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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20089989 | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis | Unknown | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | EF-hand domain containing |
| Description | Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. The protein encoded by this gene is a third distinct plastin isoform, which is specifically expressed at high levels in the small intestine. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Feb 2010] |
| Chromosome | 3 |
| Location | 3q23 |
| Start | 142596387 |
| End | 142713664 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 117278 |
| OMIM ID | 602734 |
| HGNC ID | HGNC:9090 |
| Unigene ID | Hs.203637 |
| Ensembl ID | ENSG00000120756 |
| PharmGKB ID | PA33417 |
mRNA Information
| mRNA ID | NM_001145319.1 |
|---|---|
| Exon | join(1..123,67816..67921,73004..73167,74607..74736, 79771..79903,81646..81727,87620..87785,87867..88009, 89898..89990,93232..93427,98083..98161,101567..101681, 107482..107615,108077..108200,115115..115239, 115486..117278) | mRNA Sequence | Download Select all |
| Length | 3720 |
CDS Information
| Location | join(67852..67921,73004..73167,74607..74736,79771..79903, 81646..81727,87620..87785,87867..88009,89898..89990, 93232..93427,98083..98161,101567..101681,107482..107615, 108077..108200,115115..115239,115486..115621) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS3125.1 |
Protein Information
| Protein ID | NP_001138791.1 |
|---|---|
| Protein Name | Plastin 1 (I isoform) |
| Molecular Wt. (Da) | 70123 |
| Protein Sequence | Download Select all |
| Length | 629 |
| Uniprot ID | O14493 |
| Ensembl Protein ID | ENSP00000342445 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00014 | 123-238 | CH |
| cl00030 | 123-238 | CH superfamily |
| cd00014 | 267-376 | CH |
| cl00030 | 267-376 | CH superfamily |
| cd00051 | 15-81 | EFh |
| cl08302 | 15-81 | EFh superfamily |
| pfam00307 | 269-376 | CH |
| smart00033 | 127-234 | CH |
| pfam00307 | 127-237 | CH |
| smart00033 | 399-502 | CH |
| cl00030 | 399-502 | CH superfamily |
| smart00033 | 270-372 | CH |
| pfam00307 | 398-503 | CH |
| pfam00307 | 519-624 | CH |
| cl00030 | 519-624 | CH superfamily |
| smart00033 | 520-621 | CH |
| cd00052 | 17-80 | EH |
| cd00014 | 519-625 | CH |
| cd00213 | 35-83 | S-100 |
| pfam13833 | 14-83 | EF-hand_8 |
| cd00014 | 397-503 | CH |
| smart00054 | 56-83 | EFh |
| cl23347 | 56-83 | EFh superfamily |
| cd05031 | 27-80 | S-100A10_like |
| pfam00036 | 56-83 | EF-hand_1 |
| cl23489 | 56-83 | EF-hand_1 superfamily |
| cd05025 | 31-83 | S-100A1 |
| smart00054 | 15-42 | EFh |
| pfam13405 | 15-42 | EF-hand_6 |
| cl23634 | 15-42 | EF-hand_6 superfamily |
| pfam00036 | 15-42 | EF-hand_1 |
| pfam13202 | 56-80 | EF-hand_5 |
| cl23632 | 56-80 | EF-hand_5 superfamily |
| cd00051 | 56-95 | EFh |
| COG5069 | 13-621 | SAC6 |
| pfam13499 | 22-80 | EF-hand_7 |
| COG5126 | Apr-88 | FRQ1 |
| COG5126 | Mar-90 | FRQ1 |
| COG5069 | 388-595 | SAC6 |
| PTZ00184 | 14-80 | PTZ00184 |
| PTZ00183 | Mar-93 | PTZ00183 |
| smart00027 | Aug-80 | EH |
| PTZ00183 | Oct-80 | PTZ00183 |
| PTZ00184 | Aug-87 | PTZ00184 |
Ontology Information
| HPRD ID | 7520 |
|---|---|
| Molecular Class | Cytoskeletal protein |
| Molecular Function | Transporter activity (GO:0005215) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.