Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| LGR4 | 55366 | leucine-rich repeat containing G protein-coupled receptor 4  | 11 |   |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23803691    | 2013 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Up-regulation | - | GPR48 could serve as both a prognostic biomarker and a therapeutic target for resectable CRC patients. GPR48 was overexpressed in primary CRC and metastatic lymph nodes and closely correlated with tumor invasion and metastasis. GPR48 increased nuclear beta-catenin accumulation, T-cell factor 4 (TCF4) transcription activity, and expression of its target genes including Cyclin D1 and c-Myc in CRC cells. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | GPCR / Class A : Orphans |
| Description | G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Members of the leucine-rich GPCR (LGR) family, such as GPR48, have multiple N-terminal leucine-rich repeats (LRRs) and a 7-transmembrane domain (Weng et al., 2008 [PubMed 18424556]).[   |
| Chromosome | 11 |
| Location | 11p14-p13 |
| Start | 27365961   |
| End | 27472787   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 106827   |
| OMIM ID | 606666    |
| HGNC ID | HGNC:13299    |
| Unigene ID | Hs.502176    |
| Ensembl ID | ENSG00000205213    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_018490.2 |
|---|---|
| Exon | join(1..670,59928..59999,80270..80341,81623..81694, 87320..87535,88381..88452,90532..90600,91822..91893, 92077..92148,92449..92517,94020..94091,95565..95630, 96418..96489,98742..98813,99112..99237,100390..100505, 101090..101173,103645..106827)   | mRNA Sequence |    Download   Select all |
| Length | 5248   |
CDS Information
| Location | join(486..670,59928..59999,80270..80341,81623..81694, 87320..87535,88381..88452,90532..90600,91822..91893, 92077..92148,92449..92517,94020..94091,95565..95630, 96418..96489,98742..98813,99112..99237,100390..100505, 101090..101173,103645..104921) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS31449.1 |    
Protein Information
| Protein ID | NP_060960.2 |
|---|---|
| Protein Name | leucine-rich repeat containing G protein-coupled receptor 4 |
| Molecular Wt. (Da) | 102281 |
| Protein Sequence |    Download   Select all |
| Length | 951   |
| Uniprot ID | Q13751 |    
| Ensembl Protein ID | ENSP00000348384   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 332 |
| S | Phosphorylation | 333 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00116 | 44-239  | LRR_RI |
| cl23707 | 44-239  | LRR_RI superfamily |
| cd00116 | 83-375  | LRR_RI |
| cd00116 | 221-426  | LRR_RI |
| cl23707 | 221-426  | LRR_RI superfamily |
| pfam12799 | 345-381  | LRR_4 |
| cl19302 | 345-381  | LRR_4 superfamily |
| smart00013 | 29-61  | LRRNT |
| cl02423 | 29-61  | LRRNT superfamily |
| pfam01462 | 29-56  | LRRNT |
| cl02423 | 29-56  | LRRNT superfamily |
| pfam12799 | 154-196  | LRR_4 |
| cl19302 | 154-196  | LRR_4 superfamily |
| pfam12799 | 177-218  | LRR_4 |
| pfam12799 | 202-242  | LRR_4 |
| pfam12799 | 105-145  | LRR_4 |
| pfam12799 | 320-363  | LRR_4 |
| pfam12799 | 226-264  | LRR_4 |
| pfam12799 | 83-122  | LRR_4 |
| pfam12799 | 131-170  | LRR_4 |
| pfam13855 | 177-237  | LRR_8 |
| pfam13855 | 83-141  | LRR_8 |
| pfam13855 | 345-401  | LRR_8 |
| pfam00001 | 575-801  | 7tm_1 |
| pfam13855 | 248-305  | LRR_8 |
| pfam13855 | 389-444  | LRR_8 |
| COG4886 | 62-253  | LRR |
| COG4886 | 60-362  | LRR |
| PLN00113 | 34-443  | PLN00113 |
| PLN00113 | 61-426  | PLN00113 |
| COG4886 | 134-441  | LRR |
| PRK15370 | 48-288  | PRK15370 |
| PRK15387 | 33-293  | PRK15387 |
| PRK15370 | 47-284  | PRK15370 |
| PRK15370 | 48-285  | PRK15370 |
| pfam13855 | 107-165  | LRR_8 |
| pfam13855 | 201-260  | LRR_8 |
| pfam13855 | 155-213  | LRR_8 |
| pfam13855 | 367-425  | LRR_8 |
| pfam13855 | 62-117  | LRR_8 |
| PRK15370 | 41-194  | PRK15370 |
| PHA03087 | 531-814  | PHA03087 |
| pfam13306 | 187-303  | LRR_5 |
| PRK15370 | 225-429  | PRK15370 |
| pfam13855 | 320-377  | LRR_8 |
| PLN00113 | 198-445  | PLN00113 |
| pfam14580 | 306-427  | LRR_9 |
| PRK15370 | 36-190  | PRK15370 |
| pfam13306 | 257-410  | LRR_5 |
| PLN03150 | 82-169  | PLN03150 |
| PLN03150 | 158-283  | PLN03150 |
| PLN00113 | 62-155  | PLN00113 |
| pfam13855 | 60-93  | LRR_8 |
Ontology Information
| HPRD ID | 1030 |    
|---|---|
| Molecular Class | G protein coupled receptor |
| Molecular Function | Extracellular matrix structural constituent (GO:0005201) |
| Biological Process | Cell growth and/or maintenance (GO:0008151)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
