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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
BRD7 29117 bromodomain containing 7  16CELTIX1, BP75 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23215825   2013Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : -

Stage : -

Real time RT-PCR, Western blotting, immunohistochemistryDown-regulation-BRD7 may serve as a potential prognostic biomarker of human colorectal cancer.

BRD7 was down-regulated in colorectal cancer cell lines and cancerous tissues compared with that in normal colon epithelial cells and adjacent noncancerous tissue samples.


Gene Details



Chromosome 16 - NC_000016.10 (50319018..50368966, complement)

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Gene Type protein coding
Gene Family
Description This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants.  
Chromosome 16
Location 16q12.1
Start 50319018  
End 50368966  
Strand -  
Gene Sequence

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Length 49949  
OMIM ID    
HGNC ID HGNC:14310   
Unigene ID Hs.437894   
Ensembl ID ENSG00000166164   
PharmGKB ID -   

mRNA Information


mRNA ID NM_013263.4
Exon join(33..241,669..877,14045..14174,14485..14542, 18800..18944,28881..28991,34072..34256,35270..35393, 40223..40298,42576..42683,43084..43219,45269..45380, 46929..46985,48193..48304,48576..48719,48937..49080, 49701..49949)  
mRNA Sequence

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Length 2330  



CDS Information


   
Locationjoin(193..241,669..877,14045..14174,14485..14542, 18800..18944,28881..28991,34072..34256,35270..35393, 40223..40298,42576..42683,43084..43219,45269..45380, 46929..46985,48193..48304,48576..48719,48937..49080, 49701..49756)
CDS Sequence

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CCDS ID CCDS10742.1



Protein Information


      
Protein IDNP_001167455.1
Protein Namebromodomain containing 7
Molecular Wt. (Da)74136
Protein Sequence

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Length 652  
Uniprot IDP13647
Ensembl Protein ID ENSP00000252242  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation279;-
SPhosphorylation279;-
SPhosphorylation622
SPhosphorylation621

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                      
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1855DVL13220NP_004412.2in vitro;in vivo;yeast 2-hybrid12941796   
4747NEFL1206NP_006149.2yeast 2-hybrid15383276   
5783PTPN132602NP_542416.1in vivo;yeast 2-hybrid10526152   
8290HIST3H34156NP_003484.1in vitro12489984   
8332HIST1H2AL9103NP_003502.1in vitro12489984   
8349HIST2H2BE3494NP_003519.1in vitro12489984   
8553BHLHE4016050NP_003661.1yeast 2-hybrid16169070   
9001HAP12972NP_003940.3yeast 2-hybrid15383276   
11100HNRNPUL110428NP_008971.2in vitro;in vivo;yeast 2-hybrid12489984   
55183RIF110603NP_060621.3yeast 2-hybrid15383276   


Pathway Information


No matching records could be found.

Structure Information


PDB ID2I7K
Resolution
MethodSOLUTION NMR
Chains A  
Molecule Bromodomain-containing protein 7  
Model View



Domain Information




ID Location Description
cd05513135-232  Bromo_brd7_like
cl02556135-232  Bromodomain superfamily
pfam12024286-534  DUF3512
cl13461286-534  DUF3512 superfamily
smart00297129-235  BROMO
cd04369136-225  Bromodomain
cd05512135-232  Bromo_brd1_like
cd05509135-224  Bromo_gcn5_like
pfam00439140-223  Bromodomain
cd05500145-224  Bromo_BDF1_2_I
cd05507153-235  Bromo_brd8_like
cd05511140-242  Bromo_TFIID
cd05504139-225  Bromo_Acf1_like
cd05499137-224  Bromo_BDF1_2_II
cd05502151-224  Bromo_tif1_like
cd05498141-224  Bromo_Brdt_II_like
cd05497136-224  Bromo_Brdt_I_like
cd05510129-221  Bromo_SPT7_like
cd05529139-224  Bromo_WDR9_I_like
cd05516166-224  Bromo_SNF2L2
cd05503141-215  Bromo_BAZ2A_B_like
cd05528136-247  Bromo_AAA
cd05519166-224  Bromo_SNF2
cd05495136-224  Bromo_cbp_like
cd05506142-225  Bromo_plant1
cd05515166-221  Bromo_polybromo_V
cd05518166-224  Bromo_polybromo_IV
cd05517166-236  Bromo_polybromo_II
cd05505156-213  Bromo_WSTF_like
cd05524166-224  Bromo_polybromo_I
cd05520155-225  Bromo_polybromo_III
cd05508143-235  Bromo_RACK7
cd05496142-217  Bromo_WDR9_II
cd05522166-224  Bromo_Rsc1_2_II
cd05492165-225  Bromo_ZMYND11
cd05521166-221  Bromo_Rsc1_2_I
COG507699-224  COG5076
COG5076114-237  COG5076


Ontology Information


   
HPRD ID1015
Molecular ClassTranscription factor
Molecular FunctionStructural molecule activity (GO:0005198)
Biological ProcessCell growth and/or maintenance (GO:0008151)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO