Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| BIRC6 | 57448 | baculoviral IAP repeat containing 6 | 2 | BRUCE |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25933218 | 2015 | Cell line : LoVo, SW620, DLD 1, HT 29, HCT116, SW480, SW1116 Source : Type Culture Collection of Chinese Academy of Sciences (Shanghai, China) and Tissue sample from Zhongshan Hospital, Fudan University Sample Type : CRC tumor and normal tissue No. of Sample : 126 Stage : - | Western blotting and immunohistochemistry | Up-regulation | - | BIRC6 overexpression is a predictor of poor prognosis in colorectal cancer and BIRC6 could be a potential target of CRC therapy. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Baculoviral IAP repeat containing, "Ubiquitin-conjugating enzymes E2" |
| Description | This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq, Jul 2008] |
| Chromosome | 2 |
| Location | 2p22.3 |
| Start | 32581735 |
| End | 32843966 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 262232 |
| OMIM ID | 605638 |
| HGNC ID | HGNC:13516 |
| Unigene ID | Hs.150107 |
| Ensembl ID | ENSG00000115760 |
| PharmGKB ID | PA25363 |
Protein Information
| Protein ID | NP_057336.3 |
|---|---|
| Protein Name | baculoviral IAP repeat containing 6 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 4857 |
| Uniprot ID | Q9BRR0 |
| Ensembl Protein ID | ENSP00000252211 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 480;- |
| S | Phosphorylation | 1717;- |
| S | Phosphorylation | 482 |
| S | Phosphorylation | 577 |
| T | Phosphorylation | 580 |
| S | Phosphorylation | 488 |
| S | Phosphorylation | 4523 |
| S | Phosphorylation | 486 |
| Y | Phosphorylation | 301 |
| S | Phosphorylation | 638 |
| S | Phosphorylation | 4571 |
| S | Phosphorylation | 3649 |
| S | Phosphorylation | 3660 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 332 | BIRC5 | 4520 | NP_001012271.1 | in vivo | 18329369 |
| 836 | CASP3 | 2799 | NP_004337.2 | in vivo | 15200957 |
| 842 | CASP9 | 3756 | NP_001220.2 | in vitro | 15300255 |
| 983 | CDK1 | 302 | NP_001777.1 | in vivo | 18329369 |
| 4218 | RAB8A | 1296 | NP_005361.2 | in vivo | 18329369 |
| 5347 | PLK1 | 3652 | NP_005021.2 | in vivo | 18329369 |
| 5604 | MAP2K1 | 1469 | NP_002746.1 | in vivo | 18329369 |
| 9101 | USP8 | 4405 | NP_005145.3 | in vivo | 18329369 |
| 11336 | EXOC3 | 9738 | NP_009208.2 | in vivo | 18329369 |
| 27429 | HTRA2 | 5919 | NP_037379.1 | in vitro;in vivo | 15200957 |
| 56616 | DIABLO | 5560 | NP_063940.1 | in vitro;in vivo | 15200957 |
| 60412 | EXOC4 | 12185 | NP_068579.3 | in vivo | 18329369 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Ubiquitin mediated proteolysis | hsa04120 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00195 | 4597-4735 | UBCc |
| cl00154 | 4597-4735 | UBCc superfamily |
| cd00022 | 287-360 | BIR |
| cl00035 | 287-360 | BIR superfamily |
| pfam12356 | 3462-3618 | DUF3643 |
| cl13752 | 3462-3618 | DUF3643 superfamily |
| pfam00179 | 4602-4735 | UQ_con |
| smart00212 | 4599-4709 | UBCc |
| pfam00653 | 289-359 | BIR |
| smart00238 | 285-360 | BIR |
| PTZ00390 | 4602-4704 | PTZ00390 |
| PLN00172 | 4613-4704 | PLN00172 |
| COG5078 | 4599-4698 | COG5078 |
Ontology Information
| HPRD ID | 13747 |
|---|---|
| Molecular Class | Adapter molecule |
| Molecular Function | Protease inhibitor activity (GO:0030414) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.