Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ARF1 375 ADP-ribosylation factor 1  1- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
15946480   2005Cell line : LoVo,SW480

Source : -

Sample Type : -

No. of Sample : -

Stage : -

cDNA microarray,RT-PCR and Western blottingUp-regulation-CLST has specific gene expression profile. ARF1 is overexpressed in CLST, and may mediate specific biological function of CLST.


Gene Details



NC_000001.10 (228270361..228286913)

View Larger Image
   
Gene Type protein coding
Gene Family ADP-ribosylation factors, "Endogenous ligands"
Description ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]  
Chromosome 1
Location 1q42.13
Start 228270361  
End 228286913  
Strand +  
Gene Sequence

   Download   Select all

Length 16553  
OMIM ID 103180   
HGNC ID HGNC:652   
Unigene ID Hs.286221   
Ensembl ID ENSG00000143761   
PharmGKB ID PA24934   

mRNA Information


mRNA ID NM_001024226.1
Exon join(1..191,14419..14603,14683..14793,14932..15056, 15193..16553)  
mRNA Sequence

   Download   Select all

Length 1986  



CDS Information


   
Location 229..774
CDS Sequence

   Download   Select all

CCDS ID CCDS1565.1



Protein Information


      
Protein IDNP_001019397.1
Protein NameADP-ribosylation factor 1
Molecular Wt. (Da)20566
Protein Sequence

   Download   Select all

Length 181  
Uniprot IDP08493
Ensembl Protein ID ENSP00000228938  



Post-translational Modification Information (Source : HPRD)


Residue Type site
GMyristoylation2
GMyristoylation2
GMyristoylation2
SPhosphorylation147
SPhosphorylation147
SPhosphorylation147
SPhosphorylation147
KAcetylation36
KAcetylation36
KAcetylation36
KAcetylation36
SPhosphorylation62
SPhosphorylation62
SPhosphorylation62
SPhosphorylation62

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                        
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
123PLIN257NP_001113.2in vitro;yeast 2-hybrid15336557   
1937EEF1G11745NP_001395.1yeast 2-hybrid16169070   
3643INSR975NP_000199.2in vitro9197239   
9463PICK116176NP_036539.1yeast 2-hybrid10623590   
50807ASAP15809NP_060952.2in vitro;in vivo16223492   
51729WBP1118293NP_057396.1yeast 2-hybrid16169070   
57584ARHGAP216445NP_065875.3in vitro;yeast 2-hybrid1   579   356   417   347   640   
84273C4orf1412823NP_115689.1yeast 2-hybrid16169070   


Pathway Information


                        
Pathway Name Pathway ID
Endocytosis hsa04144
Legionellosis hsa05134
Phospholipase D signaling pathway hsa04072
Vibrio cholerae infection hsa05110


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0415018-176  Arf1_5_like
cl2145518-176  P-loop_NTPase superfamily
smart001775-179  ARF
PLN002231-180  PLN00223
PTZ001331-181  PTZ00133
pfam000255-177  Arf
cd0087819-176  Arf_Arl
cd0414912-175  Arf6
cd0415119-176  Arl1
cd041533-176  Arl5_Arl8
cd0415515-173  Arl3
cd0415416-175  Arl2
cd0415619-170  ARLTS1
cd0415819-177  ARD1
cd0415218-173  Arl4_Arl7
cd0415720-176  Arl6
cd008791-174  Sar1
cd0416020-174  Arfrp1
cd0416220-162  Arl9_Arfrp2_like
cd0415920-173  Arl10_like
cd0416120-173  Arl2l1_Arl13_like
cd0088223-173  Ras_like_GTPase
COG222911-174  Srp102
cd0410520-143  SR_beta
cd0015418-132  Rab
cd0186319-165  Rab18
cd0186718-132  Rab8_Rab10_Rab13_like
smart0017518-132  RAB
pfam0847719-129  Miro
cd0186919-145  Rab1_Ypt1
cd0412049-129  Rab12
cd0411719-97  Rab15
cd0412318-132  Rab21
cd0411219-130  Rab26
cd0412718-164  Rab27A
cd0411919-177  RJL
cd0411319-130  Rab4
cd0411519-93  Rab33B_Rab33A
cd0411119-132  Rab39
cd0410848-168  Rab36_Rab34
cd0991417-168  RocCOR
cd0186519-145  Rab3
cd0186419-130  Rab19
cd0087719-98  Ran
cd0006646-130  G-alpha
cd0412919-96  Rho2
cd0411019-131  Rab35
cd0186019-132  Rab5_related
cd0411419-130  Rab30
cd0410918-131  Rab28
cd0015720-77  Rho
cd0412221-130  Rab14
cd0412618-130  Rab20
pfam0192619-127  MMR_HSR1
cd0412118-97  Rab40
cd0413919-130  RalA_RalB
cd0087619-132  Ras
cd0186650-131  Rab2
smart0017423-77  RHO
cd0088023-133  Era_like
cd0410618-130  Rab23_like
cd0186119-130  Rab6
cd0189822-143  Obg
cd0412818-73  Spg1
cd0991519-96  Rag
cd0413419-96  Rho3
COG110013-139  Gem1
smart0017815-145  SAR
TIGR0023117-133  small_GTP
PLN0311819-98  PLN03118
pfam0007119-132  Ras
pfam0943915-143  SRPRB
pfam0050342-130  G-alpha
PLN0311019-138  PLN03110
smart0027546-130  G_alpha
pfam0467019-96  Gtr1_RagA
PLN0307119-97  PLN03071
PLN0310855-130  PLN03108
PTZ0013217-97  PTZ00132
smart0017623-97  RAN
PTZ0009961-163  PTZ00099
COG053622-181  Obg


Ontology Information


   
HPRD ID705
Molecular ClassGTPase
Molecular FunctionGlutathione transferase activity (GO:0004364)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091); Xenobiotic metabolism (GO:0006805)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO