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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
NUP98 4928 Nucleoporin 98kDa  11ADIR2; NUP96; NUP196 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20089989   2010Cell line : -

Source : VU University Medical Center, Amsterdam, The Netherlands.

Sample Type : -

No. of Sample : -

Stage : -

Biochemical isolation to nano-LC-MS/MS analysis and using spectral counting combined with statisticsUp-regulation-This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue.

CRC tissue was collected at the VU University Medical Center, Amsterdam, The Netherlands.


Gene Details



Chromosome: 11; NC_000011.9 (3696240..3819022, complement)

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Gene Type protein coding
Gene Family -
Description Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, May 2010]  
Chromosome 11
Location 11p15.5
Start 3675010  
End 3797792  
Strand -  
Gene Sequence

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Length 122783  
OMIM ID 601021   
HGNC ID HGNC:8068   
Unigene ID Hs.524750    
Ensembl ID ENSG00000110713   
PharmGKB ID PA31856   

mRNA Information


mRNA ID NM_139132.3
Exon join(1..393,15648..15751,18536..18637,18744..18920, 21772..21911,24054..24161,25865..26045,29049..29212, 34754..34891,37167..37254,44385..44477,53144..53284, 62469..62602,66215..66402,72574..72690,74338..74636, 76968..77081,78243..78381,83798..83975,85065..85229, 91166..91348,92437..92593,94901..95330,96954..97183, 98445..98711,102187..102344,104418..104561,106304..106446, 114352..114593,118085..118239,121173..121284, 121417..122783)  
mRNA Sequence

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Length 6758  



CDS Information


   
Location join(15676..15751,18536..18637,18744..18920,21772..21911, 24054..24161,25865..26018,29049..29212,34754..34891, 37167..37305,44385..44477,53144..53284,62469..62602, 66215..66402,72574..72690,74338..74636,76968..77081, 78243..78381,83798..83975,85065..85229,91166..91348, 92437..92593,94901..95330,96954..97183,98445..98711, 102187..102344,104418..104561,106304..106446,
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDNP_005378.4
Protein NameNucleoporin 98kDa
Molecular Wt. (Da)97706
Protein Sequence

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Length 937  
Uniprot IDP51681
Ensembl Protein ID ENSP00000292303  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation606
SPhosphorylation623
SPhosphorylation606
SPhosphorylation606
FProteolytic Cleavage863
FProteolytic Cleavage880
FProteolytic Cleavage863
FProteolytic Cleavage863
SPhosphorylation871
SPhosphorylation888
SPhosphorylation871
SPhosphorylation871
TPhosphorylation983;-
TPhosphorylation983;-
SPhosphorylation822;-
SPhosphorylation839;-
SPhosphorylation822;-
SPhosphorylation822;-
SPhosphorylation606;-
SPhosphorylation623;-
SPhosphorylation606;-
SPhosphorylation606;-
SPhosphorylation664;-
SPhosphorylation681;-
SPhosphorylation664;-
SPhosphorylation664;-
SPhosphorylation591;-
SPhosphorylation608;-
SPhosphorylation591;-
SPhosphorylation591;-
SPhosphorylation595;-
SPhosphorylation612;-
SPhosphorylation595;-
SPhosphorylation595;-
SPhosphorylation871;-
SPhosphorylation888;-
SPhosphorylation871;-
SPhosphorylation871;-
SPhosphorylation1752;-
SPhosphorylation1678;-
TPhosphorylation529
TPhosphorylation546
TPhosphorylation529
TPhosphorylation529
SPhosphorylation601
SPhosphorylation608
SPhosphorylation618
SPhosphorylation625
SPhosphorylation601
SPhosphorylation608
SPhosphorylation601
SPhosphorylation608
TPhosphorylation899
SPhosphorylation917
TPhosphorylation899
SPhosphorylation917
SPhosphorylation1006
SPhosphorylation1011
SPhosphorylation1006
SPhosphorylation1011
TPhosphorylation1024
TPhosphorylation1024
SPhosphorylation1026
SPhosphorylation1026
SPhosphorylation1043
TPhosphorylation1053
SPhosphorylation1043
TPhosphorylation1053
SPhosphorylation1047
SPhosphorylation1047
TPhosphorylation1751
TPhosphorylation1677
TPhosphorylation1755
TPhosphorylation1681
TPhosphorylation653
SPhosphorylation656
TPhosphorylation670
SPhosphorylation673
TPhosphorylation653
SPhosphorylation656
TPhosphorylation653
SPhosphorylation656
TPhosphorylation916
TPhosphorylation899
KAcetylation586
KAcetylation603
KAcetylation586
KAcetylation586
TPhosphorylation1005
TPhosphorylation1005
SPhosphorylation1672
SPhosphorylation1598
SPhosphorylation662
SPhosphorylation679
SPhosphorylation662
SPhosphorylation662
SPhosphorylation666
SPhosphorylation683
SPhosphorylation666
SPhosphorylation666
SPhosphorylation880
SPhosphorylation897
SPhosphorylation880
SPhosphorylation880
YPhosphorylation831
YPhosphorylation848
YPhosphorylation831
YPhosphorylation831
TPhosphorylation1788
TPhosphorylation1714
SPhosphorylation1021
SPhosphorylation1021
SPhosphorylation1017
SPhosphorylation1017
TGlycosylation184
TGlycosylation184
TGlycosylation184
TGlycosylation184
TGlycosylation550
TGlycosylation567
TGlycosylation550
TGlycosylation550
TGlycosylation551
TGlycosylation568
TGlycosylation551
TGlycosylation551
SPhosphorylation507
SPhosphorylation524
SPhosphorylation507
SPhosphorylation507
TPhosphorylation519
TPhosphorylation536
TPhosphorylation519
TPhosphorylation519
TPhosphorylation531
TPhosphorylation548
TPhosphorylation531
TPhosphorylation531
TPhosphorylation536
TPhosphorylation553
TPhosphorylation536
TPhosphorylation536
SPhosphorylation636
SPhosphorylation653
SPhosphorylation636
SPhosphorylation636
TPhosphorylation670
TPhosphorylation687
TPhosphorylation670
TPhosphorylation670
SPhosphorylation688
TPhosphorylation720
SPhosphorylation705
TPhosphorylation737
SPhosphorylation688
TPhosphorylation720
SPhosphorylation688
TPhosphorylation720
SPhosphorylation915
SPhosphorylation915
SPhosphorylation1038
SPhosphorylation1038

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                             
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1104RCC11559NP_001041659.1in vitro10875935   
1387CREBBP2534NP_004371.2in vitro;in vivo9858599   
6396SEC132538NP_109598.2in vitro;yeast 2-hybrid14517296   


Pathway Information


            
Pathway Name Pathway ID
Influenza A hsa05164
RNA transport hsa03013


Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam121101329-1627  Nup96
cl135361329-1627  Nup96 superfamily
pfam04096740-880  Nucleoporin2
cl04399740-880  Nucleoporin2 superfamily
pfam1363439-149  Nucleoporin_FG
cl2244639-149  Nucleoporin_FG superfamily
pfam13634216-320  Nucleoporin_FG
cl22446216-320  Nucleoporin_FG superfamily
pfam1363426-131  Nucleoporin_FG
pfam13634261-421  Nucleoporin_FG
pfam13634352-466  Nucleoporin_FG
cl22446352-466  Nucleoporin_FG superfamily
pfam1363469-172  Nucleoporin_FG
pfam13634104-275  Nucleoporin_FG
pfam13634214-303  Nucleoporin_FG
pfam1363425-82  Nucleoporin_FG
pfam13634378-485  Nucleoporin_FG
pfam1059943-127  Nup_retrotrp_bd
cl1238843-127  Nup_retrotrp_bd superfamily
COG5651208-480  COG5651
COG565125-316  COG5651
COG565138-385  COG5651
PHA0258425-175  34
pfam0510931-387  Herpes_BLLF1
PTZ0047326-100  PTZ00473
pfam0668225-144  DUF1183
PRK1268862-508  PRK12688
COG529527-387  Hia
PRK1470830-508  PRK14708


Ontology Information


   
HPRD ID3847
Molecular ClassTransport/cargo protein
Molecular FunctionCytoskeletal protein binding (GO:0008092)
Biological ProcessCell growth and/or maintenance (GO:0008151)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO