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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| LAMC2 | 3918 | Laminin, gamma 2  | 1 | B2T; CSF; EBR2; BM600; EBR2A; LAMB2T; LAMNB2  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22930170    | 2012 | Cell line : KM 12C, KM 12SM , HT 30 Source : ATCC Sample Type : - No. of Sample : - Stage : - | Microarray analysis,Real time RT-PCR and Flow cytometry | Up-regulation | - | Gene differentially expressed and analysed bye by Microarray. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Laminins |
| Description | Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized by blisters due to disruption of the epidermal-dermal junction. Two transcript variants resulting from alternative splicing of the 3' terminal exon, and encoding different isoforms of gamma 2 chain, have been described. The two variants are differentially expressed in embryonic tissues, however, the biological significance of the two forms is not known. Transcript variants utilizing alternative polyA_signal have also been noted in literature. [provided by RefSeq, Aug 2011]   | Chromosome | 1 |
| Location | 1q25-q31 |
| Start | 183186039   |
| End | 183245127   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 59089   |
| OMIM ID | 150292    |
| HGNC ID | HGNC:6493    |
| Unigene ID | Hs.591484     |
| Ensembl ID | ENSG00000058085    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_005562.2 |
|---|---|
| Exon | join(1..393,21843..22031,29415..29550,32352..32450, 34787..34923,36051..36173,37097..37286,39570..39682, 40660..40878,41477..41659,42336..42581,44923..45065, 46149..46305,46614..46819,48329..48408,49537..49692, 50422..50566,51314..51466,52269..52383,53326..53525, 54002..54160,54254..54353,57109..59089)   | mRNA Sequence |    Download   Select all |
| Length | 5623   |
CDS Information
| Location | join(315..393,21843..22031,29415..29550,32352..32450, 34787..34923,36051..36173,37097..37286,39570..39682, 40660..40878,41477..41659,42336..42581,44923..45065, 46149..46305,46614..46819,48329..48408,49537..49692, 50422..50566,51314..51466,52269..52383,53326..53525, 54002..54160,54254..54353,57109..57362) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS1352.1 |    
Protein Information
| Protein ID | NP_005553.2 |
|---|---|
| Protein Name | Laminin, gamma 2 |
| Molecular Wt. (Da) | 128745 |
| Protein Sequence |    Download   Select all |
| Length | 1193   |
| Uniprot ID | P06493 |    
| Ensembl Protein ID | ENSP00000325970   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 265;- |
| Y | Phosphorylation | 250;- |
| Y | Phosphorylation | 273;- |
| Y | Phosphorylation | 265;- |
| Y | Phosphorylation | 250;- |
| Y | Phosphorylation | 273;- |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 649 |    BMP1 |    209 |    NP_006120.1 |    in vitro;in vivo |    10806203    |
| 1294 |    COL7A1 |    358 |    NP_000085.1 |    in vitro;in vivo |    9989793    |
| 2199 |    FBLN2 |    630 |    NP_001004019.1 |    in vitro |    11733994    |
| 4811 |    NID1 |    574 |    NP_002499.2 |    in vitro |    11733994    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Amoebiasis |    hsa05146 |    
| ECM-receptor interaction |    hsa04512 |    
| Focal adhesion |    hsa04510 |    
| Pathways in cancer |    hsa05200 |    
| PI3K-Akt signaling pathway |    hsa04151 |    
| Small cell lung cancer |    hsa05222 |    
| Toxoplasmosis |    hsa05145 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00055 | 83-127  | EGF_Lam |
| cl22875 | 83-127  | EGF_Lam superfamily |
| cd00055 | 516-565  | EGF_Lam |
| cl22875 | 516-565  | EGF_Lam superfamily |
| cd00055 | 139-185  | EGF_Lam |
| cl22875 | 139-185  | EGF_Lam superfamily |
| cd00055 | 461-509  | EGF_Lam |
| cl22875 | 461-509  | EGF_Lam superfamily |
| cd00055 | 572-604  | EGF_Lam |
| cl22875 | 572-604  | EGF_Lam superfamily |
| cd00055 | 28-78  | EGF_Lam |
| cl22875 | 28-78  | EGF_Lam superfamily |
| smart00281 | 245-370  | LamB |
| cl02548 | 245-370  | Laminin_B superfamily |
| pfam00052 | 250-380  | Laminin_B |
| smart00180 | 84-128  | EGF_Lam |
| pfam00053 | 84-123  | Laminin_EGF |
| pfam00053 | 139-184  | Laminin_EGF |
| pfam00053 | 517-564  | Laminin_EGF |
| smart00180 | 139-184  | EGF_Lam |
| smart00180 | 517-561  | EGF_Lam |
| cd13406 | 437-517  | TNFRSF4 |
| cl22855 | 437-517  | TNFRSF superfamily |
| smart00180 | 462-508  | EGF_Lam |
| pfam00053 | 573-604  | Laminin_EGF |
| smart00180 | 573-604  | EGF_Lam |
| cd00176 | 891-1111  | SPEC |
| cl02488 | 891-1111  | SPEC superfamily |
| PRK08476 | 999-1067  | PRK08476 |
| cl21478 | 999-1067  | Mt_ATP-synt_B superfamily |
| pfam00053 | 484-504  | Laminin_EGF |
| pfam00053 | 28-77  | Laminin_EGF |
| cd13406 | 550-612  | TNFRSF4 |
| cl22855 | 550-612  | TNFRSF superfamily |
| pfam04012 | 851-1058  | PspA_IM30 |
| TIGR02168 | 614-1173  | SMC_prok_B |
| COG1196 | 648-1032  | Smc |
| COG0419 | 620-1180  | SbcC |
| COG1196 | 613-1180  | Smc |
| COG0419 | 613-1180  | SbcC |
| TIGR02168 | 867-1181  | SMC_prok_B |
| pfam01576 | 624-1175  | Myosin_tail_1 |
| COG1196 | 648-1018  | Smc |
| COG1196 | 868-1174  | Smc |
| TIGR02169 | 671-1075  | SMC_prok_A |
| pfam05557 | 819-1174  | MAD |
| TIGR02169 | 913-1175  | SMC_prok_A |
| TIGR02168 | 813-1150  | SMC_prok_B |
| PRK03918 | 648-1180  | PRK03918 |
| pfam13514 | 756-1135  | AAA_27 |
| TIGR02168 | 816-1176  | SMC_prok_B |
| pfam07111 | 624-1153  | HCR |
| COG1196 | 813-1145  | Smc |
| pfam13514 | 610-1127  | AAA_27 |
| COG0419 | 822-1180  | SbcC |
| pfam10174 | 658-1193  | Cast |
| COG0840 | 826-1156  | Tar |
| pfam12128 | 625-1181  | DUF3584 |
| pfam01576 | 867-1180  | Myosin_tail_1 |
| COG4372 | 758-1036  | COG4372 |
| TIGR02168 | 648-996  | SMC_prok_B |
| TIGR02169 | 813-1118  | SMC_prok_A |
| PRK04863 | 669-1147  | mukB |
| pfam01576 | 626-1152  | Myosin_tail_1 |
| COG4372 | 789-1045  | COG4372 |
| pfam10174 | 832-1163  | Cast |
| COG2268 | 736-1059  | YqiK |
| pfam05262 | 809-1100  | Borrelia_P83 |
| COG1842 | 884-1062  | PspA |
| TIGR00618 | 654-1151  | sbcc |
| COG5281 | 754-1101  | COG5281 |
| COG4717 | 897-1152  | YhaN |
| TIGR02168 | 614-952  | SMC_prok_B |
| TIGR00606 | 652-1153  | rad50 |
| TIGR00618 | 614-1093  | sbcc |
| COG4913 | 758-1019  | COG4913 |
| pfam13514 | 811-1151  | AAA_27 |
| TIGR02680 | 619-1064  | TIGR02680 |
| TIGR02977 | 885-1028  | phageshock_pspA |
| COG1842 | 816-1058  | PspA |
| pfam05701 | 646-1095  | WEMBL |
| PRK07735 | 889-1068  | PRK07735 |
| TIGR00606 | 619-1180  | rad50 |
| PRK02224 | 646-1103  | PRK02224 |
| pfam06008 | 946-1163  | Laminin_I |
| PRK02224 | 850-1068  | PRK02224 |
| COG3096 | 648-977  | MukB |
| pfam13166 | 828-1035  | AAA_13 |
| PRK02224 | 817-1180  | PRK02224 |
| pfam06008 | 813-1041  | Laminin_I |
| pfam08429 | 738-1009  | PLU-1 |
| PRK04863 | 758-1093  | mukB |
| COG1196 | 1041-1180  | Smc |
| pfam01576 | 861-1147  | Myosin_tail_1 |
Ontology Information
| HPRD ID | 307 |    
|---|---|
| Molecular Class | Structural protein |
| Molecular Function | Protein tyrosine/serine/threonine phosphatase activity (GO:0008138) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
