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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
LAMC2 3918 Laminin, gamma 2  1B2T; CSF; EBR2; BM600; EBR2A; LAMB2T; LAMNB2 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22930170   2012Cell line : KM 12C, KM 12SM , HT 30

Source : ATCC

Sample Type : -

No. of Sample : -

Stage : -

Microarray analysis,Real time RT-PCR and Flow cytometryUp-regulation-Gene differentially expressed and analysed bye by Microarray.


Gene Details



Chromosome: 1; NC_000001.10 (183155174..183214262)

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Gene Type protein coding
Gene Family Laminins
Description Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized by blisters due to disruption of the epidermal-dermal junction. Two transcript variants resulting from alternative splicing of the 3' terminal exon, and encoding different isoforms of gamma 2 chain, have been described. The two variants are differentially expressed in embryonic tissues, however, the biological significance of the two forms is not known. Transcript variants utilizing alternative polyA_signal have also been noted in literature. [provided by RefSeq, Aug 2011]  
Chromosome 1
Location 1q25-q31
Start 183186039  
End 183245127  
Strand +  
Gene Sequence

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Length 59089  
OMIM ID 150292   
HGNC ID HGNC:6493   
Unigene ID Hs.591484    
Ensembl ID ENSG00000058085   
PharmGKB ID -   

mRNA Information


mRNA ID NM_005562.2
Exon join(1..393,21843..22031,29415..29550,32352..32450, 34787..34923,36051..36173,37097..37286,39570..39682, 40660..40878,41477..41659,42336..42581,44923..45065, 46149..46305,46614..46819,48329..48408,49537..49692, 50422..50566,51314..51466,52269..52383,53326..53525, 54002..54160,54254..54353,57109..59089)  
mRNA Sequence

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Length 5623  



CDS Information


   
Locationjoin(315..393,21843..22031,29415..29550,32352..32450, 34787..34923,36051..36173,37097..37286,39570..39682, 40660..40878,41477..41659,42336..42581,44923..45065, 46149..46305,46614..46819,48329..48408,49537..49692, 50422..50566,51314..51466,52269..52383,53326..53525, 54002..54160,54254..54353,57109..57362)
CDS Sequence

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CCDS ID CCDS1352.1



Protein Information


      
Protein IDNP_005553.2
Protein NameLaminin, gamma 2
Molecular Wt. (Da)128745
Protein Sequence

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Length 1193  
Uniprot IDP06493
Ensembl Protein ID ENSP00000325970  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation265;-
YPhosphorylation250;-
YPhosphorylation273;-
YPhosphorylation265;-
YPhosphorylation250;-
YPhosphorylation273;-

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                            
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
649BMP1209NP_006120.1in vitro;in vivo10806203   
1294COL7A1358NP_000085.1in vitro;in vivo9989793   
2199FBLN2630NP_001004019.1in vitro11733994   
4811NID1574NP_002499.2in vitro11733994   


Pathway Information


                                          
Pathway Name Pathway ID
Amoebiasis hsa05146
ECM-receptor interaction hsa04512
Focal adhesion hsa04510
Pathways in cancer hsa05200
PI3K-Akt signaling pathway hsa04151
Small cell lung cancer hsa05222
Toxoplasmosis hsa05145


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0005583-127  EGF_Lam
cl2287583-127  EGF_Lam superfamily
cd00055516-565  EGF_Lam
cl22875516-565  EGF_Lam superfamily
cd00055139-185  EGF_Lam
cl22875139-185  EGF_Lam superfamily
cd00055461-509  EGF_Lam
cl22875461-509  EGF_Lam superfamily
cd00055572-604  EGF_Lam
cl22875572-604  EGF_Lam superfamily
cd0005528-78  EGF_Lam
cl2287528-78  EGF_Lam superfamily
smart00281245-370  LamB
cl02548245-370  Laminin_B superfamily
pfam00052250-380  Laminin_B
smart0018084-128  EGF_Lam
pfam0005384-123  Laminin_EGF
pfam00053139-184  Laminin_EGF
pfam00053517-564  Laminin_EGF
smart00180139-184  EGF_Lam
smart00180517-561  EGF_Lam
cd13406437-517  TNFRSF4
cl22855437-517  TNFRSF superfamily
smart00180462-508  EGF_Lam
pfam00053573-604  Laminin_EGF
smart00180573-604  EGF_Lam
cd00176891-1111  SPEC
cl02488891-1111  SPEC superfamily
PRK08476999-1067  PRK08476
cl21478999-1067  Mt_ATP-synt_B superfamily
pfam00053484-504  Laminin_EGF
pfam0005328-77  Laminin_EGF
cd13406550-612  TNFRSF4
cl22855550-612  TNFRSF superfamily
pfam04012851-1058  PspA_IM30
TIGR02168614-1173  SMC_prok_B
COG1196648-1032  Smc
COG0419620-1180  SbcC
COG1196613-1180  Smc
COG0419613-1180  SbcC
TIGR02168867-1181  SMC_prok_B
pfam01576624-1175  Myosin_tail_1
COG1196648-1018  Smc
COG1196868-1174  Smc
TIGR02169671-1075  SMC_prok_A
pfam05557819-1174  MAD
TIGR02169913-1175  SMC_prok_A
TIGR02168813-1150  SMC_prok_B
PRK03918648-1180  PRK03918
pfam13514756-1135  AAA_27
TIGR02168816-1176  SMC_prok_B
pfam07111624-1153  HCR
COG1196813-1145  Smc
pfam13514610-1127  AAA_27
COG0419822-1180  SbcC
pfam10174658-1193  Cast
COG0840826-1156  Tar
pfam12128625-1181  DUF3584
pfam01576867-1180  Myosin_tail_1
COG4372758-1036  COG4372
TIGR02168648-996  SMC_prok_B
TIGR02169813-1118  SMC_prok_A
PRK04863669-1147  mukB
pfam01576626-1152  Myosin_tail_1
COG4372789-1045  COG4372
pfam10174832-1163  Cast
COG2268736-1059  YqiK
pfam05262809-1100  Borrelia_P83
COG1842884-1062  PspA
TIGR00618654-1151  sbcc
COG5281754-1101  COG5281
COG4717897-1152  YhaN
TIGR02168614-952  SMC_prok_B
TIGR00606652-1153  rad50
TIGR00618614-1093  sbcc
COG4913758-1019  COG4913
pfam13514811-1151  AAA_27
TIGR02680619-1064  TIGR02680
TIGR02977885-1028  phageshock_pspA
COG1842816-1058  PspA
pfam05701646-1095  WEMBL
PRK07735889-1068  PRK07735
TIGR00606619-1180  rad50
PRK02224646-1103  PRK02224
pfam06008946-1163  Laminin_I
PRK02224850-1068  PRK02224
COG3096648-977  MukB
pfam13166828-1035  AAA_13
PRK02224817-1180  PRK02224
pfam06008813-1041  Laminin_I
pfam08429738-1009  PLU-1
PRK04863758-1093  mukB
COG11961041-1180  Smc
pfam01576861-1147  Myosin_tail_1


Ontology Information


   
HPRD ID307
Molecular ClassStructural protein
Molecular FunctionProtein tyrosine/serine/threonine phosphatase activity (GO:0008138)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO