CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
LAMB3	3914	Laminin, beta 3	1	LAM5; LAMNB1; BM600-125KDA

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
22930170	2012	Cell line : KM 12C, KM 12SM , HT 29 Source : ATCC Sample Type : - No. of Sample : - Stage : -	Microarray analysis,Real time RT-PCR and Flow cytometry	Up-regulation	-	Gene differentially expressed and analysed bye by Microarray.

Gene Details

Chromosome: 1; NC_000001.10 (209788215..209825820, complement)
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Gene Type	protein coding
Gene Family	Laminins
Description	The product encoded by this gene is a laminin that belongs to a family of basement membrane proteins. This protein is a beta subunit laminin, which together with an alpha and a gamma subunit, forms laminin-5. Mutations in this gene cause epidermolysis bullosa junctional Herlitz type, and generalized atrophic benign epidermolysis bullosa, diseases that are characterized by blistering of the skin. Multiple alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	1
Location	1q32
Start	209614870
End	209652475
Strand	-
Gene Sequence	>gi\|568815597:c209652475-209614870 Homo sapiens chromosome 1, GRCh38.p2 Primary Assembly CAGAGGTGAGGCTGTTGTTTAAAAACCTGGAGCCGGGAGGGGAGACCCCCACATTCAAGAGGAGCTTTCA GGCGATCTGGAGAAAGAACGGCAGAACACACAGCAAGGTATGTTACCTGTCTTTACCTGCCTGGTGCGGG CCGGATGCGGGAGGAGGACTGTATCTCTGGATGCCTGGGGCCTGGTTTCAGGGCCTGATTTATTCCTCTT CCTGGGAGCTCACTCAGGTGAGCTAGGTTAAAATGTCTGCTACAGTTTTGATTTCTTTTTCACATTTGAT AAGCACCTCAGTGGCTTAGAAGAAAGCAGGTTCAGATCCGGGGTTGAGCACAAAAGAGAAGTGAGAAGGG TGGGCTGGCCTGGCTCAGAATGCCTACTTGCAGGGGGATTTTCAGTCAGGGGTGGGAAAGCTGAGAAAGC ACTGGATGAAAGTCAGAAGATGGGTCTCTCTTAGGCCATCGTTAGCTGTGGGACCCCAGGCCACATGTTC CCTCCCTGGGCCCATGACTCTTTTAGGAGAGGGATTGGAAGGAATGATTTTGAAGCATTAGGATCTATAA TTTAAAGATGCCAGAAATGTCCTCAATTTCCCCCCCCGCCCCTGCCTTGCCAAGCCCCCAGCCCTCCACC CCAGCCAAAAGAGTTTGTGGCTGTCATTGGAACAGAGTGAACATCCAATTCAAGGCAGAAGGGTCACTGC ATGAGCAAGGGTGGGGCATGTTTCCACAAGGCAGGCCTGCCTCTGGGACCCCACGGTGGCTTTCGAGCAT CCTTCCCCAGCCTCCTTCAGAATCCCTGCTTTGTGGCCTCCCAGCCCCACCCCTCTTGTCGAGCCCCAGC CCATCATTGAAGACATTTTGGGTTGCTTCCCTTTCAGAAGAAACCCTCACTCACTTGTTAAAGACAGCCA TACATCTCTCCCTGTTGCATCCCAGAATTGTGGGCACAGAGCCTCAAACTCAAAGTGGCCCTGAATGGTA TTGGAGGCCATGCCCGTGACAGGAGAAGGTTTGCCTCCAGGCCGTCAGCCACTCTGACTCATTCACTTTG GGCGGGGCTGGGTTGAGGCTGCTGGTCTAGGCCCTGAGAAAAGCCAGCCCTCTCTCTTGGGGCTGGAACT AGGTCTTGGCCCTTTCTACAGCTTTTCTCCTGCAAAGGGTCCAGCCTTTTCCTGCTCCCCACGTTGTCCT TACGGCTGTGTGGGGTAGGGCAGGGTCCACACTCCTTCCCATCCATTTTAGAGGAGGAAGCTGGAGTCTG GGAAGGGATGGGATTTTCCCAGGGCACCCTGTGAGTCACATGCCACTTGAGACAAGGGTCTAGAGCTCCA GCATTTTCCAAGCTACAAATGTATCTGCTGCTCCAAGTGTCCTAGATCAGGACCCTAGGTAAAGACTTCT GAAAAATACTTGAGTCTAGAAACAGAAAAGAAAAAGGGCTAGTGTGCTCTAGGGGTTTGCACTGTTGTAC CCAGTTTGCTTTGCTGTGTCCTAGGAAAGGTCCTTTCTGGGGATCACCCCATTGGCTGAAGATGAGACCA TTCTTCCTCTTGTGTTTTGGTAAGTACCCCTTCCCATCCTTCCAGGCCCTGTTATATGGCAGGGAGGCAA CAGCCACAGGGAGAAGGAGAGTTTACCAAAGTGTGGGCATCACCTGTCACCTGTAGTCCCTTCAGTTGGG AATACTTGTCTACTGGGGACACCTGTGAGATTTCCCCATTCCTTTGGGCCTTTGGGGAAGAAGTTTCTCT GCCACTCTGGAAAGGCTCCCAAATGTCTTCTTATTCTCAGCCGAGGGTGGTTTGTGGTTTCCTGAGTGCT CTCCACAGTTTCCCATCCTTTCTCAAGCTGGTTCCAGAGCCACTGTGGCTTAAGTTCCTGTTTTCCAGTG AATTGTAGCTGGGCACTCACAAAGTATGGCTGGGGCAGCTTTGAAGATAAAGGAGCAGAATAAATGCAGG CCTTTCTTAATGTTCTGCCAATGGCTCAGCAGTCAGCCCTCCTCTGGGCTGCTGACAGAGGCCACAATGC AGGTGGAAAGAGCTGCGGACCTTGTCATGATGGCCGAGTCTATGTCTCCAGTCTGGTTCTAAAAGCCATA TTTTAGGGTCATCTATGGTTTTTGGTTGCCAGTGTTTCTCCTCTTCTCCTTTTCAAGTTTTGAGTTCTGG AATATGAAATCAACTTTCAAAATATAACAGTATCAATACTGCAATTATTACTGCCAGCAGCGAGTGGAAG CTTGAGTGAGGGAAAGGATATAATCTTGCTAATGTCAGCTTCCCTGAAAGATACTGGGGTGGCCAGTGAG GTCCCTTTTTTTCTGGACTGCTCCATCACACATCCCTGTGATTTCAGCCCTGCCTGGCCTCCTGCATGCC CAACAAGCCTGCTCCCGTGGGGCCTGCTATCCACCTGTTGGGGACCTGCTTGTTGGGAGGACCCGGTTTC TCCGAGCTTCATCTACCTGTGGACTGACCAAGCCTGAGACCTACTGCACCCAGTATGGCGAGGTAGGCCC TACTTCCCAGGACTGGAGGAAGGCGGGATGGGAGGGGTGTGTGAGCTGCCATTTGTCCACTGAATACTTA GAATGTACTTGGTGTAGGCCAAGCCCTGTGTACTACACGGACTGGGGAGTGCAGTAAAAGTATAAGGCCA GATCCTTGCCTCTAAGGAATTTACCTGTTGGTTGGGCAAGAGGAAATGTACTCAGAATTAACTAAATAGC TCATTTCTCTCTTATCTCTCTGAGATGACACGGAGTCTTTTCTCAGTCCTTGGGCATGGGCAGGATAGTC TTTCAAGTCTTGGGAATAGGCAAATAGGCCAAACACTGGCCGTTTATGTGTATGGAGCCTCATGTGTTAT TTGGTGCTGGGATGTGTGGGCCGAACTGTGTTCTTGCCATGGCAGGAACTGAGCTGTGCCATGGTCAGTG AGATAGATGAGGAAGTGACTTGAGCTTATCCAGCAGGGTCAGAGGCTCAGATGTAAGTTGGATCAAATCC AGAAACACGATGCTTTGAGCTATGACTAACATTGCCTGTTAGTCATGGCTTTTACAAACTTTTCTTCTAA TTTGTCTCTGGGTCTTTTTTTATAGGAACTTTGGTTTTCTTTTTGTTTGCCCTCAACAGGGGGGAATCTT TCTTTACCAAAGTTGAAATCACTCAGTGTTTTCTTGTCTACCAGCTGCCTCATTTAGCCATTTTGCTTGA ACAAGGGAATGGATAAGGGAGTGATTTGTCCCGAGTTGCTGTAGCCTTTTGGGGAAAGAGACCGGGGTTA TCTGTCCCCTTTCCAGGCTGCCCTTGTCTTCTGGGCTGTGGAAGGTGGTATCTGATATGGCCTCTGGGCC TCACTGCCCTTCTAGTCCCTGTGTTCTCTTGGCTATTTTAGCACAGATGGTATAGGGAAATGACTGGAGT TGCTGAGCAGAGATGGCTGTGGTTTTTGCATCTCACCCACTTGGATGTGGGGAAGCTCATTTGACAGGGT TGGGTAAGATGGCCAGCCCTAGCCAGGACTCCCTGTGGGTCTAGATTACTCCATGAGCATCAGGGGACCT GGCAGTATTGAGTATTGAATTTTTAAAAAAATAAAAATTAAAAAAATTTTTTTTTTTAGGCAACAGAGTG ATTTTGGCTGTTCCCTCCACCCATAACCTCCAAATTATGAGCCCATATCTAAAAATTTCAGGGAGACCTC TGCCGATTTCCTTTCTCAGGCTGACTTGCATTTTGGGAGGGGAGGCAAGGAGAGGTCAGAGACCCCTATG TTGGGATGTACCCTTGATCCCAGTCCTGTCTGAAAAGTTTCTCCTCCTCCAGGCCTGGGGCTTTTGGCTT AACACTGGCCTGCCCTCTGCCTCTCTGATGCCCCAGGAAGCCAGCTGTCTTCTCTGCTCCTAAGTAGCCC CTTGAGAGCAAAACAGGGTGCTTATAAAACAGAGTCTAGACTTTTGCAACCCTGGGGATGGATAAATCTC AGCTATTTTTCTGCTGTGAAAGCTGAGAAGCACTGGCTGTTTCTTCTTTTTTTTCTAAGGGGGAATAAAT TTATCTAGCCTTTTGGAAAGAATAGAGGATAGCAGGGAGTATCTTTCATGTAGTGTGTAGTTTCAGGTCT GCCACTGACTTGAGGTGTGACCTTGGGCAAGAGATTACCCCTGTGTAAGCCTCGCTGTCCTTTTCTGTAA GTGAGTATTAGATGAGATGGTCTTTAGGGTCCCTCCTTTTCCCTAACATTCTTTGGCAATGAGCCGACTG CTGACAATCAGCATCTCTCCCCCATCTTCCACCTCTCTGTCTTGTTTCATTTCTCTTTCCCTCACTACTA CATGCCTACCCTTTGCAGAGGCCATGGGTTCCAGCAATGAAGATAGATACTAAAGGCATAGAGACTCCCT TTTTGTCCTCTGGACAGATGTACCCTGAACCCCCTCTGGGTGCTCTGGTGGCTGCATGATAAGAATTAGA AATTCAGGTTTTAATTCTGCTGAGTTCTAATTTCAGTTTTTGTTTATTTTGTTATTAAATGATACTAATG GCAATTATAATTCATTAAGCATATCATATGTGTCTTTGGCATCATATTAAGAGTTTTATATAAATTATCT CAAATAATTCTTATAACACCCATGAAGTGGCTCATGTTTTCCCTGTGAGCTATTGGGAGGGTTTGGTTGT GTGCTGGGATCTTAGACTTCCGAGAGAAACATATCGTGTATTGAGTTTTCTGAGTAGTTAGAGATAGGGG GTGTACTGGACAGCCACAGCCAGAAATGAGGCTGGCCGAATGCAATGCTGTATTCCTACTGCCTCTCCCT TCACCCTTCCCTATCACCCCTCTCTAGTAGTTCCCACTCCCACAGACACACTTCCCTGAAGCCAAGGCCT CTGGCTAGTGCCTCTGTTCTATCTCCATGCAGGGATGACATAGCGAGCCCTGAGCCCAGGACCAGATCAT TCTTCTGTGCCACATCCTACTGATGTGCCATGAATGCAAGGACAATGGGGTGGAGATTTATGACCCCTGG ACATTTCTGCCTTGCTCACTCCACTCCCCAACCCAGTTCCAGCCGACTAACAGAGGGCGACTCAGCAGAA TGGAGTTACAGGAGCAGTAGAGACTCCTTTTAGTTCCAAAATTGTCTCTCCTAGTTCCCTTCCTCCAAGT GTGGCTTCCTTTTTGTGGACCAGTCTTAGCCTGTTTGCATGTTACCTCCTCCACCCAATTCTGTCTCAGT TGCTGAATCCCACTGGTCTCAAGGGCTTGCTTCTGTAAATTCCGGGTCCATGTTGCAACCCTTGCAATGG ACATAGGTCTTGGCCAGCTTTGCCTTATGGCATCTTCTCTGCCTCCCCAACTTTGCCCTTCTGGGCTCAT CTGCTTTGATGACCCATTAACTGTCTGTGGTTGGGACAAGGCTGTTCTTTGCCAAAATGGCCTGAAGCTG TAGTCCCATCACCCTGGCCTCTTGCTTTCTTTCTTCCAGCTCCTAGATGGATTCTAGGAAAACTCACTGC ACTATTATTCCCTCAATCTCAAGGCATGGATGAAAATGTCTGTGATTCTGTGATGCTTCCCTGCCCTCAT TTACTTCTGTGCTATCCGTTGGCCTCATTTGAAAAATGGGCTTCAGTGGTTGTCATGAGCACTCTATAAA AGAATGTGTAAAGTGACCACCAGCATAGTGCCTGGCAGATGCAAACTGTTCTATCCAACCCTTCTCTCCT GCCTGCCTCCTGGTGGCTGCATCCACATGCAGAGGCTGCCCCATCTGCAAATCACACTCCTGAGCATTTC TTCCCTGATCAGGACATGCGTTCGCGTACCTCACTAAAATCCACCCATCCCTGGGCTGCCCTCCTCTGTG CCTCCCAAGGTGATCGGTGCCAATCTGACTTAGAGTGAGCTGTTGAAGAATCCACAGGCGGTCATGGTTA GTGAAGTCACCCCAGACTGGGGGTGAGGACTCCCTCATTCTGGTTCTGGTTTTGACACTAATAACAGGGA TGTGGCCTTGTGAAAGTCAGGGCTCTTCACCAAACCACCATTTTTCCATGTGTGAAGTGAAGGAGCTGGG TTAGTCAACCTTTGCCGTTTATTCAGCGCTGGCCACTCAGCTTGCTTCTCAGAGACAGATGGGCTGTGTG TGACCCTGAGAGTCCACTGTCCTCTCTCAGGGCGTGTGAAGGCAGGGGCTGCACCATGCCCTTCGGTCAT CTCTGGGATGACACGCATTCCTCAAGAACCAGCGGATTTGCCGGAAAGCTTTCCATCCCTGATTTCTGCT CCCGACAATGTCTCCTCCAGTGTTGTGTCTGCTCCCCTAAATGCTTTATTTATCCCCCATTCCCTCCCTT TCTGGGGAAAAACTTAATTGCCCAGCTGCCTTAATAACAGTCTTACACAGCGCATTCCTCAGGTTAATTA TCTAAGCCAAACAGCTGTCATTTTTATCTCTTGGAAACAAGCTGAGGAACAGTAGCCAGTTGGAAGTCCC TCCTCTCTAATACGCGCAGGCGCACATGCATGTAAATGCACCCTTATCCCCCTGCCCGCTGACACACACA CTCCAACGACCACTGCCTTTCTTTGTTTGACAGTTGTCTGTTTTCTTGATTTTCAGGAAGGCTAATGTGT AGGCAGAGGATGTGTTCATATATGTACTATGATCCCTGTACTCAACCCACAAGGGATTTTGAGCCCGCCT CTGACCAAAATATCTGCTTTTTTTTTTTTTTTTCCCCTGGGACACAGAGTCTTGCTCTGCCACCCAGGCT GGAGTACAGTGGCATGATCTCGGCTCACAGCAACCTCTGCTTCCCAGGTTCAAGTAATTCTCCTGCCTCA GCTTCCTGAGTAGCTGGGATTACAGGCATATGCCACCATGCCCAGTTGATTTTTGTATTTTTAGTAGAGA CAGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAAGCGATCTGCCCGCCTTGGCCTC CCAAAGTGCTGGATTACAGGTGTGAGCCACTCCCCCCGGCCCAAAATATCTGCTTTTTTGTTTCCCAGAA GCCCTAAGCAGGTCTAAAGCTTCCAGAGCTCTACCTTGGGAGTTTACTGTTTTGGATGAAGCATTACTGA GTTCCTTGTTTAAAACACAGATAGCCTTGAGAAAAGCACCATATCAATCTATGACCTGCCATTCATCCCT CAGCAAGACTATGTTTATCAGAAACTTAGATGTGACTTTTGCAAAGGGACCCACGAGACCCAAAATGAGT CTTGTTTTGAGGGGATAGAAGAAAATGGAAAGGGACATTGTAGGGAAAAATTGCTATCAGAGAGAAGCAA AACTTGGGTTGGTGGAATGTGAGATTCTTGGGTCCTAATTGTTATGGGCTAAGGGGTAGGCCTTGTGAGG TTAAAAGCAGAGAGGAGAAATGTGAAATGGGAAGGCCCGAAGACAAACCTGGATGGCCTCACAACTTTGC TAGCCTGGCTTCTCACTCCATTGCTTCTGGGGTCCAGGCCCACAGAAGCCTCTGGGAACTGTCTTGCAGA CCTACCTTGCTTCTTTTCCTGGCCATCTACCCCCTGCCTGGGTGCCATATGAGGGTCTGTAGCCATTGCC ACTGGCAGGACCTGTAGAGGTCCCCGGCACACTAGCCAACTTTCTGCACTCAGGTCCAGGGGACATCCCT CTTTCTGGAGATGTCTGTGCTGAAGTTGAGGTTGCCTTTCCAGTGGGGTGGAATGAAGCAGAAGAAGGGA GTTTCCTGAAAACCAACTCTGAAATTTTCAGTGATTGCCAAGTGACTGCTATGCTCCTTGAATCAGAACA GCACCAGTATGCTGGGGAGGAAAGAAAAAAAAAAAAGAACAGCACAGGTAGTTTTGGAGTCAGACAGGTG GGACAAGAATCTGTGCTTCATCCCTTGCTAACTTTATGGGCTTGGACACATTTCTTAACTTATCACTTTC CTAATCTGCAAAATGGGGATACCTACCATTTGTAAATGTAGTATAGCTACCTCAGAGATTTTTGAAGGAT GGAATAAGATAATATATGTACACTGCTGAGGACTGAGGCTGGTGCAGTGTAATTTTTGAGTGTGTAGCAT ATATCATCTCTATAATCAGCTTCAGAGAGTGATTTCTGAATTTAGTTAGGATGGAAATAACAGCTGTACT GAGTTAAGGCTTTGGTCAAAATTTCACTTCGTGATAAGGAAAAACACAAAGTTGAAAGTATCTCACATAC GGCTGTCCTCCCACCCAGCGCCTGCACTAGGTGCTGCCTTTTGATCTTCATTGCCAATATGCATTGACAT AGAAATGCTGAGGCTTTTGAACTGCGGTGGGTTCTAATGGAGGCCTGACTGACCATAGGCCTCAAGGATC TCCTTCTCCCTGTCCATATTGCTGGAAAAAGTGTTTCTCCAGGATAGCATCTGGGGAATGTCTTGTTTTT CTCTTGCTTTCTTTGTCTACTTGCTGAGAGTACCTTTAACTTCTGGGCTGATGTGCTAGAGCAGGGAAGA ACTCTAAGAGCATGTTAGAACAAGATGGAACTTTATTATCTCATTCAACCCTTGTATTTCACCAATAGGA ATGTGGAAGTGGAGGAAATGTATTTTCTTGAAGGCAGCTAGATTTTTTTTTTTTTTTTGCTTTTGGCCCT GGCTGGTGGCCATGACCCGATCGTAGCTTCTTAGATGAACTCAGACAGCCCTCTGGCTTCCTCATGGGAG GGAGCTGGGCCATGCATAATCAGAGCCTGTTTTCCTATTCTCCCCCAGAATTAGCTCTGTGTTTTACAAA GGCTCAGAGTTTTTAGTTGTGTGTGCCCTCCTTTTCCACCCATCTCCACCATGATTCAGGCCCCTGCTGG CTCTTGCCCTCTTGCTCCTTTGCCCTCCCCTGGCTCTCTGGGAGGGTTCATCTTCCAGCCAGACTGCTGA GCTTCTAGAAAGCTCTAGGATAAGGGAGAAGGCCTAGCCTTTCCAGCTGGAGAGCAAGTAGGAGCCAAAC TGGCTGGAGGCCTGACAGGCTGAATTGATAATAGTACTGTGTCTCTGAGGTAATGCAGCCAGGAGAATGC CAGCCAAATGACCCCAGAGAGGGAGGCAGCTGCAGCAGAGAGCTGCCATCACTGGGAGAGATGGGGGCAT ATCACATATGAGAGATTCTCACACTGAGAATCACACATGCACACGACGCTTACAAATGTGTGCACCCTAC ATATAAGCATACAAGAATAAAGCAGAAAGGGAAACTGAGACCCAGAGGGGAAGGATAAATTAGCAGCTTG TCTTCATGTGGGCTTCTGCCATAAACTACTCTATTTCAGGCTTCTGTCCTGCTAGCTCGTTGACAGGCAG AGCTACTTAAAATACCTGTCTTGCCTGTTGGCTTAGCCTGTCTCTGAGGATTGAGGTAAATTCCTCCTTC GGCTATGTTACTGTGATAAGCAGCATGCAGTTTGTAAGCCTATGATGCCATCTGATCCTGCCATCAGTGC CTGCACACGTGGACAGAAGGAGAAGAAGGCATGGGTGCCCCAGATTATCCCCATGAAGACTGAGGGAGGA GCAGGGCAATAAACCCTGGCCATTTTTAGTTGGTTTTGTTTTATGATACTATTTGCTCTCCTGAATATAA AAGTTAATATGTATCCAAGGTATAAAAATTTAAACAAGCTGGGTGCAAGTGGCTCACACCTGTAATCTCA GCACTTTGGGAGGCTGGGGTGGGTGGATCATTTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGT GAAATCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCATAGTGGCATGTGCCTGTAATCCTAGCTAC TCGGGAGGCCGAGGCGGGAGAATCGCTTGAGCCTGGGAGGCAGAGGGTTGCAGTGAGCAGAGATCGCGGC ACTGCACTCCAGAGTCTGGGTGAGAGAGTGAGACCCTATCTCAAAAAACAAACAAACAAACAAACAAAAA AGCTTAAACATAATAAAAAATAACAGAGAAGGAAAAAAAGTTATCTATGATTCCACTACCCAGAGATATC AGGTTGAACTGTATGCAGTTGCCATTTTTGTAGGTCAAAATGGGTGAATATCAGCAATTTCATGTTTTCA CTTAATATATTGGTGTATTTCCTTCCAAATACTTTACATTCCTTTAAATGGAAATATATACATATATATA TATTCACACACACACATATATTTGAGATTATAATGTATATGCAAGTGTATGCCCAGCTTTTTTTCATAAA ACATAATATAATCATTTCTCCATGCAATTAAAATTTTTTCTCTAAACAGTGTTTTTAATAGTTACATAAT ATCCTGTCGTTTGGGAGTATCAGGGGCATTTCCGCAGTCTCCAGCTCCTTGTCCCATGGCCCAGGGAAAG AAAGAGGCTTGTTTCTGGCACTCTCTTGACCAGGGAAGGGCTGGACCAGCTCCCAGCAGAGCTGGGGAGA AAGCTCTGGTGACAGGCGGCCGGAAGGCAGCTGGCCCTTGTCTCTCCTCAGGACATGTGCTGAGTGCAGA CAGAGGACGGGAGTGGAAAAGTTTGTTCCTGAGAGGCTGGGAAGAGTATAAAGAAGGGCATGCTCACTGC CAGGGACCAAAATAGGGGTCTGGAGGGGAGTCAGGCTCTAGCAAGGGCCTTCTCTTGCCCAGAAAGGATT ATTTTAAGTGCTCAGGTATTTCAGCCAGCGACAGGTCTCCAGTTTCTGTGGTAACTGAGCTGAGTCAGCT GGAGAAGCCCCGTTTCTTCCCAAAGTGCTCTCTCTGCCTTAGCCTTCCCTGTGATAAGCTTCAAGGTCAG ACCAAGCCCTTCTTGGGGCCTTGGGGCTCGCTGTGTGAGACAGAGACTGCTACCCTTTAGCATACTTCCC TACATCTTTGCCACTCAGCTAGTTTCGAGTGGAAGTGAGAGGATGAAAGAAGGGAGAAAGAGAGAGAGGA GAGGGACCCTTTCTGATGCTAACGTTGGGGATCAGTCAATAGCAAAGTCATGTTGCCTCTTTGTGCCTCA GCATTCCCCTCTGTAAATGGGGCTAATACTACTTATCATGTAGGGTTATTGTGAGATTTAAGTAGGTTAT TGCATTGAAACTACCAAGGACTCCACTGCACATGGTTGTACTCCACCACTTACTACTGATGCTTTATTAC CTACTCACTCTTCCACCCCTCCTTTCAAACTCCCTGAGTGCAGGAAGGGAGTGCCTAGTAATAATGCTAA TGCAAATAGTTTGCCTTTACTGAAAATTTGCTATTCGTTTATTCAAGAAGTATTTAGTGAGGGTGTATTA TGTGCTAGGTATTTTTCTTTCTTTTTTTTTTTTTAAATTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTC TGTTGCCCAGGCTGGAGTGCAGTGGCACGGTCTCAGCTCACTGCAAGCTCTGCCTCCATGGGTCATGCCA TTCTCCTGCCTCAGCCTCCAGAGTAGCTGGGACTACAGGGGCCCGCCACCATGCCCAGTTAATTTTTTTT GTATTTTTAGTAGAGAGGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCG CCCGCCTTGGCCTCCCAAAGCGCTGGGATTATAGGCGTGAGCCACCGCGCCTGGCCTGTGCTAGGTATTT TTCTAAGCACTGGGAATACAGCAGTGAAGGAATGCAAATTCCTGCCCTCATGGAGTATGCATTCTAGAAG AGGGAGGCAGACAATATACAAATAAATAAATAGACAGTAAATATGCAATGTGTCAAGTGGAGATATGTAC TATGAAAAAAATATAACAGGGCAAGGGAATGCACAGTGAGTGGTGGGAGGTGGGGCAATGGGTGCTACTT TATTTTATTTTATTACTTTTTTTTTTTTGAGACAGAGTCTCGCTCTGTCGCCTAGGCTGGAGTGCAGTGG CACGATCTCGTCTCACTGCAACCTCTGCCTCCCAAGTTCAAGCGATTCTCTTGCCCCAGCCTCCCGAGTA GCTGGGACTACAGGCACCTGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACC ATATTGGCCAGGCTGGTCTTGAACTCCTGACCTCGTGATCTGCCTGCCTTGGCCTCCTAAAGTGCTGGGA TTACAGGCGTGAGCCACCACACCCCACCAATGGGTACTACTTTATAAAGGGCTTATGTGCCAGCTGTTAT TTGAGCCTTAAACACCCAAAGAATGAATGTTTAATAAAGCATTTTTGGACATGCCAAGGGCACCTCCAAG CACTAGGAAGGGTGATAGTTCTCTTCATTTGCAGACTGGGTGAGACCTGGAAAGTGGAGTGGGAAGCAGA GGCCCAGGGAACCAAGACACCTGGCTCCCCTCTTTGCTCTCTCCTGTTGCAGGCTGTGCCAGCTTTGGAG AGGGAAGATGGGTGTTGGGCAGGGAGGTTCTATCACTCAAGGCATAGGCCCCATATATCCACTCAGACTC TTTGGGTCGGTTCTTTGTTCTGGTGAGTGGAGGCTTAGAGGAAAGCAGCGGTACAGGGTGTGTGGAGGGA CAGTTTTCCCTACCCAGAAGGACCTGCAGGTCCAGGAGTTTCTTGTCCAAGACTTGCATCTATTTGTGGG TAAATCTGGAGCCCTCTGGACAGTATGGTTTAAGCTGCGCACAGGGTTTGGGATCATGGCTACTCAGAGA AAGCAGATTTTATGTATGTTATATGGGGGAGCTGGGAAAAGGTCGTGTTATCTGTGTGTGTGTGTGTGCG TGTGCGCATGTGCACGCGTGTGCGTGTGTGTGTGTGTGTGTATGTGTATATGTATGCACATAGGCACAAG CTAAAAGAACAAGGGATATATCGCCTCTCTGGCCATGCTCTTTTTCTTGGTGATCCTTGCTCTGCCATGA AACCTATGGGGTTCAGTTCTGGCTCCTGTCTCATTCCAAGAGATAAGCGTAGGCCAGGTTATTGGTGACC TCCCCAGTGAGGCCGGTTGCTCTCCTGTAGGTAGGGAATACCGAACCTGAGAAAGATCCTCACGCCCCAG ATGTCACTGCTGGAAGGCCTTAGAGATCATTTGAATGTCACTAGAATTTTGGGTCCCTGAGGGCAGGGCC TTTGTTTTGTTCCCTATTGTAACTCCAGAGCCCAGAGTAGAGTCTGGCACATAGTATATGCTAAATAAGC ATTTGCTGGGTAAATGAAAAGCTCTAGCTCAATCCCCACTTAATTTATGGAGGAGAAAGTTAAGCCTAGG AAGTAGAGGTGACAGAGCTAGGACTGTAACTCCACATTTCCTTGTCCTCTTTTGGAGTCCTCTCTCTCTG ATCCTTAAAACCCCAGAATTTCCCAGGCTGCCAGGATTAAATGAGGTAAACTATAAAACTTTCCAGCCTG TGCCCAGTATGTCGTAGATGCTCAAATAATATGAATTTCTCCCCCCGCCCCCCTTTTTTTTTTCTCGGCA CTTTTCTCAAGTTTCTCTGCAAGGCAATATCATATACTCAAGTATTTTTTCCCACCTCGTACCTCTTCTC CGTTCACACATCTATTCACCATTCACTTGCTATGTGTTAGGAGGGGCACCAAGGAATTAAAAGATGACCA ATTAAAAGGTGATCAATAGCTGTGTTTTAAGAGATTAACCCTTCAAATTGTATTAATAAAATTAGTGATT CCTAAGGGCAGGATTTCCACAGAGGAGATATGCTGGGATCTCAGGACGCAAGGGGGAATTCTATCAGGAC CCCACCTCTGAGTGTCTGCTATCTCCCTCTCCCACAGTGGCAGATGAAATGCTGCAAGTGTGACTCCAGG CAGCCTCACAACTACTACAGTCACCGAGTAGAGAATGTGGCTTCATCCTCCGGCCCCATGCGCTGGTGGC AGTCACAGAATGGTGAGCATTTGCCATCTACGGGAACTCAAACTGTACAGCCTCCACAGGATAAGACGGA TGGAAGGTGCCCTATAACCCTTTGGGTTTCCCAGGCATTTCTTATGGTGGTGTGACATGGGTGATTGATA AGAAGAATCTTTCTGCCTCATATTTGGGGTCTGTTGGATGTTATGGTAGAAGAATTTATTGGAGGTGAAA GAAAGGGTGTGAGGAGAGAGGAATGTCTTTATTTCCCTCCACTCAGTCTCAGTGGGTGGGCTTGCAGAAT TAAGTTTGGGGAACAAGTCTGTGTGGAACAGACAAGTTGAAGCCCTCCAAAGTATTGAAGACATCAGGTG ATGGTGGGAAGGAAACTTAGCCAAAAACAGATAGGATCTTGAATAGATAATATAAGCAGAAACATACCAC TCCCCACTCCTCTCCAAGAGGGAGTTTGGAAAATCAAGGTTAGAGAGTTTCTGAGTTCCTAGAGCTAGTC TAATCCAGGGCTTCCTTCAGGGCTGGGGAAGTGGACAGTCTCTGGATGACAGTTTCTATTTTTTGTCCTT CCAGATGTGAACCCTGTCTCTCTGCAGCTGGACCTGGACAGGAGATTCCAGCTTCAAGAAGTCATGATGG AGTTCCAGGTGTGCCTCCTGGGGGTGGCAGTGGATAGGAGAGGGGCTCCTGGGCCATGTGGGCGTGGAGC CATGGAGGAGCACAGTGTCCTTGTCTCTCTGGGTTGGGGCAACACTCACCATGAGCCTATATCATGGTGA CAGAAGAGGACTCGCTCCTGGGCTAAAAGTGGCACCTCCTGGCTCCCTGTCTTGGCCGTGCAGTGGTTGC ATATCCTCTTCCTCTCTCATTCTCCACCCTCAACCCATCTAATTAATTCAGCTCTGCCAAGTACCAATTC TACTGGGCCCGGTTGCTTGTTGTACAGTTGTGTATTCTTGGTATACTCTGTTTTAATAACTTTGCATATT AGATTGACTTTAACAAGCAGCCAAGAACTTGCCTATCCAACTAACTGATGGATATTCCTTTGGTGCAGCT CTCTTGGTGGGCAATCTACTCATTCAGCGCCATTACTTCTCAAAGCACTTTCAGATTCTGCCTTTAGAAC ATCCTTCTAGATACTTCTTTTGGAGGAAACATTTTCATTTAATTGCCATAGGTCAATTTTTTCTTTTCAG AGATGATTTGGTTTTATTCTTTCTACAGAAATAGTCAGATATTCAATGATCAAATTTGGTTAATAAGATT AAAGGATTAGGAAGGGAGATATAATTTTCAGGAGTTAAAATGAGCTTGGAATAAAAAGTAATAGGACCTA ATTTCTTACATGACTGAAGAAGTTGGCTCTAAGAGCCTTGCCCCATCTAAAGGTCAAAAATATTTTGAGA AATGCCAGCATTGTTTGAATAAATGCCCAGTCTCTAAAGGTGGCAACTTTGAAGGGCAGCATATTCATTT GATAGACAGTGTTAAATAGTCTCCTCACTTTATCATCGCTCACCTGTTCATTTATTTGTCATTTATTTGT GAGCGCTTATTGAACACTGATTACTCATTAGGCTTGGTGTCAGATGTTAGGGATATAAAGATGAATAAAA CCAAATCACAGTCTTCAAGCTGCTTTCACCATACGTGGGGAAGTCAGTAGTGAGAGAGTGCAATGTGTGC TCTGATATTGGTAAGAAGAGGTGCTGGGAGCCCAGAATGGGGCTCTTGCATGGTCTGTCTTGGGAGGGCT TGTCAGGGAGTGCACCCAGGGGAAGATGAACTTTCATAGACCAGTAATGGCCAGGGGAAGGGCAATGTTT ATTCCAAGAAAACAGAACCATAAGCACAAAGGCCGGGAGGCAGGCGGCAAGAAGATGAGGTATATGACTG GGGTTGGGGGCAAGGGAATGCACACAGGGCCTGGAGGGTGAAATGTGCTTGGTGGCAAGAGGCAGGGATG TGGAGGGCTGAAGACTGCTGCGAGATGAGTTTCCAGGTATACACAGGGGGAGGGGAGCAGACTGAAGATT CACCATTTGTTCAACAAATATGTGCTAAACACCCATGTGCTAGGTGTTGGGGGTCCACCTGTGAACCACA GACAATAGGGGCTACAGCCTGGTTTACTGAGTCTCAACCAGGGGCACTGTTTTGCCCTCTCCTCTCCCCC AGGGGATATCTGACAATTTCTGGAGACATTTTTGGTTGTCATAACTATGGGTATGTAATGATAACTGGTG GGTAGAAGTCAGGGACGCTGTTCACCAGGCTACAGTGCACAGGACAGCTTCTAGGACTAAGATTTCTCCA ACTCAATACTTTAACAGTGAGAACGGTTGAGAAATCCTGGTCTCACAGGAAAAGAATAAAAAGCAAGAAA CCAACAAGTAAATAATTGGAAATCGTGGTGACGTTTCTGAAGGAAACAAGATGCTGAAATAGAAAATAAT GGGGCAGGGTGGGGTGGGCCAGACGTGAGCAGGAGAATGCAGTTCAGTCAGGTATCAAAAGATCTGTACC AGGAAATGACATTTCAGCTGAGAACAAAAGATGAGAGGGAACCCACCAGCGGGAGGAGCATTCCAAGAAA GACTGGACAAAGGCTCTGAGGAGGGAATGAGCTTGGTTTAGGGCTTGAAGAGAAGAGGTGGCCTGAGAGG AGGCAGGGCCCAGGGAGCCTGGGGCCTCTTCACTCATGGTCAGAAGTTCAGATTTCGTTCCAGAATAGTA TTGGAGGATTTTTAGCAGAGGACTGACAAGGCCCATTTTATGTTTTAAAATCATTAAGAAGATGACCAGC CTGGCCAACATGGCAAAACCCTGTCTCTACTAAAAATATGATTAGCTGGGCACAGTGGCTCACACCTGCA ATCTCAGCACGTTGGGAGGCCGAGGCGGGTGGATCACTTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAA CATGGTGAAAACCCATTTCTACTAAAAATACAAAAATTAGCAGGGCATGGTGGTGTGCGCCTGTAATTCC AGCTACTCAGGAGGCTGAGACATGAGAATCGCTGGAACCTAGGAGGCGGAGGTTGCAGTGAGCCAAGATC GTACCACTGCACTCTGGCCTGAGTGACGGAGTGAGGCTCTGTTTCAAAACAAACAAACAAACAAACAAAC AAACAAAAAACAGAAGATATGACTGAGTAAGAGTGAACGTGGGGAAAGGGGAAATCAGATGAAGCTTACT AGGGAGATCAGGCAGGAGGGGACCCTGAAGCTGGAGAGACAGGCCTGGGCCTGGTTCAGTATCTGCTTTG GAGGCTGAGTTTATTATAGACCTGCAGTTCCAGGAAGTTGTTCAAGCTGGGAGCTGTCAGCATAAAGACC ACATTTAAAGCCACCCAAAATGGATGAAATCATTTTGTAGGAAGGAGCAGGGACTCAATATGTCATGCTA AGGTGCTCAGTTTATATCATGAGATCAATGCAGACTGATTGAAGCTCTCACAGATCAGATAATCACCCAG GAAGAGCTCTCTGGTGAGTGGGGAATGTGGTTTGGAGGGCCATGACAGAGGAGGCTGGACATGAGTTCCA GGAGAGAGACAGAGAGAGGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAATAAAAAATGGT CAACTGTGCGAAGTGTAGGAGCAGAGAAATGTCTATCCTGGAAGCCTGGTGAGCTGAGCTAGGGATCACT CCTGGAAGGCAGATCCTGGGAGAAACTTCTGTGGCCTGTGGTATGCCAGGAGGTTTGGACCCGGATGCTC CGAGCCCACTTGCTCCCACTGGGCCCCCTTTCTCCCGAGTTCACTGGAGGAGCCTGTCTCTCTGCTTGTG TCTCCACGGGGCACAGCCCCAGTGCCTCCCCTCTGCACACTGCCCCTGTCTCCACAGGGGCCCATGCCCG CCGGCATGCTGATTGAGCGCTCCTCAGACTTCGGTAAGACCTGGCGAGTGTACCAGTACCTGGCTGCCGA CTGCACCTCCACCTTCCCTCGGGTCCGCCAGGGTCGGCCTCAGAGCTGGCAGGATGTTCGGTGCCAGTCC CTGCCTCAGAGGCCTAATGCACGCCTAAATGGGGGGAAGGTAGGTAGAGGGAATCCTGAAAAGTAGGCCT GGGGAGAAATCCCTGATGTCCCACTGTTCACACAGCCACACGGACTCCTGAGAAGGGACGGAAACACCCT CGCCAGCTCCCCTTGCTGACTTTCCTGAATTCCCACCAGTAATGACCCCTGTGGCCACCCTCAAAACATT TGCTGCTTATCCTCTTTGCTGAGGAAGGATATTTCAGCAACACCTTGGGGCCACCGCATTACTCACCCCT GCCGTCTTCCACAGCCCCCTCCCCCGTGACTCATTGGCTCATCCCTCTAGTGGGAAGATGAAATCGACCC TACTTTGATATGAGGACTTTGGGATGCTAGTTAGATGCAAGTGAGCAAATTACACAAATTTCATTTCACC TTGGTAGGGTTTAACACAAAAATAAACATTTTCAGTTTAATCTATCCATCTAACCCAGTCTTAGCCCTTG GAGGGAATTCTGGTAAACCCAGAGCCCGAATTCTCCTGAGCTTAAACCCTGAGCTAGAAATAAGAACCTG CCTGAAGAAAAACTCAGAATGTTTCTCCCTAAGTCCTCCCAACGTGGGTCAAATTCTTTCATAACTGCGT TTCCCCATCCCCTGGCAGAGGAGGCTGTAGTTTCTCTTCTCCTTTCCCTGGCTGAGACACAGGTGAGCCC TCAGAGCTGCTCTCATGTGGACCGATGCTCAGAGTGGGGCCCTCTATGCAGGCCATGCAACTCTTCCTTT GGTTTTAGCAGTTCCTCCTTGGTTATACCCTTACGCAAATCTATGTTAACTACATTCTTCACACACCAGA TAAGAACTTTTTCCTAACTTGTGGAGGGCTGATGTGAAAACTCTTCCTGGGATATGTAGATGATGAGTGG ATTTTTTTTTTTTGAATAAATCAAAGCATAGTTGAAACTGGGATTGTCCAGAGTGCTGTGGTCACCCACA TTCACGCATCCTTGGGTTTTAGATTTCTCACTCATCCTGAGTCATCAGAAAATTAGTATCTCCTAAACCC TTATATGTAGATGATATATCTTACCATACTTTTTGACCCAGGGAACTCAGAAAATTCTTAGGATACTTAT ATTTTCAACTGGCAGGGGTTGGGGGTGGGGTACACACACACACACGTTTAGGGCCCAGTGATCATCTTTC TCCCCCACAGCAGATGACAAGCCTCATAGCCATGGTCTATCTCAGGTTCCAGGTAACAAGGACTTCAAGT GTGAGGCATATAATGGAAAGAAAGGTTTCTTCTGAACTCGGGGCACACTATTTGTCTCTTCTTCAGCGCT TCTCTTTCCCTTCCCTCTGTAGGTCCAACTTAACCTTATGGATTTAGTGTCTGGGATTCCAGCAACTCAA AGTCAAAAAATTCAAGGTCAGTGTGGTTACTTCTCTTGTCCATGGAACTATGGGTGGGAAAGGAAACAGA GTTGGAGCCCAGGTCATGGAAATTTCCTGGTCTTTCATGTTTTTGTCAACGTGGTTGGGGATTTGATACT TGCCCTGCTTGCCCCATAGGGATATTGTCTGTGGGATGCTATGGGATGGTTGAGGTCTGGAGAGGATGGC CCACGGTATCACATATGAAGGAGACTCTATGTGCCTCTAACTTCCTTTCTTTATTTTCCATTCTCCAACT CTTCCCTCCTTGCTGTTTGGCCCTCTCAGAGGTGGGGGAGATCACAAACTTGAGAGTCAATTTCACCAGG CTGGCCCCTGTGCCCCAAAGGGGCTACCACCCTCCCAGCGCCTACTATGCTGTGTCCCAGCTCCGTCTGC AGGGGAGCTGCTTCTGTCACGGCCATGCTGATCGCTGCGCACCCAAGCCTGGGGCCTCTGCAGGCCCCTC CACCGCTGTGCAGGTAACAGCCTAGGGTGGGAAGGGGAGAGGAAGGGGGCAGGACCAGGGCAGACTACAG ACATTCTTGGGGCTCCTGTAAAGCAGGAAGGGCACTAAATCTAAGACTTGGGTATTTAATACTTCAGCAG CAACAACAAAAAATCGAAGTGGTTTTCGTTCCAAAAATCAGAATCATTTAGTACTTCTTTAGATCTGCTT CCTAATTTGAGATGATTTTCATTTCATTTACATAAGTGTGGAAATTGGGAGGGAGTTTAAGCCAATGATT CTCAACCCTCGTTATGCATTATAATTTCACTGAGAGCTAAAAATGTTGCCCAGCCCTCCACCCTAAGATA TTCTAATTTTATGATTGGCTTTTAAAGCTCCCAGGTGACTCGAATGTACTGCCAGGTCTGAGAGCCACTG GTTTGGGGATTTTAAAGTCTCAGCTAGTGGTGAGATATGGGGCACGGTGAGAGACCAATGTTTAGTACAG ATGCTAAGTCTACCCTAGACCAGGCGGATTGGCTTCAGCAGGGATGGGGTTTGAGACGTTCCAGTTTAAC AAGCCCTCCCCTCCCAAGGGGTTTTGCTGTGAAACCAAGCTTGAGAACCACAGGTAGAGAAGAGAGAACC TTGAGCAAAGAAGCAGAGGGACCCAACATGGGAGCGTGACAGCTGTCCTAGTGACAGGGGGACAGGAGGA AATCATGTAAGATGGCCTGAGTGGGAAATAGAGGTGGCACAAGCCTCAGCTGGCATTCTTCTTTCCACTT CTGGGCCAAATTCTGCCCCAGGCTGCAGAGGTGTACAGAGGGAGGCCAGCTCAGGGAGTGTGTCATCTGT CAGGGCCCATGAGACATACTCCTAGAACCCAAGGCTGAGTGACACAGAGGGAATACAACATGCTATGACA TGACGAGGTGGGAGGGAGCCACCCAGCCCTGGTGGTCCTCAAATCTGGCCATGCAGTGGAATCACCACTT TTAAAAGGTGCCACTGCCTGGGTCTCATCCCTGAGATTCAGAGTGAATTGGGTCTGGACCTTGGCATTTT AAAAAATGTTCCCCAGGTGACACTGAGGTACAGGCAGTGTTGAGATCTATGGAATTAGAGGCACCAGGGA GGCCTTATGAGAGAGGTGCCGTTCTAGCTGGAGCCTAGCTGGCAGGATTTTGTGAATGAATACAGAGAGA AGAGAATTCTAGGCAGAAGAAAAACCATTGCTAAAGGCCAAAAGGTGGAGAAAGTAGGGCTTGCAGAGGG AGCAGCTAGAAGTTCATCTTGCTATGCTGTCAGCAGGACATGGGAGCTGAGAATGCAGCTAACATGATAC AGGTCCTTGAATGCCAAGCTGAAGGTGTTGGGCTTAATTTGGAAGGCAATTAGCACGCAACAGCTATTCT ATTTTTATACCTTAATGAGTCTAGTGACAGTTCATCACAACAGTTCCATTAACCAAACAACTGTATTCAT AGATTGTTGGAATAGAAATCTCCAGAGGGCCCCACCAGCTTCTGGATCCCACAGTTTGCCAAGGGTGTCT GAGCACCTGCCAAGCGCTGCCTCTGACTGGGTGTCATGGGGGTGTCCAAGTGCAAGCAGCGAGCTTGCAA AAACCTCACTAGGGGAGCAGTGCGGGCACACGCACGTGCACACACACACATGCTCATATGTGCAGAACAA TAGCAGACAGTTTCACAGGAGCTGGGTGAAGTCTGCGGCATTCAGAGGAAGCTTCCTGGAAGGGTTGGGA TCTAAGCCAGATCCTGAGTGGTGCGCAGAGGGTCAGAGGGCAGTGGGCAGGTCCATCCCTGGTGCCCTTC TTTGTTGATTACTCCTGATGGCTGACGGTCCCCCTCCCAGGTCCACGATGTCTGTGTCTGCCAGCACAAC ACTGCCGGCCCAAATTGTGAGCGCTGTGCACCCTTCTACAACAACCGGCCCTGGAGACCGGCGGAGGGCC AGGACGCCCATGAATGCCAAAGTAGGAGCTTTGGATCACCCCTCCCCTGTAGGGTCTGGGTCGAGTGCTG GCCCCTCTAGGCCTTGATGATCTCACCTGGGATGCAGGGGGATCCAGTCTTTCTTATGTAAATCTAAACT GAATTGCACCATTACAATTCAAGCTCTCCTGGCTCTGTGAGGATGGAGAGAGTATTTGGGTGACATCCTC CCACTGTCCCCAGCTAGAGCCTGCTTCTTCTGGCCTCTCCAGTTGCTTTACCCTGTTTAGGACATATCTG GTTTTTCTATTGTCATTTTTCCTACTTCAAATGGCTCCCTAGAATCAGGCCCTTTGTTTACATAAATGAG GAAAACAGAGATTCTCATCCTGGAGACAGGCAGTGACCCAGGAGGAGACCAGTGTTGGCAGTGGGAGGGT TGGGGATAGAGCATTCAAAGGGCTCTTTCTTTGGCCCAACATGGCCACTGTTCTTGGGTTTATTCCAACA GTAAGAATCAGGAAGGCTGAGTTCTTATTCTCCTCTGCTTTCTTATTGGTCATGTAACCTTAAATAAGTT ATACAAACCTCCCTTGCCCTCAGTTTCCCCACTTCCCTGCCTTGATCATCTTGCAGAGTTGTTACAGATG CCAGTGAGCTTTTGTGGAGCATGCTCTGTAGATAGCAAAGGTGTGGGTCAGATGTCAGCCCTGGGACTCT CTTTTTCCAGGGTGCGACTGCAATGGGCACTCAGAGACATGTCACTTTGACCCCGCTGTGTTTGCCGCCA GCCAGGGGGCATATGGAGGTGTGTGTGACAATTGCCGGGACCACACCGAAGGCAAGAACTGTGAGCGGTG TCAGCTGCACTATTTCCGGAACCGGCGCCCGGGAGCTTCCATTCAGGAGACCTGCATCTGTGAGTAGAGG CTCCGGAGTCCCAGAGTGTCATTTGTCTGTTACTCCCCATCTCCTCTGGGTACAATAGAGTACATGTTCC TGGGCACACCAAGGCCCTCAGGGAGCATGAAAACTTGGCTGTGAGTCAGGATTTGTGGGAGATTATTTTA ATTTAGCTATTACTGAGCAAGTCACTTAACCTCTCTGGACCATCAATCAGACAATCAATCAAGAGTTAGG CTTTATTTGGGGCATAGGGAAGAAAAAAGTAAACATAAGATACAGTTTGTGCCATCAGGGAACACACACA CTGTTTGGCAATATAAACTGTATACACCTGCAGAAGAGGGATGAAAGCACCTTTTCCGTATGTATATGAT TGCCTTTACCATGTTGTAATGAGGTTTGTGATTTAATTTTCTATTTCTCCCAACATCGAGAACTCCTCCA TGGCGAGGATTATTTCTCACATCCTCTAGCCCTAGCACACTGACTGGAAAATAACTGATGCTCAGGGAGT GTTTGTGAATGTAATGGGAGGCAACAGGCAGAGGCAGCTTAACATGCACACAAGAGCCAGCGACTTCATA TAGGAGAGGGCTGCCTGGACTGAAGCAATCAGATTCGGGCAGGTTTAGTCAGAAAAGACTTTCTGGATGA AGGGGTCTTACATTTTGAAAGGTCTGAAAGAAGTCAGGGAGTGGGGGTTGGGGAAAGCTGAGTCACTTTC TGTTGATGTTTGTTTCTGGGAAGAGTGAGACAGAACTGAGTTTGATCCCTGTTTCTTGCATGAACTTGTA ATGAGAACTTGAATAAGTTATTTGACATATCTGAGCCTCGGTTTCCTCCTCTGTACAATGAGAATAATAA TCTCCAGGATTATCATGAAGATTACATGAGGCAACATATGACAGTTCCCAGTTCAGTGGTTGGCACAGAG TAGTTGCTCAGTAAGTAATGACAACAAAACCGCTTCTATAGTACTTAGCATGTGCCAAATATGCTCCCCC TGCTTTATGTTTACTCATTTCTTTCTCTCTCTCTCTCTCTCTTTTTTAATGGAGATGGTTTCGCTCTTGT TGCCCAGGCTGGAGTGCAATGGCGCCATCTCAGCTTACTGCAACCTCCGCCTCCCAGGTTCAAGTGATTC TTCTGCCTCAGCCTCCTGGTAGCTGGCATTACAGGCATGCGCCACCGTGCCTGGCTAATTTTGTATTTTT AGTAGAGACAGGGTTTCACCATGTTGGTCAGGTTGGTCTCGAACTCCTGACCTCAGGTGATCCACCTGCC TCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCACAGCCATTTACTAATTTATTTCTCA TAAGAAGCCTATGAAGGCTGTATCATTATTTTTATTTTATAGACAAGGAAATTGAGGCACAGAGGGATTA AGTAACTTGACTAAGGCTGTGAATTTGAAATCCAGTGGTGGAACAAGGATTTGAACCAGGCAGCCTGGCT CCTGGAATCTGCTCTGAACTCTACTTTTCTTTGTTCCTACTGCGGTGGCTGCTGTTGTCTCTCAGCCTGC GAGTGTGATCCGGATGGGGCAGTGCCAGGGGCTCCCTGTGACCCAGTGACCGGGCAGTGTGTGTGCAAGG AGCATGTGCAGGGAGAGCGCTGTGACCTATGCAAGCCGGGCTTCACTGGACTCACCTACGCCAACCCGCA GGGCTGCCACCGTGAGTAGGGGGCTTGGCCCAGCATGACGTGGGGTGGGCTGCATGGGGCCACCAGACCC ACGGCTTGCCCTGCTCACTGTGCTCTCTTCAGAGGAAATCCCACTGCAGGGTAGACAGAGGGGGTATGCC CGGGCCTTTGCCAGGAGTCCGGACTTCTTGCCCTCTTACCCAGCGCCAGATGCTGTGCCACTGGCCTCCA GCAGGTGGCAGCACACGTCCGAGTTGGAAGGTGGGACTGAGTCAGCCAGATGGAGGGTGGGCAGGCAGGC GGCTGAGCTGCCAGGTGGCTGGAACTGGTGGGACAGCGCAGGGGTCCTGTGAGTCAGCCATGTCATCTGC AGGGAAGGGCCCTGCCCAGTTCTTTTCCCAGGCAGCGCCCCTCCCTGGATGTGTGTCCTCTGGGGGTGAG TTTTTCATGGAGCGTCTGCCTGAGCTCAGCAGCTCTCCTCCTGCAGGCTGTGACTGCAACATCCTGGGGT CCCGGAGGGACATGCCGTGTGACGAGGAGAGTGGGCGCTGCCTTTGTCTGCCCAACGTGGTGGGTCCCAA ATGTGACCAGTGTGCTCCCTACCACTGGAAGCTGGCCAGTGGCCAGGGCTGTGAACCGTGTGCCTGCGAC CCGCACAACTCCCTCAGCCCACAGTGCAACCAGGTACGAAGTGAGGGTGGTCCGGGGGCCCCCTCAGTGG GAGGGGGGTCCTGAGCACCAGCCTCTCTGCTGCCCCTCCATGCTGCCCTTCTAGGCCTCTCCCCTGTCAG ACTGGGCGTCTTCTGTCCCCGTTCTCATTTGGGGAAGTCACCAGATGTCCCTCCCTCTGTGGCTCTTGGC CGTCAGTAATACCATATGCACCACACCTTCTGAAGGGCCTATGCTGGGCCTTGACTTCAAGGCTCATCTC TGAGTGGGAGCCCTTGTTTTGTGGGCACAGCAGCTCTGGAGGTGGCCATGAGCCCTGGATTCTACCTGTG GACCAGGAATCTAGGACACAGTCCCTGACACCAGGGTAAGGCAGAGGCTGTGAGGCAGGGTCCACTGACG GTGCTCTCCCCACGCAGTTCACAGGGCAGTGCCCCTGTCGGGAAGGCTTTGGTGGCCTGATGTGCAGCGC TGCAGCCATCCGCCAGTGTCCAGACCGGACCTATGGAGACGTGGCCACAGGATGCCGAGGTGCATGCTCA AAGCCTGGGGGACGCTGAGGCTCTGGGGGCCGAGCACGCGGGTGGGCACATGGTGGGGGCGTGTAGGTCT GCAGCAGGGCAGGATGTCCTGTACTGATGCATGTGGTGTGGGCCTGGGCAGCCCTGTGAGTGCACACACT CCGGCCTGTTGGCATGGCCTCCAAGCCCCTGAGGCAGGCCTATGCCCGCTGTTCCTGCGTCCCCGTGACA TGCTGGTTGCTTTGCTCCCCACTTCCCTGAGAGAGAGAGAGCATTTCCCAGAAGCCATCTCCAGGGCAGC AGCAAGGAGGGGAGGCTGTTTCTTCCCTCTTCATAGATGGAGGAAGTGAGTCCTGAAGGGGAAAGGGTGT CGTTTCCCACGGAGTCAGTTTGATGTCACCACAGGAGCACAGGCCTTGGAGTGTGCAGACCAGATTGTGG TCCCAGCTCTGCCCCTGCCTCACTGAGTGACTTTGAGGGAGCTGCTTCCCCTCTTTAGACTTGGTTTCCT TCTTAGAGGAAGAGGCATGCTGTACTTAACCTCTCTGTCCCTCAGTTGCCTCATCTAGAAAAAGTGGGAA AACAAGAGTGCTAATTCCCAGAGTGGTGTGAAGATCAAATGAGTTAATGTGTGTGTGTGACTTTAAGTGG TGCCTGGCACATGGTAGGTGCTAAGTAAGCGTTTGCTTTCACTGCAGCTGTTACCATGGCTTTTATTCTG GCTGCGACTTCTGTTATTCTAAGTCATGTAGAAAGAGCCTCAGGTCAGACCTCCTCTTCAGGGCTCTCCC TGACAGCTGCTTCTGTCTCCCTGACCCCTGTCTCTGACTGTCATTTTTCTTGGCCCTAGCCTGTGACTGT GATTTCCGGGGAACAGAGGGCCCGGGCTGCGACAAGGCATCAGGCCGCTGCCTCTGCCGCCCTGGCTTGA CCGGGCCCCGCTGTGACCAGTGCCAGCGAGGCTACTGTAATCGCTACCCGGTGTGCGTGGCCTGCCACCC TTGCTTCCAGACCTATGATGCGGACCTCCGGGAGCAGGCCCTGCGCTTTGGTAGACTCCGCAATGCCACC GCCAGCCTGTGGTCAGGGCCTGGGCTGGAGGACCGTGGCCTGGCCTCCCGGATCCTAGATGCAAAGAGTA AGATTGAGCAGATCCGAGCAGTTCTCAGCAGCCCCGCAGTCACAGAGCAGGAGGTGGCTCAGGTGGCCAG TGCCATCCTCTCCCTCAGGTAATTCCCTTTCCCTGCCAAGCATTTGCAAGAATTATGCTCCAGGGGTTCC AGTACCGGGCATGCTGGTCCTTCCTTACATTTGTACAGTGCATTACAGTTTAAAGGCATTTTCACAGTGC TCTCTCTTTCAACCATTACAACAGTCCTGTGAGGCTGGTGTGGTTTTGCAGATGAGAAAACAGGCACAGA CAGGTGATGTGACAGAGCCACATGACCACCGAAGGGCAGAGCTGGGCCTCAGAACACAGTCCAGGAGCCC AAGCCCAGCGTTCTTTTAAGTGCCCAGTGCTGCCTGTGGGAGAGAGTCAGCTCTGGATTAGTCACCCTGG CGGAGGGCATCCGAGAGGCAGGGGCTCTAAAAATAACTCACGTGTGGCTTTGGAATGGAAGTTGGTCCCG CCCACACCCCCATCCCACCAGCAGAGGTGCCTTCTTAGTGAGGTTCAGTTCTGGAAGCTTCTATAATTAG TTTGCATTCCCTGAGCACTGGCTTTCTGACTGTGCACAGAGCCATCCAGGTGTGTGAGTGGTGGGGAAGG AAAAGGCAGCCTGAGAAGAATGAAAATGGAGGCTCCGTGACTCACGATGTGCTAGAGCTTCTGGCTGGGG GCTCCGGGAGAGGAACTCAAGCGAATATTGAAAACCAACCTACCTTCCTTCCTTCCTTCTTTTCCTTCTT TTTTCCTTCCTTCCTTCCTTCCCTTTTTTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTT CCTTCCTTCCTTCCTCTCTCTCTTTCTTTCTCTTTACATAATTTTAGAGCATCTATGATGAAACAAGCAT TGTACAGGCATTGGGGATATTGAAATTAGTATGACATAATCTTTGCGCTCAAGAAGCTCGCACTGGGGAG AATGATGTGTAAATGGTAAACTATAATGTGACGCATGTTATAATGTGTCATGGCAGGCTTCACAGAGGTG CCTTCTGACCTAAGTCTCAGATTCGGGCAGTCAGTCCACCAGATTCAGTAGGTTGGAAACACAGGCATGG AGGGGCATTCCATGGAAGGGCGTTCTGTGCCTGATCAAAGCCTGGAGGTGGAGAATGTGAGGCTTGGAGG AGGGAGCTGGTGGTTGGGTTGGTGGAGCTGCAAAGGGCACAGGGAGAGAGGACTCTCCAAGAGCTCAGTG GCCAAGGGCCTGGGAGGTAGACTCTGAGCCTCCTTCGGGGGGATGACCAGCTGGCAGCAGTGATGGGATC TGGAGCTGAGTGGGAGGTGTGGACTGTGGAAGAGATTTTGGAGCTGCAGCTGTACAGATGGTAGCTGAAG CCAGCCCATAGAGAGCGAAGGAGGAGGGCATCAGGGCATTGCTCCTCATGGAAGCCAGGATCTGGAAGAG GGGGAGGAGAATTGGGAATGTTGGGTCATAGAAGTCAAGGGAGGAGAGTTTTGTGGCTCCATCTGCACCT GGACAGAGAAAGATTGTGCTGGTCGCCAAGCCTCTGTCCAGCGGAACCCCCTTAGCCTGTGGATTCTCTG TTCTGTTGCCTTTGCCCAAGGTCTCTGTTTGTTCTGACTCAGTAGCAGTTGCTCTGAGGGGATAGCTGCT TTGGGGAGGCAAAACTCCCTCCTATATTTTAGTGTAAGCTCCTCTCCCTTCTCAGGCGAACTCTCCAGGG CCTGCAGCTGGATCTGCCCCTGGAGGAGGAGACGTTGTCCCTTCCGAGAGACCTGGAGAGTCTTGACAGA AGCTTCAATGGTCTCCTTACTATGTATCAGAGGAAGAGGGAGCAGTTTGAAAAAATAAGCAGTGCTGATC CTTCAGGTGAGGAGAGGGGCACCCGGATAACCCCGGGCATGGGCACTGCCGTGGTGGGCATGCCACCCCC TCTCCCTCCTGCTCCTCCTCCATCTCCATTCCTCATGCTTCTCGCCACAGGAGCCTTCCGGATGCTGAGC ACAGCCTACGAGCAGTCAGCCCAGGCTGCTCAGCAGGTCTCCGACAGCTCGCGCCTTTTGGACCAGCTCA GGGACAGCCGGAGAGAGGCAGAGAGGCTGGTGCGGCAGGCGGGAGGAGGAGGAGGCACCGGCAGCCCCAA GCTTGTGGCCCTGAGGCTGGAGATGTCTTCGTTGCCTGACCTGACACCCACCTTCAACAAGGTGACTTGG GGCATGGAGTCCCACTTCCTGGAGCCCACACCCCAGCTTGTCACACACCAACTGCTGCCACCTGCTTCCT ATTAGGGCAGATCTGCCCCTGTGAGAACCCCACTCCCCCAGCCATCCCGACCCTTGTACTGCTCACTGTG AGCTCAGTGGTTGCCAAGGAAACCAGTTTCTGGTCCTTAGCTCTCATGGAGATGTCTGGCTGTTTCTGGT GCTTGGTTGTCATGGAGATGTCTGGCTGTTGGTTTCCCAGGTGTGGGGTGGGATTGGTTATTGAGGGGCT TTGGGTAGCCTCTTTAACACCGCCATCTGTCCACAGCTCTGTGGCAACTCCAGGCAGATGGCTTGCACCC CAATATCATGCCCTGGTGAGCTATGTCCCCAAGACAATGGCACAGCCTGTGGCTCCCGCTGCAGGGGTGT CCTTCCCAGGGCCGGTGGGGCCTTCTTGATGGCGGGGCAGGTGGCTGAGCAGCTGCGGGGCTTCAATGCC CAGCTCCAGCGGACCAGGCAGATGGTAAGTGCAGCCGAGGCGGGGTGGGCACAGGTAGGAGGAGGCAGAC AGGATAGATCCCCCGGGCAAGTCAGAGTTCCCATTTTACACTAAAGTCCAGAGATTTTAGGTGACCTGCT TAAGGTGCCACAGCAAGTGCAAGATAGTTTTTTTTCTCTTTTACTGAACATCCACATGTAAGCTGGGTTG GTTACAAATGCTTCCTAGGTAGGTCTTGGCATAGAGGATGATCCGCAGAATCGTGGGGCTGCTGAGAGGT TCCCTTGGGGCCTTACCCCTTCTGACCTAGAGTGTATGTCAACAGATTAGGGCAGCCGAGGAATCTGCCT CACAGATTCAATCCAGTGCCCAGCGCTTGGAGACCCAGGTGAGCGCCAGCCGCTCCCAGATGGAGGAAGA TGTCAGACGCACACGGCTCCTAATCCAGCAGGTCCGGGACTTCCTAACAGGTGAGCCCAGTCTCCACCCC ACCTTGGCTGCTGTTCCAGTCCTGCCTGTCCCGCATTCCCATGTTCAGTGCATCAGCCAGCCCTCCCTCC CTAGTCCCAGGCCTGCAACATCCAGGCCTCCACTTCTCCTTGGCACCATGGCCATGACCTTCTCGTTCTC CCGTCTGCCCTCCCCACCCACTCCAATCCCTTGTGACCCATTCTCATTCTCAACACAACAGCTGAAATAT CTCTTTTAAAATGCATAAGTCAGATCACATCTCACTCCTGCTTAAAATCCTTCAGTGGCTTCACCTTGTT CTTGGAATGAGCTCTCAACTCCCATCGTGGCTACAGAGCCTGGCCTCTGTCCATCTCTTGGGAGTGACCT TGGGCTCTTCTCTGCTTTGTTCACTGGCTGTCCTTGAACATGTCAGGCTCTTGCCTGCTTCAGGGATGTT TATTTGCTCTTTGTCTGCCTGAAGTCCTCTTTCCAGGGCTGCTGCTTCTTGTCCTCTGGGTCATCTCCCC AGAGAGGTGTTTCCTGACCATCCGATCTGTTTGTCCCCCATCATCTTACTTTCCTTGCACTACTCACCCT CATTCAGTTGTCAACAAGTGGATTGTCACTCCACTAGAATGGGGACTCCAGGAGGGCAAGGATGGTTGTC TGTCTTGTTGACTACTGTGTCACCAGCACCTAACATAAGGCCAGACACAGAAAGACATCTGACATTGGTG GCATGAATAAATGAACCAGACACCCTTCCTCACTGCTCTGGGGAGTGAGGAAGGGCTGTACAATGGAAAG ATCCCTAAACAGGACCCGGGAGACTCGTGTGACATTGGGCAGGCTGCTTTTCTCTTTGCCTCATCTTTTG CTTCTATAAATGGGGACGGTAGTATTTCACAAGTTTATTCTGAGGATCAAATAACTGATGTAAAATGTGT TTTGAAAAAGGAAAAGTGCCTCAGGAACAAGAGTTGATATTGTTAGATTTCTGGTTCCTGCCAGGTTATT TGCTTGGCTGGGAGCCCAGTTAATACGAGCCCAGGGCTTGGTGTAATGACAGTGGCTCCTCTTGCTACTA TTACAGTGTTTTTGCCCCAGATAGGCCGAAGTCCCCTCCTGAGTGCAGGTGGCAGGTCAGAGAGGGGCAG GAAAGTTCTTCTGAGGTCTCATGACTTGCATAAGGCCTTGAGGCACTCACCTGGGGAAAATATTACCTGG GGATGTAGGGAGATTGTGCCCCACAAACGTGGATGATGGGGGAGGTCAAGGTGTGGGGCTTAGGCTCATG GATAAGGGATTCTTGCCCCTGAGTCAAGTCCAGTGAGGCTGAATGGCCACTCATCCTGCATTAATCTCAG CCAGGGCTCTGGCCTCAGTGGGTGGGAGGTGAGTTGGAATTCTCTCCTGCCGGGTGCAGCTGAGGCTCAT GTGAACAGACAGGGAGCTGCCAGGCCCCTTTTGTCCTCTCTCTTATACTTGTATCTCAGGTCAAGTCTTA TGATGAGTCCAGGGTCAGAGAGAAAAAGCAGGGCCTGAGAGAGGCCTGGCCCCAGGGGGAAACCCAGGAA AATTTTCTGTAGCGGTGGGCTTGGACTCTGGTCTCCAGAGTCCTGGTGCAGAAGCCACTGAGCGCTGGCT GCTGTCCGATATAGGGTCACAGTGTGGGAGGGAGAGTGGAAAGTCTGTGGAGGGAGGAGGAAACATCGCC TTTCCCAGTTCTTCAAATGGAATTGACAAAATGAATAGTTAAGGCTTATTAAGTTCTAACTGAGTCCAGG CACTGTTCCAAGTGCTTTGCATGTATTACATCATTTATTCCTGACTACATGAACTAAGTACTCTTATTAC TTCCACTTTGCACACAAGTAATCTAGGCACAGAGAGGTTAAGCAACTTGCCTAAAGGCATCTAGCTTGGC AGTGGTGCAGGTAGGCTTCAAGCCTAATTGTCTGACTCTGTCATTCACACCCTATTGCTTTACGGCATAG ACACACAAATACATACACACATGCGAGTGTGCATACACAAACACACTTTCTCTTGCCTCTTGCCTTTGCG AATGTTTTTCCTCTCTCTGGATCGTCTCCCCTCTCCCACCTCTGCTGACCTGTCTAGCTCCTGCTCATCC TCTAGGAATCTAGGCATCCCACTCTCCAGGCAGCCTCCCTGGACCTATCAGATGGCGCTGGGGGCCCCTT CCATGGCCATCATAGCACCTGTGTTTACTCCGCTCACTCAAAGCTGTACTTCCTTGTTCATGTGCCTGTC TCCCATTAGATTTCCAGCTCCATAAAGGCAGGGACTGAGTTTAATTTGATTTGCAGTCTCAACTCCTCCC ATGCTTTTGCTCAAAGCAGTAAATATTTACTGAGCCCATCCTGAGACCCAGAAGGCTCTGCGACTGAATG TCATACCGATTGACCCTGAGGATGCAGCTGAAGTGGTGCAGAGTAAAGGAAGGGCAAGATCTAGGTGGGG ATGTGCTCATCCTGGAAGGCTTTCTTGAGAAGGTGCACATGAAGCCTTGTTTTGAGAGTGGGACTCTGGG TTAGAAGAGAGGTTGACGAGCTCTATTAGGAAGGTCCTTATGAAAGCTTGCTGCTGGGATAAACCCACTT AATGAAACTCAACCACAGTTATGCTGCATGCAAGCCCCGAGGGACACAGCAATGAACAAGCATGGCTTCC ACCCTCCAGGAGTGTCCTTCCACCTGGCATGGGATGGGGCAGGGAATGAGACCTGTGTGACCAGCTAGTA TCCTCTAGTTGTAGAGTGAAACTGGGCCTGGGGCCCCAGAGGAGTTCAGATTCCAGGGCAAATCATCTGG TGAGTGGGTGCCCCCCTCCTTAATACCTCAATACCAGTGAAATCTGTAAAAGCAAATTGGGAGAGATGGG GAGGAGATGTCATCTCTGTACTTCTGACCTTACCCTCTGACCCAGAGTTGGTTTGTAACAACTCTTGCAA ATGGATTGTTTCATGTTGTACCTTCAGATTGGGGATTGATATTCCTTTTTCACCGATCAGGAAACTGAGC TTAGAGGAACCACTTGACTTGCCCAGGTGGCTTGAATAGTAAAGCAGAGATCTGAACCTGAAGCCCTGTC AATCATTCATTCACTCTACGCACATGAGGACCTCCAAGTGCCAGGCACTGTGCTGGGGTCTGGGGATATA GCTGTGGACAAAACCCAGGCCCTGCCCTTGTAGAGCTTACATTCTAGAGGAAAAGAGACCAAACAAACCA GTTAAATGAGTACAGTGTTTGGCACATGGGTGGTGCAAGTGCTAGACAGAAAGATAAGGCAGGGAGGGAC GATAAGGTGTGCTACAGTCCAGGGTGGAGGTTGCAATTCTAGATTGGATGGCTGGGGTTGGCCTCCCTGA GAAGGTGATATTCCAGCAGAGACTTGATCATTCTTATTTGCCTTTGCACAAATGAGCAATCTTGCCTGAG GGGGAATGCAGGGAAGGGGTCTTTTTGCCAAGGAAGCAGCTCCAGTTTCTGGCCACTCTTCCCAATTTAG GGCTGATTGTGCATGTGCTGCAGGCATTGTTCAGTACCAGCTGTCTGGCACCACCTCCTTCTCCCCAGCC CGCAGCTTCCTGTGGCACCAGACACTTAGTTGGCACAGCTGTGACGACACCCCTCCTCCTCCCTGCTGCA GCATGGAGCACAGGATAGTCATCCTCCTACAGCATTCCCAGAAATCCCTGGAGAACAGGCGCCTGAGTCT GGTTGAAAGGGGGCAGCAGCTCCTTGGGACACCACGGTAGAGGGGCCACTGTGGGTGCCTTCCACAAGTG CTGCTCAGCTAGGAGAGGCCTCGTATCTCTGGGGAGGTTAGTGGGCTCCTACAGTCAAATGCGTGTTGTC TTCCAGACCCCGACACTGATGCAGCCACTATCCAGGAGGTCAGCGAGGCCGTGCTGGCCCTGTGGCTGCC CACAGACTCAGCTACTGTTCTGCAGAAGATGAATGAGATCCAGGCCATTGCAGCCAGGCTCCCCAACGTG GACTTGGTGCTGTCCCAGACCAAGCAGGACATTGCGCGTGCCCGCCGGTTGCAGGCTGAGGCTGAGGAAG CCAGGTATGGCCTTGGGCCCTGAACTTCTCTCTGCCCAGGATTAAGCTGGCGTTTTGCTCCTCAACCCCG TTGCTGGGAGAGGGGTACAGAGGGCTGGGAGACAGGAGGGGGTGCTTACCATGGTGGAGAGTGGTACACA GAGTCCAGAGTGCAGGTTAAACTTAATTTGCATGACTGTGTCTTCCGTATTGGAAACCGCCCAGAAGGTG TCTTGGGCATAATGGGAACATTCATCACGTCTGCTTGGTGGGGTCCTGGGACATCAAAGCTACTGAGTTA ATACTTTCCTTGCTCTTTGCCTTGGCTGGGAAGGGTGTTCTTTTGGACTGGTGTGTGAGTCGAACCACAC ATTGATTCACTGTTCACTCATTCTCTCTCTCCTCTCCCTGCTGCTTCTCTCACCCAGGAGCCGAGCCCAT GCAGTGGAGGGCCAGGTGGAAGATGTGGTTGGGAACCTGCGGCAGGGGACAGTGGCACTGCAGGAAGCTC AGGACACCATGCAAGGCACCAGCCGCTCCCTTCGGCTTATCCAGGACAGGGTTGCTGAGGTGAGGCATTA TGGCTTCCTCCGCCCATATTTGGGCATAAACAGGAAAATTTGGGCACCAGGCATAGAAAATGCCAGAAAG TGACTAGATAAAACCTGAGGTGGAGTTCTAGAGGAGAGTGACAAGCTTTGGGCAGGCTATGGGCCTTGGA TTTTCTGGTCTTGTGGCTGGGATGCAGAAGGAGGGGTGAGAGGTGGGCAATTGTGTTTGTTCTGGTTGGA GAGGGTTTTTGCTGCCTGATGAGTTGGAGAAAAAATGGGGATGAACCCCCCGACCTATGAGACCCACCAC AAAGGCCAGATCTCCCTCTTTCCACAAAGGTTCAGCAGGTACTGCGGCCAGCAGAAAAGCTGGTGACAAG CATGACCAAGCAGCTGGGTGACTTCTGGACACGGATGGAGGAGCTCCGCCACCAAGCCCGGCAGCAGGGG GCAGAGGCAGTCCAGGCCCAGCAGCTTGCGGAAGGTGCCAGCGAGCAGGCATTGAGTGCCCAAGAGGTAC AGAGAAGGCGGAGTTAGCTCAATGATGTACGGCCAGTGAGGGGGTCCTGAGCAGAGGAGGACTTTGCACA CTTTATAAGACCACAAACTCAAAAGTGCTTAGAATAACAGAACCAGAAGAGGCTTGAGAGTCAACCCAAA CCTGGCCAGGCATCTGATTTCTCCCTCCACTGCTTTTGGTATAGCTGGCTCAGGGACACTGGAGATGACC TAGTCCAGTCCCTTTCCTTTTACAGATGAGGTGGTGACTCGTTCACAGGCCTAAGAATCATCTACAAAGC AGGTCCCCTGACACTGGATCCAGAGCTTGTCTCTTGGATTCCCAGCCTGGACAGATGCTCTTTGCTTAAC CTAACCTGGGCTCCATGATTGTCAGAATTAGATGAGAGAGAAGATCAAAGAGCCCATTCTCAGTGTCTCA AGCACACTACCTGCTCCCGCTATGGCCAGGAACATTGGCACTTTCAATCCTGGCACAGTGACCAAGTTGC TAAGTATGCTATTAAGTGACAGCCTACTATTAATATCCTATGATGTGACTGACATTGTCCTGGGAGTGAG GTGGGTCATGTCAAGAGCTGGAGATGGGAAGAGGGAAACACAGAAGTTTAAGTCATAGTCTGTGGCTCAG GGGTTTCAATAGGCAAAACCAATGCTATTGGGGGCTAATAGGAGGCACCTTCCCACTGTGTATTGATTTG GGTGATATCAAGTGCTTTGGCCACAGGTCTTTAGGACCTTGCATGATGACAATGACACTGAGACTATTCT ACCTTTTTCAGGGATTTGAGAGAATAAAACAAAAGTATGCTGAGTTGAAGGACCGGTTGGGTCAGAGTTC CATGCTGGGTGAGCAGGGTGCCCGGATCCAGAGTGTGAAGACAGAGGCAGAGGAGCTGTTTGGGGAGACC ATGGAGATGATGGACAGGATGAAAGGTGAGGGAATGGTTTAGGGGCATGGACTATTGGGCATTCATGAAG GCTGGTCCCACCCAACCCAAGGCTTCTGAAGCCCGTTCTTATTGGAGCTAGCCGTGCTATGGGAGTGAGA TCAAATGAGATTTTTTCTGGGCATCTAGCATGTATGAGGCTGGGGAATGCAGAGATGGTCCCATGACTTG TCCTGGCCTCAAAAAGCTTGCAATTAATGGGACCATTTTCTCTGTTTTTGCAAACAGTGGGGTCATATTT TTTATTCCTATTGCTTTATGCTTAAGATGCATAGAATTATATTTAACAGGATGAGGTGGTCTCTGATAGG GGTTGAATAATAAGAGTTCTGGGGTTCAGGGAATAAATAATTTGAGAGAGACATGTTCAGTGAAGGTAAG AAAAGAAGATTTGAGATGGGCCTGGAAGGATGTGTAGGCCTGGGAGAAGCTGTGAGGAAGAGGAGGGACA TTAGGATAAGGGTGTTGGGAAGCCCCAACAAGATATGTTCTGACATAGGGACAGGAGAAGAGGGTTGCTG AGGAGCTGGTAGGAAAGAAGTGGCATGAGGTCAACATGACTTGTCCCTGTGCCTGGCTTCTAGTGTGAGG ATGAGGAGGGTAGATAGCTCAGGAGGCGGTAGGGCACATCCAAGGGCTTTGAATATGACAGAAACATAAT GAAAGTAGCTTTCAAAAGGGTTCCAAAAATTCCTTAGAAAGGAGAACAGGGGCTCCTGGGAACTAGAGTC ATCGCTAAGATATGATGATGGGTGTTTGTGACCTCCTTCATTAGCCTTGGACAACTGTGAGAGCCCAGAG GGTCAGGGGCCCAGGGATAATTAGGAGTGGGAGCCTGCTGGGTTTGGCCCCTGCCAGGTTACTAAGCATG GGATGGGGCTGGAGAGGCATGAAGCTGGAGGGGCACCACTGCTTTAGAGGCCAGATTTTTCTGGAGGGGA TTCCTCTACACATGCTACCTCCAGTTAGCAGGAGGGGAAGGAAGGGTTGGGAGTCTTGGGGAGTCTCACC ATCAACTCCTCCTCCTGCTGCTGTTCCATTTGCCTCAGACATGGAGTTGGAGCTGCTGCGGGGCAGCCAG GCCATCATGCTGCGCTCAGCGGACCTGACAGGACTGGAGAAGCGTGTGGAGCAGATCCGTGACCACATCA ATGGGCGCGTGCTCTACTATGCCACCTGCAAGTGATGCTACAGCTTCCAGCCCGTTGCCCCACTCATCTG CCGCCTTTGCTTTTGGTTGGGGGCAGATTGGGTTGGAATGCTTTCCATCTCCAGGAGACTTTCATGCAGC CTAAAGTACAGCCTGGACCACCCCTGGTGTGTAGCTAGTAAGATTACCCTGAGCTGCAGCTGAGCCTGAG CCAATGGGACAGTTACACTTGACAGACAAAGATGGTGGAGATTGGCATGCCATTGAAACTAAGAGCTCTC AAGTCAAGGAAGCTGGGCTGGGCAGTATCCCCCGCCTTTAGTTCTCCACTGGGGAGGAATCCTGGACCAA GCACAAAAACTTAACAAAAGTGATGTAAAAATGAAAAGCCAAATAAAAATCTTTGGAAAAGAGCCTGGAG GTTCAACGAGGAAAAA Download Select all
Length	37606
OMIM ID	150310
HGNC ID	HGNC:6490
Unigene ID	Hs.497636
Ensembl ID	ENSG00000196878
PharmGKB ID	-

mRNA Information

mRNA ID	NM_000228.2
Exon	join(1..107,1495..1559,2358..2512,13828..13942, 14495..14568,17838..18029,19343..19406,19700..19893, 21741..21861,22551..22739,24286..24441,24897..25093, 25498..25609,26450..26828,28476..28636,28751..28971, 29297..29494,29796..29940,33817..34024,34428..34569, 34890..35066,35852..36005,37069..37606)
mRNA Sequence	>3914 CAGAGGTGAGGCTGTTGTTTAAAAACCTGGAGCCGGGAGGGGAGACCCCCACATTCAAGAGGAG CTTTCAGGCGATCTGGAGAAAGAACGGCAGAACACACAGCAAGGAAAGGTCCTTTCTGGGGATC ACCCCATTGGCTGAAGATGAGACCATTCTTCCTCTTGTGTTTTGCCCTGCCTGGCCTCCTGCAT GCCCAACAAGCCTGCTCCCGTGGGGCCTGCTATCCACCTGTTGGGGACCTGCTTGTTGGGAGGA CCCGGTTTCTCCGAGCTTCATCTACCTGTGGACTGACCAAGCCTGAGACCTACTGCACCCAGTA TGGCGAGTGGCAGATGAAATGCTGCAAGTGTGACTCCAGGCAGCCTCACAACTACTACAGTCAC CGAGTAGAGAATGTGGCTTCATCCTCCGGCCCCATGCGCTGGTGGCAGTCACAGAATGATGTGA ACCCTGTCTCTCTGCAGCTGGACCTGGACAGGAGATTCCAGCTTCAAGAAGTCATGATGGAGTT CCAGGGGCCCATGCCCGCCGGCATGCTGATTGAGCGCTCCTCAGACTTCGGTAAGACCTGGCGA GTGTACCAGTACCTGGCTGCCGACTGCACCTCCACCTTCCCTCGGGTCCGCCAGGGTCGGCCTC AGAGCTGGCAGGATGTTCGGTGCCAGTCCCTGCCTCAGAGGCCTAATGCACGCCTAAATGGGGG GAAGGTCCAACTTAACCTTATGGATTTAGTGTCTGGGATTCCAGCAACTCAAAGTCAAAAAATT CAAGAGGTGGGGGAGATCACAAACTTGAGAGTCAATTTCACCAGGCTGGCCCCTGTGCCCCAAA GGGGCTACCACCCTCCCAGCGCCTACTATGCTGTGTCCCAGCTCCGTCTGCAGGGGAGCTGCTT CTGTCACGGCCATGCTGATCGCTGCGCACCCAAGCCTGGGGCCTCTGCAGGCCCCTCCACCGCT GTGCAGGTCCACGATGTCTGTGTCTGCCAGCACAACACTGCCGGCCCAAATTGTGAGCGCTGTG CACCCTTCTACAACAACCGGCCCTGGAGACCGGCGGAGGGCCAGGACGCCCATGAATGCCAAAG GTGCGACTGCAATGGGCACTCAGAGACATGTCACTTTGACCCCGCTGTGTTTGCCGCCAGCCAG GGGGCATATGGAGGTGTGTGTGACAATTGCCGGGACCACACCGAAGGCAAGAACTGTGAGCGGT GTCAGCTGCACTATTTCCGGAACCGGCGCCCGGGAGCTTCCATTCAGGAGACCTGCATCTCCTG CGAGTGTGATCCGGATGGGGCAGTGCCAGGGGCTCCCTGTGACCCAGTGACCGGGCAGTGTGTG TGCAAGGAGCATGTGCAGGGAGAGCGCTGTGACCTATGCAAGCCGGGCTTCACTGGACTCACCT ACGCCAACCCGCAGGGCTGCCACCGCTGTGACTGCAACATCCTGGGGTCCCGGAGGGACATGCC GTGTGACGAGGAGAGTGGGCGCTGCCTTTGTCTGCCCAACGTGGTGGGTCCCAAATGTGACCAG TGTGCTCCCTACCACTGGAAGCTGGCCAGTGGCCAGGGCTGTGAACCGTGTGCCTGCGACCCGC ACAACTCCCTCAGCCCACAGTGCAACCAGTTCACAGGGCAGTGCCCCTGTCGGGAAGGCTTTGG TGGCCTGATGTGCAGCGCTGCAGCCATCCGCCAGTGTCCAGACCGGACCTATGGAGACGTGGCC ACAGGATGCCGAGCCTGTGACTGTGATTTCCGGGGAACAGAGGGCCCGGGCTGCGACAAGGCAT CAGGCCGCTGCCTCTGCCGCCCTGGCTTGACCGGGCCCCGCTGTGACCAGTGCCAGCGAGGCTA CTGTAATCGCTACCCGGTGTGCGTGGCCTGCCACCCTTGCTTCCAGACCTATGATGCGGACCTC CGGGAGCAGGCCCTGCGCTTTGGTAGACTCCGCAATGCCACCGCCAGCCTGTGGTCAGGGCCTG GGCTGGAGGACCGTGGCCTGGCCTCCCGGATCCTAGATGCAAAGAGTAAGATTGAGCAGATCCG AGCAGTTCTCAGCAGCCCCGCAGTCACAGAGCAGGAGGTGGCTCAGGTGGCCAGTGCCATCCTC TCCCTCAGGCGAACTCTCCAGGGCCTGCAGCTGGATCTGCCCCTGGAGGAGGAGACGTTGTCCC TTCCGAGAGACCTGGAGAGTCTTGACAGAAGCTTCAATGGTCTCCTTACTATGTATCAGAGGAA GAGGGAGCAGTTTGAAAAAATAAGCAGTGCTGATCCTTCAGGAGCCTTCCGGATGCTGAGCACA GCCTACGAGCAGTCAGCCCAGGCTGCTCAGCAGGTCTCCGACAGCTCGCGCCTTTTGGACCAGC TCAGGGACAGCCGGAGAGAGGCAGAGAGGCTGGTGCGGCAGGCGGGAGGAGGAGGAGGCACCGG CAGCCCCAAGCTTGTGGCCCTGAGGCTGGAGATGTCTTCGTTGCCTGACCTGACACCCACCTTC AACAAGCTCTGTGGCAACTCCAGGCAGATGGCTTGCACCCCAATATCATGCCCTGGTGAGCTAT GTCCCCAAGACAATGGCACAGCCTGTGGCTCCCGCTGCAGGGGTGTCCTTCCCAGGGCCGGTGG GGCCTTCTTGATGGCGGGGCAGGTGGCTGAGCAGCTGCGGGGCTTCAATGCCCAGCTCCAGCGG ACCAGGCAGATGATTAGGGCAGCCGAGGAATCTGCCTCACAGATTCAATCCAGTGCCCAGCGCT TGGAGACCCAGGTGAGCGCCAGCCGCTCCCAGATGGAGGAAGATGTCAGACGCACACGGCTCCT AATCCAGCAGGTCCGGGACTTCCTAACAGACCCCGACACTGATGCAGCCACTATCCAGGAGGTC AGCGAGGCCGTGCTGGCCCTGTGGCTGCCCACAGACTCAGCTACTGTTCTGCAGAAGATGAATG AGATCCAGGCCATTGCAGCCAGGCTCCCCAACGTGGACTTGGTGCTGTCCCAGACCAAGCAGGA CATTGCGCGTGCCCGCCGGTTGCAGGCTGAGGCTGAGGAAGCCAGGAGCCGAGCCCATGCAGTG GAGGGCCAGGTGGAAGATGTGGTTGGGAACCTGCGGCAGGGGACAGTGGCACTGCAGGAAGCTC AGGACACCATGCAAGGCACCAGCCGCTCCCTTCGGCTTATCCAGGACAGGGTTGCTGAGGTTCA GCAGGTACTGCGGCCAGCAGAAAAGCTGGTGACAAGCATGACCAAGCAGCTGGGTGACTTCTGG ACACGGATGGAGGAGCTCCGCCACCAAGCCCGGCAGCAGGGGGCAGAGGCAGTCCAGGCCCAGC AGCTTGCGGAAGGTGCCAGCGAGCAGGCATTGAGTGCCCAAGAGGGATTTGAGAGAATAAAACA AAAGTATGCTGAGTTGAAGGACCGGTTGGGTCAGAGTTCCATGCTGGGTGAGCAGGGTGCCCGG ATCCAGAGTGTGAAGACAGAGGCAGAGGAGCTGTTTGGGGAGACCATGGAGATGATGGACAGGA TGAAAGACATGGAGTTGGAGCTGCTGCGGGGCAGCCAGGCCATCATGCTGCGCTCAGCGGACCT GACAGGACTGGAGAAGCGTGTGGAGCAGATCCGTGACCACATCAATGGGCGCGTGCTCTACTAT GCCACCTGCAAGTGATGCTACAGCTTCCAGCCCGTTGCCCCACTCATCTGCCGCCTTTGCTTTT GGTTGGGGGCAGATTGGGTTGGAATGCTTTCCATCTCCAGGAGACTTTCATGCAGCCTAAAGTA CAGCCTGGACCACCCCTGGTGTGTAGCTAGTAAGATTACCCTGAGCTGCAGCTGAGCCTGAGCC AATGGGACAGTTACACTTGACAGACAAAGATGGTGGAGATTGGCATGCCATTGAAACTAAGAGC TCTCAAGTCAAGGAAGCTGGGCTGGGCAGTATCCCCCGCCTTTAGTTCTCCACTGGGGAGGAAT CCTGGACCAAGCACAAAAACTTAACAAAAGTGATGTAAAAATGAAAAGCCAAATAAAAATCTTT GGAAAAGAGCCTGGAGGTTCAACGAGGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA Download Select all
Length	4093

CDS Information

Location	join(1532..1559,2358..2512,13828..13942,14495..14568, 17838..18029,19343..19406,19700..19893,21741..21861, 22551..22739,24286..24441,24897..25093,25498..25609, 26450..26828,28476..28636,28751..28971,29297..29494, 29796..29940,33817..34024,34428..34569,34890..35066, 35852..36005,37069..37205)
CDS Sequence	>gi\|62868214:145-3663 Homo sapiens laminin, beta 3 (LAMB3), transcript variant 1, mRNA ATGAGACCATTCTTCCTCTTGTGTTTTGCCCTGCCTGGCCTCCTGCATGCCCAACAAGCCTGCTCCCGTG GGGCCTGCTATCCACCTGTTGGGGACCTGCTTGTTGGGAGGACCCGGTTTCTCCGAGCTTCATCTACCTG TGGACTGACCAAGCCTGAGACCTACTGCACCCAGTATGGCGAGTGGCAGATGAAATGCTGCAAGTGTGAC TCCAGGCAGCCTCACAACTACTACAGTCACCGAGTAGAGAATGTGGCTTCATCCTCCGGCCCCATGCGCT GGTGGCAGTCACAGAATGATGTGAACCCTGTCTCTCTGCAGCTGGACCTGGACAGGAGATTCCAGCTTCA AGAAGTCATGATGGAGTTCCAGGGGCCCATGCCCGCCGGCATGCTGATTGAGCGCTCCTCAGACTTCGGT AAGACCTGGCGAGTGTACCAGTACCTGGCTGCCGACTGCACCTCCACCTTCCCTCGGGTCCGCCAGGGTC GGCCTCAGAGCTGGCAGGATGTTCGGTGCCAGTCCCTGCCTCAGAGGCCTAATGCACGCCTAAATGGGGG GAAGGTCCAACTTAACCTTATGGATTTAGTGTCTGGGATTCCAGCAACTCAAAGTCAAAAAATTCAAGAG GTGGGGGAGATCACAAACTTGAGAGTCAATTTCACCAGGCTGGCCCCTGTGCCCCAAAGGGGCTACCACC CTCCCAGCGCCTACTATGCTGTGTCCCAGCTCCGTCTGCAGGGGAGCTGCTTCTGTCACGGCCATGCTGA TCGCTGCGCACCCAAGCCTGGGGCCTCTGCAGGCCCCTCCACCGCTGTGCAGGTCCACGATGTCTGTGTC TGCCAGCACAACACTGCCGGCCCAAATTGTGAGCGCTGTGCACCCTTCTACAACAACCGGCCCTGGAGAC CGGCGGAGGGCCAGGACGCCCATGAATGCCAAAGGTGCGACTGCAATGGGCACTCAGAGACATGTCACTT TGACCCCGCTGTGTTTGCCGCCAGCCAGGGGGCATATGGAGGTGTGTGTGACAATTGCCGGGACCACACC GAAGGCAAGAACTGTGAGCGGTGTCAGCTGCACTATTTCCGGAACCGGCGCCCGGGAGCTTCCATTCAGG AGACCTGCATCTCCTGCGAGTGTGATCCGGATGGGGCAGTGCCAGGGGCTCCCTGTGACCCAGTGACCGG GCAGTGTGTGTGCAAGGAGCATGTGCAGGGAGAGCGCTGTGACCTATGCAAGCCGGGCTTCACTGGACTC ACCTACGCCAACCCGCAGGGCTGCCACCGCTGTGACTGCAACATCCTGGGGTCCCGGAGGGACATGCCGT GTGACGAGGAGAGTGGGCGCTGCCTTTGTCTGCCCAACGTGGTGGGTCCCAAATGTGACCAGTGTGCTCC CTACCACTGGAAGCTGGCCAGTGGCCAGGGCTGTGAACCGTGTGCCTGCGACCCGCACAACTCCCTCAGC CCACAGTGCAACCAGTTCACAGGGCAGTGCCCCTGTCGGGAAGGCTTTGGTGGCCTGATGTGCAGCGCTG CAGCCATCCGCCAGTGTCCAGACCGGACCTATGGAGACGTGGCCACAGGATGCCGAGCCTGTGACTGTGA TTTCCGGGGAACAGAGGGCCCGGGCTGCGACAAGGCATCAGGCCGCTGCCTCTGCCGCCCTGGCTTGACC GGGCCCCGCTGTGACCAGTGCCAGCGAGGCTACTGTAATCGCTACCCGGTGTGCGTGGCCTGCCACCCTT GCTTCCAGACCTATGATGCGGACCTCCGGGAGCAGGCCCTGCGCTTTGGTAGACTCCGCAATGCCACCGC CAGCCTGTGGTCAGGGCCTGGGCTGGAGGACCGTGGCCTGGCCTCCCGGATCCTAGATGCAAAGAGTAAG ATTGAGCAGATCCGAGCAGTTCTCAGCAGCCCCGCAGTCACAGAGCAGGAGGTGGCTCAGGTGGCCAGTG CCATCCTCTCCCTCAGGCGAACTCTCCAGGGCCTGCAGCTGGATCTGCCCCTGGAGGAGGAGACGTTGTC CCTTCCGAGAGACCTGGAGAGTCTTGACAGAAGCTTCAATGGTCTCCTTACTATGTATCAGAGGAAGAGG GAGCAGTTTGAAAAAATAAGCAGTGCTGATCCTTCAGGAGCCTTCCGGATGCTGAGCACAGCCTACGAGC AGTCAGCCCAGGCTGCTCAGCAGGTCTCCGACAGCTCGCGCCTTTTGGACCAGCTCAGGGACAGCCGGAG AGAGGCAGAGAGGCTGGTGCGGCAGGCGGGAGGAGGAGGAGGCACCGGCAGCCCCAAGCTTGTGGCCCTG AGGCTGGAGATGTCTTCGTTGCCTGACCTGACACCCACCTTCAACAAGCTCTGTGGCAACTCCAGGCAGA TGGCTTGCACCCCAATATCATGCCCTGGTGAGCTATGTCCCCAAGACAATGGCACAGCCTGTGGCTCCCG CTGCAGGGGTGTCCTTCCCAGGGCCGGTGGGGCCTTCTTGATGGCGGGGCAGGTGGCTGAGCAGCTGCGG GGCTTCAATGCCCAGCTCCAGCGGACCAGGCAGATGATTAGGGCAGCCGAGGAATCTGCCTCACAGATTC AATCCAGTGCCCAGCGCTTGGAGACCCAGGTGAGCGCCAGCCGCTCCCAGATGGAGGAAGATGTCAGACG CACACGGCTCCTAATCCAGCAGGTCCGGGACTTCCTAACAGACCCCGACACTGATGCAGCCACTATCCAG GAGGTCAGCGAGGCCGTGCTGGCCCTGTGGCTGCCCACAGACTCAGCTACTGTTCTGCAGAAGATGAATG AGATCCAGGCCATTGCAGCCAGGCTCCCCAACGTGGACTTGGTGCTGTCCCAGACCAAGCAGGACATTGC GCGTGCCCGCCGGTTGCAGGCTGAGGCTGAGGAAGCCAGGAGCCGAGCCCATGCAGTGGAGGGCCAGGTG GAAGATGTGGTTGGGAACCTGCGGCAGGGGACAGTGGCACTGCAGGAAGCTCAGGACACCATGCAAGGCA CCAGCCGCTCCCTTCGGCTTATCCAGGACAGGGTTGCTGAGGTTCAGCAGGTACTGCGGCCAGCAGAAAA GCTGGTGACAAGCATGACCAAGCAGCTGGGTGACTTCTGGACACGGATGGAGGAGCTCCGCCACCAAGCC CGGCAGCAGGGGGCAGAGGCAGTCCAGGCCCAGCAGCTTGCGGAAGGTGCCAGCGAGCAGGCATTGAGTG CCCAAGAGGGATTTGAGAGAATAAAACAAAAGTATGCTGAGTTGAAGGACCGGTTGGGTCAGAGTTCCAT GCTGGGTGAGCAGGGTGCCCGGATCCAGAGTGTGAAGACAGAGGCAGAGGAGCTGTTTGGGGAGACCATG GAGATGATGGACAGGATGAAAGACATGGAGTTGGAGCTGCTGCGGGGCAGCCAGGCCATCATGCTGCGCT CAGCGGACCTGACAGGACTGGAGAAGCGTGTGGAGCAGATCCGTGACCACATCAATGGGCGCGTGCTCTA CTATGCCACCTGCAAGTGA Download Select all
CCDS ID	CCDS1487.1

Protein Information

Protein ID	NP_000219.2
Protein Name	Laminin, beta 3
Molecular Wt. (Da)	127645
Protein Sequence	>3914 MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYGEWQM KCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVMMEFQGPMP AGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQRPNARLNGGKVQLN LMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYAVSQLRLQGSCFCHGHA DRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNG HSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPD GAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDMPCDEES GRCLCLPNVVGPKCDQCAPYHWKLASGQGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCS AAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYP VCVACHPCFQTYDADLREQALRFGRLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSS PAVTEQEVAQVASAILSLRRTLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFE KISSADPSGAFRMLSTAYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLV ALRLEMSSLPDLTPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMA GQVAEQLRGFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVR DFLTDPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARAR RLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQVLRP AEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFERIKQKYAEL KDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAIMLRSADLTGLEK RVEQIRDHINGRVLYYATCK Download Select all
Length	1172
Uniprot ID	P48509
Ensembl Protein ID	ENSP00000324101

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
T	Phosphorylation	1170
T	Phosphorylation	1170

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
649	BMP1	209	NP_006120.1	in vitro;in vivo	10806203
1294	COL7A1	358	NP_000085.1	in vitro;in vivo	9989793
3918	LAMC2	1031	NP_005553.2	in vivo	10964684

Pathway Information

Pathway Name	Pathway ID
Amoebiasis	hsa05146
ECM-receptor interaction	hsa04512
Focal adhesion	hsa04510
Pathways in cancer	hsa05200
PI3K-Akt signaling pathway	hsa04151
Small cell lung cancer	hsa05222
Toxoplasmosis	hsa05145

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd00055	378-429	EGF_Lam
cl22875	378-429	EGF_Lam superfamily
cd00055	533-582	EGF_Lam
cl22875	533-582	EGF_Lam superfamily
cd00055	430-479	EGF_Lam
cl22875	430-479	EGF_Lam superfamily
cd00055	480-532	EGF_Lam
cl22875	480-532	EGF_Lam superfamily
cd00055	249-304	EGF_Lam
cl22875	249-304	EGF_Lam superfamily
cd00055	315-369	EGF_Lam
cl22875	315-369	EGF_Lam superfamily
smart00136	20-248	LamNT
cl02806	20-248	Laminin_N superfamily
pfam00055	26-248	Laminin_N
pfam00053	379-428	Laminin_EGF
smart00180	379-428	EGF_Lam
smart00180	534-576	EGF_Lam
pfam00053	431-478	Laminin_EGF
pfam00053	534-571	Laminin_EGF
smart00180	431-478	EGF_Lam
pfam00053	481-534	Laminin_EGF
smart00180	481-531	EGF_Lam
pfam00053	250-307	Laminin_EGF
cd11386	862-1076	MCP_signal
cl21547	862-1076	MCP_signal superfamily
pfam00053	316-367	Laminin_EGF
cd00176	894-1092	SPEC
cl02488	894-1092	SPEC superfamily
smart00180	278-302	EGF_Lam
smart00180	316-369	EGF_Lam
smart00283	844-1071	MA
TIGR02168	820-1115	SMC_prok_B
pfam13514	602-1166	AAA_27
TIGR02169	826-1162	SMC_prok_A
COG1196	817-1135	Smc
COG1196	832-1157	Smc
COG0419	590-1115	SbcC
PRK02224	834-1158	PRK02224
TIGR02169	853-1158	SMC_prok_A
TIGR02168	645-1162	SMC_prok_B
COG1196	837-1132	Smc
COG1196	933-1162	Smc
COG1196	600-970	Smc
TIGR02169	933-1162	SMC_prok_A
pfam12128	836-1025	DUF3584
TIGR02168	832-1162	SMC_prok_B
TIGR02168	958-1162	SMC_prok_B
COG4372	827-1112	COG4372
pfam04012	951-1127	PspA_IM30
TIGR02168	601-1114	SMC_prok_B
COG4942	827-1137	EnvC
TIGR02168	836-1119	SMC_prok_B
COG0419	845-1159	SbcC
pfam10174	836-1158	Cast
COG0840	840-1082	Tar
COG4477	909-1162	EzrA
COG1842	951-1129	PspA
pfam06008	820-1061	Laminin_I
pfam01576	838-1133	Myosin_tail_1
COG3206	867-1113	GumC
TIGR02168	934-1159	SMC_prok_B
TIGR00606	620-1160	rad50
pfam01576	838-1164	Myosin_tail_1
pfam12128	837-1135	DUF3584
TIGR02956	830-1063	TMAO_torS
COG0845	832-1075	AcrA
COG4372	833-1025	COG4372
COG4477	843-1165	EzrA
TIGR00618	936-1157	sbcc
PRK03918	930-1162	PRK03918
pfam10174	847-1161	Cast
pfam12128	618-1140	DUF3584
pfam05557	843-1158	MAD
TIGR02680	836-1078	TIGR02680
COG4372	942-1156	COG4372
pfam04012	970-1158	PspA_IM30
COG1196	994-1159	Smc
pfam10174	949-1162	Cast
pfam15070	834-1100	GOLGA2L5
TIGR01843	931-1109	type_I_hlyD
COG4372	1005-1164	COG4372
COG4477	862-1124	EzrA
pfam10174	835-1161	Cast
COG1579	932-1168	COG1579
PRK06975	825-964	PRK06975
TIGR02680	641-1094	TIGR02680
pfam00015	832-989	MCPsignal
pfam07111	831-1092	HCR
pfam07111	839-1134	HCR
PRK10246	828-1020	PRK10246
PRK02224	824-1159	PRK02224
pfam04012	930-1077	PspA_IM30
TIGR02977	934-1128	phageshock_pspA
pfam07888	838-1133	CALCOCO1
PRK04863	843-1155	mukB
pfam13514	609-1118	AAA_27
COG1538	845-1079	TolC
TIGR03007	845-1100	pepcterm_ChnLen
PRK14473	1008-1125	PRK14473
COG1538	837-1027	TolC
pfam00529	830-1011	HlyD
COG1842	850-1070	PspA
pfam06818	928-1091	Fez1

Ontology Information

HPRD ID	305
Molecular Class	Extracellular matrix protein
Molecular Function	Protein tyrosine/serine/threonine phosphatase activity (GO:0008138)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO