Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
LGR4 55366 leucine-rich repeat containing G protein-coupled receptor 4  11 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23803691   2013Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

-Up-regulation-GPR48 could serve as both a prognostic biomarker and a therapeutic target for resectable CRC patients.

GPR48 was overexpressed in primary CRC and metastatic lymph nodes and closely correlated with tumor invasion and metastasis.

GPR48 increased nuclear beta-catenin accumulation, T-cell factor 4 (TCF4) transcription activity, and expression of its target genes including Cyclin D1 and c-Myc in CRC cells.


Gene Details



Chromosome 11 - NC_000011.10 (27365961..27472787, complement)

View Larger Image
   
Gene Type protein coding
Gene Family GPCR / Class A : Orphans
Description G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Members of the leucine-rich GPCR (LGR) family, such as GPR48, have multiple N-terminal leucine-rich repeats (LRRs) and a 7-transmembrane domain (Weng et al., 2008 [PubMed 18424556]).[  
Chromosome 11
Location 11p14-p13
Start 27365961  
End 27472787  
Strand -  
Gene Sequence

   Download   Select all

Length 106827  
OMIM ID 606666   
HGNC ID HGNC:13299   
Unigene ID Hs.502176   
Ensembl ID ENSG00000205213   
PharmGKB ID -   

mRNA Information


mRNA ID NM_018490.2
Exon join(1..670,59928..59999,80270..80341,81623..81694, 87320..87535,88381..88452,90532..90600,91822..91893, 92077..92148,92449..92517,94020..94091,95565..95630, 96418..96489,98742..98813,99112..99237,100390..100505, 101090..101173,103645..106827)  
mRNA Sequence

   Download   Select all

Length 5248  



CDS Information


   
Locationjoin(486..670,59928..59999,80270..80341,81623..81694, 87320..87535,88381..88452,90532..90600,91822..91893, 92077..92148,92449..92517,94020..94091,95565..95630, 96418..96489,98742..98813,99112..99237,100390..100505, 101090..101173,103645..104921)
CDS Sequence

   Download   Select all

CCDS ID CCDS31449.1



Protein Information


      
Protein IDNP_060960.2
Protein Nameleucine-rich repeat containing G protein-coupled receptor 4
Molecular Wt. (Da)102281
Protein Sequence

   Download   Select all

Length 951  
Uniprot IDQ13751
Ensembl Protein ID ENSP00000348384  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation332
SPhosphorylation333

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0011644-239  LRR_RI
cl2370744-239  LRR_RI superfamily
cd0011683-375  LRR_RI
cd00116221-426  LRR_RI
cl23707221-426  LRR_RI superfamily
pfam12799345-381  LRR_4
cl19302345-381  LRR_4 superfamily
smart0001329-61  LRRNT
cl0242329-61  LRRNT superfamily
pfam0146229-56  LRRNT
cl0242329-56  LRRNT superfamily
pfam12799154-196  LRR_4
cl19302154-196  LRR_4 superfamily
pfam12799177-218  LRR_4
pfam12799202-242  LRR_4
pfam12799105-145  LRR_4
pfam12799320-363  LRR_4
pfam12799226-264  LRR_4
pfam1279983-122  LRR_4
pfam12799131-170  LRR_4
pfam13855177-237  LRR_8
pfam1385583-141  LRR_8
pfam13855345-401  LRR_8
pfam00001575-801  7tm_1
pfam13855248-305  LRR_8
pfam13855389-444  LRR_8
COG488662-253  LRR
COG488660-362  LRR
PLN0011334-443  PLN00113
PLN0011361-426  PLN00113
COG4886134-441  LRR
PRK1537048-288  PRK15370
PRK1538733-293  PRK15387
PRK1537047-284  PRK15370
PRK1537048-285  PRK15370
pfam13855107-165  LRR_8
pfam13855201-260  LRR_8
pfam13855155-213  LRR_8
pfam13855367-425  LRR_8
pfam1385562-117  LRR_8
PRK1537041-194  PRK15370
PHA03087531-814  PHA03087
pfam13306187-303  LRR_5
PRK15370225-429  PRK15370
pfam13855320-377  LRR_8
PLN00113198-445  PLN00113
pfam14580306-427  LRR_9
PRK1537036-190  PRK15370
pfam13306257-410  LRR_5
PLN0315082-169  PLN03150
PLN03150158-283  PLN03150
PLN0011362-155  PLN00113
pfam1385560-93  LRR_8


Ontology Information


   
HPRD ID1030
Molecular ClassG protein coupled receptor
Molecular FunctionExtracellular matrix structural constituent (GO:0005201)
Biological ProcessCell growth and/or maintenance (GO:0008151)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO