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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PPP2R2C 5522 Protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform  4PR52; PR55G; IMYPNO; IMYPNO1; B55-GAMMA 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21531130   2011Cell line : -

Source : Japanees patients

Sample Type : CRC tumor and normal tissue

No. of Sample : 113 CRC patients

Stage : -

Peptide Nucleic Acid (PNA)-clamp real-time-PCR TaqMan assay, Gene expression profiles.Up-regulation-113 (55 male nad 23 female with average age 65 year)patients who underwent a surgical resection of the primary CRC were included in this study.


Gene Details



Chromosome: 4; NC_000004.11 (6322305..6565327, complement)

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Gene Type protein coding
Gene Family Serine/threonine phosphatases / Protein phosphatase 2, regulatory subunits, WD repeat domain containing
Description The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]  
Chromosome 4
Location 4p16.1
Start 6320578  
End 6563600  
Strand -  
Gene Sequence

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Length 243023  
OMIM ID 605997   
HGNC ID HGNC:9306   
Unigene ID Hs.479069    
Ensembl ID ENSG00000074211   
PharmGKB ID -   

mRNA Information


mRNA ID NM_001206994.1
Exon join(1..41,28224..28330,182507..182604,185029..185194, 187670..187782,190901..191078,215591..215755, 229870..230039,234248..234339,240008..243023)  
mRNA Sequence

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Length 4161  



CDS Information


   
Location join(28282..28330,182507..182604,185029..185194, 187670..187782,190901..191078,215591..215755, 229870..230039,234248..234339,240008..240299)
CDS Sequence

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CCDS ID CCDS56305.1



Protein Information


      
Protein IDNP_001193923.1
Protein NameProtein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform
Molecular Wt. (Da)50505
Protein Sequence

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Length 440  
Uniprot IDP15336
Ensembl Protein ID ENSP00000264110  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


                                                            
Pathway Name Pathway ID
Adrenergic signaling in cardiomyocytes hsa04261
AMPK signaling pathway hsa04152
Chagas disease (American trypanosomiasis) hsa05142
Dopaminergic synapse hsa04728
Hepatitis C hsa05160
Hippo signaling pathway hsa04390
mRNA surveillance pathway hsa03015
PI3K-Akt signaling pathway hsa04151
Sphingolipid signaling pathway hsa04071
Tight junction hsa04530


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0020015-366  WD40
cl0256715-366  WD40 superfamily
cd00200112-381  WD40
COG517021-438  CDC55
COG231967-384  WD40


Ontology Information


   
HPRD ID422
Molecular ClassSerine/threonine phosphatase
Molecular FunctionComplement activity (GO:0003811)
Biological ProcessImmune response (GO:0006955)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO