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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PRKAG2 51422 Protein kinase, AMP-activated, gamma 2 non-catalytic subunit  7AAKG; CMH6; WPWS; AAKG2; H91620p 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20622004   2010Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

-Polymorhpism-PRKAA1 and PRKAG2 phosphorylates proximal substrates like tuberous sclerosis complexes (TSCs) 1 and 2.

21999454   2011Cell line : -

Source : Utah, the Northern California Kaiser Permanente Medical Care Program (KPMCP), and the Twin Cities Metropolitan area of Minnesota (colon cancer study only).

Sample Type : Population-based case-control studies

No. of Sample : colon 1,574 cases, 1,970 controls and rectal 791 cases, 999 controls

Stage : -

HapMap and the Illumina Platform tagSNP database, multiple-gene analysis, PROC HAPLOTYPE.Polymorhpism-Analyses show that genetic variation influences risk of colorectal cancer associated with diet and illustrate the importance of evaluating dietary interactions beyond the level of single SNPs or haplotypes.

Evaluation of dietary interactions with multiple genes in this candidate pathway showed several interactions with pairs of genes: Akt1 and PDK1, PDK1 and PTEN, PDK1 and TSC1, and PRKAG2 and PTEN.


Gene Details



Chromosome: 7; NC_000007.13 (151253200..151574316, complement)

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Gene Type protein coding
Gene Family -
Description AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family and encodes a protein with four cystathionine beta-synthase domains. Mutations in this gene have been associated with ventricular pre-excitation (Wolff-Parkinson-White syndrome), progressive conduction system disease and cardiac hypertrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]  
Chromosome 7
Location 7q36.1
Start 151556114  
End 151877231  
Strand +  
Gene Sequence

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Length 321118  
OMIM ID 602743   
HGNC ID HGNC:9386   
Unigene ID Hs.647072    
Ensembl ID ENSG00000106617   
PharmGKB ID -   

mRNA Information


mRNA ID NM_016203.3
Exon join(1..725,90691..90762,95801..96080,201595..201812, 245094..245163,281778..281887,300780..300861, 302283..302341,304523..304568,307007..307061, 308390..308516,311347..311512,311849..311886, 313008..313154,316615..316708,320000..321118)  
mRNA Sequence

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Length 3423  



CDS Information


   
Locationjoin(612..725,90691..90762,95801..96080,201595..201812, 245094..245163,281778..281887,300780..300861, 302283..302341,304523..304568,307007..307061, 308390..308516,311347..311512,311849..311886, 313008..313154,316615..316708,320000..320031)
CDS Sequence

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CCDS ID CCDS5928.1



Protein Information


      
Protein IDNP_057287.2
Protein NameProtein kinase, AMP-activated, gamma 2 non-catalytic subunit
Molecular Wt. (Da)62935
Protein Sequence

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Length 569  
Uniprot IDP07332
Ensembl Protein ID ENSP00000331504  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation162;-
SPhosphorylation157;-
TPhosphorylation167;-
SPhosphorylation113;-
TPhosphorylation123;-
SPhosphorylation118;-
SPhosphorylation143
SPhosphorylation99
SPhosphorylation196
SPhosphorylation152
SPhosphorylation164
SPhosphorylation120
TPhosphorylation165
TPhosphorylation121
SPhosphorylation129
SPhosphorylation130
SPhosphorylation85
SPhosphorylation86
SPhosphorylation71
SPhosphorylation27
KAcetylation9
SPhosphorylation135
SPhosphorylation138
SPhosphorylation91
SPhosphorylation94
SPhosphorylation161
TPhosphorylation170
SPhosphorylation117
TPhosphorylation126

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                             
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
5564PRKAB14116NP_006244.2yeast 2-hybrid10698692   
5565PRKAB24117NP_005390.1yeast 2-hybrid10698692   
5571PRKAG14118NP_002724.1yeast 2-hybrid10698692   


Pathway Information


                                                                        
Pathway Name Pathway ID
Adipocytokine signaling pathway hsa04920
AMPK signaling pathway hsa04152
Circadian rhythm hsa04710
FoxO signaling pathway hsa04068
Glucagon signaling pathway hsa04922
Hypertrophic cardiomyopathy (HCM) hsa05410
Insulin resistance hsa04931
Insulin signaling pathway hsa04910
Longevity regulating pathway - mammal hsa04211
Longevity regulating pathway - multiple species hsa04213
Non-alcoholic fatty liver disease (NAFLD) hsa04932
Oxytocin signaling pathway hsa04921


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd04641434-553  CBS_pair_28
cl15354434-553  CBS_pair superfamily
cd04618278-407  CBS_pair_5
cl15354278-407  CBS_pair superfamily
cd02205434-553  CBS_pair
cd04631362-479  CBS_pair_18
cd04642439-551  CBS_pair_29
cd04585359-481  CBS_pair_ACT_assoc2
cd04627359-481  CBS_pair_14
cd04803359-481  CBS_pair_15
cd04631435-553  CBS_pair_18
cd04633359-481  CBS_pair_20
cd04584359-479  CBS_pair_ACT_assoc
cd02205278-407  CBS_pair
cd04612439-553  CBS_pair_SpoIVFB_EriC_assoc
cd04586439-553  CBS_pair_BON_assoc
cd04629434-553  CBS_pair_16
smart00116439-483  CBS
cd04623434-553  CBS_pair_10
pfam00571434-484  CBS
cd04600441-553  CBS_pair_HPP_assoc
cd04637361-479  CBS_pair_24
cd04601438-553  CBS_pair_IMPDH
cd04588359-481  CBS_pair_CAP-ED_DUF294_assoc_arch
cd04605359-481  CBS_pair_MET2_assoc
cd04622434-553  CBS_pair_9
cd04600361-479  CBS_pair_HPP_assoc
cd04611434-553  CBS_pair_PAS_GGDEF_DUF1_assoc
cd04635441-553  CBS_pair_22
cd04624439-553  CBS_pair_11
cd04615439-552  CBS_pair_2
smart00116360-409  CBS
cd04584439-553  CBS_pair_ACT_assoc
cd04636359-479  CBS_pair_23
smart00116508-555  CBS
cd04609438-551  CBS_pair_PALP_assoc2
cd04588439-553  CBS_pair_CAP-ED_DUF294_assoc_arch
cd04605434-550  CBS_pair_MET2_assoc
cd04586359-479  CBS_pair_BON_assoc
pfam00571517-555  CBS
cd04636441-553  CBS_pair_23
cd04621361-479  CBS_pair_8
cd04632441-553  CBS_pair_19
pfam00571359-408  CBS
cd04595360-480  CBS_pair_DHH_polyA_Pol_assoc
cd04611359-480  CBS_pair_PAS_GGDEF_DUF1_assoc
cd04612434-479  CBS_pair_SpoIVFB_EriC_assoc
cd04626362-479  CBS_pair_13
cd04802359-479  CBS_pair_3
cd04624359-481  CBS_pair_11
cd04587434-470  CBS_pair_CAP-ED_DUF294_PBI_assoc
cd04633439-553  CBS_pair_20
cd04621434-553  CBS_pair_8
cd04623359-478  CBS_pair_10
smart00116280-328  CBS
cd04631279-389  CBS_pair_18
cd04640439-550  CBS_pair_27
cd04607364-475  CBS_pair_NTP_transferase_assoc
cd04634435-553  CBS_pair_21
cd04629361-480  CBS_pair_16
cd04601362-470  CBS_pair_IMPDH
cd04604439-470  CBS_pair_KpsF_GutQ_assoc
cd04609359-481  CBS_pair_PALP_assoc2
cd04583359-475  CBS_pair_ABC_OpuCA_assoc2
cd04638447-553  CBS_pair_25
cd04800438-553  CBS_pair_CAP-ED_DUF294_PBI_assoc2
cd04599359-405  CBS_pair_GGDEF_assoc2
cd04590435-551  CBS_pair_CorC_HlyC_assoc
cd04802359-406  CBS_pair_3
cd04801441-552  CBS_pair_M50_like
cd04635439-479  CBS_pair_22
cd04595438-553  CBS_pair_DHH_polyA_Pol_assoc
cd04634359-389  CBS_pair_21
cd04639461-553  CBS_pair_26
cd04583439-553  CBS_pair_ABC_OpuCA_assoc2
cd04642359-480  CBS_pair_29
cd04589360-407  CBS_pair_CAP-ED_DUF294_assoc_bac
cd02205517-554  CBS_pair
cd04610434-479  CBS_pair_ParBc_assoc
cd04608359-480  CBS_pair_PALP_assoc
cd04800359-407  CBS_pair_CAP-ED_DUF294_PBI_assoc2
cd04638372-480  CBS_pair_25
cd04606434-470  CBS_pair_Mg_transporter
cd04612360-407  CBS_pair_SpoIVFB_EriC_assoc
cd04615358-481  CBS_pair_2
cd04637333-407  CBS_pair_24
cd04606491-554  CBS_pair_Mg_transporter
cd04643435-553  CBS_pair_30
cd04630316-389  CBS_pair_17
cd04642278-389  CBS_pair_29
cd04613517-554  CBS_pair_SpoIVFB_EriC_assoc2
cd04597439-474  CBS_pair_DRTGG_assoc2
cd04593442-553  CBS_pair_EriC_assoc_bac_arch
cd04599439-551  CBS_pair_GGDEF_assoc2
cd04590364-470  CBS_pair_CorC_HlyC_assoc
cd04802435-553  CBS_pair_3
cd04613364-479  CBS_pair_SpoIVFB_EriC_assoc2
cd04639364-472  CBS_pair_26
cd04620439-553  CBS_pair_7
COG0517359-479  CBS
COG0517435-551  CBS
COG2524439-555  COG2524
PRK05567438-553  PRK05567
COG3448361-479  COG3448
PHA0330746-221  PHA03307
COG2524359-485  COG2524
COG3620435-554  COG3620
pfam00478435-553  IMPDH
COG3448441-554  COG3448
TIGR01302435-555  IMP_dehydrog
COG2524277-408  COG2524
PRK05567362-470  PRK05567
PRK14869435-550  PRK14869
COG2905359-405  COG2905
COG2905355-529  COG2905
COG0517284-405  CBS
PHA0324760-221  PHA03247
TIGR00393439-470  kpsF


Ontology Information


   
HPRD ID1289
Molecular ClassSerine/threonine kinase
Molecular FunctionGrowth factor activity (GO:0008083)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
Q9UGJ0DB00945Acetylsalicylic acidSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO