Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| LTBP2 | 4053 | Latent transforming growth factor beta binding protein 2  | 14 | WMS3; GLC3D; LTBP3; MSPKA; MSTP031; C14orf141  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20089989    | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis | Down-regulation | - | This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Latent transforming growth factor, beta binding proteins |
| Description | The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. This protein is the largest member of the LTBP family possessing unique regions and with most similarity to the fibrillins. It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion. [provided by RefSeq, Jul 2008]   | Chromosome | 14 |
| Location | 14q24 |
| Start | 74498183   |
| End | 74618609   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 120427   |
| OMIM ID | 602091    |
| HGNC ID | HGNC:6715    |
| Unigene ID | Hs.512776     |
| Ensembl ID | ENSG00000119681    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | XM_011536767.1 |
|---|---|
| Exon | join(1..26,14905..14975,32492..32756,62917..63107, 65548..65718,66217..66423,67260..67546,68645..68747, 82610..82684,86062..86184,89488..89652,89912..90127, 91244..91263,92496..92535,93385..93486,95692..95820, 96571..96699,101669..101788,107246..107365,108397..108519, 108751..108876,109247..109372,109658..109780, 109881..110006,110515..110637,111300..111431, 111787..111912,112419..112562,113436..113627, 113749..113832,114556..114684,115004..115141, 115224..115391,115676..115957,117020..117169, 117581..120427)   | mRNA Sequence |    Download   Select all |
| Length | 8568   |
CDS Information
| Location | join(16..26,14905..14975,32492..32756,62917..63107, 65548..65718,66217..66423,67260..67546,68645..68747, 82610..82684,86062..86184,89488..89652,89912..90127, 91244..91263,92496..92535,93385..93486,95692..95820, 96571..96699,101669..101788,107246..107365,108397..108519, 108751..108876,109247..109372,109658..109780, 109881..110006,110515..110637,111300..111431, |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | - |    
Protein Information
| Protein ID | NP_000419.1 |
|---|---|
| Protein Name | Latent transforming growth factor beta binding protein 2 |
| Molecular Wt. (Da) | 191198 |
| Protein Sequence |    Download   Select all |
| Length | 1821   |
| Uniprot ID | Q9Y6N8 |    
| Ensembl Protein ID | ENSP00000264463   |    
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00054 | 1303-1335  | EGF_CA |
| cl21504 | 1303-1335  | EGF_CA superfamily |
| cd00054 | 930-961  | EGF_CA |
| cl21504 | 930-961  | EGF_CA superfamily |
| cd00054 | 1218-1249  | EGF_CA |
| cl21504 | 1218-1249  | EGF_CA superfamily |
| cd00054 | 1135-1170  | EGF_CA |
| cl21504 | 1135-1170  | EGF_CA superfamily |
| cd00054 | 1010-1041  | EGF_CA |
| cl21504 | 1010-1041  | EGF_CA superfamily |
| cd00054 | 887-921  | EGF_CA |
| cl21504 | 887-921  | EGF_CA superfamily |
| cd00054 | 1176-1217  | EGF_CA |
| cl21504 | 1176-1217  | EGF_CA superfamily |
| cd00054 | 622-655  | EGF_CA |
| cl21504 | 622-655  | EGF_CA superfamily |
| cd00054 | 970-1005  | EGF_CA |
| cl21504 | 970-1005  | EGF_CA superfamily |
| cd00054 | 1774-1808  | EGF_CA |
| cl21504 | 1774-1808  | EGF_CA superfamily |
| pfam00683 | 681-723  | TB |
| cl02926 | 681-723  | TB superfamily |
| smart00179 | 930-960  | EGF_CA |
| pfam00683 | 1423-1462  | TB |
| cl02926 | 1423-1462  | TB superfamily |
| smart00179 | 1303-1335  | EGF_CA |
| smart00179 | 1218-1249  | EGF_CA |
| pfam07645 | 1218-1257  | EGF_CA |
| smart00179 | 1135-1175  | EGF_CA |
| smart00179 | 1010-1041  | EGF_CA |
| pfam07645 | 1051-1091  | EGF_CA |
| cl21504 | 1051-1091  | EGF_CA superfamily |
| pfam07645 | 1135-1174  | EGF_CA |
| smart00179 | 1176-1217  | EGF_CA |
| smart00179 | 887-918  | EGF_CA |
| pfam07645 | 1093-1133  | EGF_CA |
| cl21504 | 1093-1133  | EGF_CA superfamily |
| pfam07645 | 1303-1343  | EGF_CA |
| pfam07645 | 1010-1049  | EGF_CA |
| smart00179 | 622-651  | EGF_CA |
| smart00179 | 1774-1808  | EGF_CA |
| pfam00683 | 1594-1635  | TB |
| cl02926 | 1594-1635  | TB superfamily |
| pfam12662 | 1031-1054  | cEGF |
| pfam07645 | 1176-1216  | EGF_CA |
| pfam07645 | 1774-1817  | EGF_CA |
| smart00179 | 1485-1518  | EGF_CA |
| cl21504 | 1485-1518  | EGF_CA superfamily |
| smart00179 | 970-1002  | EGF_CA |
| smart00181 | 933-964  | EGF |
| cd01475 | 1004-1047  | vWA_Matrilin |
| cl00057 | 1004-1047  | vWFA superfamily |
| smart00179 | 1051-1092  | EGF_CA |
| pfam12662 | 1157-1179  | cEGF |
| PHA03247 | 31-165  | PHA03247 |
| PRK07003 | 30-162  | PRK07003 |
| PHA03247 | 47-163  | PHA03247 |
| PRK12323 | 2-159  | PRK12323 |
| PHA03247 | 2-162  | PHA03247 |
| PHA03378 | 45-161  | PHA03378 |
| PRK07764 | 47-161  | PRK07764 |
| PHA03307 | 9-175  | PHA03307 |
| PRK00030 | 44-158  | minC |
| pfam06247 | 939-1077  | Plasmod_Pvs28 |
| PRK07764 | 30-160  | PRK07764 |
| PRK14951 | 35-164  | PRK14951 |
| PHA03247 | 3-162  | PHA03247 |
| PRK12323 | 39-159  | PRK12323 |
| PRK07764 | 35-161  | PRK07764 |
| PRK03427 | 35-150  | PRK03427 |
| PRK07764 | 32-161  | PRK07764 |
| pfam06247 | 1151-1315  | Plasmod_Pvs28 |
| PRK14951 | 39-158  | PRK14951 |
| pfam03276 | 83-217  | Gag_spuma |
| PRK07003 | 45-161  | PRK07003 |
| PRK12678 | 54-166  | PRK12678 |
| PRK07764 | 19-168  | PRK07764 |
| pfam15240 | 31-161  | Pro-rich |
| PRK07764 | 73-166  | PRK07764 |
| pfam06247 | 855-996  | Plasmod_Pvs28 |
| PHA03307 | 2-173  | PHA03307 |
| PRK12757 | 74-141  | PRK12757 |
| PRK07764 | 61-162  | PRK07764 |
| PRK06995 | 54-155  | flhF |
Ontology Information
| HPRD ID | 3219 |    
|---|---|
| Molecular Class | Extracellular matrix protein |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell growth and/or maintenance (GO:0008151)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
