Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MEP1A | 4224 | Meprin A, alpha (PABA peptide hydrolase)  | 6 | PPHA  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 10070973    | 1999 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | RT-PCR, Cell Culture, Biosynthetic Labeling, Immunoprecipitation, Northern Blot, Immunohistochemistr | Unknown | - | Protease is known to cleave extracellular matrix components in vitro, meprin a may contribute to tumor progression by facilitating migration, intravasation, and metastasis of carcinoma cells. |
| 22096485    | 2011 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Cell migration assay, Angiogenesis assay, Northern blotting, Immunoblots, Immunoprecipitation, Immunohistochemistry | Up-regulation | - | Meprin-a activity is regulated differently in primary tumors and metastases, leading to high proteolytic activity in primary tumors and low activity in liver metastases. By virtue of its pro-migratory and pro-angiogenic activity, meprin-a may promote tumor progression in colorectal cancer. The study included 72 patients (49/23 male/female). |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | -   |
| Chromosome | 6 |
| Location | 6p12-p11 |
| Start | 46793357   |
| End | 46845987   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 52631   |
| OMIM ID | 600388    |
| HGNC ID | HGNC:7015    |
| Unigene ID | Hs.179704     |
| Ensembl ID | ENSG00000112818    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | XM_011514629.1 |
|---|---|
| Exon | join(1..111,196..220,310..360,5250..5290,5750..5825, 16064..16181,26173..26348,31916..32137,32998..33147, 36000..36215,39718..40182,41222..41395,41893..42193, 52184..52631)   | mRNA Sequence |    Download   Select all |
| Length | 2947   |
CDS Information
| Location | join(43..111,196..220,310..360,5250..5290,5750..5825, 16064..16181,26173..26348,31916..32137,32998..33147, 36000..36215,39718..40182,41222..41395,41893..42193, 52184..52217) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | - |    
Protein Information
| Protein ID | NP_005579.2 |
|---|---|
| Protein Name | Meprin A, alpha (PABA peptide hydrolase) |
| Molecular Wt. (Da) | 77089 |
| Protein Sequence |    Download   Select all |
| Length | 746   |
| Uniprot ID | P49918 |    
| Ensembl Protein ID | ENSP00000413720   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| R | Proteolytic Cleavage | 65 |
Enzyme Information
| EC | 3.4.24.21 |    
|---|---|
| Name | astacin Astacus proteinase crayfish small-molecule proteinase |
| Class | Hydrolases; Acting on peptide bonds (peptidases); Metalloendopeptidases |
| Sysname |   |
| Substrate |   |
| Product |   |
| Reaction (IUBMB) | ![]() |
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 183 |    AGT |    106 |    NP_000020.1 |    in vitro |    11278902    |
| 885 |    CCK |    321 |    NP_000720.1 |    in vitro |    11278902    |
| 2335 |    FN1 |    626 |    NP_997647.1 |    in vitro |    8063866    |
| 2641 |    GCG |    676 |    NP_002045.1 |    in vitro |    734   033   711   278   902    |
| 2796 |    GNRH1 |    8860 |    NP_000816.3 |    in vitro |    11278902    |
| 2922 |    GRP |    8845 |    NP_002082.2 |    in vitro |    11278902    |
| 3827 |    KNG1 |    1970 |    NP_001095886.1 |    in vitro |    11278902    |
| 5443 |    POMC |    1462 |    NP_000930.1 |    in vitro |    11278902    |
| 5741 |    PTH |    1345 |    NP_000306.1 |    in vitro |    11278902    |
| 6343 |    SCT |    8354 |    NP_068739.1 |    in vitro |    11278902    |
| 6863 |    TAC1 |    8876 |    NP_003173.1 |    in vitro |    11278902    |
| 284217 |    LAMA1 |    1033 |    NP_005550.2 |    in vitro |    10620696    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Protein digestion and absorption |    hsa04974 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd04282 | 30-259  | ZnMc_meprin |
| cl00064 | 30-259  | ZnMc superfamily |
| cd03783 | 431-594  | MATH_Meprin_Alpha |
| cl02446 | 431-594  | MATH superfamily |
| cd06263 | 269-431  | MAM |
| cl18943 | 269-431  | MAM superfamily |
| cd00054 | 672-710  | EGF_CA |
| cl21504 | 672-710  | EGF_CA superfamily |
| cd03771 | 431-594  | MATH_Meprin |
| cd04280 | 78-257  | ZnMc_astacin_like |
| cd04283 | 78-259  | ZnMc_hatching_enzyme |
| cd03782 | 431-594  | MATH_Meprin_Beta |
| cd04281 | 79-259  | ZnMc_BMP1_TLD |
| cd00203 | 77-257  | ZnMc |
| cd04268 | 76-257  | ZnMc_MMP_like |
| pfam00917 | 438-595  | MATH |
| cd00270 | 435-589  | MATH_TRAF_C |
| cd00121 | 435-594  | MATH |
| cd03781 | 435-594  | MATH_TRAF4 |
| cd03776 | 435-589  | MATH_TRAF6 |
| cd04327 | 92-215  | ZnMc_MMP_like_3 |
| cd03778 | 435-513  | MATH_TRAF2 |
| cd03777 | 433-591  | MATH_TRAF3 |
| smart00061 | 435-533  | MATH |
| cd03779 | 433-513  | MATH_TRAF1 |
| cd03780 | 437-591  | MATH_TRAF5 |
| cd00053 | 673-710  | EGF |
| smart00179 | 672-710  | EGF_CA |
| pfam00008 | 674-708  | EGF |
| pfam01400 | 73-261  | Astacin |
| smart00137 | 264-431  | MAM |
| pfam00629 | 269-432  | MAM |
| smart00235 | 71-210  | ZnMc |
Ontology Information
| HPRD ID | 450 |    
|---|---|
| Molecular Class | Metallo protease |
| Molecular Function | Protein tyrosine/serine/threonine phosphatase activity (GO:0008138) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    

