CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
NPM1	4869	nucleophosmin (nucleolar phosphoprotein B23, numatrin)	5	B23, NPM

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
24716928	2014	Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 57 normal human colon, 40 adenoma and 185 CRC samples Stage : TNM Stage I-IV	Immunohistochemistry	Up-regulation	-	NPM expression can predict the survival of CRC patients.
23536448	2013	Cell line : - Source : Dongguan Shilong Peoples Hospital Sample Type : CRC tumor and normal tissue No. of Sample : 161 Stage : -	Tissue microarray, immunohistochemistry	Up-regulation	11-Jul	The differential expression of NPM1 along the normal colon-adenoma-carcinoma progression and its involvement in resisting p53 related senescent growth arrest in CRC cell lines implicate its role in supporting CRC tumorigenesis.

Gene Details

Chromosome 5 - NC_000005.10 (171387648..171410884)
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Gene Type	protein coding
Gene Family
Description	This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.
Chromosome	5
Location	5q35.1
Start	171387648
End	171410884
Strand	+
Gene Sequence	>gi\|568815593:171387648-171410884 Homo sapiens chromosome 5, GRCh38.p2 Primary Assembly AGTGCGCGTGCTCGGTGGGAGCCCGCGGAGTACCTGGAAGGAGGTGGGGGCGAGGTAGAAAGGAGTGGGG TTGAAAAGCGCTTGCGCAGGACGGCTACGGTACGGGGGTGGGAGGGCTTCGGAGCACGCGCGCGGAGGCG GGACTTGGGAAGCGCTCGCGAGATCTTCAGGGTCTATATATAAGCGCGGGGAGCCTGCGTCCTTTCCCTG GTGTGATTCCGTCCTGCGCGGTTGTTCTCTGGAGCAGCGTTCTTTTATCTCCGTCCGCCTTCTCTCCTAC CTAAGTGCGTGCCGCCACCCGATGGAAGATTCGATGGACATGGACATGAGCCCCCTGAGGCCCCAGAACT ATCTTTTCGGTAACTGCTGGGGGGAGCTGGAGCGAGGCCGAGCGGGGCCTGGTGGCGGTGAGGGTGGGGG TGAGGGGCGGGAATCCGGCTGCAACCGGGTCTGGTGGAGACCGCCAGACCGACGGGAGGCCTGAGCGGGT GGGAAGAGCTGCCTGAGCCCTGGACCTGGAGGGATTGGAGCCGCGGGGGGAGCCGGTGGCGTGAAGGGGG AGGAGACGAGCGGCCTGAAGCGTCTGGGGCGTGAGCGGTCCGAGGCCCGGGGCCTGAGGTAAAGTGGAAC CGGCCGCCTGGAAGTTCGGCCTTTGCCGGGGATACGTGGCGGAGCTCCAGGCGTGGTTTATTTTCTAACG GCGGTGGTTCATAGGCTTCTGATGCCAGGCCCCGGGTTGGTGGTCCTGGAGGCTGGGTTCACCGGGAAGC ATGGGCCTGCTTGTTGGAGCGGGTAGATGCACAGCCTGGCGTTATTCTGGCCTCAGAGCCTGGAGCTGCC GGACGTAGACTTACCTCGCGTGCTTCGGCCAGTTACTGGGGGTGGGGAGGCGCGGCGCGGCGTGAGGAGG CCGCAACCGCTGGGAGCACGTGGTTGCCACGTGGTTGGGGGAGGGAGGGGGGTGTGGGCGCTACATCCGG GACTCACCGGCGTGTTGCCACTCGTGAGCCAGGGATGCTGTGGCTCTGTTGAAGTGGGAAATGTTAAGAG GCTGGTAGCACTAGGGTTCTGGAGGTCTTTGTTCAGTGCTTACAGCATGTACTGTGATGGCAGCTCTCAT TTTTTTGAGCCCCTTTTCTGTCTCACTGCGGTAGGTGGAGCTAGCCCCACTTTGCAGATGAGGATACTGG TGCCCAGAGATAAACTCACTTAACGAAGGTTGTACTTAGTAAAGGCAATAAGAGACTAAATCTAAACCAA GACGCTTGACTCCGTAGCTGCTGCTTCGTGAATATTAATGAGGCTTCGTTTTAGGGGGACGTCCTCGCAT GCCGCCATTTGTGCGGCATTGACCAAACTGCTTTTCTAAATACAAGAAACACGTAGAGTGTTCGGTTTGA GTCAGATCAAGACCTAAGACTATTCGCAGAATTTTGGGAGCACCACCCCCCTCGACTTGCGGTAGTCCTG CCCCAAAAAGGAGAGTCCCACTTGGGTTTTTGATCTCAGTAGGATTAATTGCAGAAGCCTAATCTTTGTA CTATTCAGACTTTGAAGTAAATGCAAATCCTACCGTGAATTTTATCTTGTTCATTATCCGTGCTGAGATT TGTTAATTAAACGTCTGTTCACATTTAAGCATGTATATGTATTGGTAACGGTTAGATGATAGTTAAATGG AATCATTTAAAATTTTTATTCTGACAGTGTTTTGAAGAATTTTGCCCATTCATGGAGTGAGAGTAGACAT ATGTATTCAAAACATTAAGGCTTTAATTCCTAGTTATTTTGGATAGCTGAGAATTCTGGTAAATTTATAT CAGTACTTTTTGATAACTATCGGAAAGAACCCTCCTTGTCTTAAACATAATTTCTGAATATAGTTTGAGG CGTATGTCACTTTCTGTTGCTTTAAAGAGTGGAGTGTTGATCCCTGTAGCAAACTTCGGTTCTTTTACTT TTGTCATTTTTCTTTTGTAATAGTAAGCTATTCATGTTTGTAACCGTTCTCATTTCGAAATTGCCATTTG GGAATTTAGGTAGGTAAATCAGCTGTTTTAAATAGTGGGAAACTTAACATTGGACATTACATTTGGTTTC AGATAATTGCTTCAGGTTGAGATTTACTAAACCATTGAGCTTGTTTATGCAGAATAACAGTACCTATCAG CGTAGTTAGAGATGAAATATGGTATGATGAGAGAATGGAATTATAGTCTTTTATGGGTGTCTGTAGAGGT TTCTGTTCAAGAAATCTAGGAATTGATCATTCTGCTTTGCCCTCTGGTAGCTAAAATAGTGAAAAACTAG TTCAAAAGTTAGACCTGACCTTTTTGGTTACCCACACTTAAGTTTCAGTGTTATTTTTCTCCTTGTTAGA GTTGCTTTTTTCTTCATTTACAGGTTGTGAACTAAAGGCCGACAAAGATTATCACTTTAAGGTGGATAAT GATGAAAATGAGCACCAGTTATCTTTAAGAACGGTACTTAAACTTTCAAAATAAACTACTTAACCCTACT TGATTTCAGCCTTTTAGTTTCTATTCATGTGGCTTGAGACTTTTTTTCCTTTGCTGACTGCTTATAAAAT ACTATTTCTTACACCTGGGTATTGTGTGTACCTCACTGTCTGTACATCTTTGAAGAACTTGGCATCTATA CCACTCATTTGGTAACCATGTAAATTCCAGTCACACTGTTCAACTTGCCTTATTTTCTTCAGTTGAATTA CAAAGCCCTTGTAAAAGGCATCGATAATCTTTCATGTCTACCAGAGACTAGCCTTCTGCTCAACTTAGAA GTTGCTCAATAAATATGTTAGGTGGTCTATATTGTGTGTATGCATATTTATGCATTTCTTAAATTTTCTG AATATGAGAAACTGATTTGCCAAGATCACAAAACCTGAGGACAACATTGCACAAATTTGTTTTCCAGGGT AATAGTGAGAGGTTTATACTTGTTTTTTAAAAAAATCACAGTCATGTGCCTCATTGCAACTGCTGGGTCA ACAGATGGATCGCATATACAATGGTGGTCCCATAAGATTATTATACCTTATTTTTAATATACCTTTCCTG TTTTTTTTTTTCTTTGGAGGCAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGTAATCTCGGCTC ACTGCAACCTCTGATTTCCGAGTTCAAGTAATTCCCTGCCTCACCCTCCCGAGTAGCTGGGATTACAGGC ATGTGCCACCACACCTGGCTAATTTTTGTGTTTTTAGTAGAGACGAGGTTGTTACCATGTTGTCCAGGCT GGTCTCAAACTCCTGACCTCATGATCTGCCCGCCTCAGCCTCCCTAAGTGTTGGGATTACAGGCATGAGC CACCAAGCCCGGCCCTTTCCTATGCTTAGATGCACAAATACTGTGTTTCGGTTGCTTACAGTATTCAGTA CAGTAACACTGTACAGGTTTGTAGCCTAGGTGTGTGTAGTAGGCTATACCATCTAGGTTTGTATAAGCAC ATTCTTATGATTGTACAAAGATGAAATTGTCTAACAACACATTTCTCAGAACCTAGCCCTGTGGTTAAGT GACGCATGGCTGCATATAACATTTAGTGGGGGGGTGTAAAATAGGTGGAACTCAAAAGTTGAAGTAGTAT TTTTTTTTTGTTCACAGGTCAGTTTAGGGGCTGGTGCAAAGGATGAGTTGCACATTGTTGAAGCAGAGGC AATGAATTACGAAGGCAGTCCAATTAAAGTAACACTGGCAACTTTGAAAATGTCTGTACAGCCAACGGTA AGGGCACTTACATACTTTGGATGTTGTGTCAAGGTTTAATTCTGTTTTAAGGTAGGTTTGGTGTCATTTA GTTGTGCCAAGGAGATAGAAAGTGGTTCTTTATCTTCTGTCACTGGAGTTCGATGGTCAACTCTTGAACA TGGGGGCTTCTGCTGCTACTTTTATCAGAGGTGGAAAAACAGGTTCACTGGTTTGTTGATTTGGCTTATG TGTTTGCCTGTAATGTTTATTGTTCATTTTCTTCACATGTTTAGTGATGAAAAATTTCTCCCTTCTAGGT TTCCCTTGGGGGCTTTGAAATAACACCACCAGTGGTCTTAAGGTTGAAGTGTGGTTCAGGGCCAGTGCAT ATTAGTGGACAGCACTTAGTAGGTATGTTATTTTTATATATTATACTACTTAGTTTGTCCTCTTTAGTGC AGTTGCTTGGTTCCCAGTTTGGACTTAAAGCATGGGTATAGTACTACTGTCTTTTTAATAGGTTCCAATG TGAGTCTAGAAATTGGAGAGGACAAATAAATTTTTGGGGCGGGGGGGAGAGGAAATCTTGCTGTCACCCA GGCTAGAGTACAGTGGCACGATCTTGGCTCACTGGAACCTCTCCGGGATTCAAGCGATCCTCCTGTCTCA GCCTCCCCAGTAGCTGGGGCCACAGACGTGCACCACCAAGTCCAGTTGCGTTTCATAGTTATAGTAGAGA AGGGGTTTCGTGATGTTGGCCAGGCCGATCTTGAACTCCTGGCCTTAACGTGATCTGCACGCCCTGGCCT CTCAAAGTGCTAGTATTACACGTGTCAGCCACTGTGCCTGGCCTAAAAATTATTTTTTAATAAAGACAGT CTCATTATAACGGCTGGAGTGCAGTGATGTGATCATAGCTTGCTATATCCTCGAACTGCTACTGGGTTCA CCTCAGCCTCTGGAATAGCTAGAACTACAGGCACACTCCACGCCTGGCTAATTTTTTTTGTATATGTGCA GATGGGGTCTCAGTATGTTGCCCAGATTGGACTCTTGGCCTCAAGTGGTCCGCCTTGGCCTCCCCAAAGT GAGATTACAGGCATGAGCCACCCTCCCCAGGCTTCTTGCATTTAAAACCTGGCAGTGAACATTAGGCCTC AAAATACTTTTGTTAAAAAGTTCCTTTTCCCATGTGCTCTTTTTTTTTTTTTTTTTAAATAGAATAGAAG TCTCAGTTTTTAGAGTATTTACTATCAGTGTTCTTTTTTTTTCTGACTTCTTGCTGCTTGAGTTTTATAA TGTCTAATAAATTGTATTTTAGCTGTGGAGGAAGATGCAGAGTCAGAAGATGAAGAGGAGGAGGATGTGA AACTCTTAAGTATATCTGGAAAGCGGTCTGCCCCTGGAGGTGGTAGCAAGGTTCCACAGGTAGAGATGGC AATTTTATTATAGGTTTTGTATTATAGCTTTTAGTTTGGTGATAGAACAGCTCTTGTTCATGAGTACGTA TCTTTTCTTTTAAAAGAAAAAAGTAAAACTTGCTGCTGATGAAGATGATGACGATGATGATGAAGAGGAT GATGATGAAGAGTAAGTATGATTTTAGAAACTTGATATACTTCCGGAATCTTGACAAAAAAAGGAATTTG ACATAGTTATATGCATGAGGGTTTTATAAAAGTCATTTACAAAAAGCCATCCTATGTAATAGTTTATAAT AAAAGGGCAGGTGGTCATCTGTTGTCAGTTTAAGTTAAATGAGCTGAGTTGAAAGGATATTGGGTCTGTG AGCCTTTACAATGCTGTGACTTGTGACTCTTCAGAAGGGTAGACTATAGTGTTTGTGAAGTTTGATTATG TCCCTTTGTTCTGAAGATTTAGTGGATGTGTTATACCCATCAAGCCTGGTATGTTTTATGGTGAGCAGTT AATGAGATTGGGTTGAAAGAAAATATGATTAAATAGCTCTATATTCATTTTACAAGTTGTTACTCAAGGT TTGTTATTCCCTAAAAGGATTTTGTCTTATGGTTTTATGTAGATATTTATTGACAAAAATAAGATTCTAA AAGGGATATTAAGATTTTCTTGGGATTTAAAATATGGTTGGAAACAATATTTGATGACTTTATATTAAAC TAGATCAAACTATTGTTACAAACAGTTAATACGCACACTGGTATAAAGTACTGTTTATAATTGGTCTTAT GTGTGCCAGTACCAGTAATGCATTGAATACTTTGATTTGGCTCTCAGCTTTGTCCTTCAGTTCTGAGGTT GGTCCATATGCATTTATTGAAAACAAATATAAGAACATGCACTTTAAAAGAGAACCTGCATGAAAGATCA AATTGGGAGTTTAGGTTTTAAGCTGGTGGTTCTTCAAAATCTTTGAGCATGACGATGAAGGCAGAAAACA GGAAAAAGGCCGAAAGAGCCGAAAGCTTAAAAATTCAAAGTATGACCAGGCGCAGTGGTTCACACCCGTA ATCCTAACACCCAGCCAAGATGAGAGGATCTCTTGAGGCCAGCCCGGTCAAAATAGCAAGACCCAATCTC AAAAGAAAAATAAAAATTCAAAGTACTTGCATGTCAAACTTATAAATGAACGCAAACTTAAAGGTAGTAT TTGACTGTTGCTGTTTTTGTTTTCTTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTCCAGTTGCTCAGG CTGGAGTGCGGTGGCGCCATCTCGGCTCACCACAACCTCTGCCTCCTGGGTTCAAGCGATTGTCCTGCCT CAGCCTCCCGGGTAGCTGGGACTGCAGGCTCGGGGCACCATGCCCTGCTAATTTTTGTATTTAGTAGAGA CAGGGTTTCAGTATGTTGGTCCGGCTGGTCTTGAACTCCTAACCTCGTGATCTACCTGCCTCGGTCTCCC AAAGTGCTGGGATTGCAGATGTGAACCACTGCGCCCAGCCAAATTTTTGTATTTTTAATAGACATGGGGT TTCACCACGTTGGCTAGGCTATTCTCAAACTCCTAACCTCGGGCGATCTGGTCACCTCATCCTCCCAAAG TGCTGGGATTACAGGCATGAGCCACCGTGCCCGGCCACTTTTTTTCTTGAGATGGTGTTTTACCATGCTA CTCAGACTGGACTTGAATCTCTGGGCACAAGCTATCCTCCCCTCTCAGACTATGAAGCAGGTGGGGTTAC AGGAGCATAACCAAGCCCAGCTTGTTTGGTTATCACTTTTAAGAATATTTCTCGTTAGTAAGAATTGAAA TACATTCCAAGAGAAGAATGGGAAACAGGCTAAAAACACAAATTAGAAATAGGGATGGTATGGTTCGGAT TGGTTTAGTCTGATTTTGAGTTACCTTTGTACAAGTTTATAAAATAAGTGTTTAATAGCATTCACCGAGG CTCGGGGACAAGCAATCCCTTCCAGAAAGGCTTTGGAGTAGGACCTGATTGTAGTATTGACCCTGTTGGG GCTTTGGAAGATTTCCTTTTTTAAAAATTGATATAATTAGGCCAGGCATGGTGGCTCACGCCTGTAATCC CAGCACTTTGGGAGGCTGAGGTGGGTGGATCACTTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATG GTGAAACCCGGTATCTACTAAAAATACAAAAATTAGCTGGGTATCGTGGTGCCTGCCTATTGGTCCCAGT TACTTAGGAGGTTGAGTCAGGAGAATTGCTTGAACCTGGGAGGTGGAGGTTGCAGCAAGCCAAGAATGCG CCACCGTGTTCCATCCTGGGCAACAGAGGGAGACTCCCATCTCAGAAAAATGGGTATAAATTCATGATGT AACCACAATGTAATTTTGTTTGTCTTTAAGTTGGGCATTGATAGGAATGAAAAGTGTAGATATCAAGGTC CAAATCAGTACCTGGTTTTTTTTGTGGGATTTTTTTTTTTTCGGCAAGTCTCGCTCTTGTGCCCCAGGCT GGTGTGCAATGGTATGATCTCTGCTCGCTGCAACCTCTGCCTTCCAGGTTCAAGTGATTCTCCTGCCTCG GCCTCCAGAGTAGCTTGGATTACAGGCACTTGCCACCACGCCTGGCTAAGTTTTGTATTTTTAGTAGAGA CGGGGTTTCACCATGTTGGCCAAGCTGGTCTCGAACTCCAAAGTGCTGGGATTACAGGCGTGAGCCACCA TGCACCGCCGCAAGTTTTCATATAAGTTGAAGAAAGTGTACTAAGGTCTGCATAGTAGTAAAGGATGCCT TGAGGGAAACAAATATTAATAGAAACTTCAGTGGTGAGATGGCAAGGGCCCAGCATAGATAGATGGCAAT GAAAATGCAAAGAGGTGCATGAAGGTTCGTTATAGTTACTTAGAAATCTAACCTTTTGAACACAGATCAA AGGGGAATTTGGTTCCTTTTTGAGGATGGAATGGGTATATGGTGTGGGCTCAGATGACTCTTGATTTAAG CAAGAAAGGCTATGTAATGTGCATAGTGCTGATGTATACTATACATAGATGTATGTAATACGTTGATAGT ATGTGGCCCTTAAATGTCTTTTTTAATTTTTGGGGAATTTCTTAAGTAAAGCTGAATTTTTTTTTTTTTT TTTGGAGACAGTCTCTGTTGCCCCGGCTGAAGTGCATTGTTGGCTAGGCTGGAGTGCAGTGGTGCAATCA TGGCTCACTGTAACTTCTGCCTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGAT TACAGGCATGTGCCAGCATGCCAGGCTAATTTTTTGTATTTTTAATAGAGATGGGGTTTCGCCATGTTGG TCAGGCTAGTCTTGAACTCCTGACCTCAGGTGATCTGCCCACCCCAGCCTCCCAGAGTGCTGAGATTACA GGTGTGAGCCACCACACCCTGCCAGTAAAGCTGTTTTGATAGTAGTTTTGATAGCTATTTTGATAGTAGT TTAATAGACTTGTTTTAACAAATAAGAAAAAATGTTTAAAAAAAGCATTCTCATCTTGTTTCTAGCACAG GGGAGGCACCTGCAGGGATTGGGTTCTAATGCCAGAAACTTGTACTGACAAAATCACTGTTAAAAAGCCA CTTGAAGGGCTATTTGTGACAGCTTTTTAAGTTATGATACTTTTTCTAAATACAGCAAATATTTCTTCGG TATTGGAAAGATAGGTGTTTCTTACATGAAGTTGCTGTATTGGGATTTAGAGACCAGTACGTTCAGTTGT TGAATTAAACGTGAACCCCTTGGTATTTGCTAATAGAGACTTCTGCCTGACTTGCCCTCCAGTGACTCGA TTTGATTACTCCCCTCCATTGTTTACCTATTAACAGTTCACACCTGTAATCCCAGCACTTTGGGTGGTCG ATGCGGGCAGATCACCTGAGGTCAGGAGTTGAAGACCAGCCTGGCCAATATGGTGAAACCCCGTCTCTGC TAACATACAGCTGGGTGTGATGGTGGGCGCTTGCAATCCCAGCTGCTGGGGAGGCTGAGGCAGGAGAATT GCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATCGCACCATTGCATTCCAGATTGGGCAACAAG AGTAAAACTCAAAAAAAAATAGTGTGCAGTTCAGTGGTTTTAGTATGCATAGTTGTGTAGCCATCACCAT AATCAATTTTAGAACATTTCATCACCTCAATGAGAAATCGTACTCTATAGGTATTACCCCTCATGCTCTT CAGCTCTAGTCAACCACGAATGAACTTTGTCTATAGGTTTCCTGTCCCTCATATTTTGCACGAATGGACT TCTGTGACTGTTTTCTTAGCACAGTGTTTTCAAGTTTCATCCATGTTATAGCATTATCAGTACTCCATTT ATTTATATGGTTGAATACATTGTATGGGTATGTTTGGTTATTCATCAGTTGGTGAGCATTTGAGTTGCTT CTACTTGTTGACTGCTATGAACGCTTGTAGACATGTCATTTTACTTGGATGTACACCTAAAGCAGAGTGG CTCACCCATTGTATTCCCACTAGCAGTGTATGGGGCTTCTGATTTCACTCCAACCTACTGATTTCACTAC ACCCTCACTTGCCATTATCTGACTCTAATCCTGGTGGTATGAAGTGCTGATTGTGGGTTTGATTGCGTCT CCCTGTGGACTAATAATGAGCATCTTTTCATGTATTCATTGGCCATATATCTTTGGAGAAATGTTTTTGC CCACTTAAATCCATTTACTTCTCTTTGTCTTTACTAAGTTGTAAGAATTCTTTTTTCTTTTTTCTTTTTG ATATGATTTTTGTATTTTTAGTAGAGAAGGGGTTTTGCCATGTTGGCCAGGCTGTTCTTAAACTCCTGTC TTCAGTGATCCACCTCCCTCTGCCTCCCAAACTGCTGAGATTACAGCTGTGAGCCACTGTGCCTGGCAAG AATTCTTTTTTTTTTTTTTTTGACAAGTCTCTGTTGCCCAGGCTTGAGTGCAGTGATGTGATCTTGGCTC ACTGCAACCTCCTCCTCCCTTGTTCAAGCAATTCTTCTGCCTCTCCCAAGTAGTTGGGATTACAGGCACC CCCCCCACCACGCCCGGCTAATTTTCTGTATTTTAAATAGAGACCGGGTTTCGCCATGTTGGCCAGGCTG GTCTTGAACTCCTGAGGTCAGGCCCGCCTCGGCCTCCCACAAGTGCTGGGATTACAGGCGTGAGCCACTG CACTGGGCCCAAGAATTCTTTATGTATTCTGCAAACAAGTCCCTTATCAGACACAAGATTTACAGATTAT CTTCCACCATTCCGTGAATTGTTACTTAACTTTCATGATGGTGGCCTTTGAACAAGTTTTTAATTTTTAT GACGTCCGATTTCTTTTGTTGCTTGTGCCTTTGGTGTCAATCCTAAGAAATCATTGCTAAATTCAAAGTT GTGAAAATTTGCCCCCTTAATTCTGAGTTTTGTCCTTTATATTTAGGGCTTTGTTCCATTTTGAGTAAAC TTATGTGTATGGTGTGAATGGAGGGGTCTAAATATAGACTTTGGATGTAGATTAGCAGTTGCCCCAACAT GATTTGTTCAAAAACTATTTTTTCCCCATTGAATGATCTTGGCAACCTTTAAAAGAGTCACTTATGGCTG GGTGTGGTGGCTCACACCTGTAATCCCGGCACTTTGAGAGGCTGAGGCAGGCGGATCATGACCAGGAGAT TGAGACTATCCTGGCCAATTTGGTGAAACCCTGTCTCTACTAAAAATACAAATTTTAGCTGGGCATGGTA GCGTGTGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCTGGAGAATTCGCTTGAACCTGGGAGGCAGAG GTTGCAGTGATCTGAGATTGCACCACTGCACTCCAGCCTGGCGACAGAGCGAGACTCCGCCTCAAAAAAC AAAAAAATCACTGTTTCTGGACTGTTCTGTTGATGTGTCTATCCTTAACATGTAAGAACAGTACAACACT GTTCCTCTGTGGTTTTTATTTATTTATTTTTTTGAAATGAGTCTCACTGTCACCCAGGCTGTAGCACAGT GGCGTGATCTTGGCTCACTGCAACCTCCGCCTCCTGGTTCCTCCTGCTTCAGCTTCCTGAGTAGCTGGGA TTACAGGCGCCCGCCACCATGCCCGGCTAATTTTTGTATTTTTAGTAGAGACTGGGTTTCCCCATTAGCC AGGCTGGTCTCAAACTCCTGACCTCAGGTGATCTGGCCGTCTCGGCCTCCTAAAAAGTGCCGGGATTACA AGCGTGAGCCACGGTGCCTTGGCCCCTTTGTAGGTCTTATAGCTGATTTTTTGAAATCAAGTGTGAGTTT TCTAGCTTTCTTCCTTTCCAGATTGCATTTGGCCTCTTTGGGTCCCTTAAGTGTCTTTTTTGTTTTTGTT TTTTGAGATAGGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCAGAATTACACAGTTACAGTTCAC TGTCTCAAGCAGATCCTCCTGCCTTAGCTTTTCAAATAGCTAGGACTACAGGCGCACACCACCACGCCTG CTAATTAAAAATTTTTTTTGTAGAGAGGGTTCTCATTATGTTGCCTAGGCTGGTCTTGAACTAAAACGAT CCTCCCACCTCAGCCTCCCAAAGTGTTAGGATTATAGGTGTGAGACACTGTGCCAGTTCTTGGGTTTGTT TATAAATTTTAGGATCTGTTTCTACAGAGAAACCAGCTTGGGGAGTCTTCTAACGATTGTATTTAACCTG TATATTCGGGGAGTGTTTCCATCTTGGCAATATCTGAACATGGAATGTTTCTATTTAGGTCTTTAATTTT TTTTTTTAACACAAATTCACTCTGAGTGTACAGTTTAATAGAACTATACATTACTTAAATATACATACAT TATACAGTGGTATAGTGTGTATTTATGCAAAACTACTCATTGAGCAACTTCATTTCCCAGCCCCTAGCGA TCACAATTATACCTTCTATTTCTTTGAGTTTGACTACTTTTAGATACTTAATGAATAGAATCATACAGTG TTTGTTCTTTTGTGGCTGGCTTATTTCACTTTGTTCAAGGTTCAGTCATGTAGCATGCAAGAGGATTTTC ATTGTGTGTACATATACATTTTCATTTAGTCATTTAACACTTGGGTTGCTTTCACCTCTTGGCTGTTGTG AACAATGCTTCGATAAACATGGGTGCACAAATAATCACTTCAAGGTCCTGCTTTCAATTCTTGTGTCTAC TCCCAAATTTTGAAAGTGCTTAATGTCTTGACATTTCATTTGTAGTGATGATGATGATGATTTTGATGAT GAGGAAGCTGAAGAAAAAGCGCCAGTGAAGAAAGTGAGTAGATACAATGCTACAAGGTTGTTAAACTAAC AATAGAAATGGTGATTTTTTAGTGCTATTTGCTTGTTTTGTAGTTAAGGGAAGCTGGTGTGGGAGATCAT CTCATACTGAAAATTAGTCCTGAGGAGGATTACAGAAAACTTAAGAGTGGGGAATGGTCTGTTTTCTTTA TCCATGTGGCCCTCCACCCAGTTTGTTAGTCTTGTGTAACCTTTTGTCCAAGTGGTTGCTGCTTTTTCCT TCCTTTTTTTTTTTTTTTTGAGACGGAGTCTCAATGTCACCCGGGCTGGAGTACAGTGGCGCGATCTCAG CTCACTGCAACTTCTGCCTCCCGGGTTGAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGAATTAC AGACTCATGCCACCACACCCAGCTAATTTTTGCATTTTTAGTAGACCACCATGTCGGCCAGGCTGGTCTC GAACTCCTGACCTCGTGATCCACCTGCCTCGGCCTCCCAAAGTCCTGGGATTACAGGCATGAGCCACCAC GCCAAGCCTGTGGTTGCTGCTTGTCTTACATGGCTTGGACAGCTTTGTTTGCACTGTTGTTGGGGTCAGG GACAGTGATTAAGATAAATTTCTAATTGCAGTCTATACGAGATACTCCAGCCAAAAATGCACAAAAGTCA AATCAGAATGGAAAAGACTCAAAACCATCATCAACACCAAGATCAAAAGTAAGTGGCTACATTTACACGT GGGTCTCATTGATCTAGTTGGGGAAAAAGATTCTACTGTGGAAGAATCTAGTGTGTCTGAAATTTGATAG GCCTTTATAGAACCCCTGTAATTGCTGTTTAAAAGTTAAAATCAGCTTGCTGCAGCCAGGCTCAGTGGCT CACTCCTGTAATCCCAGCACTTTGGGAGGGAGGCCAAGGTGGGTGGGATCACCTGAGGTCAGGAGTTTGA GACTAGCCCGGCCAACATCGTGAAACCCTGTCTTTACTAAAAACACAAAAATTAGCCAGGCATGGTGGTA TGTGCCTGTAATTCCACCTACTCAGGAGGTGGAGACAGGAGAATTGCTTGAACCTGGGAGGTGGAGTGCA GTGAGATTGCACCACTGCACTCCAGCTTGGGCAAAAGAGCGAGACTCCGCCTCCAAAAAAAAAAATCAGC TTGTTGTGTGTTGTAGGTACACACACACACACAAACATACTAAATGTAAGGTGGTGGGGCGGGGGGAGCC AATAGACTTTTTTGAAAGAGATGGACCCTCACTTTGTCACTCAGTCTGGGTTAGAGTTGCGTGATCTCGG CTTACTGCAACCTTCACTTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCTTCCCAAGTAGCTGGGACTAC ATGCGCGTGCCACCAGGCCCAGCGTATTTTTGTATTTTTGAGTAGAGATGGGGTTTCACTCTATATGTTG GCCAGGCTGGTCTCAAACCCCTGACTGCAGGTGATCCGCCCTCCTGGGCCTCTCAAAGTGTGTGAGCCAC CACGCCTGGCCTGAATTTTTTGTGATTGTGAAGTCAATAGTTGTTTCCTGTAAGGAATCTTTGTTGAAAG GTATGTCTGCATAGAGTAGAAGTTCTCAACCTTGGCTGCATGTTAGCTTGAAGTAGAACATTTGGGCCTA GACAGGGTGTATTGATCTCATTCCTGACCCTACCCACTTCCCTGCAGAAAATGGAATTTAAAGGAAAAAA AGTTTAAAGGAACCCCAGTACTTGTGCTCTACTTATGGAGATTGTCATAAAAATGGTCTGGGGTGGGCGC CAGGCATCAGACTACAGTGACTTTCTTGCTTTATTCTTAGGGATTTTCTGATTTCCTTTTTTTTTTTTTT TTAACCTGATGAAATAGTTTATTTACAATTTAAACGAATAAATTTCATATTCTACAACACATATAATCTA TTGACTAAATGTAACTAATGATGAACCTCCATACAAACAACCCCACTAAAAAGTGGGCAAAGGACATAAA CAGACACTTTTCAAAAGACATACAAGTGGCCAAAAAGCATATGAAAAACAGCTCAATATCACTGATTAGA GAAATGCAAATCGAAACCACAATGAGATACCATCTCACACCAGTCAGAATAGCTATTATTAAAAACTCAA AAAACAACAGCTGCTGGCAAGGTTGCAGAAAAAAGGGAATGCTTACACACTCTTGGTGGGAGTGTAAATT AGTTCAACCATTGTGGAAAGCAGAGTGGCGATTCCTCAAAGAGCTAAAAACAGAACTACCATTTGACCCA GCAATCCCATTACATTCCCAAAGGAATATAAATCATTCTACCATAAAGATACATGCACACAAATATTCAC TGCAGCACTATTCACAATAGCAAAGACATGGAATCAACCTAATACCTGATATGGTCTGGCTTTGTGTCCC CACCCACATCTCATCTCAAATTGTAATCCCCACGTGTTGGAAGAGGGGCCTGGTGGGAGGTAATTGGATC ATGGGGTAGATTTCCCTCTTGCTGTTCTGTTGATAGTGAATTCTCATGAGATCTGGTTGTTTGAAAGTGT GTAGCACCTCCCCCTTTGTGCTCTCTCTCTTCTGCTGCCATGTAAGATGTGCCTTGCTTCCCCTTTGCCT TCTGCCATGATTGTAAATTTCCTGTGGCCTCCTAGCCATGCTTCCTATACAGCCTACAGCACTGTAAGTC AATTAAACCTCTTTTCTTCATAAATTACCCAATCTCAGGTAGTTCTTTTTTTTTTTTTTCATTTTATTTA TTTATTTATTTATTTTTTATTTTTATTTTTTTTTTAATTTATTTTTTTATTGATAATTCTTGGGTGTTTC TCACAGAGGGGGATTTGGCAGGGTCATGGGACAATAGTGGAGGGAAGGTCAGCAGATAAACAAGTGAACA AAGGTCTCTGGTTTTCCTAGGCAGAGGACCCTGCGGCCTTCCGCAGTGTTTGTGTACCTGATTACTTGAG ATTAGGGATTGGTGATGACTCTTAACGAGCATGCTGCCTTCAAGCATCTGTTTAACAAAGCACATCTTGC ACCGCCCTTAATCCATTTAACCCTGAGTGGACACAGCACATGTTTCAGAGAGCACAGGGTTGGGGGTAAG GTCACAGATCAACAGGATCCCAAGGCAGAGGAATTTTTCTTAGTGCAGAACAAAATGAAAAGTCTCCCAT GTCTACTTCTTTCTACACAGACACGGCAACCATCCGATTTCTCAATCTTTTCCCCACCTTTCCTGCCTTT CTATTCCACAAAGCTGCCATCGTCATCCTGGCCCGTTCTCAATGAGCTGTTGGGCACACCTCCCAGACGG GGTGGTGGCCGGGCAGAGGGGCTCCTCACTTCCCAGTAGGGGCGGCTGGGCAGAGGCGCCCCTCACCTCC CGGACGGGGCGGCTGGCCGGGCAGGGGGGCTGACCCCCCCCACCTCCCTCCCGGACGGGGCGGCTGGCCA GGCGGGGGGCTGACCCCCCCACCTCCCTCCCGGACAGGGCGGCCGGCCGGGCGGGGGGCTGACCCCCCCA CCTCCCTCCCGGACGGGGCGGCTGGCCGGGCAGAGGGGCTCCTCACTTCCCAGTAGGGGCGGCCGGGCAG AGGCGCCCCTCACCTCCCAGACGGGGCGGCTGGCCGGGCGGAGGGCTGACCCCCCCACCTCCCTCCCGGA CGGGGCGGCCGGCCAGGCGGGGGGCTTACCCCCCCACCTCCCTCCCGGACGGGGCGGCTGGCCGGGTGGG GGGGCTGACCCCCCCATCTCCCGGACGGGGTGGCTGGCCGGGCTGAGGGGCTCCTCACTTCCCAGTAGGG GCGGCCGGGCAGAGGCAACCCTCACCTCCCGGACGGGGCGGCTGGCCGGGCGGGGGGCTGACCCCCCCAC CTCCCTCCCGGACGGCACGGCTGGCCAGGTGGGGGGCTGACCCCCCCACCTCCCTCCCGGATGGCACGGC TGGCCGGTCGGGGGGGCTGACCCCCCACCTCCCTCCCAGATAGGGCGGCTGGCCGGGCGGGGGGTTGACC CCCCCCCACCTCCCTCCCGGACGGGGTGGCTGCTGGGCGGAGATGCTCCTCACTTCCCAGATGGGGTGGC TGCCGGGCGGAGAGGCTCCTCACTTCTCAGACGGGGCAGCTGCCGGGCGGAGGGGCTCCTCACTTCTCAG ACGGGGTGGTTGCCAGGCAGAGGGTCTCCTCACTTCTCAGACGGGGCGGCCAGGCAGAGACGCTCCTCAC CTCCCAGACGGGGTCTCGGCCGGGCAGAGGCGCTCCTCACATCCCAGATGGGGCGGCGGGGCAGAGGCGC TCCCCACATCTCAGACGATGGGCGGCCGGGCAGAGACGCTCCTCACTTCCTAGATGTGATGGCGGCTGGG AAGAGGCGCTCCTCACTTCCTAGATGGGATGGCGGCCGGGCGGAGACGCTCCTCACTTTCCAGACTGGGC AGCCAGGCAGAGGGGCTCCTCACATTCCAGACGATGGGCGGCCAGGCAGAGACACTCCTCACTTCCCAGA CGGGGTGGCGGCCGGGCAGAGGCTGCAATCTCGGCACTTTGGGAGGCCAAGGCAGGCGGCTGGGAGGTGT AGGTTGTAGTGAGCCGAGATCACGCCACTGCACTCCAGCCTGGGCACCATTGAGCACTGAGTGAACGAGA CTCTGTCTGCCCTGATTTCCTTTTTTGAACTGACTTAGTACTGTGCATAAAAGCAAACTCCCAAGTTACT CTTTTTTTTTTTATTTAAAGAGATGGGTGGCCTACTCTTGCCCAGGTTGAAGTACAGTGGTATGATCATA GCTCACTACAGCCTCCAGCTGCTGGGCTTAAGCAATCCTCCTGCCTTAGCCTCCTGAGTAGCTGGGATTA CAGGCATGCACCACCATGCCTAGCTAATCATCTTATTCCTTCCTTAAAGGAAAGATTTTAAGAACAAAAT TATATGGCGTGAATTTATTGATGATAATTCCAGTTGTATAATTAGCTTTATAAGGGAGTTTTGTGAGAAT ATTTGAGGAAATCCAGATAGAATGGGTTTTAATTAGGAATTGTATTTATTCTTATGACCTTTTGGAAATT CATTTCTTTTTCAGGGACAAGAATCCTTCAAGAAACAGGAAAAAACTCCTAAAACACCAAAAGGACCTAG TTCTGTAGAAGACATTAAAGCAAAAATGCAAGCAAGTATAGAAAAAGTGAGTAAAGTTATCTTAAAAAAA CTTTGTCTCCCCCCTCAAATTGCACGTGTCTGGTTTGCATAGACTTGAATGTTTCTTGTTTTTTTGTTTG TTTTGGTTTAATATACTTGCCTGGTTCGTGGTATGAATTTTTTCAAAAATTTCTTATAAAACATTTATAA TCGTGTCTGTGGTGATTTTTGCATATGCAAAATTAAATATGCCTTATTTTCCATTATGCAAGGAACGTAG TGCACTGGTTGCAAGATAACATTCTGACCTTCCATGTTAAAATAGATCAGTGAAAACCCTTTGCCTATTC TGGTTGTAAGATATGCTAGAGAACCAACAGAGGGCGTATGAGACTTCATTAAAATTACAAACAGCTGGAA AAGTAGATGCTGGCTGTTGCTTGGTATTATAGTTAATATTCATGATTGACCCTAGTCAGAAGTGATTTTC AGCAGATTGAGACATTTCTCTTTGCCCTTTACACCAAGTTGTCACCAGTTAATACATGTAGTAATAGCTA GATTTCGTGAATGACTAATAGGCTTAAATCTAGTTTCCTTTTGTCTTAAATAATGGAAATGTGGGAAGAG GGTTAGGTCTCTCATCTGCTTGACTGGGGGATTTGAGTAGGATATGGAATAAATGGTTTAAATGCCTTGG AAGCACATTTGAGAGAAGCTTTAATTCTATGAATAATACTTTTAGACTCCAACTATTGAGAGCAAATGTG GGGTGGTGAAAAATTGCCAACTCATTTCCCCATGTTTTTCTTGTAATCTATAGATTTTTCGTGGCTTCAG TAGATTCCTTGTACAGTGATAAGTCCACTGGAAAAAGAATTTTAGAACTGGAACATATTTCTTTTAGTCA CACTGTAAACCCTTTAGCCTTCCTGGTTATCACTGATTTTTGTCCCTTGGATACAATGCTAAAATGACAT CTTTTAGATGCCCCTCCCCTCCATTTTAATATGGTCCTATCTCCTTGGTTTAATTGCAGGCGCATTGAAC AGTCCTGGGCACTACATGTAAATTAAGCCCAAAGATGGGGAGAAAGGAAAAGGAGAGACAAATATAGTCC ATACTGAGTGTCATCAACAATCCAGACTGAAGTCTTCTATTTTAATCTCAATCCCCTTTTCTGATTTGCC ACCCATGCCTCTTCAGGCTGGAAACAATCTCTTGGTTCCCTAAAGCACTTTCTTCTGACTGCTGTGATTC AGTGAACCTTGCCCTTTGCTTTCTATTACTTGTGCATTTGCCTCACCTGACAATGTTTTAAATCGCCTTT GTATCTCCTTAGCTGCTCAATAAATATTTGAATGCATCAATTAAGAATGTATGTGACAATAATTTTGAAA TGGAAATTGTGAGGTTTATTTTACTAGGTTATTGGAGGCAGTTAAGTTTCTTAATGCTATACCTGATTCT GCCAAAGTCCCTTGGACATTTGAAAACCTTTTCAATCTTTTAAAAATGCATAAAAGATACTTAGAGGGAA AGGTATTAATTAAATTTAGTAAAAACAAATATATTCAATGCTTTAAATTCCAAAGTAGTGATAAATACAA ACATTTCAAGATATTTGCAATAGTAATGTTTTGAAATTTTGGTTACAAAGTCACAGGTCTTGCCAATACT GTTGTAGTTTCTTGCCTATATCCGTAATTTGAAGGAAATGGTGAGAGTGATTAGAGAAGTGTAATTACTG TAATTTTTTCCCCTATTGTAGTTTCTTGCCTGTATCCATAATTTGAAGGAAATGGTAAGAGTGATTAGTG AAATGTAATTACTGTAATTTTTTCCCCATTCAACTTTATATATCTTTAACTGATGACCAGATCATTGTTG TTCTGAACCAGTTTGTGGTCAGCAAGTGTTTTGTGGGGTTTTGTTTGTTTGTTTTTAAAGAACAGTTTGG GTCACTTGACATGGTTCTCCAAAGGGATGTTATGGGTTGTATTTGGTTCTGGGTGATAACCGACTTGTTA GATAATTTAGATAAGCAACCGAGTTGCCATGTTTGTTTGTCGAATCTCAAGTGTAGCTTATATTTTATGT TCCTAGAGAGGTTGTCAGGGAAGATTTGACCCTTTGGCAAATCTGTTTGAATAGAGATACTAGCCATGCT GCCCAATAGGGCTTTCTGGCCCTGAAAAAGATACGGAGTATTCTTGGAAAGTTGAAGGGAAAAAGAATAA ACTGATCCATGTAGTAGCATGCAGATTATTGAGGAATTTTCTAAAGGTATCTCTCTCGGTGTATTTCTCT ACTTACCTGTAATAATGCTTTTGTCTTAATAGGGTGGTTCTCTTCCCAAAGTGGAAGCCAAATTCATCAA TTATGTGAAGAATTGCTTCCGGATGACTGACCAAGAGGTAACTGGATTTTCTGGGGACATGATTAAATCC AAGTTTTTTTGTGATTTATTATGATTCTGCCTTTACCCTTTTTAAGTGTTGGCTCTTTTTAAAAAGTTCC TAACCACAGATAATATTTCATTTAATGAAATACCTGAAAACTCATGTATTTAATGAAATGCATGAAGAAT ACAGTTGGCAGTCTGAGATGATAACTTTAGTATATTTTTCCCAGATTTCCTATAGTTGGTAAATTATTTC TTGGTTATTGAATTCAGTTTTACTTTTTTGGTACTATGTTGGTTAAGGAAATTGCTGTGGTTTTCCTTGC TGTTCCATTTGACTGCTTGGGGCAGTCTGGTCTTGGCTTTTTTGGGAGTTGGTAGAGATCTTTTTTTTTT TTTTCCTAGATCTTATGGGAAATACATTATGCCAAAATCATCCTAACATGAAATCTGGAAGCAAGACACT AAATTGTGGCTACTACCAGATACATAAGCTTGAGTTAGCTGTTAGATTTTACAGTTAGTACATGTGAAAG TCTTAGTCAACATAAAGATTATGCATTTATTTTTGCTCTTATTTACAGTTGACTCATAAGTGTAAGGACA ATGTAAAAGTGGTTAAATAGGGATGTTAGGTATCGTGTGGAGAACGGATGCTGCATTTAATGGTCTTTAG GTTTCCTGTGGTCAGCTTTTTTCAAAAAATTAGGAAAATTTGGCAATTAGCTGGTTTTTTTTCTGCCATA GTATTTTGCACTTCAATTATTTAATTGCACTTCAATTTTTAGTTTTCGGGTTCGTAAAACCCTGATAATG GTTAATTTTGAGTTTAGCTTTGTGAAAGTTGTAGTGATGGGCTATAAGATGATCAGGTTCAGTCTTTGGT TGCTGTTCTGTTTTTTCTCTACATTTGAATCCTAAAGTTTAAAGTGTGAGTTTTGGGAGTTTATTTGGAA TACTAAACATTGATTAATCATAAATTATTTTGAAACTCCGCGTTATGCAACTGTTTATTTAATATTGAAA ATAGTGGAAAGTCAGACATAAATAACCAGCATGTACTAACAGCTAAGCAGCATAAGAGATGCATTCTTCA ACTACTGCCAAGGAAAGTGATGATAAATTTAATGATTAAGTTGCAGTAGTCTTCTGTACTTTATAACAAA GGCTTGTAGCTACAAAGTCTTGTAGCTATTAAATTACTGAACCAGCACTTCTACAAGAAGTATTTTCTTT TTATAAAAAGTATTTTTGGCCAGGTTGGTCTTGAACTCCTGGCCTCAAGCAGTCCTCCCATCTTTTCCTC CCAAAGTGCTAGGATTACAGGCACGAGCCACCTTGCCCAGCCTACCAGAAGTATTTTTTTGCTCTAGAAT TGAAAGTGTTCTCAAGTGTCAGAATGAAATTTCTGGAATAAATAGTAAATGTTTAATAACTTGAACTTGA ATTGCTGTTACAGAGATTATCAAAACTAAATGCTTCCTGTTTTTGACATAGAGATGCATGATGCAAGCAA CGACAATGTATATTTGTTTGAACCTGATGATAAGATCTCTGGCTGGGCGTGGTAGTTCATGCCTATAATC CCAGCACTTTGGGAGGCAACATGGCAAAACTCTGTCTCTACTAAAAATACTAAATTTAGCTGGGCATGGT GGCATGTACCTGTAATCCCACCTACTCAAGAGGCGGAGGCAGGAGGATCGCTTGAACCTGGGAGGCAGAG GTTGCAGTGAGCGCCACTGCACTCCAGTCTGGGTGGCAGAGTGAGAGTCTATCTCAGAAAGAAAGATTTC TATGATATTTAATATTGGCATTCGGTATTCAGTTACCTTGTACCTGAGAACCCATTGGCTGTGAAACAGT GACAGCTGAGAGAATCCTGAGTCATCTCATTTCTAGTTCTTGGTGAACTTCTGGACTTTTCTTCAGAACC ACCTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCTCAGGTGATCCAACACCTTGGCCTCTTA AAGTGCTGGGATTACAGGCATGAGCCACCATGCCTGGCCAGCTGTTTTTTTTGTTGGTTTGTTTTTTGTT TTGGTACCCATCTGTAGTGTGATCTTGGCTCACTGCAACCTCTGCCTCTTGGGCTCAGGCAGTCCTCCCA CCTCAGCCTCCTGAGTAGCTGGGCCTCCTGTAGTTGCACACCACCAAGCCTGGCTAATTTTTGCATTTTT AGTAGACAGGGTTTCACCATGTTGCCCAGGCTGGTCTCAAATTCCTGAGCTGAAGTGATCTGCCCGCCTC AGTCTCCCAAAGTGTAGGGATTACAGGCGTGAGCCACCATGCCTAGCCTCAGCATATAGTTTTTTCTAAA TGTACACATGCCCAGGCACACATGCACAGGCAATTCAGAATAAGTTTCTGGTGTTTATGTAACTTTATTT GCCAAATCTGGCCAACTCTAAAGCTGATCTCGGGAGATGAAGTTGGAAGTAACATTGGCCATATGGGTCT CTGTTCTTTCTGTTGATTTCCTTAAGTAAATAATGCTAAACTATTAAATAATTATTAGTATATTGTTCAC ATTTTTATGACTGATTAAAGTGTTTGGAATTAAATTACATCTGAGTATAAATTTTCTTGGAGTCATATCT TTATCTAGAGTTAACTCTCTGGTGGTAGAATGAAAAATAGATGTTGAACTATGCAAAGAGACATTTAATT TATTGATGTCTATGAAGTGTTGTGGTTCCTTAACCACATTTCTTTTTTTTTTTTTCCAGGCTATTCAAGA TCTCTGGCAGTGGAGGAAGTCTCTTTAAGAAAATAGTTTAAACAATTTGTTAAAAAATTTTCCGTCTTAT TTCATTTCTGTAACAGTTGATATCTGGCTGTCCTTTTTATAATGCAGAGTGAGAACTTTCCCTACCGTGT TTGATAAATGTTGTCCAGGTTCTATTGCCAAGAATGTGTTGTCCAAAATGCCTGTTTAGTTTTTAAAGAT GGAACTCCACCCTTTGCTTGGTTTTAAGTATGTATGGAATGTTATGATAGGACATAGTAGTAGCGGTGGT CAGACATGGAAATGGTGGGGAGACAAAAATATACATGTGAAATAAAACTCAGTATTTTAATAAAGTA Download Select all
Length	23237
OMIM ID	164040
HGNC ID	HGNC:7910
Unigene ID	Hs.557550
Ensembl ID	ENSG00000181163
PharmGKB ID	-

mRNA Information

mRNA ID	XM_005265920.2
Exon	join(1..359,2404..2483,3658..3777,4059..4152,5063..5169, 5267..5331,12506..12563,17655..17756,18750..19525)
mRNA Sequence	>4869 AGAAAGGAGTGGGGTTGAAAAGCGCTTGCGCAGGACGGCTACGGTACGGGGGTGGGAGGGCTTC GGAGCACGCGCGCGGAGGCGGGACTTGGGAAGCGCTCGCGAGATCTTCAGGGTCTATATATAAG CGCGGGGAGCCTGCGTCCTTTCCCTGGTGTGATTCCGTCCTGCGCGGTTGTTCTCTGGAGCAGC GTTCTTTTATCTCCGTCCGCCTTCTCTCCTACCTAAGTGCGTGCCGCCACCCGATGGAAGATTC GATGGACATGGACATGAGCCCCCTGAGGCCCCAGAACTATCTTTTCGGTTGTGAACTAAAGGCC GACAAAGATTATCACTTTAAGGTGGATAATGATGAAAATGAGCACCAGTTATCTTTAAGAACGG TCAGTTTAGGGGCTGGTGCAAAGGATGAGTTGCACATTGTTGAAGCAGAGGCAATGAATTACGA AGGCAGTCCAATTAAAGTAACACTGGCAACTTTGAAAATGTCTGTACAGCCAACGGTTTCCCTT GGGGGCTTTGAAATAACACCACCAGTGGTCTTAAGGTTGAAGTGTGGTTCAGGGCCAGTGCATA TTAGTGGACAGCACTTAGTAGCTGTGGAGGAAGATGCAGAGTCAGAAGATGAAGAGGAGGAGGA TGTGAAACTCTTAAGTATATCTGGAAAGCGGTCTGCCCCTGGAGGTGGTAGCAAGGTTCCACAG AAAAAAGTAAAACTTGCTGCTGATGAAGATGATGACGATGATGATGAAGAGGATGATGATGAAG ATGATGATGATGATGATTTTGATGATGAGGAAGCTGAAGAAAAAGCGCCAGTGAAGAAATCTAT ACGAGATACTCCAGCCAAAAATGCACAAAAGTCAAATCAGAATGGAAAAGACTCAAAACCATCA TCAACACCAAGATCAAAAGGACAAGAATCCTTCAAGAAACAGGAAAAAACTCCTAAAACACCAA AAGGACCTAGTTCTGTAGAAGACATTAAAGCAAAAATGCAAGCAAGTATAGAAAAAGCGCATTG AACAGTCCTGGGCACTACATGTAAATTAAGCCCAAAGATGGGGAGAAAGGAAAAGGAGAGACAA ATATAGTCCATACTGAGTGTCATCAACAATCCAGACTGAAGTCTTCTATTTTAATCTCAATCCC CTTTTCTGATTTGCCACCCATGCCTCTTCAGGCTGGAAACAATCTCTTGGTTCCCTAAAGCACT TTCTTCTGACTGCTGTGATTCAGTGAACCTTGCCCTTTGCTTTCTATTACTTGTGCATTTGCCT CACCTGACAATGTTTTAAATCGCCTTTGTATCTCCTTAGCTGCTCAATAAATATTTGAATGCAT CAA Download Select all
Length	1347

CDS Information

Location	join(302..359,2404..2483,3658..3777,4059..4152,5063..5169, 5267..5331,12506..12563,13192..13278,17655..17756, 20053..20127,22880..22918)
CDS Sequence	>lcl\|NM_001037738.2_cds_NP_001032827.1_1 [gene=NPM1] [protein=nucleophosmin isoform 3] [protein_id=NP_001032827.1] [location=246..1025] ATGGAAGATTCGATGGACATGGACATGAGCCCCCTGAGGCCCCAGAACTATCTTTTCGGTTGTGAACTAA AGGCCGACAAAGATTATCACTTTAAGGTGGATAATGATGAAAATGAGCACCAGTTATCTTTAAGAACGGT CAGTTTAGGGGCTGGTGCAAAGGATGAGTTGCACATTGTTGAAGCAGAGGCAATGAATTACGAAGGCAGT CCAATTAAAGTAACACTGGCAACTTTGAAAATGTCTGTACAGCCAACGGTTTCCCTTGGGGGCTTTGAAA TAACACCACCAGTGGTCTTAAGGTTGAAGTGTGGTTCAGGGCCAGTGCATATTAGTGGACAGCACTTAGT AGCTGTGGAGGAAGATGCAGAGTCAGAAGATGAAGAGGAGGAGGATGTGAAACTCTTAAGTATATCTGGA AAGCGGTCTGCCCCTGGAGGTGGTAGCAAGGTTCCACAGAAAAAAGTAAAACTTGCTGCTGATGAAGATG ATGACGATGATGATGAAGAGGATGATGATGAAGATGATGATGATGATGATTTTGATGATGAGGAAGCTGA AGAAAAAGCGCCAGTGAAGAAATCTATACGAGATACTCCAGCCAAAAATGCACAAAAGTCAAATCAGAAT GGAAAAGACTCAAAACCATCATCAACACCAAGATCAAAAGGACAAGAATCCTTCAAGAAACAGGAAAAAA CTCCTAAAACACCAAAAGGACCTAGTTCTGTAGAAGACATTAAAGCAAAAATGCAAGCAAGTATAGAAAA AGCGCATTGA Download Select all
CCDS ID	CCDS4376.1

Protein Information

Protein ID	NP_001032827.1
Protein Name	nucleophosmin (nucleolar phosphoprotein B23, numatrin)
Molecular Wt. (Da)	28269
Protein Sequence	>4869 MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIVEAEA MNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVEEDAESEDE EEEDVKLLSISGKRSAPGGGSKVPQKKVKLAADEDDDDDDEEDDDEDDDDDDFDDEEAEEKAPV KKSIRDTPAKNAQKSNQNGKDSKPSSTPRSKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIE KAH Download Select all
Length	259
Uniprot ID	P05114
Ensembl Protein ID	ENSP00000370125

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Phosphorylation	125
S	Phosphorylation	227
S	Phosphorylation	125
S	Phosphorylation	198
T	Phosphorylation	219
T	Phosphorylation	234
T	Phosphorylation	237
T	Phosphorylation	205
T	Phosphorylation	208
T	Phosphorylation	199
S	Phosphorylation	4
S	Phosphorylation	4
S	Phosphorylation	70
S	Phosphorylation	70
S	Phosphorylation	254
S	Phosphorylation	225
S	Phosphorylation	125;-
S	Phosphorylation	125;-
S	Phosphorylation	125;-
S	Phosphorylation	70;-
S	Phosphorylation	70;-
S	Phosphorylation	70;-
S	Phosphorylation	254;-
S	Phosphorylation	225;-
S	Phosphorylation	254;-
Y	Phosphorylation	67;-
Y	Phosphorylation	67;-
Y	Phosphorylation	67;-
S	Phosphorylation	10;-
S	Phosphorylation	10;-
S	Phosphorylation	10;-
S	Phosphorylation	4;-
T	Phosphorylation	95;-
T	Phosphorylation	95;-
T	Phosphorylation	95;-
S	Phosphorylation	139
S	Phosphorylation	139
S	Phosphorylation	139
S	Phosphorylation	260
S	Phosphorylation	231
S	Phosphorylation	243
S	Phosphorylation	214
S	Phosphorylation	243
S	Phosphorylation	195
S	Phosphorylation	195
S	Phosphorylation	137
S	Phosphorylation	137
S	Phosphorylation	137
T	Phosphorylation	234
T	Phosphorylation	237
T	Phosphorylation	199
T	Phosphorylation	75
T	Phosphorylation	75
T	Phosphorylation	75
K	Acetylation	32
K	Acetylation	32
K	Acetylation	32
K	Acetylation	257
K	Acetylation	228
K	Acetylation	273
K	Acetylation	244
K	Acetylation	267
K	Acetylation	238
K	Acetylation	257
K	Acetylation	150
K	Acetylation	150
K	Acetylation	150
K	Acetylation	27
K	Acetylation	27
K	Acetylation	27
Y	Phosphorylation	17
Y	Phosphorylation	17
Y	Phosphorylation	17
S	Phosphorylation	43
S	Phosphorylation	43
S	Phosphorylation	43
T	Phosphorylation	78
T	Phosphorylation	78
T	Phosphorylation	78
S	Phosphorylation	88
S	Phosphorylation	88
S	Phosphorylation	88
T	Phosphorylation	279
T	Phosphorylation	250
S	Phosphorylation	106
S	Phosphorylation	112
S	Phosphorylation	106
S	Phosphorylation	112
S	Phosphorylation	106
S	Phosphorylation	112
T	Phosphorylation	46
T	Phosphorylation	46
T	Phosphorylation	46
S	Phosphorylation	227
S	Phosphorylation	242
S	Phosphorylation	213
S	Phosphorylation	242
S	Phosphorylation	222
T	Phosphorylation	219
S	Phosphorylation	222
S	Phosphorylation	217
S	Phosphorylation	217
S	Phosphorylation	218
S	Phosphorylation	218

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
238	ALK	104	NP_004295.2	in vitro;in vivo	11888936
375	ARF1	54	NP_001649.1	in vitro;in vivo	1 463 657 415 684 370
1017	CDK2	310	NP_001789.2	in vitro;in vivo	1 127 899 116 376 870
1647	GADD45A	528	NP_001915.1	in vitro;yeast 2-hybrid	15644315
4691	NCL	1245	NP_005372.2	in vitro;in vivo;yeast 2-hybrid	105 038 778 620 867
4839	NOP2	1244	NP_006161.2	in vitro	8089149
5336	PLCG2	2570	AAH11772.1	in vivo	9819383
6464	SHC1	2780	NP_001123512.1	in vitro	8633037
7020	TFAP2A	128	NP_003211.1	in vitro;in vivo	17318229
7157	TP53	1859	NP_000537.3	in vitro;in vivo	1 208 034 816 376 880
7514	XPO1	3975	NP_003391.1	in vivo	16041368

Pathway Information

No matching records could be found.

Structure Information

PDB ID	2LLH
Resolution
Method	SOLUTION NMR
Chains	A
Molecule	Nucleophosmin
Model	View

Domain Information

ID	Location	Description
pfam03066	13-119	Nucleoplasmin
cl03870	13-119	Nucleoplasmin superfamily

Ontology Information

HPRD ID	3206
Molecular Class	Chaperone
Molecular Function	MRNA binding (GO:0003729)
Biological Process	Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO