Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| WSB2 | 55884 | WD repeat and SOCS box containing 2  | 12 | SBA2, MGC10210  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 11819827    | 2001 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 30 Stage : - | real time RT-PCR | Up-regulation | - | SBA2 gene might be a promising novel biomarker of cell differentiation in colorectal cancer. SBA2 expression was significantly (0.01>P < 0.05) correlated with the grade of differentiation in CRC, with relatively higher levels in well-differentiated samples and lower in poorly-differentiated cases. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | WD repeat domain containing |
| Description | This gene encodes a member of the WD-protein subfamily. The encoded protein contains five WD-repeats spanning most of the protein and an SOCS box in the C-terminus. The SOCS box may act as a bridge between specific substrate-binding domains and E3 ubiquitin protein ligases. Three transcript variants encoding different isoforms have been found for this gene.   |
| Chromosome | 12 |
| Location | 12q24.23 |
| Start | 118032687   |
| End | 118062174   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 29488   |
| OMIM ID |     |
| HGNC ID | HGNC:19222    |
| Unigene ID | Hs.506985    |
| Ensembl ID | ENSG00000176871    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | XM_011538643.1 |
|---|---|
| Exon | complement(<28611..29230)   | mRNA Sequence |    Download   Select all |
| Length | 2798   |
CDS Information
| Location | join(13..76,9697..9865,18798..19042,19203..19334, 23787..23887,25665..25837,26851..26961,27082..27189, 27817..27979) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS61252.1 |    
Protein Information
| Protein ID | NP_001265486.1 |
|---|---|
| Protein Name | WD repeat and SOCS box containing 2 |
| Molecular Wt. (Da) | 47056 |
| Protein Sequence |    Download   Select all |
| Length | 421   |
| Uniprot ID | Q14847 |    
| Ensembl Protein ID | ENSP00000325240   |    
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00200 | 121-360  | WD40 |
| cl02567 | 121-360  | WD40 superfamily |
| cd03733 | 364-402  | SOCS_WSB_SWIP |
| cl02533 | 364-402  | SOCS superfamily |
| cd00200 | 114-360  | WD40 |
| cd00200 | 120-321  | WD40 |
| cd00200 | 190-360  | WD40 |
| cd03745 | 364-402  | SOCS_WSB2_SWIP2 |
| cd00200 | 231-360  | WD40 |
| smart00253 | 360-402  | SOCS |
| cd03746 | 364-403  | SOCS_WSB1_SWIP1 |
| cd03587 | 368-402  | SOCS |
| pfam00400 | 230-267  | WD40 |
| smart00320 | 228-267  | WD40 |
| pfam00400 | 143-182  | WD40 |
| cd03717 | 367-402  | SOCS_SOCS_like |
| smart00969 | 367-402  | SOCS_box |
| smart00320 | 142-182  | WD40 |
| pfam07525 | 367-400  | SOCS_box |
| pfam00400 | 187-225  | WD40 |
| smart00320 | 187-225  | WD40 |
| cd03716 | 368-402  | SOCS_ASB_like |
| pfam00400 | 292-320  | WD40 |
| smart00320 | 292-320  | WD40 |
| cd03736 | 368-404  | SOCS_SOCS2 |
| cd03740 | 368-399  | SOCS_SOCS6 |
| COG2319 | 119-367  | WD40 |
| COG2319 | 30-370  | WD40 |
| COG2319 | 122-372  | WD40 |
| COG2319 | 33-263  | WD40 |
| PTZ00421 | 126-267  | PTZ00421 |
| PLN00181 | 132-267  | PLN00181 |
| PTZ00420 | 138-226  | PTZ00420 |
| PTZ00421 | 125-304  | PTZ00421 |
| COG0823 | 133-283  | TolB |
| PTZ00421 | 149-268  | PTZ00421 |
| PTZ00420 | 105-199  | PTZ00420 |
Ontology Information
| HPRD ID | 1080 |    
|---|---|
| Molecular Class | Ubiquitin proteasome system protein |
| Molecular Function | Protein-tyrosine kinase activity (GO:0004713) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
