Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PTK2 | 5747 | protein tyrosine kinase 2 | 8 | FAK, FADK, FAK1, PPP1R71 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20811717 | 2010 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Up-regulation | - | Overexpression of Pak1 increased colorectal cancer cell motility and invasion. |
| 22733437 | 2013 | Cell line : - Source : - Sample Type : CRC tumor No. of Sample : 183 Stage : TNM Stage I,II,III,IV | Immunohistochemistry | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits |
| Description | This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only four of them have been determined. [provided by RefSeq, Oct 2015] |
| Chromosome | 8 |
| Location | 8q24.3 |
| Start | 141668481 |
| End | 142011412 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 342932 |
| OMIM ID | 600758 |
| HGNC ID | HGNC:9611 |
| Unigene ID | Hs.395482 |
| Ensembl ID | ENSG00000169398 |
| PharmGKB ID | PA33955 |
mRNA Information
| mRNA ID | ?NM_001199649.1 |
|---|---|
| Exon | join(1..189,75565..75653,110545..110771,121677..121843, 136915..137002,154636..154715,154992..155054, 170788..170842,182294..182434,182960..183037, 197664..197771,200738..200855,207930..207960, 211788..211840,237024..237080,240052..240149, 248998..249082,254454..254554,256547..256662, 257984..258084,262207..262296,265859..266063, 283605..283716,295109..295195,298607..298744, 300292..300423,314620..314682,325815..325854, 326910..327016,332890..333045,336317..336397, 341636..342932) | mRNA Sequence | Download Select all |
| Length | 4561 |
Protein Information
| Protein ID | NP_001186578.1 |
|---|---|
| Protein Name | protein tyrosine kinase 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 1052 |
| Uniprot ID | Q92945 |
| Ensembl Protein ID | ENSP00000381216 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Sumoylation | 153 |
| S | Phosphorylation | 744 |
| S | Phosphorylation | 862 |
| S | Phosphorylation | 865 |
| S | Phosphorylation | 932 |
| K | Sumoylation | 131 |
| S | Phosphorylation | 722 |
| S | Phosphorylation | 840 |
| S | Phosphorylation | 843 |
| S | Phosphorylation | 910 |
| Y | Phosphorylation | 429 |
| Y | Phosphorylation | 598 |
| Y | Phosphorylation | 599 |
| Y | Phosphorylation | 883 |
| Y | Phosphorylation | 947 |
| Y | Phosphorylation | 407 |
| Y | Phosphorylation | 576 |
| Y | Phosphorylation | 577 |
| Y | Phosphorylation | 861 |
| Y | Phosphorylation | 925 |
| Y | Dephosphorylation | 419 |
| Y | Dephosphorylation | 397 |
| Y | Phosphorylation | 397 |
| Y | Phosphorylation | 861 |
| Y | Phosphorylation | 419 |
| Y | Phosphorylation | 947 |
| Y | Phosphorylation | 397 |
| Y | Phosphorylation | 925 |
| Y | Dephosphorylation | 419 |
| Y | Dephosphorylation | 397 |
| D | Proteolytic Cleavage | 726 |
| D | Proteolytic Cleavage | 704 |
| Y | Phosphorylation | 598 |
| Y | Phosphorylation | 599 |
| Y | Phosphorylation | 576 |
| Y | Phosphorylation | 577 |
| Y | Phosphorylation | 397 |
| Y | Phosphorylation | 598 |
| Y | Phosphorylation | 599 |
| Y | Phosphorylation | 576 |
| Y | Phosphorylation | 577 |
| Y | Phosphorylation | 429 |
| Y | Phosphorylation | 407 |
| Y | Phosphorylation | 577 |
| S | Phosphorylation | 51;- |
| S | Phosphorylation | 29;- |
| S | Phosphorylation | 850;- |
| S | Phosphorylation | 872;- |
| S | Phosphorylation | 390;- |
| S | Phosphorylation | 412;- |
| Y | Phosphorylation | 1016;- |
| Y | Phosphorylation | 1038;- |
| T | Phosphorylation | 936;- |
| T | Phosphorylation | 914;- |
| S | Phosphorylation | 914 |
| S | Phosphorylation | 892 |
| T | Phosphorylation | 35 |
| T | Phosphorylation | 13 |
| S | Phosphorylation | 909 |
| S | Phosphorylation | 887 |
| S | Phosphorylation | 590 |
| S | Phosphorylation | 568 |
| T | Phosphorylation | 408 |
| T | Phosphorylation | 386 |
| Y | Phosphorylation | 592 |
| Y | Phosphorylation | 570 |
| S | Phosphorylation | 727 |
| S | Phosphorylation | 705 |
| S | Phosphorylation | 738 |
| S | Phosphorylation | 716 |
| T | Phosphorylation | 46 |
| T | Phosphorylation | 24 |
| S | Phosphorylation | 38 |
| S | Phosphorylation | 16 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 87 | ACTN1 | 20 | NP_001123476.1 | in vivo | 11369769 |
| 660 | BMX | 2111 | NP_975010.1 | in vitro;in vivo | 11331870 |
| 1445 | CSK | 496 | NP_004374.1 | in vitro;in vivo | 7529872 |
| 1630 | DCC | 391 | NP_005206.2 | in vitro;in vivo | 15494733 |
| 1956 | EGFR | 579 | NP_005219.2 | in vitro;in vivo | 10806474 |
| 1969 | EPHA2 | 1494 | NP_004422.2 | in vivo | 10655584 |
| 2064 | ERBB2 | 1281 | NP_004439.2 | in vivo | 11807823 |
| 2065 | ERBB3 | 1820 | NP_001973.2 | in vivo | 11807823 |
| 2268 | FGR | 1288 | NP_005239.1 | in vivo | 12387730 |
| 2321 | FLT1 | 1297 | NP_002010.2 | in vivo | 12023386 |
| 2534 | FYN | 655 | NP_002028.1 | in vitro | 11278857 |
| 2885 | GRB2 | 150 | NP_002077.1 | in vitro;in vivo | 7997267 |
| 3667 | IRS1 | 943 | NP_005535.1 | yeast 2-hybrid | 9822703 |
| 3685 | ITGAV | 1903 | NP_002201.1 | in vitro | 11927607 |
| 3688 | ITGB1 | 628 | NP_391987.1 | in vitro | 8649427 |
| 3689 | ITGB2 | 2506 | NP_000202.2 | in vitro | 8649427 |
| 3690 | ITGB3 | 1428 | NP_000203.2 | in vitro;in vivo | 8649427 |
| 3717 | JAK2 | 993 | NP_004963.1 | in vivo | 955 313 110 925 297 |
| 4067 | LYN | 1301 | NP_002341.1 | in vivo | 11389892 |
| 4756 | NEO1 | 3549 | NP_002490.2 | in vitro | 15494733 |
| 5159 | PDGFRB | 1423 | NP_002600.1 | in vitro;in vivo | 10806474 |
| 5295 | PIK3R1 | 1381 | NP_852664.1 | in vivo | 7 537 275 864 942 710 000 000 |
| 5335 | PLCG1 | 1398 | NP_002651.2 | in vitro;in vivo | 866 085 310 430 888 |
| 5781 | PTPN11 | 1470 | NP_002825.3 | in vitro;in vivo | 106 555 847 589 239 000 000 000 000 000 |
| 5829 | PXN | 3937 | BAA18998.1 | in vitro;in vivo | 9 658 172 113 374 900 000 000 |
| 6093 | ROCK1 | 3414 | NP_005397.1 | in vitro | 15247219 |
| 6401 | SELE | 566 | NP_000441.2 | in vitro | 8609175 |
| 6464 | SHC1 | 2780 | NP_001123512.1 | in vitro;in vivo | 11980671 |
| 6772 | STAT1 | 2777 | NP_009330.1 | in vitro;in vivo | 11278462 |
| 6850 | SYK | 2514 | NP_003168.2 | in vivo | 93 422 359 169 439 |
| 7094 | TLN1 | 1726 | NP_006280.3 | in vitro;in vivo | 7622520 |
| 7157 | TP53 | 1859 | NP_000537.3 | in vitro;in vivo | 15855171 |
| 7204 | TRIO | 3537 | NP_009049.2 | in vitro;in vivo | 12551902 |
| 7249 | TSC2 | 1850 | NP_000539.2 | in vivo | 17043358 |
| 7414 | VCL | 1900 | NP_054706.1 | in vivo | 10545505 |
| 7430 | EZR | 475 | NP_003370.2 | in vitro;in vivo | 11468295 |
| 8737 | RIPK1 | 4583 | NP_003795.2 | in vitro;in vivo | 15121855 |
| 8835 | SOCS2 | 5490 | NP_003868.1 | yeast 2-hybrid | 16189514 |
| 9140 | ATG12 | 8496 | NP_004698.2 | yeast 2-hybrid | 16189514 |
| 9564 | BCAR1 | 4248 | NP_055382.2 | in vitro;in vivo;yeast 2-hybrid | 1 151 461 774 798 640 000 000 000 000 000 000 000 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Amoebiasis | hsa05146 |
| Axon guidance | hsa04360 |
| Bacterial invasion of epithelial cells | hsa05100 |
| Chemokine signaling pathway | hsa04062 |
| ErbB signaling pathway | hsa04012 |
| Focal adhesion | hsa04510 |
| Leukocyte transendothelial migration | hsa04670 |
| Pathways in cancer | hsa05200 |
| PI3K-Akt signaling pathway | hsa04151 |
| Proteoglycans in cancer | hsa05205 |
| Regulation of actin cytoskeleton | hsa04810 |
| Small cell lung cancer | hsa05222 |
| Transcriptional misregulation in cancer | hsa05202 |
| VEGF signaling pathway | hsa04370 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05056 | 415-684 | PTKc_FAK |
| cl21453 | 415-684 | PKc_like superfamily |
| cd13190 | 254-364 | FERM_C_FAK1 |
| cl17171 | 254-364 | PH-like superfamily |
| cd14473 | 143-248 | FERM_B-lobe |
| cl09511 | 143-248 | FERM_B-lobe superfamily |
| cd00192 | 426-676 | PTKc |
| cd05060 | 428-681 | PTKc_Syk_like |
| cd05040 | 428-677 | PTKc_Ack_like |
| cd05033 | 422-677 | PTKc_EphR |
| cd05032 | 415-677 | PTKc_InsR_like |
| cd05068 | 415-676 | PTKc_Frk_like |
| cd05041 | 428-676 | PTKc_Fes_like |
| cd05034 | 426-676 | PTKc_Src_like |
| pfam03623 | 914-1052 | Focal_AT |
| cl04185 | 914-1052 | Focal_AT superfamily |
| cd05039 | 415-679 | PTKc_Csk_like |
| cd05044 | 428-676 | PTKc_c-ros |
| cd05057 | 421-680 | PTKc_EGFR_like |
| cd05085 | 425-678 | PTKc_Fer |
| cd05084 | 425-676 | PTKc_Fes |
| cd05048 | 416-678 | PTKc_Ror |
| cd05116 | 428-676 | PTKc_Syk |
| cd05052 | 415-679 | PTKc_Abl |
| cd05038 | 428-680 | PTKc_Jak_rpt2 |
| cd05065 | 422-680 | PTKc_EphR_B |
| cd05066 | 417-680 | PTKc_EphR_A |
| cd05115 | 428-693 | PTKc_Zap-70 |
| cd05036 | 416-681 | PTKc_ALK_LTK |
| cd05148 | 415-679 | PTKc_Srm_Brk |
| cd05059 | 424-676 | PTKc_Tec_like |
| cd05053 | 409-680 | PTKc_FGFR |
| cd05063 | 416-680 | PTKc_EphR_A2 |
| cd05067 | 414-676 | PTKc_Lck_Blk |
| cd05099 | 409-680 | PTKc_FGFR4 |
| cd05061 | 415-672 | PTKc_InsR |
| cd05072 | 415-689 | PTKc_Lyn |
| cd05050 | 416-672 | PTKc_Musk |
| cd13999 | 428-672 | STKc_MAP3K-like |
| cd05064 | 416-680 | PTKc_EphR_A10 |
| cd05108 | 426-695 | PTKc_EGFR |
| cd05075 | 421-682 | PTKc_Axl |
| cd05109 | 426-679 | PTKc_HER2 |
| cd05074 | 413-680 | PTKc_Tyro3 |
| cd05035 | 424-680 | PTKc_TAM |
| cd05058 | 426-682 | PTKc_Met_Ron |
| cd05049 | 416-676 | PTKc_Trk |
| cd05083 | 420-678 | PTKc_Chk |
| cd05110 | 413-695 | PTKc_HER4 |
| cd14204 | 414-681 | PTKc_Mer |
| cd05051 | 416-672 | PTKc_DDR |
| cd05090 | 423-676 | PTKc_Ror1 |
| cd05091 | 416-678 | PTKc_Ror2 |
| cd05082 | 415-679 | PTKc_Csk |
| cd14203 | 428-676 | PTKc_Src_Fyn_like |
| cd05055 | 405-672 | PTKc_PDGFR |
| cd05062 | 415-672 | PTKc_IGF-1R |
| cd05112 | 428-677 | PTKc_Itk |
| cd05073 | 415-676 | PTKc_Hck |
| cd05092 | 417-676 | PTKc_TrkA |
| cd05045 | 421-680 | PTKc_RET |
| cd05101 | 407-680 | PTKc_FGFR2 |
| cd05098 | 409-687 | PTKc_FGFR1 |
| cd05071 | 415-688 | PTKc_Src |
| cd00180 | 428-676 | PKc |
| cd05100 | 409-680 | PTKc_FGFR3 |
| cd05111 | 425-677 | PTK_HER3 |
| cd05070 | 415-688 | PTKc_Fyn |
| cd05054 | 415-677 | PTKc_VEGFR |
| cd05069 | 415-688 | PTKc_Yes |
| cd05046 | 428-677 | PTK_CCK4 |
| cd05113 | 417-680 | PTKc_Btk_Bmx |
| cd05043 | 417-677 | PTK_Ryk |
| cd05114 | 426-681 | PTKc_Tec_Rlk |
| cd05080 | 418-681 | PTKc_Tyk2_rpt2 |
| cd14205 | 428-679 | PTKc_Jak2_rpt2 |
| cd05093 | 417-679 | PTKc_TrkB |
| cd05102 | 415-682 | PTKc_VEGFR3 |
| cd05097 | 416-678 | PTKc_DDR_like |
| cd14207 | 415-679 | PTKc_VEGFR1 |
| cd05079 | 426-680 | PTKc_Jak1_rpt2 |
| cd05094 | 417-676 | PTKc_TrkC |
| cd05096 | 416-677 | PTKc_DDR1 |
| cd05081 | 428-676 | PTKc_Jak3_rpt2 |
| cd05095 | 416-676 | PTKc_DDR2 |
| cd05103 | 415-681 | PTKc_VEGFR2 |
| cd05047 | 428-681 | PTKc_Tie |
| cd05089 | 420-685 | PTKc_Tie1 |
| cd06606 | 421-672 | STKc_MAPKKK |
| cd05106 | 384-683 | PTKc_CSF-1R |
| cd14014 | 421-678 | STKc_PknB_like |
| cd05105 | 405-680 | PTKc_PDGFR_alpha |
| cd14058 | 428-681 | STKc_TAK1 |
| cd14003 | 423-674 | STKc_AMPK-like |
| cd05088 | 417-684 | PTKc_Tie2 |
| cd14061 | 428-679 | STKc_MLK |
| cd14145 | 416-679 | STKc_MLK1 |
| cd06627 | 424-672 | STKc_Cdc7_like |
| cd05122 | 423-673 | PKc_STE |
| cd05104 | 405-672 | PTKc_Kit |
| cd05107 | 405-680 | PTKc_PDGFR_beta |
| cd14059 | 428-676 | STKc_MAP3K12_13 |
| cd14007 | 423-674 | STKc_Aurora |
| cd08215 | 414-667 | STKc_Nek |
| cd14206 | 428-677 | PTKc_Aatyk3 |
| cd14060 | 429-679 | STKc_MLTK |
| cd14147 | 420-679 | STKc_MLK3 |
| cd05037 | 422-669 | PTK_Jak_rpt1 |
| cd14148 | 428-679 | STKc_MLK2 |
| cd14146 | 428-679 | STKc_MLK4 |
| cd05117 | 423-667 | STKc_CAMK |
| cd14008 | 428-673 | STKc_LKB1_CaMKK |
| cd13978 | 428-676 | STKc_RIP |
| cd05042 | 428-677 | PTKc_Aatyk |
| cd14009 | 428-672 | STKc_ATG1_ULK_like |
| cd05087 | 428-677 | PTKc_Aatyk1 |
| cd08224 | 414-667 | STKc_Nek6_7 |
| cd06623 | 422-672 | PKc_MAPKK_plant_like |
| cd06632 | 425-672 | STKc_MEKK1_plant |
| cd06612 | 423-672 | STKc_MST1_2 |
| cd06609 | 420-672 | STKc_MST3_like |
| cd14065 | 428-676 | PKc_LIMK_like |
| cd06626 | 421-672 | STKc_MEKK4 |
| cd14221 | 428-680 | STKc_LIMK1 |
| cd07829 | 420-667 | STKc_CDK_like |
| cd14062 | 428-676 | STKc_Raf |
| cd13979 | 420-667 | STKc_Mos |
| cd14663 | 421-674 | STKc_SnRK3 |
| cd13992 | 451-679 | PK_GC |
| cd14002 | 420-672 | STKc_STK36 |
| cd14151 | 414-682 | STKc_B-Raf |
| cd08217 | 475-672 | STKc_Nek2 |
| cd14080 | 424-681 | STKc_TSSK-like |
| cd05086 | 428-667 | PTKc_Aatyk2 |
| cd14150 | 428-681 | STKc_A-Raf |
| cd08529 | 414-672 | STKc_FA2-like |
| cd14025 | 428-681 | STKc_RIP4_like |
| cd06610 | 414-672 | STKc_OSR1_SPAK |
| cd14222 | 428-679 | STKc_LIMK2 |
| cd14063 | 422-673 | PK_KSR |
| cd08225 | 421-672 | STKc_Nek5 |
| cd08228 | 428-667 | STKc_Nek6 |
| cd14099 | 420-672 | STKc_PLK |
| cd05118 | 428-667 | STKc_CMGC |
| cd14154 | 428-679 | STKc_LIMK |
| cd14027 | 466-671 | STKc_RIP1 |
| cd14064 | 428-678 | PKc_TNNI3K |
| cd14121 | 427-671 | STKc_ULK3 |
| cd14095 | 423-639 | STKc_DCKL |
| cd14010 | 451-672 | STKc_ULK4 |
| cd06611 | 428-672 | STKc_SLK_like |
| cd05581 | 414-667 | STKc_PDK1 |
| cd08219 | 426-675 | STKc_Nek3 |
| cd14137 | 421-667 | STKc_GSK3 |
| cd07830 | 423-667 | STKc_MAK_like |
| cd06628 | 425-672 | STKc_Byr2_like |
| cd07833 | 428-672 | STKc_CDKL |
| cd14149 | 411-679 | STKc_C-Raf |
| cd05123 | 475-674 | STKc_AGC |
| cd13996 | 418-667 | STKc_EIF2AK |
| cd14006 | 428-639 | STKc_MLCK-like |
| cd05077 | 468-669 | PTK_Jak1_rpt1 |
| cd08229 | 428-670 | STKc_Nek7 |
| cd14079 | 424-623 | STKc_AMPK_alpha |
| cd14072 | 421-682 | STKc_MARK |
| cd14116 | 420-667 | STKc_Aurora-A |
| cd05580 | 422-666 | STKc_PKA_like |
| cd06614 | 428-672 | STKc_PAK |
| cd14155 | 460-682 | PKc_TESK |
| cd14161 | 419-666 | STKc_NUAK2 |
| cd14096 | 420-639 | STKc_RCK1-like |
| cd06640 | 428-672 | STKc_MST4 |
| cd14119 | 428-673 | STKc_LKB1 |
| cd08223 | 423-667 | STKc_Nek4 |
| cd14048 | 423-672 | STKc_EIF2AK3_PERK |
| cd14070 | 424-667 | STKc_HUNK |
| cd06625 | 424-672 | STKc_MEKK3_like |
| cd14202 | 415-648 | STKc_ULK1 |
| cd06642 | 428-672 | STKc_STK25 |
| cd14066 | 428-672 | STKc_IRAK |
| cd14012 | 463-672 | PK_eIF2AK_GCN2_rpt1 |
| cd06616 | 422-674 | PKc_MKK4 |
| cd14152 | 421-682 | STKc_KSR1 |
| cd06917 | 421-672 | STKc_NAK1_like |
| cd06641 | 428-672 | STKc_MST3 |
| cd14097 | 425-639 | STKc_STK33 |
| cd06613 | 414-672 | STKc_MAP4K3_like |
| cd14073 | 421-666 | STKc_NUAK |
| cd14000 | 468-677 | STKc_LRRK |
| cd13998 | 427-679 | STKc_TGFbR-like |
| cd08528 | 428-678 | STKc_Nek10 |
| cd06605 | 428-672 | PKc_MAPKK |
| cd14084 | 426-672 | STKc_Chk2 |
| cd07841 | 421-667 | STKc_CDK7 |
| cd14208 | 422-669 | PTK_Jak3_rpt1 |
| cd08222 | 469-672 | STKc_Nek11 |
| cd06644 | 428-672 | STKc_STK10 |
| cd05582 | 426-666 | STKc_RSK_N |
| cd05076 | 468-669 | PTK_Tyk2_rpt1 |
| cd14069 | 424-674 | STKc_Chk1 |
| cd06608 | 420-674 | STKc_myosinIII_N_like |
| cd05078 | 431-669 | PTK_Jak2_rpt1 |
| cd06643 | 428-658 | STKc_SLK |
| cd14056 | 427-667 | STKc_TGFbR_I |
| cd07832 | 414-666 | STKc_CCRK |
| cd06630 | 425-672 | STKc_MEKK1 |
| cd14071 | 423-666 | STKc_SIK |
| cd07831 | 428-667 | STKc_MOK |
| cd06618 | 475-672 | PKc_MKK7 |
| cd06621 | 422-667 | PKc_Pek1_like |
| cd05579 | 451-674 | STKc_MAST_like |
| cd06624 | 414-672 | STKc_ASK |
| cd14187 | 419-672 | STKc_PLK1 |
| cd06620 | 463-672 | PKc_Byr1_like |
| cd14075 | 428-673 | STKc_NIM1 |
| cd13987 | 428-624 | STKc_SBK1 |
| cd14201 | 414-655 | STKc_ULK2 |
| cd14183 | 420-625 | STKc_DCKL1 |
| cd14185 | 423-666 | STKc_DCKL3 |
| cd08530 | 461-675 | STKc_CNK2-like |
| cd14105 | 423-625 | STKc_DAPK |
| cd14074 | 423-673 | STKc_SNRK |
| cd14156 | 465-681 | PKc_LIMK_like_unk |
| cd05578 | 462-666 | STKc_Yank1 |
| cd14196 | 423-635 | STKc_DAPK2 |
| cd13997 | 428-672 | PKc_Wee1_like |
| cd05572 | 428-666 | STKc_cGK |
| cd14162 | 422-642 | STKc_TSSK4-like |
| cd08220 | 465-675 | STKc_Nek8 |
| cd06631 | 425-672 | STKc_YSK4 |
| cd14081 | 423-666 | STKc_BRSK1_2 |
| cd07834 | 421-667 | STKc_MAPK |
| cd14184 | 420-644 | STKc_DCKL2 |
| cd06648 | 418-672 | STKc_PAK_II |
| cd13991 | 419-682 | STKc_NIK |
| cd08218 | 428-667 | STKc_Nek1 |
| cd14054 | 428-617 | STKc_BMPR2_AMHR2 |
| cd14164 | 424-667 | STKc_TSSK6-like |
| cd14068 | 428-667 | STKc_LRRK2 |
| cd13989 | 428-623 | STKc_IKK |
| cd13993 | 421-672 | STKc_Pat1_like |
| cd14045 | 439-679 | PK_GC_unk |
| cd06607 | 426-672 | STKc_TAO |
| cd06617 | 423-672 | PKc_MKK3_6 |
| cd14047 | 428-676 | STKc_EIF2AK2_PKR |
| cd14103 | 428-631 | STKc_MLCK |
| cd14199 | 466-675 | STKc_CaMKK2 |
| cd14120 | 428-671 | STKc_ULK1_2-like |
| cd14117 | 423-666 | STKc_Aurora-B_like |
| cd14189 | 425-624 | STKc_PLK3 |
| cd06638 | 423-672 | STKc_myosinIIIA_N |
| cd07840 | 415-625 | STKc_CDK9_like |
| cd14076 | 424-673 | STKc_Kin4 |
| cd14190 | 428-625 | STKc_MLCK2 |
| cd06633 | 428-615 | STKc_TAO3 |
| cd14086 | 428-701 | STKc_CaMKII |
| cd14026 | 426-680 | STKc_RIP2 |
| cd14188 | 425-672 | STKc_PLK2 |
| cd07852 | 451-671 | STKc_MAPK15-like |
| cd06629 | 425-673 | STKc_Bck1_like |
| cd14191 | 428-635 | STKc_MLCK1 |
| cd14094 | 420-671 | STKc_CASK |
| cd14052 | 428-626 | PTKc_Wee1_fungi |
| cd06639 | 428-672 | STKc_myosinIIIB_N |
| cd14067 | 428-667 | STKc_LRRK1 |
| cd14042 | 475-676 | PK_GC-A_B |
| cd14153 | 421-679 | PK_KSR2 |
| cd05611 | 428-666 | STKc_Rim15_like |
| cd06647 | 428-672 | STKc_PAK_I |
| cd13990 | 428-672 | STKc_TLK |
| cd14053 | 431-671 | STKc_ACVR2 |
| cd14165 | 424-672 | STKc_TSSK1_2-like |
| cd14192 | 428-637 | STKc_MLCK3 |
| cd14077 | 423-666 | STKc_Kin1_2 |
| cd14195 | 423-635 | STKc_DAPK3 |
| cd14194 | 420-635 | STKc_DAPK1 |
| cd08221 | 426-672 | STKc_Nek9 |
| cd14038 | 428-623 | STKc_IKK_beta |
| cd14158 | 419-679 | STKc_IRAK4 |
| cd07857 | 421-666 | STKc_MPK1 |
| cd05574 | 469-666 | STKc_phototropin_like |
| cd14098 | 423-674 | STKc_Rad53_Cds1 |
| cd06645 | 419-615 | STKc_MAP4K3 |
| cd14078 | 420-623 | STKc_MELK |
| cd14193 | 415-635 | STKc_MLCK4 |
| cd13983 | 465-672 | STKc_WNK |
| cd06634 | 426-615 | STKc_TAO2 |
| cd05570 | 479-666 | STKc_PKC |
| cd06622 | 428-672 | PKc_PBS2_like |
| cd14050 | 428-672 | PKc_Myt1 |
| cd14083 | 419-623 | STKc_CaMKI |
| cd14186 | 420-624 | STKc_PLK4 |
| cd14055 | 428-673 | STKc_TGFbR2_like |
| cd06656 | 428-672 | STKc_PAK3 |
| cd13982 | 450-667 | STKc_IRE1 |
| cd14043 | 433-679 | PK_GC-2D |
| cd14091 | 414-668 | STKc_RSK_C |
| cd13994 | 428-668 | STKc_HAL4_like |
| cd14200 | 466-673 | STKc_CaMKK1 |
| cd07859 | 421-700 | STKc_TDY_MAPK |
| cd14144 | 426-679 | STKc_BMPR1 |
| cd14106 | 463-625 | STKc_DRAK |
| cd14142 | 420-680 | STKc_ACVR1_ALK1 |
| cd14082 | 428-646 | STKc_PKD |
| cd06654 | 428-623 | STKc_PAK1 |
| cd07862 | 428-648 | STKc_CDK6 |
| cd07860 | 428-635 | STKc_CDK2_3 |
| cd06653 | 424-672 | STKc_MEKK3_like_u1 |
| cd14664 | 428-637 | STK_BAK1_like |
| cd05583 | 465-666 | STKc_MSK_N |
| cd14109 | 465-638 | PK_Unc-89_rpt1 |
| cd14118 | 466-673 | STKc_CAMKK |
| cd07843 | 428-635 | STKc_CDC2L1 |
| cd05612 | 423-666 | STKc_PRKX_like |
| cd07846 | 428-672 | STKc_CDKL2_3 |
| cd13975 | 479-681 | PKc_Dusty |
| cd07863 | 428-635 | STKc_CDK4 |
| cd06655 | 428-672 | STKc_PAK2 |
| cd14039 | 428-666 | STKc_IKK_alpha |
| cd14089 | 473-672 | STKc_MAPKAPK |
| cd06635 | 426-615 | STKc_TAO1 |
| cd14093 | 462-666 | STKc_PhKG |
| cd14057 | 428-669 | PK_ILK |
| cd14131 | 420-672 | PKc_Mps1 |
| cd14132 | 420-635 | STKc_CK2_alpha |
| cd06646 | 413-615 | STKc_MAP4K5 |
| cd07836 | 428-635 | STKc_Pho85 |
| cd14114 | 415-630 | STKc_Twitchin_like |
| cd14004 | 414-672 | STKc_PASK |
| cd06652 | 424-616 | STKc_MEKK2 |
| cd07866 | 407-625 | STKc_BUR1 |
| cd14665 | 421-673 | STKc_SnRK2-3 |
| cd05595 | 426-666 | STKc_PKB_beta |
| cd06636 | 423-660 | STKc_MAP4K4_6_N |
| cd05584 | 480-666 | STKc_p70S6K |
| cd14209 | 466-679 | STKc_PKA |
| cd13985 | 426-672 | STKc_GAK_like |
| cd08216 | 423-624 | PK_STRAD |
| cd06637 | 423-623 | STKc_TNIK |
| cd07854 | 451-616 | STKc_MAPK4_6 |
| cd14033 | 428-615 | STKc_WNK4 |
| cd06659 | 465-623 | STKc_PAK6 |
| cd14198 | 423-630 | STKc_DRAK2 |
| cd05614 | 423-666 | STKc_MSK2_N |
| cd14167 | 419-623 | STKc_CaMKI_alpha |
| cd07861 | 428-666 | STKc_CDK1_euk |
| cd07838 | 428-667 | STKc_CDK4_6_like |
| cd05604 | 426-666 | STKc_SGK3 |
| cd07842 | 427-667 | STKc_CDK8_like |
| cd14159 | 428-616 | STKc_IRAK1 |
| cd05602 | 426-676 | STKc_SGK1 |
| cd05620 | 426-666 | STKc_nPKC_delta |
| cd07870 | 428-628 | STKc_PFTAIRE2 |
| cd05585 | 428-666 | STKc_YPK1_like |
| cd07845 | 424-623 | STKc_CDK10 |
| cd05613 | 423-666 | STKc_MSK1_N |
| cd06619 | 428-667 | PKc_MKK5 |
| cd07835 | 420-666 | STKc_CDK1_CdkB_like |
| cd14104 | 423-639 | STKc_Titin |
| cd05619 | 424-666 | STKc_nPKC_theta |
| cd14113 | 465-623 | STKc_Trio_C |
| cd13988 | 428-662 | STKc_TBK1 |
| cd05630 | 426-666 | STKc_GRK6 |
| cd14166 | 419-639 | STKc_CaMKI_gamma |
| cd05610 | 410-674 | STKc_MASTL |
| cd14011 | 528-667 | PK_SCY1_like |
| cd05624 | 413-644 | STKc_MRCK_beta |
| cd06658 | 428-623 | STKc_PAK5 |
| cd14044 | 451-679 | PK_GC-C |
| cd05616 | 491-666 | STKc_cPKC_beta |
| cd06657 | 465-672 | STKc_PAK4 |
| cd14110 | 465-638 | STKc_obscurin_rpt2 |
| cd00836 | 256-351 | FERM_C-lobe |
| cd07839 | 428-635 | STKc_CDK5 |
| cd14092 | 480-639 | STKc_MSK_C |
| cd05573 | 420-674 | STKc_ROCK_NDR_like |
| cd07858 | 427-666 | STKc_TEY_MAPK |
| cd14177 | 432-639 | STKc_RSK4_C |
| cd14087 | 428-624 | STKc_PSKH1 |
| cd07864 | 428-648 | STKc_CDK12 |
| cd05577 | 428-675 | STKc_GRK |
| cd14005 | 423-681 | STKc_PIM |
| cd14133 | 428-668 | PKc_DYRK_like |
| cd14179 | 456-624 | STKc_MSK1_C |
| cd06651 | 425-616 | STKc_MEKK3 |
| cd14219 | 420-683 | STKc_BMPR1b |
| cd14169 | 423-623 | STKc_CaMKI_beta |
| cd07876 | 420-630 | STKc_JNK2 |
| cd05623 | 413-644 | STKc_MRCK_alpha |
| cd07873 | 428-615 | STKc_PCTAIRE1 |
| cd14041 | 420-666 | STKc_TLK2 |
| cd07877 | 428-656 | STKc_p38alpha |
| cd05593 | 426-666 | STKc_PKB_gamma |
| cd14030 | 392-615 | STKc_WNK1 |
| cd14088 | 420-623 | STKc_CaMK_like |
| cd06615 | 463-674 | PKc_MEK |
| cd14143 | 428-615 | STKc_TGFbR1_ACVR1b_ACVR1c |
| cd07865 | 428-619 | STKc_CDK9 |
| cd14016 | 421-575 | STKc_CK1 |
| cd14178 | 473-639 | STKc_RSK3_C |
| cd13995 | 428-672 | STKc_MAP3K8 |
| cd07855 | 420-616 | STKc_ERK5 |
| cd07869 | 428-635 | STKc_PFTAIRE1 |
| cd14220 | 426-679 | STKc_BMPR1a |
| cd05598 | 498-623 | STKc_LATS |
| cd14049 | 419-667 | STKc_EIF2AK1_HRI |
| cd05592 | 480-666 | STKc_nPKC_theta_like |
| cd05607 | 426-627 | STKc_GRK7 |
| cd14170 | 481-623 | STKc_MAPKAPK2 |
| cd05590 | 426-666 | STKc_nPKC_eta |
| cd07853 | 422-616 | STKc_NLK |
| cd14111 | 469-667 | STKc_SPEG_rpt2 |
| cd07878 | 420-635 | STKc_p38beta |
| cd14085 | 452-623 | STKc_CaMKIV |
| cd07850 | 470-620 | STKc_JNK |
| cd05615 | 428-635 | STKc_cPKC_alpha |
| cd14175 | 428-639 | STKc_RSK1_C |
| cd14040 | 420-666 | STKc_TLK1 |
| cd05571 | 469-666 | STKc_PKB |
| cd06650 | 463-657 | PKc_MEK1 |
| cd14031 | 408-615 | STKc_WNK3 |
| cd07871 | 422-615 | STKc_PCTAIRE3 |
| cd14172 | 481-623 | STKc_MAPKAPK3 |
| cd07847 | 420-672 | STKc_CDKL1_4 |
| cd05631 | 524-639 | STKc_GRK4 |
| cd05603 | 426-623 | STKc_SGK2 |
| cd07849 | 420-616 | STKc_ERK1_2_like |
| cd14046 | 415-568 | STKc_EIF2AK4_GCN2_rpt2 |
| cd14180 | 471-673 | STKc_MSK2_C |
| cd13977 | 421-616 | STKc_PDIK1L |
| cd14176 | 400-639 | STKc_RSK2_C |
| cd05594 | 423-666 | STKc_PKB_alpha |
| cd14019 | 428-666 | STKc_Cdc7 |
| pfam00373 | 143-248 | FERM_M |
| cd05609 | 479-639 | STKc_MAST |
| cd05601 | 423-637 | STKc_CRIK |
| cd07874 | 470-672 | STKc_JNK3 |
| cd07848 | 421-653 | STKc_CDKL5 |
| cd07875 | 470-669 | STKc_JNK1 |
| cd13986 | 459-672 | STKc_16 |
| cd05575 | 505-666 | STKc_SGK |
| cd14107 | 415-639 | STKc_obscurin_rpt1 |
| cd14210 | 421-625 | PKc_DYRK |
| cd14032 | 422-615 | STKc_WNK2_like |
| cd13968 | 428-566 | PKc_like |
| cd14090 | 425-625 | STKc_Mnk |
| cd06649 | 416-615 | PKc_MEK2 |
| cd05589 | 426-642 | STKc_PKN |
| cd05605 | 524-635 | STKc_GRK4_like |
| cd14108 | 469-637 | STKc_SPEG_rpt1 |
| cd05587 | 491-729 | STKc_cPKC |
| cd05632 | 524-639 | STKc_GRK5 |
| cd08226 | 443-667 | PK_STRAD_beta |
| cd07851 | 475-635 | STKc_p38 |
| cd14001 | 452-616 | PKc_TOPK |
| cd14197 | 529-625 | STKc_DRAK1 |
| cd14181 | 462-623 | STKc_PhKG2 |
| cd07856 | 451-671 | STKc_Sty1_Hog1 |
| cd07880 | 419-625 | STKc_p38gamma |
| cd14036 | 421-681 | STKc_GAK |
| cd14212 | 429-646 | PKc_YAK1 |
| cd05622 | 408-623 | STKc_ROCK1 |
| cd07872 | 428-615 | STKc_PCTAIRE2 |
| cd14101 | 529-672 | STKc_PIM2 |
| cd14163 | 423-672 | STKc_TSSK3-like |
| cd07879 | 428-625 | STKc_p38delta |
| cd14135 | 428-632 | STKc_PRP4 |
| cd14168 | 419-623 | STKc_CaMKI_delta |
| cd14662 | 421-673 | STKc_SnRK2 |
| cd14115 | 428-623 | STKc_Kalirin_C |
| cd14141 | 480-615 | STKc_ACVR2a |
| cd05618 | 479-630 | STKc_aPKC_iota |
| cd14017 | 428-656 | STKc_TTBK |
| cd14100 | 423-672 | STKc_PIM1 |
| cd05617 | 491-674 | STKc_aPKC_zeta |
| cd05591 | 480-712 | STKc_nPKC_epsilon |
| cd14140 | 431-616 | STKc_ACVR2b |
| cd05597 | 526-648 | STKc_DMPK_like |
| cd14125 | 421-581 | STKc_CK1_delta_epsilon |
| cd14020 | 442-666 | STKc_KIS |
| cd05608 | 491-669 | STKc_GRK1 |
| cd08227 | 459-624 | PK_STRAD_alpha |
| cd13183 | 270-350 | FERM_C_FRMPD1_FRMPD3_FRMPD4 |
| pfam07714 | 422-676 | Pkinase_Tyr |
| smart00295 | 36-258 | B41 |
| smart00219 | 422-676 | TyrKc |
| smart00221 | 422-676 | STYKc |
| smart00220 | 423-674 | S_TKc |
| pfam00069 | 422-673 | Pkinase |
| COG0515 | 423-741 | SPS1 |
| PTZ00267 | 446-716 | PTZ00267 |
| PLN00034 | 420-672 | PLN00034 |
| PTZ00263 | 404-623 | PTZ00263 |
| PHA02988 | 400-678 | PHA02988 |
| PTZ00283 | 529-681 | PTZ00283 |
| PTZ00036 | 374-700 | PTZ00036 |
| PTZ00426 | 408-623 | PTZ00426 |
| PTZ00024 | 422-652 | PTZ00024 |
| PHA03209 | 469-616 | PHA03209 |
| PHA03212 | 454-615 | PHA03212 |
| PHA03211 | 470-623 | PHA03211 |
| PTZ00266 | 409-643 | PTZ00266 |
| PRK13184 | 420-681 | pknD |
| PHA03390 | 475-630 | pk1 |
| PLN00009 | 418-569 | PLN00009 |
| TIGR03903 | 450-654 | TOMM_kin_cyc |
Ontology Information
| HPRD ID | 2164 |
|---|---|
| Molecular Class | Tyrosine kinase |
| Molecular Function | Protein serine/threonine kinase activity (GO:0004674) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.