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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20089989    | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis | Up-regulation | - | This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Laminins |
| Description | Components of the extracellular matrix exert myriad effects on tissues throughout the body. In particular, the laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It is thought that laminins mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha, beta, and gamma chains, with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene, but the full-length nature of one of them has not been determined. [provided by RefSeq, Jul 2008]   | Chromosome | 20 |
| Location | 20q13.2-q1 |
| Start | 62309060   |
| End | 62367320   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 58261   |
| OMIM ID | 601033    |
| HGNC ID | HGNC:6485    |
| Unigene ID | Hs.473256     |
| Ensembl ID | ENSG00000130702    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | XM_011528819.1 |
|---|---|
| Exon | join(5..372,4769..4921,14070..14187,14961..15079, 15242..15412,15520..15617,20293..20408,20521..20639, 20725..20815,21106..21240,21444..21503,28713..28853, 28952..29089,29171..29305,30535..30587,30876..30981, 32052..32104,32195..32300,32700..32799,32979..33135, 33282..33420,33615..33757,33840..33946,34078..34231, 34604..34764,34841..34949,36192..36289,36377..36578, 36707..36833,37405..37544,38068..38183,38266..38477, 38876..39080,39311..39455,39652..39792,39915..40088, 40355..40456,40561..40644,41775..42005,42767..42880, 43117..43241,43465..43545,43651..43865,44563..44663, 44872..45052,45153..45302,46431..46582,46652..46762, 47526..47637,48308..48478,48671..48867,49543..49659, 49822..49976,50298..50439,50548..50650,51   | mRNA Sequence |    Download   Select all |
| Length | 11445   |
CDS Information
| Location | join(76..372,4769..4921,14070..14187,14961..15079, 15242..15412,15520..15617,20293..20408,20521..20639, 20725..20815,21106..21240,21444..21503,28713..28853, 28952..29089,29171..29305,30535..30587,30876..30981, 32052..32104,32195..32300,32700..32799,32979..33135, 33282..33420,33615..33757,33840..33946,34078..34231, 34604..34764,34841..34949,36192..36289,36377..36578, |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | - |    
Protein Information
| Protein ID | NP_005551.3 |
|---|---|
| Protein Name | Laminin, alpha 5 |
| Molecular Wt. (Da) | 396313 |
| Protein Sequence |    Download   Select all |
| Length | 3695   |
| Uniprot ID | P34810 |    
| Ensembl Protein ID | ENSP00000250092   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 2715 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1294 |    COL7A1 |    358 |    NP_000085.1 |    in vitro;in vivo |    9245798    |
| 1605 |    DAG1 |    546 |    NP_004384.3 |    in vitro |    10207021    |
| 2199 |    FBLN2 |    630 |    NP_001004019.1 |    in vitro;in vivo |    9006922    |
| 3915 |    LAMC1 |    1030 |    NP_002284.3 |    in vitro |    11133776    |
| 4059 |    BCAM |    197 |    NP_005572.2 |    in vitro;in vivo |    1   224   406   611   133   770    |
| 4224 |    MEP1A |    2666 |    NP_005579.2 |    in vitro |    10620696    |
| 55729 |    ATF7IP |    9811 |    NP_060649.3 |    yeast 2-hybrid |    15231748    |
| 84280 |    BTBD10 |    17045 |    NP_115696.2 |    yeast 2-hybrid |    16169070    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Amoebiasis |    hsa05146 |    
| ECM-receptor interaction |    hsa04512 |    
| Focal adhesion |    hsa04510 |    
| Metabolic pathways |    hsa01100 |    
| Pathways in cancer |    hsa05200 |    
| PI3K-Akt signaling pathway |    hsa04151 |    
| Small cell lung cancer |    hsa05222 |    
| Toxoplasmosis |    hsa05145 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00110 | 3340-3497  | LamG |
| cl22861 | 3340-3497  | LamG superfamily |
| cd00110 | 3521-3671  | LamG |
| cl22861 | 3521-3671  | LamG superfamily |
| cd00110 | 2943-3095  | LamG |
| cl22861 | 2943-3095  | LamG superfamily |
| cd00055 | 540-583  | EGF_Lam |
| cl22875 | 540-583  | EGF_Lam superfamily |
| cd00110 | 3124-3267  | LamG |
| cl22861 | 3124-3267  | LamG superfamily |
| cd00055 | 1576-1626  | EGF_Lam |
| cl22875 | 1576-1626  | EGF_Lam superfamily |
| cd00055 | 2069-2115  | EGF_Lam |
| cl22875 | 2069-2115  | EGF_Lam superfamily |
| cd00055 | 676-718  | EGF_Lam |
| cl22875 | 676-718  | EGF_Lam superfamily |
| cd00055 | 1437-1479  | EGF_Lam |
| cl22875 | 1437-1479  | EGF_Lam superfamily |
| cd00055 | 1968-2021  | EGF_Lam |
| cl22875 | 1968-2021  | EGF_Lam superfamily |
| cd00055 | 2022-2068  | EGF_Lam |
| cl22875 | 2022-2068  | EGF_Lam superfamily |
| cd00055 | 1528-1572  | EGF_Lam |
| cl22875 | 1528-1572  | EGF_Lam superfamily |
| cd00055 | 494-543  | EGF_Lam |
| cl22875 | 494-543  | EGF_Lam superfamily |
| cd00110 | 2736-2901  | LamG |
| cl22861 | 2736-2901  | LamG superfamily |
| cd00055 | 587-627  | EGF_Lam |
| cl22875 | 587-627  | EGF_Lam superfamily |
| cd00055 | 775-827  | EGF_Lam |
| cl22875 | 775-827  | EGF_Lam superfamily |
| cd00055 | 1863-1899  | EGF_Lam |
| cl22875 | 1863-1899  | EGF_Lam superfamily |
| cd00055 | 828-867  | EGF_Lam |
| cl22875 | 828-867  | EGF_Lam superfamily |
| cd00055 | 428-470  | EGF_Lam |
| cl22875 | 428-470  | EGF_Lam superfamily |
| cd00055 | 299-347  | EGF_Lam |
| cl22875 | 299-347  | EGF_Lam superfamily |
| cd00055 | 631-673  | EGF_Lam |
| cl22875 | 631-673  | EGF_Lam superfamily |
| cd00055 | 1912-1967  | EGF_Lam |
| cl22875 | 1912-1967  | EGF_Lam superfamily |
| cd00055 | 358-421  | EGF_Lam |
| cl22875 | 358-421  | EGF_Lam superfamily |
| cd00055 | 2116-2145  | EGF_Lam |
| cl22875 | 2116-2145  | EGF_Lam superfamily |
| smart00136 | 44-298  | LamNT |
| cl02806 | 44-298  | Laminin_N superfamily |
| pfam00055 | 45-298  | Laminin_N |
| smart00281 | 1689-1818  | LamB |
| cl02548 | 1689-1818  | Laminin_B superfamily |
| pfam06009 | 2641-2762  | Laminin_II |
| cl05515 | 2641-2762  | Laminin_II superfamily |
| smart00282 | 3365-3499  | LamG |
| pfam02210 | 3372-3499  | Laminin_G_2 |
| pfam00052 | 1693-1829  | Laminin_B |
| smart00282 | 3545-3672  | LamG |
| pfam02210 | 3549-3671  | Laminin_G_2 |
| smart00282 | 2781-2908  | LamG |
| smart00282 | 2965-3099  | LamG |
| pfam00054 | 3549-3675  | Laminin_G_1 |
| pfam00053 | 1438-1486  | Laminin_EGF |
| pfam00053 | 1577-1625  | Laminin_EGF |
| pfam02210 | 3153-3267  | Laminin_G_2 |
| pfam00053 | 587-634  | Laminin_EGF |
| smart00180 | 2070-2114  | EGF_Lam |
| pfam00054 | 3373-3502  | Laminin_G_1 |
| smart00180 | 541-582  | EGF_Lam |
| pfam00053 | 541-589  | Laminin_EGF |
| smart00180 | 2023-2067  | EGF_Lam |
| pfam00053 | 2070-2117  | Laminin_EGF |
| smart00180 | 1577-1625  | EGF_Lam |
| pfam00053 | 1528-1579  | Laminin_EGF |
| pfam00053 | 2023-2067  | Laminin_EGF |
| smart00180 | 494-541  | EGF_Lam |
| smart00180 | 1528-1572  | EGF_Lam |
| smart00180 | 1438-1481  | EGF_Lam |
| smart00180 | 677-719  | EGF_Lam |
| pfam00053 | 677-725  | Laminin_EGF |
| pfam00053 | 494-543  | Laminin_EGF |
| smart00282 | 3151-3269  | LamG |
| pfam00053 | 632-679  | Laminin_EGF |
| pfam00053 | 1969-2019  | Laminin_EGF |
| pfam02210 | 2970-3099  | Laminin_G_2 |
| smart00180 | 587-629  | EGF_Lam |
| pfam00053 | 776-826  | Laminin_EGF |
| pfam00053 | 1913-1966  | Laminin_EGF |
| smart00180 | 776-817  | EGF_Lam |
| pfam00053 | 1864-1913  | Laminin_EGF |
| smart00180 | 1913-1959  | EGF_Lam |
| pfam02210 | 2778-2901  | Laminin_G_2 |
| pfam00054 | 2782-2906  | Laminin_G_1 |
| pfam00053 | 429-473  | Laminin_EGF |
| smart00180 | 429-471  | EGF_Lam |
| smart00180 | 829-867  | EGF_Lam |
| cd13416 | 1844-1913  | TNFRSF16 |
| cl22855 | 1844-1913  | TNFRSF superfamily |
| smart00180 | 1969-2013  | EGF_Lam |
| smart00180 | 632-674  | EGF_Lam |
| pfam00054 | 2976-3102  | Laminin_G_1 |
| cd13406 | 1983-2069  | TNFRSF4 |
| cl22855 | 1983-2069  | TNFRSF superfamily |
| smart00180 | 1864-1899  | EGF_Lam |
| pfam00053 | 829-867  | Laminin_EGF |
| pfam00053 | 359-426  | Laminin_EGF |
| pfam07996 | 2422-2604  | T4SS |
| cl02193 | 2422-2604  | VirB5_like superfamily |
| pfam00053 | 2117-2145  | Laminin_EGF |
| COG5278 | 2386-2535  | CHASE3 |
| cl05000 | 2386-2535  | CHASE3 superfamily |
| pfam05130 | 2407-2542  | FlgN |
| cl09176 | 2407-2542  | FlgN superfamily |
| pfam00053 | 300-348  | Laminin_EGF |
| smart00180 | 2117-2145  | EGF_Lam |
| smart00180 | 300-345  | EGF_Lam |
| smart00180 | 387-416  | EGF_Lam |
| cd07596 | 2361-2494  | BAR_SNX |
| cl12013 | 2361-2494  | BAR superfamily |
| pfam11740 | 2348-2415  | KfrA_N |
| cl13226 | 2348-2415  | KfrA_N superfamily |
| smart00210 | 3555-3622  | TSPN |
| cd00176 | 2353-2475  | SPEC |
| cl02488 | 2353-2475  | SPEC superfamily |
| pfam05130 | 2349-2419  | FlgN |
| cl09176 | 2349-2419  | FlgN superfamily |
| cd13416 | 1871-2037  | TNFRSF16 |
| cl22855 | 1871-2037  | TNFRSF superfamily |
| pfam06008 | 2188-2451  | Laminin_I |
| pfam04012 | 2435-2695  | PspA_IM30 |
| TIGR02680 | 2210-2624  | TIGR02680 |
| pfam13514 | 2174-2660  | AAA_27 |
| pfam10174 | 2215-2734  | Cast |
| pfam12128 | 2226-2692  | DUF3584 |
| TIGR02168 | 2361-2668  | SMC_prok_B |
| pfam12128 | 2353-2730  | DUF3584 |
| PRK02224 | 2174-2614  | PRK02224 |
| pfam01576 | 2191-2725  | Myosin_tail_1 |
| TIGR02680 | 2349-2619  | TIGR02680 |
| pfam13514 | 2171-2733  | AAA_27 |
| TIGR02168 | 2354-2689  | SMC_prok_B |
| COG1196 | 2174-2747  | Smc |
| COG1196 | 2384-2723  | Smc |
| TIGR02168 | 2228-2653  | SMC_prok_B |
| TIGR02168 | 2377-2703  | SMC_prok_B |
| COG3206 | 2348-2615  | GumC |
| PRK04863 | 2347-2659  | mukB |
| TIGR00618 | 2174-2727  | sbcc |
| COG4372 | 2424-2720  | COG4372 |
| pfam12795 | 2347-2545  | MscS_porin |
| COG0419 | 2232-2727  | SbcC |
| COG1196 | 2193-2461  | Smc |
| PRK04863 | 2175-2543  | mukB |
| pfam05622 | 2209-2628  | HOOK |
| TIGR02680 | 2185-2474  | TIGR02680 |
| pfam04094 | 2352-2823  | DUF390 |
| TIGR02168 | 2203-2727  | SMC_prok_B |
| COG4372 | 2385-2616  | COG4372 |
| COG1196 | 2241-2629  | Smc |
| PRK04863 | 2383-2758  | mukB |
| TIGR02168 | 2412-2703  | SMC_prok_B |
| COG4372 | 2347-2549  | COG4372 |
| pfam01576 | 2355-2727  | Myosin_tail_1 |
| pfam07111 | 2216-2670  | HCR |
| pfam00529 | 2349-2560  | HlyD |
| COG5281 | 2244-2687  | COG5281 |
| COG4372 | 2226-2467  | COG4372 |
| pfam10174 | 2178-2619  | Cast |
| COG1340 | 2347-2616  | COG1340 |
| COG1538 | 2187-2616  | TolC |
| pfam12795 | 2408-2618  | MscS_porin |
| COG4942 | 2349-2627  | EnvC |
| pfam07111 | 2204-2698  | HCR |
| COG5281 | 2177-2730  | COG5281 |
| pfam13514 | 2374-2720  | AAA_27 |
| pfam15070 | 2231-2580  | GOLGA2L5 |
| COG1842 | 2351-2534  | PspA |
| COG1842 | 2484-2697  | PspA |
| TIGR02168 | 2203-2444  | SMC_prok_B |
| pfam15450 | 2220-2667  | DUF4631 |
| pfam00038 | 2358-2621  | Filament |
| pfam01576 | 2177-2672  | Myosin_tail_1 |
| COG0497 | 2291-2585  | RecN |
| TIGR04211 | 2360-2462  | SH3_and_anchor |
| TIGR02169 | 2203-2582  | SMC_prok_A |
| PRK04863 | 2207-2619  | mukB |
| COG4717 | 2175-2613  | YhaN |
| COG3206 | 2347-2679  | GumC |
| COG3096 | 2348-2659  | MukB |
| pfam07111 | 2348-2722  | HCR |
| COG3096 | 2353-2860  | MukB |
| PRK03918 | 2164-2456  | PRK03918 |
| PRK10246 | 2175-2655  | PRK10246 |
| TIGR00618 | 2353-2672  | sbcc |
| COG1463 | 2413-2592  | MlaD |
| pfam00529 | 2524-2618  | HlyD |
| PRK04778 | 2353-2583  | PRK04778 |
| pfam09311 | 2351-2509  | Rab5-bind |
| pfam15035 | 2347-2471  | Rootletin |
| PRK09039 | 2396-2565  | PRK09039 |
| COG1570 | 2352-2463  | XseA |
| TIGR03185 | 2208-2489  | DNA_S_dndD |
| TIGR02169 | 2369-2701  | SMC_prok_A |
| COG3551 | 2374-2462  | COG3551 |
| pfam07888 | 2347-2615  | CALCOCO1 |
| COG1579 | 2424-2611  | COG1579 |
| TIGR04211 | 2349-2427  | SH3_and_anchor |
| TIGR02169 | 2395-2703  | SMC_prok_A |
| PRK10246 | 2226-2548  | PRK10246 |
| PRK11281 | 2398-2618  | PRK11281 |
| TIGR04320 | 2529-2619  | Surf_Exclu_PgrA |
| TIGR02169 | 2203-2466  | SMC_prok_A |
| pfam14662 | 2208-2418  | CCDC155 |
| COG4913 | 2460-2725  | COG4913 |
| pfam04632 | 2364-2558  | FUSC |
| TIGR02917 | 2260-2629  | PEP_TPR_lipo |
| pfam04012 | 2352-2499  | PspA_IM30 |
| COG1196 | 2176-2476  | Smc |
| COG5283 | 2360-2714  | COG5283 |
| COG4942 | 2353-2664  | EnvC |
| PRK00286 | 2348-2473  | xseA |
| TIGR01844 | 2349-2618  | type_I_sec_TolC |
| PRK10246 | 2450-2714  | PRK10246 |
| pfam15558 | 2347-2659  | DUF4659 |
| TIGR02168 | 2401-2703  | SMC_prok_B |
| TIGR02971 | 2347-2494  | heterocyst_DevB |
| pfam15619 | 2347-2491  | Lebercilin |
| TIGR02169 | 2345-2619  | SMC_prok_A |
| pfam12128 | 2207-2498  | DUF3584 |
| COG1570 | 2419-2573  | XseA |
| TIGR00618 | 2215-2537  | sbcc |
Ontology Information
| HPRD ID | 302 |    
|---|---|
| Molecular Class | Adhesion molecule |
| Molecular Function | Protein serine/threonine kinase activity (GO:0004674) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
