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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
MEP1A 4224 Meprin A, alpha (PABA peptide hydrolase)  6PPHA 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
10070973   1999Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

RT-PCR, Cell Culture, Biosynthetic Labeling, Immunoprecipitation, Northern Blot, ImmunohistochemistrUnknown-Protease is known to cleave extracellular matrix components in vitro, meprin a may contribute to tumor progression by facilitating migration, intravasation, and metastasis of carcinoma cells.

22096485   2011Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Cell migration assay, Angiogenesis assay, Northern blotting, Immunoblots, Immunoprecipitation, ImmunohistochemistryUp-regulation-Meprin-a activity is regulated differently in primary tumors and metastases, leading to high proteolytic activity in primary tumors and low activity in liver metastases. By virtue of its pro-migratory and pro-angiogenic activity, meprin-a may promote tumor progression in colorectal cancer.

The study included 72 patients (49/23 male/female).


Gene Details



Chromosome: 6; NC_000006.11 (46761094..46807519)

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Gene Type protein coding
Gene Family -
Description -  
Chromosome 6
Location 6p12-p11
Start 46793357  
End 46845987  
Strand +  
Gene Sequence

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Length 52631  
OMIM ID 600388   
HGNC ID HGNC:7015   
Unigene ID Hs.179704    
Ensembl ID ENSG00000112818   
PharmGKB ID -   

mRNA Information


mRNA ID XM_011514629.1
Exon join(1..111,196..220,310..360,5250..5290,5750..5825, 16064..16181,26173..26348,31916..32137,32998..33147, 36000..36215,39718..40182,41222..41395,41893..42193, 52184..52631)  
mRNA Sequence

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Length 2947  



CDS Information


   
Location join(43..111,196..220,310..360,5250..5290,5750..5825, 16064..16181,26173..26348,31916..32137,32998..33147, 36000..36215,39718..40182,41222..41395,41893..42193, 52184..52217)
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDNP_005579.2
Protein NameMeprin A, alpha (PABA peptide hydrolase)
Molecular Wt. (Da)77089
Protein Sequence

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Length 746  
Uniprot IDP49918
Ensembl Protein ID ENSP00000413720  



Post-translational Modification Information (Source : HPRD)


Residue Type site
RProteolytic Cleavage65

Enzyme Information


   
EC3.4.24.21
Nameastacin
Astacus proteinase
crayfish small-molecule proteinase
ClassHydrolases; Acting on peptide bonds (peptidases); Metalloendopeptidases
Sysname  
Substrate  
Product  
Reaction (IUBMB)



PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                    
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
183AGT106NP_000020.1in vitro11278902   
885CCK321NP_000720.1in vitro11278902   
2335FN1626NP_997647.1in vitro8063866   
2641GCG676NP_002045.1in vitro734   033   711   278   902   
2796GNRH18860NP_000816.3in vitro11278902   
2922GRP8845NP_002082.2in vitro11278902   
3827KNG11970NP_001095886.1in vitro11278902   
5443POMC1462NP_000930.1in vitro11278902   
5741PTH1345NP_000306.1in vitro11278902   
6343SCT8354NP_068739.1in vitro11278902   
6863TAC18876NP_003173.1in vitro11278902   
284217LAMA11033NP_005550.2in vitro10620696   


Pathway Information


      
Pathway Name Pathway ID
Protein digestion and absorption hsa04974


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0428230-259  ZnMc_meprin
cl0006430-259  ZnMc superfamily
cd03783431-594  MATH_Meprin_Alpha
cl02446431-594  MATH superfamily
cd06263269-431  MAM
cl18943269-431  MAM superfamily
cd00054672-710  EGF_CA
cl21504672-710  EGF_CA superfamily
cd03771431-594  MATH_Meprin
cd0428078-257  ZnMc_astacin_like
cd0428378-259  ZnMc_hatching_enzyme
cd03782431-594  MATH_Meprin_Beta
cd0428179-259  ZnMc_BMP1_TLD
cd0020377-257  ZnMc
cd0426876-257  ZnMc_MMP_like
pfam00917438-595  MATH
cd00270435-589  MATH_TRAF_C
cd00121435-594  MATH
cd03781435-594  MATH_TRAF4
cd03776435-589  MATH_TRAF6
cd0432792-215  ZnMc_MMP_like_3
cd03778435-513  MATH_TRAF2
cd03777433-591  MATH_TRAF3
smart00061435-533  MATH
cd03779433-513  MATH_TRAF1
cd03780437-591  MATH_TRAF5
cd00053673-710  EGF
smart00179672-710  EGF_CA
pfam00008674-708  EGF
pfam0140073-261  Astacin
smart00137264-431  MAM
pfam00629269-432  MAM
smart0023571-210  ZnMc


Ontology Information


   
HPRD ID450
Molecular ClassMetallo protease
Molecular FunctionProtein tyrosine/serine/threonine phosphatase activity (GO:0008138)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO