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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
WSB2 55884 WD repeat and SOCS box containing 2  12SBA2, MGC10210 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
11819827   2001Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 30

Stage : -

real time RT-PCRUp-regulation-SBA2 gene might be a promising novel biomarker of cell differentiation in colorectal cancer.

SBA2 expression was significantly (0.01>P < 0.05) correlated with the grade of differentiation in CRC, with relatively higher levels in well-differentiated samples and lower in poorly-differentiated cases.


Gene Details



Chromosome 12 - NC_000012.12(118032687..118062174, complement)

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Gene Type protein coding
Gene Family WD repeat domain containing
Description This gene encodes a member of the WD-protein subfamily. The encoded protein contains five WD-repeats spanning most of the protein and an SOCS box in the C-terminus. The SOCS box may act as a bridge between specific substrate-binding domains and E3 ubiquitin protein ligases. Three transcript variants encoding different isoforms have been found for this gene.  
Chromosome 12
Location 12q24.23
Start 118032687  
End 118062174  
Strand -  
Gene Sequence

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Length 29488  
OMIM ID    
HGNC ID HGNC:19222   
Unigene ID Hs.506985   
Ensembl ID ENSG00000176871   
PharmGKB ID -   

mRNA Information


mRNA ID XM_011538643.1
Exon complement(<28611..29230)  
mRNA Sequence

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Length 2798  



CDS Information


   
Locationjoin(13..76,9697..9865,18798..19042,19203..19334, 23787..23887,25665..25837,26851..26961,27082..27189, 27817..27979)
CDS Sequence

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CCDS ID CCDS61252.1



Protein Information


      
Protein IDNP_001265486.1
Protein NameWD repeat and SOCS box containing 2
Molecular Wt. (Da)47056
Protein Sequence

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Length 421  
Uniprot IDQ14847
Ensembl Protein ID ENSP00000325240  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00200121-360  WD40
cl02567121-360  WD40 superfamily
cd03733364-402  SOCS_WSB_SWIP
cl02533364-402  SOCS superfamily
cd00200114-360  WD40
cd00200120-321  WD40
cd00200190-360  WD40
cd03745364-402  SOCS_WSB2_SWIP2
cd00200231-360  WD40
smart00253360-402  SOCS
cd03746364-403  SOCS_WSB1_SWIP1
cd03587368-402  SOCS
pfam00400230-267  WD40
smart00320228-267  WD40
pfam00400143-182  WD40
cd03717367-402  SOCS_SOCS_like
smart00969367-402  SOCS_box
smart00320142-182  WD40
pfam07525367-400  SOCS_box
pfam00400187-225  WD40
smart00320187-225  WD40
cd03716368-402  SOCS_ASB_like
pfam00400292-320  WD40
smart00320292-320  WD40
cd03736368-404  SOCS_SOCS2
cd03740368-399  SOCS_SOCS6
COG2319119-367  WD40
COG231930-370  WD40
COG2319122-372  WD40
COG231933-263  WD40
PTZ00421126-267  PTZ00421
PLN00181132-267  PLN00181
PTZ00420138-226  PTZ00420
PTZ00421125-304  PTZ00421
COG0823133-283  TolB
PTZ00421149-268  PTZ00421
PTZ00420105-199  PTZ00420


Ontology Information


   
HPRD ID1080
Molecular ClassUbiquitin proteasome system protein
Molecular FunctionProtein-tyrosine kinase activity (GO:0004713)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO