |
| cd05503 | 141-215  | Bromo_BAZ2A_B_like |
| cd05528 | 136-247  | Bromo_AAA |
| cd05519 | 166-224  | Bromo_SNF2 |
| cd05495 | 136-224  | Bromo_cbp_like |
| cd05506 | 142-225  | Bromo_plant1 |
| cd05515 | 166-221  | Bromo_polybromo_V |
| cd05518 | 166-224  | Bromo_polybromo_IV |
| cd05517 | 166-236  | Bromo_polybromo_II |
| cd05505 | 156-213  | Bromo_WSTF_like |
| cd05524 | 166-224  | Bromo_polybromo_I |
| cd05520 | 155-225  | Bromo_polybromo_III |
| cd05508 | 143-235  | Bromo_RACK7 |
| cd05496 | 142-217  | Bromo_WDR9_II |
| cd05522 | 166-224  | Bromo_Rsc1_2_II |
| cd05492 | 165-225  | Bromo_ZMYND11 |
| cd05521 | 166-221  | Bromo_Rsc1_2_I |
| COG5076 | 99-224  | COG5076 |
| COG5076 | 114-237  | COG5076 |
Ontology Information
| HPRD ID | 1015 |    
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Structural molecule activity (GO:0005198) |
| Biological Process | Cell growth and/or maintenance (GO:0008151)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
