Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PPP2R2C | 5522 | Protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform  | 4 | PR52; PR55G; IMYPNO; IMYPNO1; B55-GAMMA  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21531130    | 2011 | Cell line : - Source : Japanees patients Sample Type : CRC tumor and normal tissue No. of Sample : 113 CRC patients Stage : - | Peptide Nucleic Acid (PNA)-clamp real-time-PCR TaqMan assay, Gene expression profiles. | Up-regulation | - | 113 (55 male nad 23 female with average age 65 year)patients who underwent a surgical resection of the primary CRC were included in this study. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Serine/threonine phosphatases / Protein phosphatase 2, regulatory subunits, WD repeat domain containing |
| Description | The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]   |
| Chromosome | 4 |
| Location | 4p16.1 |
| Start | 6320578   |
| End | 6563600   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 243023   |
| OMIM ID | 605997    |
| HGNC ID | HGNC:9306    |
| Unigene ID | Hs.479069     |
| Ensembl ID | ENSG00000074211    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_001206994.1 |
|---|---|
| Exon | join(1..41,28224..28330,182507..182604,185029..185194, 187670..187782,190901..191078,215591..215755, 229870..230039,234248..234339,240008..243023)   | mRNA Sequence |    Download   Select all |
| Length | 4161   |
CDS Information
| Location | join(28282..28330,182507..182604,185029..185194, 187670..187782,190901..191078,215591..215755, 229870..230039,234248..234339,240008..240299) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS56305.1 |    
Protein Information
| Protein ID | NP_001193923.1 |
|---|---|
| Protein Name | Protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform |
| Molecular Wt. (Da) | 50505 |
| Protein Sequence |    Download   Select all |
| Length | 440   |
| Uniprot ID | P15336 |    
| Ensembl Protein ID | ENSP00000264110   |    
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Adrenergic signaling in cardiomyocytes |    hsa04261 |    
| AMPK signaling pathway |    hsa04152 |    
| Chagas disease (American trypanosomiasis) |    hsa05142 |    
| Dopaminergic synapse |    hsa04728 |    
| Hepatitis C |    hsa05160 |    
| Hippo signaling pathway |    hsa04390 |    
| mRNA surveillance pathway |    hsa03015 |    
| PI3K-Akt signaling pathway |    hsa04151 |    
| Sphingolipid signaling pathway |    hsa04071 |    
| Tight junction |    hsa04530 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00200 | 15-366  | WD40 |
| cl02567 | 15-366  | WD40 superfamily |
| cd00200 | 112-381  | WD40 |
| COG5170 | 21-438  | CDC55 |
| COG2319 | 67-384  | WD40 |
Ontology Information
| HPRD ID | 422 |    
|---|---|
| Molecular Class | Serine/threonine phosphatase |
| Molecular Function | Complement activity (GO:0003811) |
| Biological Process | Immune response (GO:0006955)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
