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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| BIRC2 | 329 | baculoviral IAP repeat containing 2  | 11 | cIAP1, hiap-2, MIHB, RNF48, c-IAP1  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 14708638    | 2003 | Cell line : HT 29 (mutated
p53), HCT 116 (wild-type p53), SW 480, and SW 620
(mutated p53) Source : ATCC Sample Type : - No. of Sample : - Stage : - | western blotting, immunocytochemistry | Up-regulation | - | - |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Baculoviral IAP repeat containing, "RING-type (C3HC4) zinc fingers" |
| Description | The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]   | Chromosome | 11 |
| Location | 11q22 |
| Start | 102217913   |
| End | 102249401   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 31489   |
| OMIM ID | 601712    |
| HGNC ID | HGNC:590    |
| Unigene ID | Hs.696238    |
| Ensembl ID | ENSG00000110330    |
| PharmGKB ID | PA25359    |
mRNA Information
| mRNA ID | NM_001166.4 |
|---|---|
| Exon | join(1..195,1417..3568,3663..3762,15715..15793, 16487..16535,21125..21367,30315..30569,30676..30717, 30809..31489)   | mRNA Sequence |    Download   Select all |
| Length | 3813   |
CDS Information
| Location | 1453..3309 |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS58169.1 |    
Protein Information
| Protein ID | NP_001157.1 |
|---|---|
| Protein Name | baculoviral IAP repeat containing 2 |
| Molecular Wt. (Da) | 69769 |
| Protein Sequence |    Download   Select all |
| Length | 618   |
| Uniprot ID | O15151 |    
| Ensembl Protein ID | ENSP00000356150   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 140 |
| S | Phosphorylation | 157 |
| S | Phosphorylation | 147 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 836 |    CASP3 |    2799 |    NP_004337.2 |    in vitro |    938   457   111   084   335    |
| 842 |    CASP9 |    3756 |    NP_001220.2 |    in vitro;in vivo |    954   523   511   084   335    |
| 2619 |    GAS1 |    747 |    NP_002039.2 |    in vivo |    11906213    |
| 2935 |    GSPT1 |    753 |    NP_002085.2 |    in vitro |    12865429    |
| 4055 |    LTBR |    2988 |    NP_002333.1 |    in vivo |    12571250    |
| 7185 |    TRAF1 |    3418 |    NP_005649.1 |    in vitro |    119   075   839   384   571    |
| 51465 |    UBE2J1 |    15599 |    NP_057105.2 |    in vitro |    15861135    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Apoptosis |    hsa04210 |    
| Focal adhesion |    hsa04510 |    
| Hippo signaling pathway |    hsa04390 |    
| NF-kappa B signaling pathway |    hsa04064 |    
| NOD-like receptor signaling pathway |    hsa04621 |    
| Pathways in cancer |    hsa05200 |    
| Small cell lung cancer |    hsa05222 |    
| TNF signaling pathway |    hsa04668 |    
| Toxoplasmosis |    hsa05145 |    
| Ubiquitin mediated proteolysis |    hsa04120 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd08329 | 453-544  | CARD_BIRC2_BIRC3 |
| cl14633 | 453-544  | DD superfamily |
| cd00022 | 270-336  | BIR |
| cl00035 | 270-336  | BIR superfamily |
| cd00022 | 185-252  | BIR |
| cl00035 | 185-252  | BIR superfamily |
| cd00022 | 49-115  | BIR |
| cl00035 | 49-115  | BIR superfamily |
| cd14394 | 391-437  | UBA_BIRC2_3 |
| cl21463 | 391-437  | UBA_like_SF superfamily |
| cd00162 | 570-609  | RING |
| cl17238 | 570-609  | RING superfamily |
| smart00238 | 268-336  | BIR |
| smart00238 | 183-252  | BIR |
| pfam00653 | 272-337  | BIR |
| smart00238 | 45-115  | BIR |
| pfam00653 | 187-251  | BIR |
| pfam00619 | 458-542  | CARD |
| pfam00653 | 49-114  | BIR |
| smart00114 | 453-541  | CARD |
| pfam13920 | 567-612  | zf-C3HC4_3 |
| cd01671 | 461-539  | CARD |
| cd14321 | 394-437  | UBA_IAPs |
| cd08325 | 478-539  | CARD_CASP1-like |
| cd14395 | 390-437  | UBA_BIRC4_8 |
| cd14396 | 394-437  | UBA_XtBIRC7_like |
| pfam13923 | 571-605  | zf-C3HC4_2 |
| cd08330 | 461-530  | CARD_ASC_NALP1 |
| smart00184 | 571-605  | RING |
| cd08323 | 459-528  | CARD_APAF1 |
| pfam14634 | 571-606  | zf-RING_5 |
| pfam13639 | 569-606  | zf-RING_2 |
| cd08786 | 461-530  | CARD_RIP2_CARD3 |
| PHA02929 | 486-606  | PHA02929 |
Ontology Information
| HPRD ID | 2050 |    
|---|---|
| Molecular Class | Adapter molecule |
| Molecular Function | DNA binding (GO:0003677) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
