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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
LTBP1 4052 Latent transforming growth factor beta binding protein 1  2- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20089989   2010Cell line : -

Source : VU University Medical Center, Amsterdam, The Netherlands.

Sample Type : CRC tumor and normal tissue

No. of Sample : -

Stage : -

Biochemical isolation to nano-LC-MS/MS analysis Up-regulation-This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue.

CRC tissue was collected at the VU University Medical Center, Amsterdam, The Netherlands.


Gene Details



Chromosome: 2; NC_000002.11 (33172369..33624576)

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Gene Type protein coding
Gene Family Latent transforming growth factor, beta binding proteins
Description The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]  
Chromosome 2
Location 2p22-p21
Start 32947300  
End 33399509  
Strand +  
Gene Sequence

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Length 452210  
OMIM ID 150390   
HGNC ID HGNC:6714   
Unigene ID Hs.619315    
Ensembl ID ENSG00000049323   
PharmGKB ID -   

mRNA Information


mRNA ID XM_011532853.1
Exon join(1..519,1576..1646,73610..73907,163283..163452, 187494..187661,239557..239781,241278..241552, 270253..270355,274781..274852,296363..296485, 305378..305545,309985..310212,312289..312311, 315423..315525,315995..316093,326357..326482, 327666..327791,328502..328624,332740..332859, 345861..345983,353152..353274,354223..354345, 362135..362257,367845..367970,395539..395664, 400068..400211,413298..413480,414130..414216, 416091..416219,416917..417057,418034..418204, 441885..442007,449834..449983,451065..452198)  
mRNA Sequence

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Length 6168  



CDS Information


   
Location join(26..519,1576..1646,73610..73907,163283..163452, 187494..187661,239557..239781,241278..241552, 270253..270355,274781..274852,296363..296485, 305378..305545,309985..310212,312289..312311, 315423..315525,315995..316093,326357..326482, 327666..327791,328502..328624,332740..332859, 345861..345983,353152..353274,354223..354345, 362135..362257,367845..
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDNP_000618.3
Protein NameLatent transforming growth factor beta binding protein 1
Molecular Wt. (Da)150610
Protein Sequence

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Length 1395  
Uniprot IDP55283
Ensembl Protein ID ENSP00000443301  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation1600
TPhosphorylation1274
YPhosphorylation1599
YPhosphorylation1273
SPhosphorylation1596
SPhosphorylation1270

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                           
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2200FBN1618NP_000129.2in vitro;in vivo12429738   
2201FBN2416NP_001990.2in vitro;in vivo12429738   
2335FN1626NP_997647.1in vitro8756760   
3486IGFBP3899NP_001013416.1yeast 2-hybrid12962157   
3693ITGB5949NP_002204.2in vitro;in vivo12358597   


Pathway Information


      
Pathway Name Pathway ID
TGF-beta signaling pathway hsa04350


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd000541202-1243  EGF_CA
cl215041202-1243  EGF_CA superfamily
cd000541120-1160  EGF_CA
cl215041120-1160  EGF_CA superfamily
cd000541079-1111  EGF_CA
cl215041079-1111  EGF_CA superfamily
cd000541244-1276  EGF_CA
cl215041244-1276  EGF_CA superfamily
cd000541038-1069  EGF_CA
cl215041038-1069  EGF_CA superfamily
cd00054626-656  EGF_CA
cl21504626-656  EGF_CA superfamily
cd00054915-956  EGF_CA
cl21504915-956  EGF_CA superfamily
cd000541662-1696  EGF_CA
cl215041662-1696  EGF_CA superfamily
cd000541161-1201  EGF_CA
cl215041161-1201  EGF_CA superfamily
cd00054957-989  EGF_CA
cl21504957-989  EGF_CA superfamily
cd00054998-1031  EGF_CA
cl21504998-1031  EGF_CA superfamily
pfam00683688-728  TB
cl02926688-728  TB superfamily
pfam006831357-1400  TB
cl029261357-1400  TB superfamily
smart001791202-1243  EGF_CA
pfam006831534-1576  TB
cl029261534-1576  TB superfamily
smart001791120-1160  EGF_CA
smart001791079-1110  EGF_CA
pfam07645915-955  EGF_CA
smart001791244-1285  EGF_CA
smart001791038-1077  EGF_CA
smart00179626-656  EGF_CA
smart00179915-956  EGF_CA
pfam126621224-1247  cEGF
smart001791161-1201  EGF_CA
pfam076451161-1200  EGF_CA
pfam076451120-1159  EGF_CA
smart001791662-1696  EGF_CA
pfam126621059-1082  cEGF
smart00179957-997  EGF_CA
pfam126621183-1205  cEGF
pfam076451202-1242  EGF_CA
pfam076451662-1705  EGF_CA
pfam076451244-1284  EGF_CA
smart001811082-1112  EGF
cd01475909-952  vWA_Matrilin
cl00057909-952  vWFA superfamily
pfam126621100-1123  cEGF
smart001811123-1151  EGF
smart00181629-661  EGF
pfam076451038-1077  EGF_CA
pfam12662896-918  cEGF
cl21504896-918  EGF_CA superfamily
cd000531205-1234  EGF
smart001811041-1069  EGF
pfam126621141-1164  cEGF
smart00179998-1030  EGF_CA
pfam126621266-1289  cEGF
cl215041266-1289  EGF_CA superfamily
pfam00683566-609  TB
cl02926566-609  TB superfamily
pfam062471089-1239  Plasmod_Pvs28
pfam062471170-1325  Plasmod_Pvs28
PHA03247742-868  PHA03247
pfam13388749-864  DUF4106
pfam062471631-1705  Plasmod_Pvs28
PRK03427751-865  PRK03427


Ontology Information


   
HPRD ID11081
Molecular ClassExtracellular matrix protein
Molecular FunctionCell adhesion molecule activity (GO:0005194)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO