Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ING3 | 54556 | inhibitor of growth family, member 3 | 7 | p47ING3, FLJ20089, Eaf4, MEAF4 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24927342 | 2014 | Cell line : Colo201, Colo205, DLD-1, HCT-15, HCT-116, HT-29, KM-12, SW480, SW620, WiDr Source : Kouseiren Takaoka Hospital (Japan) and Affiliated Hospital, University of Toyama (Japan). Sample Type : CRC tumor and normal tissue No. of Sample : CRC tumor 319 and adjacent normal tissue 96 Stage : TNM Stage I-IV | Immunohistochemistry on tissue microarray,Western blotting, RT-PCR | Down-regulation | - | Downregulated ING3 expression might play an important role in colorectal adenoma-adenocarcinoma sequence. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Zinc fingers, PHD-type |
| Description | The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2008] |
| Chromosome | 7 |
| Location | 7q31 |
| Start | 120590817 |
| End | 120615711 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 24895 |
| OMIM ID | 607493 |
| HGNC ID | HGNC:14587 |
| Unigene ID | Hs.489811 |
| Ensembl ID | ENSG00000071243 |
| PharmGKB ID | PA29875 |
Protein Information
| Protein ID | NP_061944.2 |
|---|---|
| Protein Name | inhibitor of growth family, member 3 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 418 |
| Uniprot ID | Q9P2E7 |
| Ensembl Protein ID | ENSP00000264360 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Acetylation | 264 |
| K | Acetylation | 164 |
| S | Phosphorylation | 140 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd15585 | 362-406 | PHD_ING3 |
| cl22851 | 362-406 | PHD_SF superfamily |
| pfam12998 | 2-104 | ING |
| cl15229 | 2-104 | ING superfamily |
| cd15505 | 362-406 | PHD_ING |
| cd15587 | 362-408 | PHD_Yng1p_like |
| cd15586 | 362-406 | PHD_ING4_5 |
| cd15584 | 362-406 | PHD_ING1_2 |
| cd15685 | 362-408 | PHD_ING5 |
| cd15682 | 362-406 | PHD_ING1 |
| cd15683 | 362-406 | PHD_ING2 |
| cd15684 | 362-407 | PHD_ING4 |
| pfam00628 | 362-409 | PHD |
| cd15522 | 362-406 | PHD_TAF3 |
| smart00249 | 362-406 | PHD |
| cd15568 | 371-404 | PHD5_NSD |
| cd15553 | 362-406 | PHD_Cfp1 |
| cd15560 | 362-406 | PHD2_3_BPTF |
| cd16039 | 362-406 | PHD_SPP1 |
| cd15661 | 362-404 | PHD5_NSD3 |
| cd15489 | 362-406 | PHD_SF |
| cd15552 | 362-406 | PHD_PHF3_like |
| cd15529 | 363-406 | PHD2_PHF10 |
| cd15567 | 362-406 | PHD4_NSD |
| cd15531 | 362-406 | PHD1_CHD_II |
| cd15660 | 371-404 | PHD5_NSD2 |
| cd15648 | 364-407 | PHD1_NSD1_2 |
| cd15532 | 362-406 | PHD2_CHD_II |
| cd15574 | 363-406 | PHD_AF10_AF17 |
| cd15659 | 371-404 | PHD5_NSD1 |
| cd15606 | 362-406 | PHD2_KDM5A |
| cd15535 | 362-406 | PHD1_Rco1 |
| cd15639 | 362-406 | PHD_DIDO1_like |
| cd15518 | 362-406 | PHD_Ecm5p_Lid2p_like |
| cd15554 | 362-406 | PHD_PHF2_like |
| cd15607 | 363-406 | PHD2_KDM5B |
| cd15543 | 363-406 | PHD_RSF1 |
| cd15539 | 371-406 | PHD1_AIRE |
| cd15538 | 362-406 | PHD_PRKCBP1 |
| cd15517 | 364-406 | PHD_TCF19_like |
| cd15516 | 362-406 | PHD2_KDM5A_like |
| cd15519 | 371-406 | PHD1_Lid2p_like |
| cd15492 | 363-406 | PHD_BRPF_JADE_like |
| cd15573 | 372-406 | PHD_JADE |
| cd15523 | 363-406 | PHD_PHF21A |
| cd15627 | 364-406 | PHD_BAZ1A |
| cd15602 | 358-408 | PHD1_KDM5A |
| COG5034 | 4-410 | TNG2 |
| TIGR02169 | 4-122 | SMC_prok_A |
| pfam13863 | 24-121 | DUF4200 |
| COG4477 | 3-117 | EzrA |
Ontology Information
| HPRD ID | 13876 |
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | ATPase activity (GO:0016887); DNA repair protein (GO:0003685) |
| Biological Process | DNA repair (GO:0006281) |
Drug Information
No matching records could be found.