Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PRKAA1 | 5562 | Protein kinase, AMP-activated, alpha 1 catalytic subunit | 5 | AMPK; AMPKa1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20622004 | 2010 | Cell line : - Source : Case control studies conducted in Utah, the Northern California Kaiser Permanente Medical Care Program (KPMCP) and the Twin Cities Metropolitan area of Minnesota. Sample Type : Population based case control study No. of Sample : 871 male and 685 female colon cancer cases and 1047 male and 909 female controls Stage : - | - | Polymorhpism | - | PRKAA1 and PRKAG2 tagSNPs were associated with colon cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] |
| Chromosome | 5 |
| Location | 5p12 |
| Start | 40759379 |
| End | 40798195 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 38817 |
| OMIM ID | 602739 |
| HGNC ID | HGNC:9376 |
| Unigene ID | Hs.43322 |
| Ensembl ID | ENSG00000132356 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_006251.5 |
|---|---|
| Exon | join(1..133,20610..20751,22693..22786,26333..26477, 28693..28780,30506..30730,32958..33444,33556..33682, 35174..38817) | mRNA Sequence | Download Select all |
| Length | 5085 |
CDS Information
| Location | join(7..133,20610..20751,22693..22786,26333..26477, 28693..28780,30506..30730,32958..33444,33556..33682, 35174..35418) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS3932.2 |
Protein Information
| Protein ID | NP_006242.5 |
|---|---|
| Protein Name | Protein kinase, AMP-activated, alpha 1 catalytic subunit |
| Molecular Wt. (Da) | 63878 |
| Protein Sequence | Download Select all |
| Length | 559 |
| Uniprot ID | P46109 |
| Ensembl Protein ID | ENSP00000346300 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 198 |
| T | Phosphorylation | 183 |
| Y | Phosphorylation | 442;- |
| Y | Phosphorylation | 457;- |
| S | Phosphorylation | 184 |
| S | Phosphorylation | 199 |
| T | Phosphorylation | 355 |
| T | Phosphorylation | 370 |
| S | Phosphorylation | 356 |
| S | Phosphorylation | 371 |
| T | Phosphorylation | 382 |
| T | Phosphorylation | 397 |
| T | Phosphorylation | 482 |
| T | Phosphorylation | 497 |
| S | Phosphorylation | 486 |
| T | Phosphorylation | 490 |
| S | Phosphorylation | 501 |
| T | Phosphorylation | 505 |
| T | Phosphorylation | 488 |
| T | Phosphorylation | 503 |
| S | Phosphorylation | 496 |
| S | Phosphorylation | 511 |
| S | Phosphorylation | 506 |
| S | Phosphorylation | 521 |
| S | Phosphorylation | 476 |
| S | Phosphorylation | 491 |
| S | Phosphorylation | 508 |
| S | Phosphorylation | 523 |
| S | Phosphorylation | 523 |
| S | Phosphorylation | 538 |
| S | Phosphorylation | 530 |
| S | Phosphorylation | 545 |
| S | Phosphorylation | 527 |
| S | Phosphorylation | 542 |
| K | Acetylation | 80 |
| K | Acetylation | 80 |
| K | Acetylation | 40 |
| K | Acetylation | 40 |
Enzyme Information
| EC | 2.7.11.31 |
|---|---|
| Name | [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase AMPK AMP-activated protein kinase HMG-CoA reductase kinase beta-hydroxy-beta-methylglutaryl-CoA reductase kinase [hydroxymethylglutaryl-CoA reductase (NADPH2)] kinase 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase 3-hydroxy-3-methylglutaryl-CoA reductase kinase hydroxymethylglutaryl coenzyme A reductase kinase hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating) hydroxymethylglutaryl-CoA reductase kinase reductase kinase STK29 |
| Class | Transferases; Transferring phosphorus-containing groups; Protein-serine/threonine kinases |
| Sysname | ATP:[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphotransferase |
| Substrate | ATP [CPD:C00002]; [hydroxymethylglutaryl-CoA reductase (NADPH)] |
| Product | ADP [CPD:C00008]; [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 31 | ACACA | 1938 | NP_942131.1 | in vitro | 7 907 095 290 013 810 000 000 |
| 1080 | CFTR | 3883 | NP_000483.3 | in vitro;in vivo | 10862786 |
| 2475 | MTOR | 3134 | NP_004949.1 | in vitro | 14970221 |
| 2898 | GRIK2 | 692 | NP_068775.1 | in vivo | 80 948 928 163 463 |
| 5208 | PFKFB2 | 1383 | NP_006203.2 | in vitro | 128 534 671 322 130 |
| 5894 | RAF1 | 1265 | NP_002871.1 | in vitro;in vivo | 1 197 195 797 106 070 000 000 |
| 29904 | EEF2K | 7369 | NP_037434.1 | in vitro;in vivo | 11 500 364 147 095 500 000 000 000 000 000 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Adipocytokine signaling pathway | hsa04920 |
| AMPK signaling pathway | hsa04152 |
| Circadian rhythm | hsa04710 |
| FoxO signaling pathway | hsa04068 |
| Glucagon signaling pathway | hsa04922 |
| Hypertrophic cardiomyopathy (HCM) | hsa05410 |
| Insulin resistance | hsa04931 |
| Insulin signaling pathway | hsa04910 |
| Longevity regulating pathway - mammal | hsa04211 |
| Longevity regulating pathway - multiple species | hsa04213 |
| mTOR signaling pathway | hsa04150 |
| Non-alcoholic fatty liver disease (NAFLD) | hsa04932 |
| Oxytocin signaling pathway | hsa04921 |
| PI3K-Akt signaling pathway | hsa04151 |
| Regulation of autophagy | hsa04140 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd14079 | 24-279 | STKc_AMPK_alpha |
| cl21453 | 24-279 | PKc_like superfamily |
| cd12199 | 404-557 | AMPKA1_C |
| cl17070 | 404-557 | AMPKA_C_like superfamily |
| cd14403 | 296-360 | UBA_AID_AAPK1 |
| cl21463 | 296-360 | UBA_like_SF superfamily |
| cd14003 | 26-278 | STKc_AMPK-like |
| cd14081 | 25-279 | STKc_BRSK1_2 |
| cd14078 | 25-278 | STKc_MELK |
| cd14663 | 27-278 | STKc_SnRK3 |
| cd05117 | 26-278 | STKc_CAMK |
| cd14071 | 32-279 | STKc_SIK |
| cd14073 | 27-278 | STKc_NUAK |
| cd14077 | 25-278 | STKc_Kin1_2 |
| cd14072 | 27-278 | STKc_MARK |
| cd14080 | 27-279 | STKc_TSSK-like |
| cd14075 | 24-278 | STKc_NIM1 |
| cd14161 | 31-278 | STKc_NUAK2 |
| cd14076 | 25-278 | STKc_Kin4 |
| cd14074 | 25-278 | STKc_SNRK |
| cd14007 | 26-280 | STKc_Aurora |
| cd14008 | 33-279 | STKc_LKB1_CaMKK |
| cd05123 | 33-279 | STKc_AGC |
| cd14162 | 27-279 | STKc_TSSK4-like |
| cd14069 | 27-279 | STKc_Chk1 |
| cd14084 | 27-278 | STKc_Chk2 |
| cd14070 | 24-278 | STKc_HUNK |
| cd14014 | 26-267 | STKc_PknB_like |
| cd14099 | 26-279 | STKc_PLK |
| cd00180 | 33-277 | PKc |
| cd14095 | 26-278 | STKc_DCKL |
| cd14083 | 26-278 | STKc_CaMKI |
| cd14093 | 27-279 | STKc_PhKG |
| cd05580 | 29-280 | STKc_PKA_like |
| cd14119 | 33-279 | STKc_LKB1 |
| cd14165 | 27-279 | STKc_TSSK1_2-like |
| cd14665 | 27-278 | STKc_SnRK2-3 |
| cd14009 | 33-278 | STKc_ATG1_ULK_like |
| cd05579 | 36-280 | STKc_MAST_like |
| cd14098 | 26-278 | STKc_Rad53_Cds1 |
| cd06606 | 27-279 | STKc_MAPKKK |
| cd08215 | 26-273 | STKc_Nek |
| cd14662 | 33-278 | STKc_SnRK2 |
| cd14092 | 33-280 | STKc_MSK_C |
| cd05572 | 33-279 | STKc_cGK |
| cd05581 | 27-279 | STKc_PDK1 |
| cd14209 | 27-280 | STKc_PKA |
| cd14086 | 27-281 | STKc_CaMKII |
| cd14166 | 27-278 | STKc_CaMKI_gamma |
| cd14167 | 27-278 | STKc_CaMKI_alpha |
| cd14005 | 26-279 | STKc_PIM |
| cd14169 | 27-282 | STKc_CaMKI_beta |
| cd14085 | 27-280 | STKc_CaMKIV |
| cd05570 | 33-280 | STKc_PKC |
| cd05122 | 26-279 | PKc_STE |
| cd13999 | 33-273 | STKc_MAP3K-like |
| cd14118 | 33-278 | STKc_CAMKK |
| cd05571 | 33-279 | STKc_PKB |
| cd13994 | 33-279 | STKc_HAL4_like |
| cd14163 | 27-279 | STKc_TSSK3-like |
| cd14185 | 26-278 | STKc_DCKL3 |
| cd14002 | 27-276 | STKc_STK36 |
| cd14097 | 26-278 | STKc_STK33 |
| cd14087 | 33-278 | STKc_PSKH1 |
| cd14096 | 27-278 | STKc_RCK1-like |
| cd14006 | 33-278 | STKc_MLCK-like |
| cd05612 | 32-280 | STKc_PRKX_like |
| cd14181 | 16-279 | STKc_PhKG2 |
| cd05578 | 26-279 | STKc_Yank1 |
| cd14004 | 33-279 | STKc_PASK |
| cd14184 | 27-278 | STKc_DCKL2 |
| cd07829 | 27-279 | STKc_CDK_like |
| cd14091 | 27-281 | STKc_RSK_C |
| cd14106 | 26-279 | STKc_DRAK |
| cd05595 | 33-302 | STKc_PKB_beta |
| cd14168 | 31-282 | STKc_CaMKI_delta |
| cd08217 | 26-276 | STKc_Nek2 |
| cd14105 | 26-278 | STKc_DAPK |
| cd14116 | 29-278 | STKc_Aurora-A |
| cd14194 | 26-278 | STKc_DAPK1 |
| cd06623 | 33-281 | PKc_MAPKK_plant_like |
| cd05592 | 33-280 | STKc_nPKC_theta_like |
| cd14164 | 27-278 | STKc_TSSK6-like |
| cd05590 | 33-281 | STKc_nPKC_eta |
| cd14103 | 33-278 | STKc_MLCK |
| cd14182 | 31-281 | STKc_PhKG1 |
| cd14183 | 27-282 | STKc_DCKL1 |
| cd14197 | 30-279 | STKc_DRAK1 |
| cd05594 | 15-279 | STKc_PKB_alpha |
| cd06627 | 26-279 | STKc_Cdc7_like |
| cd05591 | 33-281 | STKc_nPKC_epsilon |
| cd14082 | 31-278 | STKc_PKD |
| cd14196 | 27-278 | STKc_DAPK2 |
| cd14120 | 33-225 | STKc_ULK1_2-like |
| cd14195 | 26-280 | STKc_DAPK3 |
| cd05118 | 27-279 | STKc_CMGC |
| cd06625 | 29-279 | STKc_MEKK3_like |
| cd06626 | 25-278 | STKc_MEKK4 |
| cd05593 | 18-279 | STKc_PKB_gamma |
| cd05584 | 33-280 | STKc_p70S6K |
| cd14117 | 21-289 | STKc_Aurora-B_like |
| cd05573 | 27-280 | STKc_ROCK_NDR_like |
| cd14186 | 27-276 | STKc_PLK4 |
| cd05611 | 36-280 | STKc_Rim15_like |
| cd05575 | 32-279 | STKc_SGK |
| cd13987 | 33-278 | STKc_SBK1 |
| cd14089 | 28-278 | STKc_MAPKAPK |
| cd05587 | 33-280 | STKc_cPKC |
| cd07841 | 27-293 | STKc_CDK7 |
| cd05619 | 21-281 | STKc_nPKC_theta |
| cd05615 | 21-281 | STKc_cPKC_alpha |
| cd14179 | 33-282 | STKc_MSK1_C |
| cd14088 | 27-278 | STKc_CaMK_like |
| cd14121 | 33-278 | STKc_ULK3 |
| cd07840 | 33-279 | STKc_CDK9_like |
| cd14199 | 24-278 | STKc_CaMKK2 |
| cd13996 | 33-273 | STKc_EIF2AK |
| cd05583 | 33-280 | STKc_MSK_N |
| cd06614 | 33-280 | STKc_PAK |
| cd14175 | 27-281 | STKc_RSK1_C |
| cd05616 | 33-280 | STKc_cPKC_beta |
| cd14187 | 27-279 | STKc_PLK1 |
| cd12122 | 404-557 | AMPKA_C |
| cd05585 | 33-307 | STKc_YPK1_like |
| cd12200 | 401-557 | AMPKA2_C |
| cd14094 | 27-280 | STKc_CASK |
| cd05589 | 33-280 | STKc_PKN |
| cd14190 | 31-228 | STKc_MLCK2 |
| cd05582 | 33-280 | STKc_RSK_N |
| cd07830 | 27-279 | STKc_MAK_like |
| cd05620 | 33-280 | STKc_nPKC_delta |
| cd08220 | 72-273 | STKc_Nek8 |
| cd14114 | 26-279 | STKc_Twitchin_like |
| cd14180 | 33-280 | STKc_MSK2_C |
| cd14189 | 27-279 | STKc_PLK3 |
| cd08529 | 27-273 | STKc_FA2-like |
| cd13993 | 33-274 | STKc_Pat1_like |
| cd14202 | 31-225 | STKc_ULK1 |
| cd08530 | 27-273 | STKc_CNK2-like |
| cd14177 | 27-286 | STKc_RSK4_C |
| cd05604 | 33-279 | STKc_SGK3 |
| cd05586 | 33-280 | STKc_Sck1_like |
| cd00192 | 31-276 | PTKc |
| cd14201 | 27-280 | STKc_ULK2 |
| cd06632 | 30-276 | STKc_MEKK1_plant |
| cd06648 | 16-280 | STKc_PAK_II |
| cd14200 | 26-278 | STKc_CaMKK1 |
| cd06629 | 27-278 | STKc_Bck1_like |
| cd07838 | 27-279 | STKc_CDK4_6_like |
| cd14090 | 26-278 | STKc_Mnk |
| cd14101 | 27-280 | STKc_PIM2 |
| cd14193 | 31-228 | STKc_MLCK4 |
| cd05603 | 33-279 | STKc_SGK2 |
| cd05609 | 36-280 | STKc_MAST |
| cd05614 | 33-280 | STKc_MSK2_N |
| cd14188 | 27-279 | STKc_PLK2 |
| cd14176 | 27-286 | STKc_RSK2_C |
| cd07835 | 33-279 | STKc_CDK1_CdkB_like |
| cd14178 | 27-278 | STKc_RSK3_C |
| cd14102 | 27-278 | STKc_PIM3 |
| cd14171 | 33-278 | STKc_MAPKAPK5 |
| cd14113 | 33-279 | STKc_Trio_C |
| cd06610 | 26-279 | STKc_OSR1_SPAK |
| cd05610 | 36-296 | STKc_MASTL |
| cd14192 | 31-225 | STKc_MLCK3 |
| cd14198 | 27-279 | STKc_DRAK2 |
| cd06605 | 31-281 | PKc_MAPKK |
| cd14170 | 28-322 | STKc_MAPKAPK2 |
| cd05596 | 21-282 | STKc_ROCK |
| cd05600 | 21-280 | STKc_Sid2p_like |
| cd07832 | 28-279 | STKc_CCRK |
| cd14172 | 33-278 | STKc_MAPKAPK3 |
| cd06609 | 33-281 | STKc_MST3_like |
| cd06611 | 28-279 | STKc_SLK_like |
| cd06612 | 27-279 | STKc_MST1_2 |
| cd14100 | 27-278 | STKc_PIM1 |
| cd07834 | 26-324 | STKc_MAPK |
| cd07860 | 33-279 | STKc_CDK2_3 |
| cd05602 | 33-279 | STKc_SGK1 |
| cd14133 | 27-279 | PKc_DYRK_like |
| cd05599 | 32-280 | STKc_NDR_like |
| cd14131 | 27-276 | PKc_Mps1 |
| cd08225 | 33-273 | STKc_Nek5 |
| cd05577 | 33-280 | STKc_GRK |
| cd07833 | 32-279 | STKc_CDKL |
| cd07836 | 33-279 | STKc_Pho85 |
| cd05618 | 10-280 | STKc_aPKC_iota |
| cd14066 | 33-273 | STKc_IRAK |
| cd14137 | 23-281 | STKc_GSK3 |
| cd06659 | 19-289 | STKc_PAK6 |
| cd05613 | 33-281 | STKc_MSK1_N |
| cd06652 | 29-260 | STKc_MEKK2 |
| cd06628 | 27-276 | STKc_Byr2_like |
| cd06655 | 27-284 | STKc_PAK2 |
| cd08224 | 27-273 | STKc_Nek6_7 |
| cd06640 | 31-300 | STKc_MST4 |
| cd05617 | 24-280 | STKc_aPKC_zeta |
| cd06653 | 29-235 | STKc_MEKK3_like_u1 |
| cd05574 | 33-280 | STKc_phototropin_like |
| cd14191 | 27-229 | STKc_MLCK1 |
| cd14111 | 27-278 | STKc_SPEG_rpt2 |
| cd06630 | 26-280 | STKc_MEKK1 |
| cd07861 | 33-279 | STKc_CDK1_euk |
| cd07846 | 33-279 | STKc_CDKL2_3 |
| cd13985 | 33-273 | STKc_GAK_like |
| cd07843 | 36-279 | STKc_CDC2L1 |
| cd14047 | 33-276 | STKc_EIF2AK2_PKR |
| cd14107 | 27-279 | STKc_obscurin_rpt1 |
| cd07847 | 33-279 | STKc_CDKL1_4 |
| cd06647 | 31-280 | STKc_PAK_I |
| cd14023 | 71-279 | PK_TRB1 |
| cd08222 | 27-276 | STKc_Nek11 |
| cd14404 | 296-360 | UBA_AID_AAPK2 |
| cd06608 | 29-278 | STKc_myosinIII_N_like |
| cd07866 | 23-279 | STKc_BUR1 |
| cd13986 | 26-276 | STKc_16 |
| cd05588 | 33-281 | STKc_aPKC |
| cd13976 | 79-279 | PK_TRB |
| cd08219 | 27-273 | STKc_Nek3 |
| cd06654 | 27-284 | STKc_PAK1 |
| cd14046 | 33-277 | STKc_EIF2AK4_GCN2_rpt2 |
| cd06624 | 33-277 | STKc_ASK |
| cd06656 | 27-284 | STKc_PAK3 |
| cd05621 | 33-282 | STKc_ROCK2 |
| cd05630 | 33-281 | STKc_GRK6 |
| cd13990 | 27-228 | STKc_TLK |
| cd14022 | 81-279 | PK_TRB2 |
| cd14024 | 80-278 | PK_TRB3 |
| cd06641 | 31-300 | STKc_MST3 |
| cd13974 | 115-276 | STKc_SHIK |
| cd06621 | 33-280 | PKc_Pek1_like |
| cd06642 | 31-288 | STKc_STK25 |
| cd13997 | 33-277 | PKc_Wee1_like |
| cd14010 | 27-278 | STKc_ULK4 |
| cd14068 | 33-269 | STKc_LRRK2 |
| cd05622 | 19-282 | STKc_ROCK1 |
| cd07865 | 17-279 | STKc_CDK9 |
| cd13979 | 29-234 | STKc_Mos |
| cd08528 | 27-273 | STKc_Nek10 |
| cd05601 | 31-280 | STKc_CRIK |
| cd14173 | 31-278 | STKc_Mnk2 |
| cd05608 | 33-281 | STKc_GRK1 |
| cd14336 | 296-360 | UBA_AID_AMPKalpha |
| cd07851 | 33-291 | STKc_p38 |
| cd14058 | 33-227 | STKc_TAK1 |
| cd06917 | 33-281 | STKc_NAK1_like |
| cd07845 | 33-285 | STKc_CDK10 |
| cd07877 | 33-320 | STKc_p38alpha |
| cd14059 | 33-227 | STKc_MAP3K12_13 |
| cd13978 | 33-271 | STKc_RIP |
| cd13989 | 33-269 | STKc_IKK |
| cd14174 | 33-280 | STKc_Mnk1 |
| cd06620 | 33-281 | PKc_Byr1_like |
| cd06613 | 26-277 | STKc_MAP4K3_like |
| cd07831 | 27-279 | STKc_MOK |
| cd14132 | 27-280 | STKc_CK2_alpha |
| cd08218 | 27-275 | STKc_Nek1 |
| cd14115 | 33-278 | STKc_Kalirin_C |
| cd07878 | 33-320 | STKc_p38beta |
| cd05624 | 33-305 | STKc_MRCK_beta |
| cd14012 | 41-277 | PK_eIF2AK_GCN2_rpt1 |
| cd05597 | 33-280 | STKc_DMPK_like |
| cd13982 | 33-279 | STKc_IRE1 |
| cd13983 | 33-279 | STKc_WNK |
| cd06651 | 30-235 | STKc_MEKK3 |
| cd14104 | 27-281 | STKc_Titin |
| cd14110 | 36-278 | STKc_obscurin_rpt2 |
| cd05038 | 33-219 | PTKc_Jak_rpt2 |
| cd14037 | 36-270 | STKc_NAK_like |
| cd06657 | 19-284 | STKc_PAK4 |
| cd05034 | 33-218 | PTKc_Src_like |
| cd05598 | 32-304 | STKc_LATS |
| cd07856 | 33-293 | STKc_Sty1_Hog1 |
| cd14210 | 27-279 | PKc_DYRK |
| cd05623 | 33-237 | STKc_MRCK_alpha |
| cd06631 | 30-276 | STKc_YSK4 |
| cd07863 | 33-279 | STKc_CDK4 |
| cd05059 | 29-271 | PTKc_Tec_like |
| cd14039 | 33-225 | STKc_IKK_alpha |
| cd05607 | 32-280 | STKc_GRK7 |
| cd07839 | 31-279 | STKc_CDK5 |
| cd07837 | 33-279 | STKc_CdkB_plant |
| cd07871 | 23-221 | STKc_PCTAIRE3 |
| cd05633 | 33-280 | STKc_GRK3 |
| cd07873 | 27-279 | STKc_PCTAIRE1 |
| cd07880 | 33-320 | STKc_p38gamma |
| cd06622 | 31-282 | PKc_PBS2_like |
| cd05148 | 29-275 | PTKc_Srm_Brk |
| cd08221 | 26-275 | STKc_Nek9 |
| cd06658 | 33-280 | STKc_PAK5 |
| cd07849 | 26-291 | STKc_ERK1_2_like |
| cd05605 | 33-280 | STKc_GRK4_like |
| cd05056 | 29-275 | PTKc_FAK |
| cd13995 | 36-277 | STKc_MAP3K8 |
| cd14158 | 30-241 | STKc_IRAK4 |
| cd05033 | 33-274 | PTKc_EphR |
| cd07859 | 27-280 | STKc_TDY_MAPK |
| cd05060 | 33-225 | PTKc_Syk_like |
| cd07855 | 32-307 | STKc_ERK5 |
| cd05628 | 33-237 | STKc_NDR1 |
| cd05632 | 33-225 | STKc_GRK5 |
| cd06639 | 31-258 | STKc_myosinIIIB_N |
| cd14146 | 33-225 | STKc_MLK4 |
| cd14060 | 34-273 | STKc_MLTK |
| cd05072 | 33-225 | PTKc_Lyn |
| cd14050 | 33-276 | PKc_Myt1 |
| cd06638 | 31-278 | STKc_myosinIIIA_N |
| cd07844 | 27-279 | STKc_PCTAIRE_like |
| cd07872 | 23-293 | STKc_PCTAIRE2 |
| cd07850 | 33-282 | STKc_JNK |
| cd05627 | 33-237 | STKc_NDR2 |
| cd05606 | 33-280 | STKc_beta_ARK |
| cd07858 | 33-307 | STKc_TEY_MAPK |
| cd14019 | 26-279 | STKc_Cdc7 |
| cd14048 | 33-277 | STKc_EIF2AK3_PERK |
| cd05631 | 26-280 | STKc_GRK4 |
| cd14065 | 33-276 | PKc_LIMK_like |
| cd14038 | 33-225 | STKc_IKK_beta |
| cd13988 | 33-225 | STKc_TBK1 |
| cd14052 | 32-277 | PTKc_Wee1_fungi |
| cd14000 | 33-269 | STKc_LRRK |
| cd06618 | 28-280 | PKc_MKK7 |
| cd07879 | 33-298 | STKc_p38delta |
| cd07864 | 20-278 | STKc_CDK12 |
| cd05084 | 30-275 | PTKc_Fes |
| cd05081 | 33-219 | PTKc_Jak3_rpt2 |
| cd14203 | 33-271 | PTKc_Src_Fyn_like |
| cd06636 | 25-229 | STKc_MAP4K4_6_N |
| cd13992 | 38-273 | PK_GC |
| cd07842 | 34-279 | STKc_CDK8_like |
| cd05082 | 29-275 | PTKc_Csk |
| cd05112 | 33-267 | PTKc_Itk |
| cd14205 | 26-219 | PTKc_Jak2_rpt2 |
| cd05048 | 33-276 | PTKc_Ror |
| cd05039 | 21-275 | PTKc_Csk_like |
| cd14664 | 33-226 | STK_BAK1_like |
| cd07852 | 74-281 | STKc_MAPK15-like |
| cd14223 | 33-267 | STKc_GRK2 |
| cd14148 | 33-225 | STKc_MLK2 |
| cd06637 | 25-229 | STKc_TNIK |
| cd08223 | 27-273 | STKc_Nek4 |
| cd05113 | 33-273 | PTKc_Btk_Bmx |
| cd13968 | 33-170 | PKc_like |
| cd14112 | 25-278 | STKc_Unc-89_rpt2 |
| cd14061 | 33-225 | STKc_MLK |
| cd14109 | 74-279 | PK_Unc-89_rpt1 |
| cd05629 | 33-237 | STKc_NDR_like_fungal |
| cd05079 | 33-219 | PTKc_Jak1_rpt2 |
| cd07870 | 27-225 | STKc_PFTAIRE2 |
| cd14108 | 26-225 | STKc_SPEG_rpt1 |
| cd05626 | 32-225 | STKc_LATS2 |
| cd06650 | 33-224 | PKc_MEK1 |
| cd05032 | 28-273 | PTKc_InsR_like |
| cd07857 | 26-276 | STKc_MPK1 |
| cd06646 | 27-278 | STKc_MAP4K5 |
| cd13991 | 33-275 | STKc_NIK |
| cd06644 | 28-281 | STKc_STK10 |
| cd05041 | 33-216 | PTKc_Fes_like |
| cd06643 | 28-218 | STKc_SLK |
| cd07848 | 28-279 | STKc_CDKL5 |
| cd06615 | 33-224 | PKc_MEK |
| cd14056 | 31-231 | STKc_TGFbR_I |
| cd05063 | 25-273 | PTKc_EphR_A2 |
| cd14145 | 28-225 | STKc_MLK1 |
| cd05080 | 33-219 | PTKc_Tyk2_rpt2 |
| cd05083 | 26-275 | PTKc_Chk |
| cd05070 | 33-294 | PTKc_Fyn |
| cd06633 | 33-284 | STKc_TAO3 |
| cd14147 | 29-225 | STKc_MLK3 |
| cd06645 | 33-281 | STKc_MAP4K3 |
| cd05085 | 30-225 | PTKc_Fer |
| cd05045 | 28-273 | PTKc_RET |
| cd05069 | 33-286 | PTKc_Yes |
| cd05074 | 27-225 | PTKc_Tyro3 |
| cd14064 | 33-225 | PKc_TNNI3K |
| cd06607 | 33-213 | STKc_TAO |
| cd14154 | 33-231 | STKc_LIMK |
| cd07854 | 33-302 | STKc_MAPK4_6 |
| cd05625 | 32-225 | STKc_LATS1 |
| cd06619 | 31-238 | PKc_MKK5 |
| cd14031 | 33-282 | STKc_WNK3 |
| cd14221 | 33-231 | STKc_LIMK1 |
| cd14016 | 26-172 | STKc_CK1 |
| cd05116 | 33-225 | PTKc_Syk |
| cd05092 | 33-273 | PTKc_TrkA |
| cd05114 | 33-273 | PTKc_Tec_Rlk |
| cd05049 | 33-275 | PTKc_Trk |
| cd08228 | 24-281 | STKc_Nek6 |
| cd14150 | 33-225 | STKc_A-Raf |
| cd05067 | 33-225 | PTKc_Lck_Blk |
| cd07862 | 33-215 | STKc_CDK6 |
| cd14027 | 33-275 | STKc_RIP1 |
| cd05068 | 33-225 | PTKc_Frk_like |
| cd06616 | 33-281 | PKc_MKK4 |
| cd05040 | 33-216 | PTKc_Ack_like |
| cd05057 | 30-287 | PTKc_EGFR_like |
| cd14063 | 29-230 | PK_KSR |
| cd07876 | 33-291 | STKc_JNK2 |
| cd14041 | 27-225 | STKc_TLK2 |
| cd06649 | 33-245 | PKc_MEK2 |
| cd14033 | 33-279 | STKc_WNK4 |
| cd05071 | 33-294 | PTKc_Src |
| cd07869 | 31-225 | STKc_PFTAIRE1 |
| cd05055 | 29-273 | PTKc_PDGFR |
| cd05576 | 85-279 | STKc_RPK118_like |
| cd14049 | 31-277 | STKc_EIF2AK1_HRI |
| cd14222 | 33-231 | STKc_LIMK2 |
| cd14151 | 19-227 | STKc_B-Raf |
| cd07853 | 33-276 | STKc_NLK |
| cd05066 | 33-225 | PTKc_EphR_A |
| cd14136 | 128-279 | STKc_SRPK |
| cd13977 | 100-267 | STKc_PDIK1L |
| cd14156 | 33-273 | PKc_LIMK_like_unk |
| cd05115 | 33-225 | PTKc_Zap-70 |
| cd08229 | 20-270 | STKc_Nek7 |
| cd05053 | 29-275 | PTKc_FGFR |
| cd14062 | 33-227 | STKc_Raf |
| cd14040 | 74-225 | STKc_TLK1 |
| cd06617 | 31-281 | PKc_MKK3_6 |
| cd05094 | 28-275 | PTKc_TrkC |
| cd14155 | 33-276 | PKc_TESK |
| cd14053 | 36-232 | STKc_ACVR2 |
| cd05073 | 29-258 | PTKc_Hck |
| cd06635 | 33-285 | STKc_TAO1 |
| cd05090 | 31-278 | PTKc_Ror1 |
| cd14134 | 31-279 | PKc_CLK |
| cd07875 | 33-295 | STKc_JNK1 |
| cd05065 | 31-227 | PTKc_EphR_B |
| cd13998 | 34-218 | STKc_TGFbR-like |
| cd05052 | 33-275 | PTKc_Abl |
| cd14025 | 33-273 | STKc_RIP4_like |
| cd14032 | 33-282 | STKc_WNK2_like |
| cd05035 | 28-225 | PTKc_TAM |
| cd05047 | 31-273 | PTKc_Tie |
| cd14036 | 36-275 | STKc_GAK |
| cd05099 | 28-275 | PTKc_FGFR4 |
| cd14138 | 31-276 | PTKc_Wee1a |
| cd14212 | 27-248 | PKc_YAK1 |
| cd05046 | 32-227 | PTK_CCK4 |
| cd05075 | 29-225 | PTKc_Axl |
| cd05111 | 30-287 | PTK_HER3 |
| cd05098 | 28-275 | PTKc_FGFR1 |
| cd05093 | 22-273 | PTKc_TrkB |
| cd13980 | 33-290 | STKc_Vps15 |
| cd14067 | 33-241 | STKc_LRRK1 |
| cd06634 | 33-284 | STKc_TAO2 |
| cd07874 | 33-215 | STKc_JNK3 |
| cd14149 | 28-225 | STKc_C-Raf |
| cd14135 | 27-226 | STKc_PRP4 |
| cd05064 | 33-273 | PTKc_EphR_A10 |
| cd05091 | 31-225 | PTKc_Ror2 |
| cd05108 | 33-226 | PTKc_EGFR |
| cd14054 | 33-231 | STKc_BMPR2_AMHR2 |
| cd14030 | 33-282 | STKc_WNK1 |
| cd05061 | 33-283 | PTKc_InsR |
| cd14152 | 29-240 | STKc_KSR1 |
| cd05097 | 29-225 | PTKc_DDR_like |
| cd05110 | 33-302 | PTKc_HER4 |
| cd05101 | 29-275 | PTKc_FGFR2 |
| cd14139 | 33-276 | PTKc_Wee1b |
| cd14011 | 49-279 | PK_SCY1_like |
| cd05089 | 31-273 | PTKc_Tie1 |
| cd05050 | 33-273 | PTKc_Musk |
| cd05100 | 29-275 | PTKc_FGFR3 |
| cd14204 | 28-218 | PTKc_Mer |
| cd14051 | 32-276 | PTKc_Wee1 |
| cd05096 | 25-225 | PTKc_DDR1 |
| cd14153 | 29-225 | PK_KSR2 |
| cd14026 | 33-312 | STKc_RIP2 |
| cd14224 | 33-228 | PKc_DYRK2_3 |
| cd14142 | 26-216 | STKc_ACVR1_ALK1 |
| cd08216 | 26-281 | PK_STRAD |
| cd05051 | 33-227 | PTKc_DDR |
| cd14018 | 59-267 | STKc_PINK1 |
| cd14159 | 33-228 | STKc_IRAK1 |
| cd05087 | 33-226 | PTKc_Aatyk1 |
| cd05054 | 29-276 | PTKc_VEGFR |
| cd05058 | 33-227 | PTKc_Met_Ron |
| cd13975 | 134-224 | PKc_Dusty |
| cd05088 | 31-273 | PTKc_Tie2 |
| cd05103 | 133-276 | PTKc_VEGFR2 |
| smart00220 | 27-279 | S_TKc |
| pfam00069 | 27-279 | Pkinase |
| COG0515 | 26-281 | SPS1 |
| PTZ00263 | 23-279 | PTZ00263 |
| smart00219 | 29-275 | TyrKc |
| smart00221 | 28-275 | STYKc |
| pfam07714 | 28-276 | Pkinase_Tyr |
| PTZ00426 | 3-279 | PTZ00426 |
| PHA03390 | 36-280 | pk1 |
| PLN00009 | 33-280 | PLN00009 |
| TIGR03903 | 49-268 | TOMM_kin_cyc |
| PTZ00024 | 29-293 | PTZ00024 |
| PTZ00283 | 27-267 | PTZ00283 |
| PLN00034 | 33-225 | PLN00034 |
| PTZ00267 | 73-280 | PTZ00267 |
| PRK13184 | 24-279 | pknD |
| PTZ00266 | 19-225 | PTZ00266 |
| PHA03209 | 32-238 | PHA03209 |
| PTZ00036 | 27-351 | PTZ00036 |
| PHA03210 | 15-219 | PHA03210 |
| PHA03211 | 75-216 | PHA03211 |
| PHA03207 | 74-232 | PHA03207 |
| COG0478 | 27-169 | RIO2 |
Ontology Information
| HPRD ID | 7226 |
|---|---|
| Molecular Class | Serine/threonine kinase |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q13131 | DB00131 | Adenosine monophosphate | SmallMoleculeDrug |
| Q13131 | DB00171 | Adenosine triphosphate | SmallMoleculeDrug |
| Q13131 | DB00914 | Phenformin | SmallMoleculeDrug |
| Q13131 | DB00945 | Acetylsalicylic acid | SmallMoleculeDrug |