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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
LTBP2 4053 Latent transforming growth factor beta binding protein 2  14WMS3; GLC3D; LTBP3; MSPKA; MSTP031; C14orf141 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20089989   2010Cell line : -

Source : VU University Medical Center, Amsterdam, The Netherlands.

Sample Type : CRC tumor and normal tissue

No. of Sample : -

Stage : -

Biochemical isolation to nano-LC-MS/MS analysis Down-regulation-This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue.


Gene Details



Chromosome: 14; NC_000014.8 (74964886..75079034, complement)

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Gene Type protein coding
Gene Family Latent transforming growth factor, beta binding proteins
Description The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. This protein is the largest member of the LTBP family possessing unique regions and with most similarity to the fibrillins. It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion. [provided by RefSeq, Jul 2008]  
Chromosome 14
Location 14q24
Start 74498183  
End 74618609  
Strand -  
Gene Sequence

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Length 120427  
OMIM ID 602091   
HGNC ID HGNC:6715   
Unigene ID Hs.512776    
Ensembl ID ENSG00000119681   
PharmGKB ID -   

mRNA Information


mRNA ID XM_011536767.1
Exon join(1..26,14905..14975,32492..32756,62917..63107, 65548..65718,66217..66423,67260..67546,68645..68747, 82610..82684,86062..86184,89488..89652,89912..90127, 91244..91263,92496..92535,93385..93486,95692..95820, 96571..96699,101669..101788,107246..107365,108397..108519, 108751..108876,109247..109372,109658..109780, 109881..110006,110515..110637,111300..111431, 111787..111912,112419..112562,113436..113627, 113749..113832,114556..114684,115004..115141, 115224..115391,115676..115957,117020..117169, 117581..120427)  
mRNA Sequence

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Length 8568  



CDS Information


   
Locationjoin(16..26,14905..14975,32492..32756,62917..63107, 65548..65718,66217..66423,67260..67546,68645..68747, 82610..82684,86062..86184,89488..89652,89912..90127, 91244..91263,92496..92535,93385..93486,95692..95820, 96571..96699,101669..101788,107246..107365,108397..108519, 108751..108876,109247..109372,109658..109780, 109881..110006,110515..110637,111300..111431,
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDNP_000419.1
Protein NameLatent transforming growth factor beta binding protein 2
Molecular Wt. (Da)191198
Protein Sequence

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Length 1821  
Uniprot IDQ9Y6N8
Ensembl Protein ID ENSP00000264463  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd000541303-1335  EGF_CA
cl215041303-1335  EGF_CA superfamily
cd00054930-961  EGF_CA
cl21504930-961  EGF_CA superfamily
cd000541218-1249  EGF_CA
cl215041218-1249  EGF_CA superfamily
cd000541135-1170  EGF_CA
cl215041135-1170  EGF_CA superfamily
cd000541010-1041  EGF_CA
cl215041010-1041  EGF_CA superfamily
cd00054887-921  EGF_CA
cl21504887-921  EGF_CA superfamily
cd000541176-1217  EGF_CA
cl215041176-1217  EGF_CA superfamily
cd00054622-655  EGF_CA
cl21504622-655  EGF_CA superfamily
cd00054970-1005  EGF_CA
cl21504970-1005  EGF_CA superfamily
cd000541774-1808  EGF_CA
cl215041774-1808  EGF_CA superfamily
pfam00683681-723  TB
cl02926681-723  TB superfamily
smart00179930-960  EGF_CA
pfam006831423-1462  TB
cl029261423-1462  TB superfamily
smart001791303-1335  EGF_CA
smart001791218-1249  EGF_CA
pfam076451218-1257  EGF_CA
smart001791135-1175  EGF_CA
smart001791010-1041  EGF_CA
pfam076451051-1091  EGF_CA
cl215041051-1091  EGF_CA superfamily
pfam076451135-1174  EGF_CA
smart001791176-1217  EGF_CA
smart00179887-918  EGF_CA
pfam076451093-1133  EGF_CA
cl215041093-1133  EGF_CA superfamily
pfam076451303-1343  EGF_CA
pfam076451010-1049  EGF_CA
smart00179622-651  EGF_CA
smart001791774-1808  EGF_CA
pfam006831594-1635  TB
cl029261594-1635  TB superfamily
pfam126621031-1054  cEGF
pfam076451176-1216  EGF_CA
pfam076451774-1817  EGF_CA
smart001791485-1518  EGF_CA
cl215041485-1518  EGF_CA superfamily
smart00179970-1002  EGF_CA
smart00181933-964  EGF
cd014751004-1047  vWA_Matrilin
cl000571004-1047  vWFA superfamily
smart001791051-1092  EGF_CA
pfam126621157-1179  cEGF
PHA0324731-165  PHA03247
PRK0700330-162  PRK07003
PHA0324747-163  PHA03247
PRK123232-159  PRK12323
PHA032472-162  PHA03247
PHA0337845-161  PHA03378
PRK0776447-161  PRK07764
PHA033079-175  PHA03307
PRK0003044-158  minC
pfam06247939-1077  Plasmod_Pvs28
PRK0776430-160  PRK07764
PRK1495135-164  PRK14951
PHA032473-162  PHA03247
PRK1232339-159  PRK12323
PRK0776435-161  PRK07764
PRK0342735-150  PRK03427
PRK0776432-161  PRK07764
pfam062471151-1315  Plasmod_Pvs28
PRK1495139-158  PRK14951
pfam0327683-217  Gag_spuma
PRK0700345-161  PRK07003
PRK1267854-166  PRK12678
PRK0776419-168  PRK07764
pfam1524031-161  Pro-rich
PRK0776473-166  PRK07764
pfam06247855-996  Plasmod_Pvs28
PHA033072-173  PHA03307
PRK1275774-141  PRK12757
PRK0776461-162  PRK07764
PRK0699554-155  flhF


Ontology Information


   
HPRD ID3219
Molecular ClassExtracellular matrix protein
Molecular FunctionCell adhesion molecule activity (GO:0005194)
Biological ProcessCell growth and/or maintenance (GO:0008151)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO