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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
BIRC2 329 baculoviral IAP repeat containing 2  11cIAP1, hiap-2, MIHB, RNF48, c-IAP1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
14708638   2003Cell line : HT 29 (mutated p53), HCT 116 (wild-type p53), SW 480, and SW 620 (mutated p53)

Source : ATCC

Sample Type : -

No. of Sample : -

Stage : -

western blotting, immunocytochemistryUp-regulation--


Gene Details



NC_000011.9 (102217913..102249401)

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Gene Type protein coding
Gene Family Baculoviral IAP repeat containing, "RING-type (C3HC4) zinc fingers"
Description The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]  
Chromosome 11
Location 11q22
Start 102217913  
End 102249401  
Strand +  
Gene Sequence

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Length 31489  
OMIM ID 601712   
HGNC ID HGNC:590   
Unigene ID Hs.696238   
Ensembl ID ENSG00000110330   
PharmGKB ID PA25359   

mRNA Information


mRNA ID NM_001166.4
Exon join(1..195,1417..3568,3663..3762,15715..15793, 16487..16535,21125..21367,30315..30569,30676..30717, 30809..31489)  
mRNA Sequence

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Length 3813  



CDS Information


   
Location1453..3309
CDS Sequence

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CCDS ID CCDS58169.1



Protein Information


      
Protein IDNP_001157.1
Protein Namebaculoviral IAP repeat containing 2
Molecular Wt. (Da)69769
Protein Sequence

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Length 618  
Uniprot IDO15151
Ensembl Protein ID ENSP00000356150  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation140
SPhosphorylation157
SPhosphorylation147

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                         
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
836CASP32799NP_004337.2in vitro938   457   111   084   335   
842CASP93756NP_001220.2in vitro;in vivo954   523   511   084   335   
2619GAS1747NP_002039.2in vivo11906213   
2935GSPT1753NP_002085.2in vitro12865429   
4055LTBR2988NP_002333.1in vivo12571250   
7185TRAF13418NP_005649.1in vitro119   075   839   384   571   
51465UBE2J115599NP_057105.2in vitro15861135   


Pathway Information


                                                            
Pathway Name Pathway ID
Apoptosis hsa04210
Focal adhesion hsa04510
Hippo signaling pathway hsa04390
NF-kappa B signaling pathway hsa04064
NOD-like receptor signaling pathway hsa04621
Pathways in cancer hsa05200
Small cell lung cancer hsa05222
TNF signaling pathway hsa04668
Toxoplasmosis hsa05145
Ubiquitin mediated proteolysis hsa04120


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd08329453-544  CARD_BIRC2_BIRC3
cl14633453-544  DD superfamily
cd00022270-336  BIR
cl00035270-336  BIR superfamily
cd00022185-252  BIR
cl00035185-252  BIR superfamily
cd0002249-115  BIR
cl0003549-115  BIR superfamily
cd14394391-437  UBA_BIRC2_3
cl21463391-437  UBA_like_SF superfamily
cd00162570-609  RING
cl17238570-609  RING superfamily
smart00238268-336  BIR
smart00238183-252  BIR
pfam00653272-337  BIR
smart0023845-115  BIR
pfam00653187-251  BIR
pfam00619458-542  CARD
pfam0065349-114  BIR
smart00114453-541  CARD
pfam13920567-612  zf-C3HC4_3
cd01671461-539  CARD
cd14321394-437  UBA_IAPs
cd08325478-539  CARD_CASP1-like
cd14395390-437  UBA_BIRC4_8
cd14396394-437  UBA_XtBIRC7_like
pfam13923571-605  zf-C3HC4_2
cd08330461-530  CARD_ASC_NALP1
smart00184571-605  RING
cd08323459-528  CARD_APAF1
pfam14634571-606  zf-RING_5
pfam13639569-606  zf-RING_2
cd08786461-530  CARD_RIP2_CARD3
PHA02929486-606  PHA02929


Ontology Information


   
HPRD ID2050
Molecular ClassAdapter molecule
Molecular FunctionDNA binding (GO:0003677)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO