Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
BIRC6 57448 baculoviral IAP repeat containing 6  2BRUCE 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25933218   2015Cell line : LoVo, SW620, DLD 1, HT 29, HCT116, SW480, SW1116

Source : Type Culture Collection of Chinese Academy of Sciences (Shanghai, China) and Tissue sample from Zhongshan Hospital, Fudan University

Sample Type : CRC tumor and normal tissue

No. of Sample : 126

Stage : -

 Western blotting and immunohistochemistryUp-regulation- BIRC6 overexpression is a predictor of poor prognosis in colorectal cancer and BIRC6 could be a potential target of CRC therapy.


Gene Details



NC_000002.11 (32581735..32843966)

View Larger Image
   
Gene Type protein coding
Gene Family Baculoviral IAP repeat containing, "Ubiquitin-conjugating enzymes E2"
Description This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq, Jul 2008]  
Chromosome 2
Location 2p22.3
Start 32581735  
End 32843966  
Strand +  
Gene Sequence

   Download   Select all

Length 262232  
OMIM ID 605638   
HGNC ID HGNC:13516   
Unigene ID Hs.150107   
Ensembl ID ENSG00000115760   
PharmGKB ID PA25363   

mRNA Information


mRNA ID ?NM_016252.3
Exon  
mRNA Sequence

   Download   Select all

Length  



CDS Information


   
Location
CDS Sequence

   Download   Select all

CCDS ID CCDS33175.2



Protein Information


      
Protein IDNP_057336.3
Protein Namebaculoviral IAP repeat containing 6
Molecular Wt. (Da)0
Protein Sequence

   Download   Select all

Length 4857  
Uniprot IDQ9BRR0
Ensembl Protein ID ENSP00000252211  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation480;-
SPhosphorylation1717;-
SPhosphorylation482
SPhosphorylation577
TPhosphorylation580
SPhosphorylation488
SPhosphorylation4523
SPhosphorylation486
YPhosphorylation301
SPhosphorylation638
SPhosphorylation4571
SPhosphorylation3649
SPhosphorylation3660

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                    
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
332BIRC54520NP_001012271.1in vivo18329369   
836CASP32799NP_004337.2in vivo15200957   
842CASP93756NP_001220.2in vitro15300255   
983CDK1302NP_001777.1in vivo18329369   
4218RAB8A1296NP_005361.2in vivo18329369   
5347PLK13652NP_005021.2in vivo18329369   
5604MAP2K11469NP_002746.1in vivo18329369   
9101USP84405NP_005145.3in vivo18329369   
11336EXOC39738NP_009208.2in vivo18329369   
27429HTRA25919NP_037379.1in vitro;in vivo15200957   
56616DIABLO5560NP_063940.1in vitro;in vivo15200957   
60412EXOC412185NP_068579.3in vivo18329369   


Pathway Information


      
Pathway Name Pathway ID
Ubiquitin mediated proteolysis hsa04120


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd001954597-4735  UBCc
cl001544597-4735  UBCc superfamily
cd00022287-360  BIR
cl00035287-360  BIR superfamily
pfam123563462-3618  DUF3643
cl137523462-3618  DUF3643 superfamily
pfam001794602-4735  UQ_con
smart002124599-4709  UBCc
pfam00653289-359  BIR
smart00238285-360  BIR
PTZ003904602-4704  PTZ00390
PLN001724613-4704  PLN00172
COG50784599-4698  COG5078


Ontology Information


   
HPRD ID13747
Molecular ClassAdapter molecule
Molecular FunctionProtease inhibitor activity (GO:0030414)
Biological ProcessProtein metabolism (GO:0019538)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO