Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| NUP98 | 4928 | Nucleoporin 98kDa  | 11 | ADIR2; NUP96; NUP196  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20089989    | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : - No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis and using spectral counting combined with statistics | Up-regulation | - | This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue. CRC tissue was collected at the VU University Medical Center, Amsterdam, The Netherlands. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, May 2010]   |
| Chromosome | 11 |
| Location | 11p15.5 |
| Start | 3675010   |
| End | 3797792   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 122783   |
| OMIM ID | 601021    |
| HGNC ID | HGNC:8068    |
| Unigene ID | Hs.524750     |
| Ensembl ID | ENSG00000110713    |
| PharmGKB ID | PA31856    |
mRNA Information
| mRNA ID | NM_139132.3 |
|---|---|
| Exon | join(1..393,15648..15751,18536..18637,18744..18920, 21772..21911,24054..24161,25865..26045,29049..29212, 34754..34891,37167..37254,44385..44477,53144..53284, 62469..62602,66215..66402,72574..72690,74338..74636, 76968..77081,78243..78381,83798..83975,85065..85229, 91166..91348,92437..92593,94901..95330,96954..97183, 98445..98711,102187..102344,104418..104561,106304..106446, 114352..114593,118085..118239,121173..121284, 121417..122783)   | mRNA Sequence |    Download   Select all |
| Length | 6758   |
CDS Information
| Location | join(15676..15751,18536..18637,18744..18920,21772..21911, 24054..24161,25865..26018,29049..29212,34754..34891, 37167..37305,44385..44477,53144..53284,62469..62602, 66215..66402,72574..72690,74338..74636,76968..77081, 78243..78381,83798..83975,85065..85229,91166..91348, 92437..92593,94901..95330,96954..97183,98445..98711, 102187..102344,104418..104561,106304..106446, |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | - |    
Protein Information
| Protein ID | NP_005378.4 |
|---|---|
| Protein Name | Nucleoporin 98kDa |
| Molecular Wt. (Da) | 97706 |
| Protein Sequence |    Download   Select all |
| Length | 937   |
| Uniprot ID | P51681 |    
| Ensembl Protein ID | ENSP00000292303   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 606 |
| S | Phosphorylation | 623 |
| S | Phosphorylation | 606 |
| S | Phosphorylation | 606 |
| F | Proteolytic Cleavage | 863 |
| F | Proteolytic Cleavage | 880 |
| F | Proteolytic Cleavage | 863 |
| F | Proteolytic Cleavage | 863 |
| S | Phosphorylation | 871 |
| S | Phosphorylation | 888 |
| S | Phosphorylation | 871 |
| S | Phosphorylation | 871 |
| T | Phosphorylation | 983;- |
| T | Phosphorylation | 983;- |
| S | Phosphorylation | 822;- |
| S | Phosphorylation | 839;- |
| S | Phosphorylation | 822;- |
| S | Phosphorylation | 822;- |
| S | Phosphorylation | 606;- |
| S | Phosphorylation | 623;- |
| S | Phosphorylation | 606;- |
| S | Phosphorylation | 606;- |
| S | Phosphorylation | 664;- |
| S | Phosphorylation | 681;- |
| S | Phosphorylation | 664;- |
| S | Phosphorylation | 664;- |
| S | Phosphorylation | 591;- |
| S | Phosphorylation | 608;- |
| S | Phosphorylation | 591;- |
| S | Phosphorylation | 591;- |
| S | Phosphorylation | 595;- |
| S | Phosphorylation | 612;- |
| S | Phosphorylation | 595;- |
| S | Phosphorylation | 595;- |
| S | Phosphorylation | 871;- |
| S | Phosphorylation | 888;- |
| S | Phosphorylation | 871;- |
| S | Phosphorylation | 871;- |
| S | Phosphorylation | 1752;- |
| S | Phosphorylation | 1678;- |
| T | Phosphorylation | 529 |
| T | Phosphorylation | 546 |
| T | Phosphorylation | 529 |
| T | Phosphorylation | 529 |
| S | Phosphorylation | 601 |
| S | Phosphorylation | 608 |
| S | Phosphorylation | 618 |
| S | Phosphorylation | 625 |
| S | Phosphorylation | 601 |
| S | Phosphorylation | 608 |
| S | Phosphorylation | 601 |
| S | Phosphorylation | 608 |
| T | Phosphorylation | 899 |
| S | Phosphorylation | 917 |
| T | Phosphorylation | 899 |
| S | Phosphorylation | 917 |
| S | Phosphorylation | 1006 |
| S | Phosphorylation | 1011 |
| S | Phosphorylation | 1006 |
| S | Phosphorylation | 1011 |
| T | Phosphorylation | 1024 |
| T | Phosphorylation | 1024 |
| S | Phosphorylation | 1026 |
| S | Phosphorylation | 1026 |
| S | Phosphorylation | 1043 |
| T | Phosphorylation | 1053 |
| S | Phosphorylation | 1043 |
| T | Phosphorylation | 1053 |
| S | Phosphorylation | 1047 |
| S | Phosphorylation | 1047 |
| T | Phosphorylation | 1751 |
| T | Phosphorylation | 1677 |
| T | Phosphorylation | 1755 |
| T | Phosphorylation | 1681 |
| T | Phosphorylation | 653 |
| S | Phosphorylation | 656 |
| T | Phosphorylation | 670 |
| S | Phosphorylation | 673 |
| T | Phosphorylation | 653 |
| S | Phosphorylation | 656 |
| T | Phosphorylation | 653 |
| S | Phosphorylation | 656 |
| T | Phosphorylation | 916 |
| T | Phosphorylation | 899 |
| K | Acetylation | 586 |
| K | Acetylation | 603 |
| K | Acetylation | 586 |
| K | Acetylation | 586 |
| T | Phosphorylation | 1005 |
| T | Phosphorylation | 1005 |
| S | Phosphorylation | 1672 |
| S | Phosphorylation | 1598 |
| S | Phosphorylation | 662 |
| S | Phosphorylation | 679 |
| S | Phosphorylation | 662 |
| S | Phosphorylation | 662 |
| S | Phosphorylation | 666 |
| S | Phosphorylation | 683 |
| S | Phosphorylation | 666 |
| S | Phosphorylation | 666 |
| S | Phosphorylation | 880 |
| S | Phosphorylation | 897 |
| S | Phosphorylation | 880 |
| S | Phosphorylation | 880 |
| Y | Phosphorylation | 831 |
| Y | Phosphorylation | 848 |
| Y | Phosphorylation | 831 |
| Y | Phosphorylation | 831 |
| T | Phosphorylation | 1788 |
| T | Phosphorylation | 1714 |
| S | Phosphorylation | 1021 |
| S | Phosphorylation | 1021 |
| S | Phosphorylation | 1017 |
| S | Phosphorylation | 1017 |
| T | Glycosylation | 184 |
| T | Glycosylation | 184 |
| T | Glycosylation | 184 |
| T | Glycosylation | 184 |
| T | Glycosylation | 550 |
| T | Glycosylation | 567 |
| T | Glycosylation | 550 |
| T | Glycosylation | 550 |
| T | Glycosylation | 551 |
| T | Glycosylation | 568 |
| T | Glycosylation | 551 |
| T | Glycosylation | 551 |
| S | Phosphorylation | 507 |
| S | Phosphorylation | 524 |
| S | Phosphorylation | 507 |
| S | Phosphorylation | 507 |
| T | Phosphorylation | 519 |
| T | Phosphorylation | 536 |
| T | Phosphorylation | 519 |
| T | Phosphorylation | 519 |
| T | Phosphorylation | 531 |
| T | Phosphorylation | 548 |
| T | Phosphorylation | 531 |
| T | Phosphorylation | 531 |
| T | Phosphorylation | 536 |
| T | Phosphorylation | 553 |
| T | Phosphorylation | 536 |
| T | Phosphorylation | 536 |
| S | Phosphorylation | 636 |
| S | Phosphorylation | 653 |
| S | Phosphorylation | 636 |
| S | Phosphorylation | 636 |
| T | Phosphorylation | 670 |
| T | Phosphorylation | 687 |
| T | Phosphorylation | 670 |
| T | Phosphorylation | 670 |
| S | Phosphorylation | 688 |
| T | Phosphorylation | 720 |
| S | Phosphorylation | 705 |
| T | Phosphorylation | 737 |
| S | Phosphorylation | 688 |
| T | Phosphorylation | 720 |
| S | Phosphorylation | 688 |
| T | Phosphorylation | 720 |
| S | Phosphorylation | 915 |
| S | Phosphorylation | 915 |
| S | Phosphorylation | 1038 |
| S | Phosphorylation | 1038 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1104 |    RCC1 |    1559 |    NP_001041659.1 |    in vitro |    10875935    |
| 1387 |    CREBBP |    2534 |    NP_004371.2 |    in vitro;in vivo |    9858599    |
| 6396 |    SEC13 |    2538 |    NP_109598.2 |    in vitro;yeast 2-hybrid |    14517296    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Influenza A |    hsa05164 |    
| RNA transport |    hsa03013 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam12110 | 1329-1627  | Nup96 |
| cl13536 | 1329-1627  | Nup96 superfamily |
| pfam04096 | 740-880  | Nucleoporin2 |
| cl04399 | 740-880  | Nucleoporin2 superfamily |
| pfam13634 | 39-149  | Nucleoporin_FG |
| cl22446 | 39-149  | Nucleoporin_FG superfamily |
| pfam13634 | 216-320  | Nucleoporin_FG |
| cl22446 | 216-320  | Nucleoporin_FG superfamily |
| pfam13634 | 26-131  | Nucleoporin_FG |
| pfam13634 | 261-421  | Nucleoporin_FG |
| pfam13634 | 352-466  | Nucleoporin_FG |
| cl22446 | 352-466  | Nucleoporin_FG superfamily |
| pfam13634 | 69-172  | Nucleoporin_FG |
| pfam13634 | 104-275  | Nucleoporin_FG |
| pfam13634 | 214-303  | Nucleoporin_FG |
| pfam13634 | 25-82  | Nucleoporin_FG |
| pfam13634 | 378-485  | Nucleoporin_FG |
| pfam10599 | 43-127  | Nup_retrotrp_bd |
| cl12388 | 43-127  | Nup_retrotrp_bd superfamily |
| COG5651 | 208-480  | COG5651 |
| COG5651 | 25-316  | COG5651 |
| COG5651 | 38-385  | COG5651 |
| PHA02584 | 25-175  | 34 |
| pfam05109 | 31-387  | Herpes_BLLF1 |
| PTZ00473 | 26-100  | PTZ00473 |
| pfam06682 | 25-144  | DUF1183 |
| PRK12688 | 62-508  | PRK12688 |
| COG5295 | 27-387  | Hia |
| PRK14708 | 30-508  | PRK14708 |
Ontology Information
| HPRD ID | 3847 |    
|---|---|
| Molecular Class | Transport/cargo protein |
| Molecular Function | Cytoskeletal protein binding (GO:0008092) |
| Biological Process | Cell growth and/or maintenance (GO:0008151)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
