Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| LTBP1 | 4052 | Latent transforming growth factor beta binding protein 1  | 2 | -  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20089989    | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis | Up-regulation | - | This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue. CRC tissue was collected at the VU University Medical Center, Amsterdam, The Netherlands. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Latent transforming growth factor, beta binding proteins |
| Description | The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]   |
| Chromosome | 2 |
| Location | 2p22-p21 |
| Start | 32947300   |
| End | 33399509   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 452210   |
| OMIM ID | 150390    |
| HGNC ID | HGNC:6714    |
| Unigene ID | Hs.619315     |
| Ensembl ID | ENSG00000049323    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | XM_011532853.1 |
|---|---|
| Exon | join(1..519,1576..1646,73610..73907,163283..163452, 187494..187661,239557..239781,241278..241552, 270253..270355,274781..274852,296363..296485, 305378..305545,309985..310212,312289..312311, 315423..315525,315995..316093,326357..326482, 327666..327791,328502..328624,332740..332859, 345861..345983,353152..353274,354223..354345, 362135..362257,367845..367970,395539..395664, 400068..400211,413298..413480,414130..414216, 416091..416219,416917..417057,418034..418204, 441885..442007,449834..449983,451065..452198)   | mRNA Sequence |    Download   Select all |
| Length | 6168   |
CDS Information
| Location | join(26..519,1576..1646,73610..73907,163283..163452, 187494..187661,239557..239781,241278..241552, 270253..270355,274781..274852,296363..296485, 305378..305545,309985..310212,312289..312311, 315423..315525,315995..316093,326357..326482, 327666..327791,328502..328624,332740..332859, 345861..345983,353152..353274,354223..354345, 362135..362257,367845.. |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | - |    
Protein Information
| Protein ID | NP_000618.3 |
|---|---|
| Protein Name | Latent transforming growth factor beta binding protein 1 |
| Molecular Wt. (Da) | 150610 |
| Protein Sequence |    Download   Select all |
| Length | 1395   |
| Uniprot ID | P55283 |    
| Ensembl Protein ID | ENSP00000443301   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 1600 |
| T | Phosphorylation | 1274 |
| Y | Phosphorylation | 1599 |
| Y | Phosphorylation | 1273 |
| S | Phosphorylation | 1596 |
| S | Phosphorylation | 1270 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2200 |    FBN1 |    618 |    NP_000129.2 |    in vitro;in vivo |    12429738    |
| 2201 |    FBN2 |    416 |    NP_001990.2 |    in vitro;in vivo |    12429738    |
| 2335 |    FN1 |    626 |    NP_997647.1 |    in vitro |    8756760    |
| 3486 |    IGFBP3 |    899 |    NP_001013416.1 |    yeast 2-hybrid |    12962157    |
| 3693 |    ITGB5 |    949 |    NP_002204.2 |    in vitro;in vivo |    12358597    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| TGF-beta signaling pathway |    hsa04350 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00054 | 1202-1243  | EGF_CA |
| cl21504 | 1202-1243  | EGF_CA superfamily |
| cd00054 | 1120-1160  | EGF_CA |
| cl21504 | 1120-1160  | EGF_CA superfamily |
| cd00054 | 1079-1111  | EGF_CA |
| cl21504 | 1079-1111  | EGF_CA superfamily |
| cd00054 | 1244-1276  | EGF_CA |
| cl21504 | 1244-1276  | EGF_CA superfamily |
| cd00054 | 1038-1069  | EGF_CA |
| cl21504 | 1038-1069  | EGF_CA superfamily |
| cd00054 | 626-656  | EGF_CA |
| cl21504 | 626-656  | EGF_CA superfamily |
| cd00054 | 915-956  | EGF_CA |
| cl21504 | 915-956  | EGF_CA superfamily |
| cd00054 | 1662-1696  | EGF_CA |
| cl21504 | 1662-1696  | EGF_CA superfamily |
| cd00054 | 1161-1201  | EGF_CA |
| cl21504 | 1161-1201  | EGF_CA superfamily |
| cd00054 | 957-989  | EGF_CA |
| cl21504 | 957-989  | EGF_CA superfamily |
| cd00054 | 998-1031  | EGF_CA |
| cl21504 | 998-1031  | EGF_CA superfamily |
| pfam00683 | 688-728  | TB |
| cl02926 | 688-728  | TB superfamily |
| pfam00683 | 1357-1400  | TB |
| cl02926 | 1357-1400  | TB superfamily |
| smart00179 | 1202-1243  | EGF_CA |
| pfam00683 | 1534-1576  | TB |
| cl02926 | 1534-1576  | TB superfamily |
| smart00179 | 1120-1160  | EGF_CA |
| smart00179 | 1079-1110  | EGF_CA |
| pfam07645 | 915-955  | EGF_CA |
| smart00179 | 1244-1285  | EGF_CA |
| smart00179 | 1038-1077  | EGF_CA |
| smart00179 | 626-656  | EGF_CA |
| smart00179 | 915-956  | EGF_CA |
| pfam12662 | 1224-1247  | cEGF |
| smart00179 | 1161-1201  | EGF_CA |
| pfam07645 | 1161-1200  | EGF_CA |
| pfam07645 | 1120-1159  | EGF_CA |
| smart00179 | 1662-1696  | EGF_CA |
| pfam12662 | 1059-1082  | cEGF |
| smart00179 | 957-997  | EGF_CA |
| pfam12662 | 1183-1205  | cEGF |
| pfam07645 | 1202-1242  | EGF_CA |
| pfam07645 | 1662-1705  | EGF_CA |
| pfam07645 | 1244-1284  | EGF_CA |
| smart00181 | 1082-1112  | EGF |
| cd01475 | 909-952  | vWA_Matrilin |
| cl00057 | 909-952  | vWFA superfamily |
| pfam12662 | 1100-1123  | cEGF |
| smart00181 | 1123-1151  | EGF |
| smart00181 | 629-661  | EGF |
| pfam07645 | 1038-1077  | EGF_CA |
| pfam12662 | 896-918  | cEGF |
| cl21504 | 896-918  | EGF_CA superfamily |
| cd00053 | 1205-1234  | EGF |
| smart00181 | 1041-1069  | EGF |
| pfam12662 | 1141-1164  | cEGF |
| smart00179 | 998-1030  | EGF_CA |
| pfam12662 | 1266-1289  | cEGF |
| cl21504 | 1266-1289  | EGF_CA superfamily |
| pfam00683 | 566-609  | TB |
| cl02926 | 566-609  | TB superfamily |
| pfam06247 | 1089-1239  | Plasmod_Pvs28 |
| pfam06247 | 1170-1325  | Plasmod_Pvs28 |
| PHA03247 | 742-868  | PHA03247 |
| pfam13388 | 749-864  | DUF4106 |
| pfam06247 | 1631-1705  | Plasmod_Pvs28 |
| PRK03427 | 751-865  | PRK03427 |
Ontology Information
| HPRD ID | 11081 |    
|---|---|
| Molecular Class | Extracellular matrix protein |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
