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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 15946480    | 2005 | Cell line : LoVo,SW480 Source : - Sample Type : - No. of Sample : - Stage : - | cDNA microarray,RT-PCR and Western blotting | Up-regulation | - | CLST has specific gene expression profile. ARF1 is overexpressed in CLST, and may mediate specific biological function of CLST. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | ADP-ribosylation factors, "Endogenous ligands" |
| Description | ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]   | Chromosome | 1 |
| Location | 1q42.13 |
| Start | 228270361   |
| End | 228286913   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 16553   |
| OMIM ID | 103180    |
| HGNC ID | HGNC:652    |
| Unigene ID | Hs.286221    |
| Ensembl ID | ENSG00000143761    |
| PharmGKB ID | PA24934    |
mRNA Information
| mRNA ID | NM_001024226.1 |
|---|---|
| Exon | join(1..191,14419..14603,14683..14793,14932..15056, 15193..16553)   | mRNA Sequence |    Download   Select all |
| Length | 1986   |
CDS Information
| Location | 229..774 |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS1565.1 |    
Protein Information
| Protein ID | NP_001019397.1 |
|---|---|
| Protein Name | ADP-ribosylation factor 1 |
| Molecular Wt. (Da) | 20566 |
| Protein Sequence |    Download   Select all |
| Length | 181   |
| Uniprot ID | P08493 |    
| Ensembl Protein ID | ENSP00000228938   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| G | Myristoylation | 2 |
| G | Myristoylation | 2 |
| G | Myristoylation | 2 |
| S | Phosphorylation | 147 |
| S | Phosphorylation | 147 |
| S | Phosphorylation | 147 |
| S | Phosphorylation | 147 |
| K | Acetylation | 36 |
| K | Acetylation | 36 |
| K | Acetylation | 36 |
| K | Acetylation | 36 |
| S | Phosphorylation | 62 |
| S | Phosphorylation | 62 |
| S | Phosphorylation | 62 |
| S | Phosphorylation | 62 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 123 |    PLIN2 |    57 |    NP_001113.2 |    in vitro;yeast 2-hybrid |    15336557    |
| 1937 |    EEF1G |    11745 |    NP_001395.1 |    yeast 2-hybrid |    16169070    |
| 3643 |    INSR |    975 |    NP_000199.2 |    in vitro |    9197239    |
| 9463 |    PICK1 |    16176 |    NP_036539.1 |    yeast 2-hybrid |    10623590    |
| 50807 |    ASAP1 |    5809 |    NP_060952.2 |    in vitro;in vivo |    16223492    |
| 51729 |    WBP11 |    18293 |    NP_057396.1 |    yeast 2-hybrid |    16169070    |
| 57584 |    ARHGAP21 |    6445 |    NP_065875.3 |    in vitro;yeast 2-hybrid |    1   579   356   417   347   640    |
| 84273 |    C4orf14 |    12823 |    NP_115689.1 |    yeast 2-hybrid |    16169070    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Endocytosis |    hsa04144 |    
| Legionellosis |    hsa05134 |    
| Phospholipase D signaling pathway |    hsa04072 |    
| Vibrio cholerae infection |    hsa05110 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd04150 | 18-176  | Arf1_5_like |
| cl21455 | 18-176  | P-loop_NTPase superfamily |
| smart00177 | 5-179  | ARF |
| PLN00223 | 1-180  | PLN00223 |
| PTZ00133 | 1-181  | PTZ00133 |
| pfam00025 | 5-177  | Arf |
| cd00878 | 19-176  | Arf_Arl |
| cd04149 | 12-175  | Arf6 |
| cd04151 | 19-176  | Arl1 |
| cd04153 | 3-176  | Arl5_Arl8 |
| cd04155 | 15-173  | Arl3 |
| cd04154 | 16-175  | Arl2 |
| cd04156 | 19-170  | ARLTS1 |
| cd04158 | 19-177  | ARD1 |
| cd04152 | 18-173  | Arl4_Arl7 |
| cd04157 | 20-176  | Arl6 |
| cd00879 | 1-174  | Sar1 |
| cd04160 | 20-174  | Arfrp1 |
| cd04162 | 20-162  | Arl9_Arfrp2_like |
| cd04159 | 20-173  | Arl10_like |
| cd04161 | 20-173  | Arl2l1_Arl13_like |
| cd00882 | 23-173  | Ras_like_GTPase |
| COG2229 | 11-174  | Srp102 |
| cd04105 | 20-143  | SR_beta |
| cd00154 | 18-132  | Rab |
| cd01863 | 19-165  | Rab18 |
| cd01867 | 18-132  | Rab8_Rab10_Rab13_like |
| smart00175 | 18-132  | RAB |
| pfam08477 | 19-129  | Miro |
| cd01869 | 19-145  | Rab1_Ypt1 |
| cd04120 | 49-129  | Rab12 |
| cd04117 | 19-97  | Rab15 |
| cd04123 | 18-132  | Rab21 |
| cd04112 | 19-130  | Rab26 |
| cd04127 | 18-164  | Rab27A |
| cd04119 | 19-177  | RJL |
| cd04113 | 19-130  | Rab4 |
| cd04115 | 19-93  | Rab33B_Rab33A |
| cd04111 | 19-132  | Rab39 |
| cd04108 | 48-168  | Rab36_Rab34 |
| cd09914 | 17-168  | RocCOR |
| cd01865 | 19-145  | Rab3 |
| cd01864 | 19-130  | Rab19 |
| cd00877 | 19-98  | Ran |
| cd00066 | 46-130  | G-alpha |
| cd04129 | 19-96  | Rho2 |
| cd04110 | 19-131  | Rab35 |
| cd01860 | 19-132  | Rab5_related |
| cd04114 | 19-130  | Rab30 |
| cd04109 | 18-131  | Rab28 |
| cd00157 | 20-77  | Rho |
| cd04122 | 21-130  | Rab14 |
| cd04126 | 18-130  | Rab20 |
| pfam01926 | 19-127  | MMR_HSR1 |
| cd04121 | 18-97  | Rab40 |
| cd04139 | 19-130  | RalA_RalB |
| cd00876 | 19-132  | Ras |
| cd01866 | 50-131  | Rab2 |
| smart00174 | 23-77  | RHO |
| cd00880 | 23-133  | Era_like |
| cd04106 | 18-130  | Rab23_like |
| cd01861 | 19-130  | Rab6 |
| cd01898 | 22-143  | Obg |
| cd04128 | 18-73  | Spg1 |
| cd09915 | 19-96  | Rag |
| cd04134 | 19-96  | Rho3 |
| COG1100 | 13-139  | Gem1 |
| smart00178 | 15-145  | SAR |
| TIGR00231 | 17-133  | small_GTP |
| PLN03118 | 19-98  | PLN03118 |
| pfam00071 | 19-132  | Ras |
| pfam09439 | 15-143  | SRPRB |
| pfam00503 | 42-130  | G-alpha |
| PLN03110 | 19-138  | PLN03110 |
| smart00275 | 46-130  | G_alpha |
| pfam04670 | 19-96  | Gtr1_RagA |
| PLN03071 | 19-97  | PLN03071 |
| PLN03108 | 55-130  | PLN03108 |
| PTZ00132 | 17-97  | PTZ00132 |
| smart00176 | 23-97  | RAN |
| PTZ00099 | 61-163  | PTZ00099 |
| COG0536 | 22-181  | Obg |
Ontology Information
| HPRD ID | 705 |    
|---|---|
| Molecular Class | GTPase |
| Molecular Function | Glutathione transferase activity (GO:0004364) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091); Xenobiotic metabolism (GO:0006805)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
