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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ATP5C1 509 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1  10- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22363440   2012Cell line : -

Source : -

Sample Type : CRC tumor and normal tissues

No. of Sample : 40 microsatellite stable and CpG island methylator phenotype-negative colorectal tumors and paired adjacent normal colon tissues

Stage : -

MSI and CIMP Testing,Microarray Analysis,Real-Time PCR ValidationPolymorhpism-ATP5C1 and DDX28 are mitochondrial proteins involved in cellular metabolism and division, respectively .Association between the low colorectal cancer risk allele (A) for rs10795668 at 10p14 and increased expression of ATP5C1 (q?=?0.024) and between the colorectal cancer high risk allele (C) for rs4444235 at 14q22.2 and increased expression of DLGAP5 (q?=?0.041), both in tumor samples.


Gene Details



NC_000010.10 (7830093..7849764)

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Gene Type protein coding
Gene Family Mitochondrial respiratory chain complex / Complex V, "ATPases / F-type"
Description This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene also has a pseudogene on chromosome 14. [provided by RefSeq, Jul 2008]  
Chromosome 10
Location 10p14
Start 7830093  
End 7849764  
Strand +  
Gene Sequence

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Length 19672  
OMIM ID 108729   
HGNC ID HGNC:833   
Unigene ID Hs.271135   
Ensembl ID ENSG00000165629   
PharmGKB ID PA25125   

mRNA Information


mRNA ID NM_001001973.1
Exon join(1..134,7992..8026,8918..9049,10861..11065, 11643..11786,11898..11962,14141..14296,14629..14725, 18845..18881,19530..19672)  
mRNA Sequence

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Length 1162  



CDS Information


   
Location79..975
CDS Sequence

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CCDS ID CCDS31142.1



Protein Information


      
Protein IDNP_001001973.1
Protein NameATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
Molecular Wt. (Da)0
Protein Sequence

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Length 298  
Uniprot IDQ03164
Ensembl Protein ID ENSP00000374157  



Post-translational Modification Information (Source : HPRD)


Residue Type site
KAcetylation197
KAcetylation197
KAcetylation154
KAcetylation154
KAcetylation55
KAcetylation55
SPhosphorylation146
SPhosphorylation146
TPhosphorylation45
TPhosphorylation45
SPhosphorylation116
TPhosphorylation122
SPhosphorylation116
TPhosphorylation122

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                           
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
498ATP5A11258NP_004037.1in vitro8065448   
506ATP5B44NP_001677.2in vitro8065448   
771CA124464NP_001209.1yeast 2-hybrid16169070   
896CCND3452NP_001751.1yeast 2-hybrid16169070   
1956EGFR579NP_005219.2yeast 2-hybrid16169070   
3698ITIH2890NP_002207.2yeast 2-hybrid16169070   
4354MPP12370NP_002427.1yeast 2-hybrid16169070   
4709NDUFB311954NP_002482.1yeast 2-hybrid16169070   
5074PAWR9051NP_002574.2yeast 2-hybrid16169070   
5764PTN1199NP_002816.1yeast 2-hybrid16169070   
10072DPP36012NP_005691.2yeast 2-hybrid16169070   
10574CCT76896NP_006420.1yeast 2-hybrid16169070   
23649POLA210160NP_002680.2yeast 2-hybrid16169070   
25791NGEF10442NP_062824.2yeast 2-hybrid16169070   
25978CHMP2B13174NP_054762.2yeast 2-hybrid16169070   
26152ZNF33715779NP_056470.1yeast 2-hybrid16169070   
51586MED1512117NP_001003891.1yeast 2-hybrid16169070   
54857GDPD26528NP_060181.2yeast 2-hybrid16169070   
56902PNO114250NP_064528.1yeast 2-hybrid16169070   
64219PJA12335NP_660095.1yeast 2-hybrid16169070   
84337ELOF114639NP_115753.1yeast 2-hybrid16169070   


Pathway Information


                              
Pathway Name Pathway ID
Alzheimer's disease hsa05010
Huntington's disease hsa05016
Metabolic pathways hsa01100
Oxidative phosphorylation hsa00190
Parkinson's disease hsa05012


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd1215126-294  F1-ATPase_gamma
cl0036526-294  F1-ATPase_gamma superfamily
TIGR0114626-297  ATPsyn_F1gamma
pfam0023126-297  ATP-synt
PRK0562125-297  PRK05621
COG022429-297  AtpG
PRK1342325-297  PRK13423
PRK1411125-297  PRK14111
PRK1342525-297  PRK13425
PRK1411025-298  PRK14110
PRK1342425-297  PRK13424
PRK1342725-298  PRK13427
PRK1342625-297  PRK13426
PRK1342225-297  PRK13422
TIGR0332331-297  alt_F1F0_F1_gam


Ontology Information


   
HPRD ID2070
Molecular ClassTransport/cargo protein
Molecular FunctionTranscription factor activity (GO:0003700)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO