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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
LAMA5 3911 Laminin, alpha 5  20- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20089989   2010Cell line : -

Source : VU University Medical Center, Amsterdam, The Netherlands.

Sample Type : CRC tumor and normal tissue

No. of Sample : -

Stage : -

Biochemical isolation to nano-LC-MS/MS analysis Up-regulation-This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue.


Gene Details



Chromosome: 20; NC_000020.10 (60884121..60942368, complement)

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Gene Type protein coding
Gene Family Laminins
Description Components of the extracellular matrix exert myriad effects on tissues throughout the body. In particular, the laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It is thought that laminins mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha, beta, and gamma chains, with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene, but the full-length nature of one of them has not been determined. [provided by RefSeq, Jul 2008]  
Chromosome 20
Location 20q13.2-q1
Start 62309060  
End 62367320  
Strand -  
Gene Sequence

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Length 58261  
OMIM ID 601033   
HGNC ID HGNC:6485   
Unigene ID Hs.473256    
Ensembl ID ENSG00000130702   
PharmGKB ID -   

mRNA Information


mRNA ID XM_011528819.1
Exon join(5..372,4769..4921,14070..14187,14961..15079, 15242..15412,15520..15617,20293..20408,20521..20639, 20725..20815,21106..21240,21444..21503,28713..28853, 28952..29089,29171..29305,30535..30587,30876..30981, 32052..32104,32195..32300,32700..32799,32979..33135, 33282..33420,33615..33757,33840..33946,34078..34231, 34604..34764,34841..34949,36192..36289,36377..36578, 36707..36833,37405..37544,38068..38183,38266..38477, 38876..39080,39311..39455,39652..39792,39915..40088, 40355..40456,40561..40644,41775..42005,42767..42880, 43117..43241,43465..43545,43651..43865,44563..44663, 44872..45052,45153..45302,46431..46582,46652..46762, 47526..47637,48308..48478,48671..48867,49543..49659, 49822..49976,50298..50439,50548..50650,51  
mRNA Sequence

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Length 11445  



CDS Information


   
Location join(76..372,4769..4921,14070..14187,14961..15079, 15242..15412,15520..15617,20293..20408,20521..20639, 20725..20815,21106..21240,21444..21503,28713..28853, 28952..29089,29171..29305,30535..30587,30876..30981, 32052..32104,32195..32300,32700..32799,32979..33135, 33282..33420,33615..33757,33840..33946,34078..34231, 34604..34764,34841..34949,36192..36289,36377..36578,
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDNP_005551.3
Protein NameLaminin, alpha 5
Molecular Wt. (Da)396313
Protein Sequence

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Length 3695  
Uniprot IDP34810
Ensembl Protein ID ENSP00000250092  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation2715

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                        
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1294COL7A1358NP_000085.1in vitro;in vivo9245798   
1605DAG1546NP_004384.3in vitro10207021   
2199FBLN2630NP_001004019.1in vitro;in vivo9006922   
3915LAMC11030NP_002284.3in vitro11133776   
4059BCAM197NP_005572.2in vitro;in vivo1   224   406   611   133   770   
4224MEP1A2666NP_005579.2in vitro10620696   
55729ATF7IP9811NP_060649.3yeast 2-hybrid15231748   
84280BTBD1017045NP_115696.2yeast 2-hybrid16169070   


Pathway Information


                                                
Pathway Name Pathway ID
Amoebiasis hsa05146
ECM-receptor interaction hsa04512
Focal adhesion hsa04510
Metabolic pathways hsa01100
Pathways in cancer hsa05200
PI3K-Akt signaling pathway hsa04151
Small cell lung cancer hsa05222
Toxoplasmosis hsa05145


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd001103340-3497  LamG
cl228613340-3497  LamG superfamily
cd001103521-3671  LamG
cl228613521-3671  LamG superfamily
cd001102943-3095  LamG
cl228612943-3095  LamG superfamily
cd00055540-583  EGF_Lam
cl22875540-583  EGF_Lam superfamily
cd001103124-3267  LamG
cl228613124-3267  LamG superfamily
cd000551576-1626  EGF_Lam
cl228751576-1626  EGF_Lam superfamily
cd000552069-2115  EGF_Lam
cl228752069-2115  EGF_Lam superfamily
cd00055676-718  EGF_Lam
cl22875676-718  EGF_Lam superfamily
cd000551437-1479  EGF_Lam
cl228751437-1479  EGF_Lam superfamily
cd000551968-2021  EGF_Lam
cl228751968-2021  EGF_Lam superfamily
cd000552022-2068  EGF_Lam
cl228752022-2068  EGF_Lam superfamily
cd000551528-1572  EGF_Lam
cl228751528-1572  EGF_Lam superfamily
cd00055494-543  EGF_Lam
cl22875494-543  EGF_Lam superfamily
cd001102736-2901  LamG
cl228612736-2901  LamG superfamily
cd00055587-627  EGF_Lam
cl22875587-627  EGF_Lam superfamily
cd00055775-827  EGF_Lam
cl22875775-827  EGF_Lam superfamily
cd000551863-1899  EGF_Lam
cl228751863-1899  EGF_Lam superfamily
cd00055828-867  EGF_Lam
cl22875828-867  EGF_Lam superfamily
cd00055428-470  EGF_Lam
cl22875428-470  EGF_Lam superfamily
cd00055299-347  EGF_Lam
cl22875299-347  EGF_Lam superfamily
cd00055631-673  EGF_Lam
cl22875631-673  EGF_Lam superfamily
cd000551912-1967  EGF_Lam
cl228751912-1967  EGF_Lam superfamily
cd00055358-421  EGF_Lam
cl22875358-421  EGF_Lam superfamily
cd000552116-2145  EGF_Lam
cl228752116-2145  EGF_Lam superfamily
smart0013644-298  LamNT
cl0280644-298  Laminin_N superfamily
pfam0005545-298  Laminin_N
smart002811689-1818  LamB
cl025481689-1818  Laminin_B superfamily
pfam060092641-2762  Laminin_II
cl055152641-2762  Laminin_II superfamily
smart002823365-3499  LamG
pfam022103372-3499  Laminin_G_2
pfam000521693-1829  Laminin_B
smart002823545-3672  LamG
pfam022103549-3671  Laminin_G_2
smart002822781-2908  LamG
smart002822965-3099  LamG
pfam000543549-3675  Laminin_G_1
pfam000531438-1486  Laminin_EGF
pfam000531577-1625  Laminin_EGF
pfam022103153-3267  Laminin_G_2
pfam00053587-634  Laminin_EGF
smart001802070-2114  EGF_Lam
pfam000543373-3502  Laminin_G_1
smart00180541-582  EGF_Lam
pfam00053541-589  Laminin_EGF
smart001802023-2067  EGF_Lam
pfam000532070-2117  Laminin_EGF
smart001801577-1625  EGF_Lam
pfam000531528-1579  Laminin_EGF
pfam000532023-2067  Laminin_EGF
smart00180494-541  EGF_Lam
smart001801528-1572  EGF_Lam
smart001801438-1481  EGF_Lam
smart00180677-719  EGF_Lam
pfam00053677-725  Laminin_EGF
pfam00053494-543  Laminin_EGF
smart002823151-3269  LamG
pfam00053632-679  Laminin_EGF
pfam000531969-2019  Laminin_EGF
pfam022102970-3099  Laminin_G_2
smart00180587-629  EGF_Lam
pfam00053776-826  Laminin_EGF
pfam000531913-1966  Laminin_EGF
smart00180776-817  EGF_Lam
pfam000531864-1913  Laminin_EGF
smart001801913-1959  EGF_Lam
pfam022102778-2901  Laminin_G_2
pfam000542782-2906  Laminin_G_1
pfam00053429-473  Laminin_EGF
smart00180429-471  EGF_Lam
smart00180829-867  EGF_Lam
cd134161844-1913  TNFRSF16
cl228551844-1913  TNFRSF superfamily
smart001801969-2013  EGF_Lam
smart00180632-674  EGF_Lam
pfam000542976-3102  Laminin_G_1
cd134061983-2069  TNFRSF4
cl228551983-2069  TNFRSF superfamily
smart001801864-1899  EGF_Lam
pfam00053829-867  Laminin_EGF
pfam00053359-426  Laminin_EGF
pfam079962422-2604  T4SS
cl021932422-2604  VirB5_like superfamily
pfam000532117-2145  Laminin_EGF
COG52782386-2535  CHASE3
cl050002386-2535  CHASE3 superfamily
pfam051302407-2542  FlgN
cl091762407-2542  FlgN superfamily
pfam00053300-348  Laminin_EGF
smart001802117-2145  EGF_Lam
smart00180300-345  EGF_Lam
smart00180387-416  EGF_Lam
cd075962361-2494  BAR_SNX
cl120132361-2494  BAR superfamily
pfam117402348-2415  KfrA_N
cl132262348-2415  KfrA_N superfamily
smart002103555-3622  TSPN
cd001762353-2475  SPEC
cl024882353-2475  SPEC superfamily
pfam051302349-2419  FlgN
cl091762349-2419  FlgN superfamily
cd134161871-2037  TNFRSF16
cl228551871-2037  TNFRSF superfamily
pfam060082188-2451  Laminin_I
pfam040122435-2695  PspA_IM30
TIGR026802210-2624  TIGR02680
pfam135142174-2660  AAA_27
pfam101742215-2734  Cast
pfam121282226-2692  DUF3584
TIGR021682361-2668  SMC_prok_B
pfam121282353-2730  DUF3584
PRK022242174-2614  PRK02224
pfam015762191-2725  Myosin_tail_1
TIGR026802349-2619  TIGR02680
pfam135142171-2733  AAA_27
TIGR021682354-2689  SMC_prok_B
COG11962174-2747  Smc
COG11962384-2723  Smc
TIGR021682228-2653  SMC_prok_B
TIGR021682377-2703  SMC_prok_B
COG32062348-2615  GumC
PRK048632347-2659  mukB
TIGR006182174-2727  sbcc
COG43722424-2720  COG4372
pfam127952347-2545  MscS_porin
COG04192232-2727  SbcC
COG11962193-2461  Smc
PRK048632175-2543  mukB
pfam056222209-2628  HOOK
TIGR026802185-2474  TIGR02680
pfam040942352-2823  DUF390
TIGR021682203-2727  SMC_prok_B
COG43722385-2616  COG4372
COG11962241-2629  Smc
PRK048632383-2758  mukB
TIGR021682412-2703  SMC_prok_B
COG43722347-2549  COG4372
pfam015762355-2727  Myosin_tail_1
pfam071112216-2670  HCR
pfam005292349-2560  HlyD
COG52812244-2687  COG5281
COG43722226-2467  COG4372
pfam101742178-2619  Cast
COG13402347-2616  COG1340
COG15382187-2616  TolC
pfam127952408-2618  MscS_porin
COG49422349-2627  EnvC
pfam071112204-2698  HCR
COG52812177-2730  COG5281
pfam135142374-2720  AAA_27
pfam150702231-2580  GOLGA2L5
COG18422351-2534  PspA
COG18422484-2697  PspA
TIGR021682203-2444  SMC_prok_B
pfam154502220-2667  DUF4631
pfam000382358-2621  Filament
pfam015762177-2672  Myosin_tail_1
COG04972291-2585  RecN
TIGR042112360-2462  SH3_and_anchor
TIGR021692203-2582  SMC_prok_A
PRK048632207-2619  mukB
COG47172175-2613  YhaN
COG32062347-2679  GumC
COG30962348-2659  MukB
pfam071112348-2722  HCR
COG30962353-2860  MukB
PRK039182164-2456  PRK03918
PRK102462175-2655  PRK10246
TIGR006182353-2672  sbcc
COG14632413-2592  MlaD
pfam005292524-2618  HlyD
PRK047782353-2583  PRK04778
pfam093112351-2509  Rab5-bind
pfam150352347-2471  Rootletin
PRK090392396-2565  PRK09039
COG15702352-2463  XseA
TIGR031852208-2489  DNA_S_dndD
TIGR021692369-2701  SMC_prok_A
COG35512374-2462  COG3551
pfam078882347-2615  CALCOCO1
COG15792424-2611  COG1579
TIGR042112349-2427  SH3_and_anchor
TIGR021692395-2703  SMC_prok_A
PRK102462226-2548  PRK10246
PRK112812398-2618  PRK11281
TIGR043202529-2619  Surf_Exclu_PgrA
TIGR021692203-2466  SMC_prok_A
pfam146622208-2418  CCDC155
COG49132460-2725  COG4913
pfam046322364-2558  FUSC
TIGR029172260-2629  PEP_TPR_lipo
pfam040122352-2499  PspA_IM30
COG11962176-2476  Smc
COG52832360-2714  COG5283
COG49422353-2664  EnvC
PRK002862348-2473  xseA
TIGR018442349-2618  type_I_sec_TolC
PRK102462450-2714  PRK10246
pfam155582347-2659  DUF4659
TIGR021682401-2703  SMC_prok_B
TIGR029712347-2494  heterocyst_DevB
pfam156192347-2491  Lebercilin
TIGR021692345-2619  SMC_prok_A
pfam121282207-2498  DUF3584
COG15702419-2573  XseA
TIGR006182215-2537  sbcc


Ontology Information


   
HPRD ID302
Molecular ClassAdhesion molecule
Molecular FunctionProtein serine/threonine kinase activity (GO:0004674)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO