Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PRKAG2 | 51422 | Protein kinase, AMP-activated, gamma 2 non-catalytic subunit  | 7 | AAKG; CMH6; WPWS; AAKG2; H91620p  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20622004    | 2010 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Polymorhpism | - | PRKAA1 and PRKAG2 phosphorylates proximal substrates like tuberous sclerosis complexes (TSCs) 1 and 2. |
| 21999454    | 2011 | Cell line : - Source : Utah, the Northern California Kaiser Permanente Medical Care Program (KPMCP), and the Twin Cities Metropolitan area of Minnesota (colon cancer study only). Sample Type : Population-based case-control studies No. of Sample : colon 1,574 cases, 1,970 controls and rectal 791 cases, 999 controls Stage : - | HapMap and the Illumina Platform tagSNP database, multiple-gene analysis, PROC HAPLOTYPE. | Polymorhpism | - | Analyses show that genetic variation influences risk of colorectal cancer associated with diet and illustrate the importance of evaluating dietary interactions beyond the level of single SNPs or haplotypes. Evaluation of dietary interactions with multiple genes in this candidate pathway showed several interactions with pairs of genes: Akt1 and PDK1, PDK1 and PTEN, PDK1 and TSC1, and PRKAG2 and PTEN. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family and encodes a protein with four cystathionine beta-synthase domains. Mutations in this gene have been associated with ventricular pre-excitation (Wolff-Parkinson-White syndrome), progressive conduction system disease and cardiac hypertrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]   | Chromosome | 7 |
| Location | 7q36.1 |
| Start | 151556114   |
| End | 151877231   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 321118   |
| OMIM ID | 602743    |
| HGNC ID | HGNC:9386    |
| Unigene ID | Hs.647072     |
| Ensembl ID | ENSG00000106617    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_016203.3 |
|---|---|
| Exon | join(1..725,90691..90762,95801..96080,201595..201812, 245094..245163,281778..281887,300780..300861, 302283..302341,304523..304568,307007..307061, 308390..308516,311347..311512,311849..311886, 313008..313154,316615..316708,320000..321118)   | mRNA Sequence |    Download   Select all |
| Length | 3423   |
CDS Information
| Location | join(612..725,90691..90762,95801..96080,201595..201812, 245094..245163,281778..281887,300780..300861, 302283..302341,304523..304568,307007..307061, 308390..308516,311347..311512,311849..311886, 313008..313154,316615..316708,320000..320031) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS5928.1 |    
Protein Information
| Protein ID | NP_057287.2 |
|---|---|
| Protein Name | Protein kinase, AMP-activated, gamma 2 non-catalytic subunit |
| Molecular Wt. (Da) | 62935 |
| Protein Sequence |    Download   Select all |
| Length | 569   |
| Uniprot ID | P07332 |    
| Ensembl Protein ID | ENSP00000331504   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 162;- |
| S | Phosphorylation | 157;- |
| T | Phosphorylation | 167;- |
| S | Phosphorylation | 113;- |
| T | Phosphorylation | 123;- |
| S | Phosphorylation | 118;- |
| S | Phosphorylation | 143 |
| S | Phosphorylation | 99 |
| S | Phosphorylation | 196 |
| S | Phosphorylation | 152 |
| S | Phosphorylation | 164 |
| S | Phosphorylation | 120 |
| T | Phosphorylation | 165 |
| T | Phosphorylation | 121 |
| S | Phosphorylation | 129 |
| S | Phosphorylation | 130 |
| S | Phosphorylation | 85 |
| S | Phosphorylation | 86 |
| S | Phosphorylation | 71 |
| S | Phosphorylation | 27 |
| K | Acetylation | 9 |
| S | Phosphorylation | 135 |
| S | Phosphorylation | 138 |
| S | Phosphorylation | 91 |
| S | Phosphorylation | 94 |
| S | Phosphorylation | 161 |
| T | Phosphorylation | 170 |
| S | Phosphorylation | 117 |
| T | Phosphorylation | 126 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 5564 |    PRKAB1 |    4116 |    NP_006244.2 |    yeast 2-hybrid |    10698692    |
| 5565 |    PRKAB2 |    4117 |    NP_005390.1 |    yeast 2-hybrid |    10698692    |
| 5571 |    PRKAG1 |    4118 |    NP_002724.1 |    yeast 2-hybrid |    10698692    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Adipocytokine signaling pathway |    hsa04920 |    
| AMPK signaling pathway |    hsa04152 |    
| Circadian rhythm |    hsa04710 |    
| FoxO signaling pathway |    hsa04068 |    
| Glucagon signaling pathway |    hsa04922 |    
| Hypertrophic cardiomyopathy (HCM) |    hsa05410 |    
| Insulin resistance |    hsa04931 |    
| Insulin signaling pathway |    hsa04910 |    
| Longevity regulating pathway - mammal |    hsa04211 |    
| Longevity regulating pathway - multiple species |    hsa04213 |    
| Non-alcoholic fatty liver disease (NAFLD) |    hsa04932 |    
| Oxytocin signaling pathway |    hsa04921 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd04641 | 434-553  | CBS_pair_28 |
| cl15354 | 434-553  | CBS_pair superfamily |
| cd04618 | 278-407  | CBS_pair_5 |
| cl15354 | 278-407  | CBS_pair superfamily |
| cd02205 | 434-553  | CBS_pair |
| cd04631 | 362-479  | CBS_pair_18 |
| cd04642 | 439-551  | CBS_pair_29 |
| cd04585 | 359-481  | CBS_pair_ACT_assoc2 |
| cd04627 | 359-481  | CBS_pair_14 |
| cd04803 | 359-481  | CBS_pair_15 |
| cd04631 | 435-553  | CBS_pair_18 |
| cd04633 | 359-481  | CBS_pair_20 |
| cd04584 | 359-479  | CBS_pair_ACT_assoc |
| cd02205 | 278-407  | CBS_pair |
| cd04612 | 439-553  | CBS_pair_SpoIVFB_EriC_assoc |
| cd04586 | 439-553  | CBS_pair_BON_assoc |
| cd04629 | 434-553  | CBS_pair_16 |
| smart00116 | 439-483  | CBS |
| cd04623 | 434-553  | CBS_pair_10 |
| pfam00571 | 434-484  | CBS |
| cd04600 | 441-553  | CBS_pair_HPP_assoc |
| cd04637 | 361-479  | CBS_pair_24 |
| cd04601 | 438-553  | CBS_pair_IMPDH |
| cd04588 | 359-481  | CBS_pair_CAP-ED_DUF294_assoc_arch |
| cd04605 | 359-481  | CBS_pair_MET2_assoc |
| cd04622 | 434-553  | CBS_pair_9 |
| cd04600 | 361-479  | CBS_pair_HPP_assoc |
| cd04611 | 434-553  | CBS_pair_PAS_GGDEF_DUF1_assoc |
| cd04635 | 441-553  | CBS_pair_22 |
| cd04624 | 439-553  | CBS_pair_11 |
| cd04615 | 439-552  | CBS_pair_2 |
| smart00116 | 360-409  | CBS |
| cd04584 | 439-553  | CBS_pair_ACT_assoc |
| cd04636 | 359-479  | CBS_pair_23 |
| smart00116 | 508-555  | CBS |
| cd04609 | 438-551  | CBS_pair_PALP_assoc2 |
| cd04588 | 439-553  | CBS_pair_CAP-ED_DUF294_assoc_arch |
| cd04605 | 434-550  | CBS_pair_MET2_assoc |
| cd04586 | 359-479  | CBS_pair_BON_assoc |
| pfam00571 | 517-555  | CBS |
| cd04636 | 441-553  | CBS_pair_23 |
| cd04621 | 361-479  | CBS_pair_8 |
| cd04632 | 441-553  | CBS_pair_19 |
| pfam00571 | 359-408  | CBS |
| cd04595 | 360-480  | CBS_pair_DHH_polyA_Pol_assoc |
| cd04611 | 359-480  | CBS_pair_PAS_GGDEF_DUF1_assoc |
| cd04612 | 434-479  | CBS_pair_SpoIVFB_EriC_assoc |
| cd04626 | 362-479  | CBS_pair_13 |
| cd04802 | 359-479  | CBS_pair_3 |
| cd04624 | 359-481  | CBS_pair_11 |
| cd04587 | 434-470  | CBS_pair_CAP-ED_DUF294_PBI_assoc |
| cd04633 | 439-553  | CBS_pair_20 |
| cd04621 | 434-553  | CBS_pair_8 |
| cd04623 | 359-478  | CBS_pair_10 |
| smart00116 | 280-328  | CBS |
| cd04631 | 279-389  | CBS_pair_18 |
| cd04640 | 439-550  | CBS_pair_27 |
| cd04607 | 364-475  | CBS_pair_NTP_transferase_assoc |
| cd04634 | 435-553  | CBS_pair_21 |
| cd04629 | 361-480  | CBS_pair_16 |
| cd04601 | 362-470  | CBS_pair_IMPDH |
| cd04604 | 439-470  | CBS_pair_KpsF_GutQ_assoc |
| cd04609 | 359-481  | CBS_pair_PALP_assoc2 |
| cd04583 | 359-475  | CBS_pair_ABC_OpuCA_assoc2 |
| cd04638 | 447-553  | CBS_pair_25 |
| cd04800 | 438-553  | CBS_pair_CAP-ED_DUF294_PBI_assoc2 |
| cd04599 | 359-405  | CBS_pair_GGDEF_assoc2 |
| cd04590 | 435-551  | CBS_pair_CorC_HlyC_assoc |
| cd04802 | 359-406  | CBS_pair_3 |
| cd04801 | 441-552  | CBS_pair_M50_like |
| cd04635 | 439-479  | CBS_pair_22 |
| cd04595 | 438-553  | CBS_pair_DHH_polyA_Pol_assoc |
| cd04634 | 359-389  | CBS_pair_21 |
| cd04639 | 461-553  | CBS_pair_26 |
| cd04583 | 439-553  | CBS_pair_ABC_OpuCA_assoc2 |
| cd04642 | 359-480  | CBS_pair_29 |
| cd04589 | 360-407  | CBS_pair_CAP-ED_DUF294_assoc_bac |
| cd02205 | 517-554  | CBS_pair |
| cd04610 | 434-479  | CBS_pair_ParBc_assoc |
| cd04608 | 359-480  | CBS_pair_PALP_assoc |
| cd04800 | 359-407  | CBS_pair_CAP-ED_DUF294_PBI_assoc2 |
| cd04638 | 372-480  | CBS_pair_25 |
| cd04606 | 434-470  | CBS_pair_Mg_transporter |
| cd04612 | 360-407  | CBS_pair_SpoIVFB_EriC_assoc |
| cd04615 | 358-481  | CBS_pair_2 |
| cd04637 | 333-407  | CBS_pair_24 |
| cd04606 | 491-554  | CBS_pair_Mg_transporter |
| cd04643 | 435-553  | CBS_pair_30 |
| cd04630 | 316-389  | CBS_pair_17 |
| cd04642 | 278-389  | CBS_pair_29 |
| cd04613 | 517-554  | CBS_pair_SpoIVFB_EriC_assoc2 |
| cd04597 | 439-474  | CBS_pair_DRTGG_assoc2 |
| cd04593 | 442-553  | CBS_pair_EriC_assoc_bac_arch |
| cd04599 | 439-551  | CBS_pair_GGDEF_assoc2 |
| cd04590 | 364-470  | CBS_pair_CorC_HlyC_assoc |
| cd04802 | 435-553  | CBS_pair_3 |
| cd04613 | 364-479  | CBS_pair_SpoIVFB_EriC_assoc2 |
| cd04639 | 364-472  | CBS_pair_26 |
| cd04620 | 439-553  | CBS_pair_7 |
| COG0517 | 359-479  | CBS |
| COG0517 | 435-551  | CBS |
| COG2524 | 439-555  | COG2524 |
| PRK05567 | 438-553  | PRK05567 |
| COG3448 | 361-479  | COG3448 |
| PHA03307 | 46-221  | PHA03307 |
| COG2524 | 359-485  | COG2524 |
| COG3620 | 435-554  | COG3620 |
| pfam00478 | 435-553  | IMPDH |
| COG3448 | 441-554  | COG3448 |
| TIGR01302 | 435-555  | IMP_dehydrog |
| COG2524 | 277-408  | COG2524 |
| PRK05567 | 362-470  | PRK05567 |
| PRK14869 | 435-550  | PRK14869 |
| COG2905 | 359-405  | COG2905 |
| COG2905 | 355-529  | COG2905 |
| COG0517 | 284-405  | CBS |
| PHA03247 | 60-221  | PHA03247 |
| TIGR00393 | 439-470  | kpsF |
Ontology Information
| HPRD ID | 1289 |    
|---|---|
| Molecular Class | Serine/threonine kinase |
| Molecular Function | Growth factor activity (GO:0008083) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165)   |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q9UGJ0 | DB00945 | Acetylsalicylic acid | SmallMoleculeDrug |
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
