Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ATP5C1 | 509 | ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1  | 10 | -  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22363440    | 2012 | Cell line : - Source : - Sample Type : CRC tumor and normal tissues No. of Sample : 40 microsatellite stable and CpG island methylator phenotype-negative colorectal tumors and paired adjacent normal colon tissues Stage : - | MSI and CIMP Testing,Microarray Analysis,Real-Time PCR Validation | Polymorhpism | - | ATP5C1 and DDX28 are mitochondrial proteins involved in cellular metabolism and division, respectively .Association between the low colorectal cancer risk allele (A) for rs10795668 at 10p14 and increased expression of ATP5C1 (q?=?0.024) and between the colorectal cancer high risk allele (C) for rs4444235 at 14q22.2 and increased expression of DLGAP5 (q?=?0.041), both in tumor samples. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Mitochondrial respiratory chain complex / Complex V, "ATPases / F-type" |
| Description | This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene also has a pseudogene on chromosome 14. [provided by RefSeq, Jul 2008]   | Chromosome | 10 |
| Location | 10p14 |
| Start | 7830093   |
| End | 7849764   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 19672   |
| OMIM ID | 108729    |
| HGNC ID | HGNC:833    |
| Unigene ID | Hs.271135    |
| Ensembl ID | ENSG00000165629    |
| PharmGKB ID | PA25125    |
mRNA Information
| mRNA ID | NM_001001973.1 |
|---|---|
| Exon | join(1..134,7992..8026,8918..9049,10861..11065, 11643..11786,11898..11962,14141..14296,14629..14725, 18845..18881,19530..19672)   | mRNA Sequence |    Download   Select all |
| Length | 1162   |
CDS Information
| Location | 79..975 |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS31142.1 |    
Protein Information
| Protein ID | NP_001001973.1 |
|---|---|
| Protein Name | ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence |    Download   Select all |
| Length | 298   |
| Uniprot ID | Q03164 |    
| Ensembl Protein ID | ENSP00000374157   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Acetylation | 197 |
| K | Acetylation | 197 |
| K | Acetylation | 154 |
| K | Acetylation | 154 |
| K | Acetylation | 55 |
| K | Acetylation | 55 |
| S | Phosphorylation | 146 |
| S | Phosphorylation | 146 |
| T | Phosphorylation | 45 |
| T | Phosphorylation | 45 |
| S | Phosphorylation | 116 |
| T | Phosphorylation | 122 |
| S | Phosphorylation | 116 |
| T | Phosphorylation | 122 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 498 |    ATP5A1 |    1258 |    NP_004037.1 |    in vitro |    8065448    |
| 506 |    ATP5B |    44 |    NP_001677.2 |    in vitro |    8065448    |
| 771 |    CA12 |    4464 |    NP_001209.1 |    yeast 2-hybrid |    16169070    |
| 896 |    CCND3 |    452 |    NP_001751.1 |    yeast 2-hybrid |    16169070    |
| 1956 |    EGFR |    579 |    NP_005219.2 |    yeast 2-hybrid |    16169070    |
| 3698 |    ITIH2 |    890 |    NP_002207.2 |    yeast 2-hybrid |    16169070    |
| 4354 |    MPP1 |    2370 |    NP_002427.1 |    yeast 2-hybrid |    16169070    |
| 4709 |    NDUFB3 |    11954 |    NP_002482.1 |    yeast 2-hybrid |    16169070    |
| 5074 |    PAWR |    9051 |    NP_002574.2 |    yeast 2-hybrid |    16169070    |
| 5764 |    PTN |    1199 |    NP_002816.1 |    yeast 2-hybrid |    16169070    |
| 10072 |    DPP3 |    6012 |    NP_005691.2 |    yeast 2-hybrid |    16169070    |
| 10574 |    CCT7 |    6896 |    NP_006420.1 |    yeast 2-hybrid |    16169070    |
| 23649 |    POLA2 |    10160 |    NP_002680.2 |    yeast 2-hybrid |    16169070    |
| 25791 |    NGEF |    10442 |    NP_062824.2 |    yeast 2-hybrid |    16169070    |
| 25978 |    CHMP2B |    13174 |    NP_054762.2 |    yeast 2-hybrid |    16169070    |
| 26152 |    ZNF337 |    15779 |    NP_056470.1 |    yeast 2-hybrid |    16169070    |
| 51586 |    MED15 |    12117 |    NP_001003891.1 |    yeast 2-hybrid |    16169070    |
| 54857 |    GDPD2 |    6528 |    NP_060181.2 |    yeast 2-hybrid |    16169070    |
| 56902 |    PNO1 |    14250 |    NP_064528.1 |    yeast 2-hybrid |    16169070    |
| 64219 |    PJA1 |    2335 |    NP_660095.1 |    yeast 2-hybrid |    16169070    |
| 84337 |    ELOF1 |    14639 |    NP_115753.1 |    yeast 2-hybrid |    16169070    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Alzheimer's disease |    hsa05010 |    
| Huntington's disease |    hsa05016 |    
| Metabolic pathways |    hsa01100 |    
| Oxidative phosphorylation |    hsa00190 |    
| Parkinson's disease |    hsa05012 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd12151 | 26-294  | F1-ATPase_gamma |
| cl00365 | 26-294  | F1-ATPase_gamma superfamily |
| TIGR01146 | 26-297  | ATPsyn_F1gamma |
| pfam00231 | 26-297  | ATP-synt |
| PRK05621 | 25-297  | PRK05621 |
| COG0224 | 29-297  | AtpG |
| PRK13423 | 25-297  | PRK13423 |
| PRK14111 | 25-297  | PRK14111 |
| PRK13425 | 25-297  | PRK13425 |
| PRK14110 | 25-298  | PRK14110 |
| PRK13424 | 25-297  | PRK13424 |
| PRK13427 | 25-298  | PRK13427 |
| PRK13426 | 25-297  | PRK13426 |
| PRK13422 | 25-297  | PRK13422 |
| TIGR03323 | 31-297  | alt_F1F0_F1_gam |
Ontology Information
| HPRD ID | 2070 |    
|---|---|
| Molecular Class | Transport/cargo protein |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
