CoReCG

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
24439672	2014	Cell line : - Source : 682 patients from Shanghai, China (training cohort) and validated in 343 patients from Guangzhou, China (validation cohort). Sample Type : Population based case control study and CRC tumor No. of Sample : 343 Stage : -	Western blotting,real time RT-PCR,Immunohistochemistry	Down-regulation	-	-
24173294	2014	Cell line : SW480, SW620, CACO2, HCT116, HT29 Source : The first affiliated hospital of Nanjing Medical University (Nanjing, China). Sample Type : Paraffin-embedded tissues and groups of frozen tissues. No. of Sample : 232 Stage : TNM Stage I-IV	Immunohistochemistry	Up-regulation	-	-

Gene Details

NC_000012.11 (112856536..112947717)
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Gene Type	protein coding
Gene Family	Protein tyrosine phosphatases / Class I Cys-based PTPs : Non-receptor, "SH2 domain containing"
Description	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Chromosome	12
Location	12q24.1
Start	112856536
End	112947717
Strand	+
Gene Sequence	Download   Select all
Length	91182
OMIM ID	176876
HGNC ID	HGNC:9644
Unigene ID	Hs.506852
Ensembl ID	ENSG00000179295
PharmGKB ID	PA33986

mRNA Information

mRNA ID	?NM_002834.3
Exon	complement(<1..107)
mRNA Sequence	Download   Select all
Length	1276

CDS Information

   

Location	345..1211
CDS Sequence	Download   Select all
CCDS ID	CCDS58280.1

Protein Information

      

Protein ID	NP_002825.3
Protein Name	protein tyrosine phosphatase, non-receptor type 11
Molecular Wt. (Da)	214324
Protein Sequence	Download   Select all
Length	597
Uniprot ID	O76061
Ensembl Protein ID	ENSP00000265087

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
Y	Phosphorylation	580
Y	Phosphorylation	542
S	Phosphorylation	576
S	Phosphorylation	576
S	Phosphorylation	576
Y	Phosphorylation	62
Y	Phosphorylation	63;-
S	Phosphorylation	558
T	Acetylation	2
S	Phosphorylation	591
K	Acetylation	280
K	Acetylation	198
Y	Phosphorylation	66
Y	Phosphorylation	279

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
392	ARHGAP1	4108	NP_004299.1	in vitro	1   516   989   815   588   980
613	BCR	1044	NP_004318.3	in vivo	12115002
624	BDKRB2	213	NP_000614.1	in vivo	12177051
634	CEACAM1	191	NP_001703.2	in vitro	986   784   812   108   545
847	CAT	282	NP_001743.1	in vitro	15556604
867	CBL	1320	NP_005179.2	in vivo	11157475
945	CD33	1165	NP_001763.3	in vitro	10206955
1147	CHUK	2811	NP_001269.3	in vivo	11136824
1439	CSF2RB	739	NP_000386.1	in vitro;in vivo	91   620   899   254   654
1441	CSF3R	737	NP_724781.1	in vivo	9824671
1493	CTLA4	474	NP_005205.2	in vitro;in vivo	8638161
1956	EGFR	579	NP_005219.2	in vitro;in vivo	7   673   163   112   231   550   000   000   000   000   000
2057	EPOR	587	NP_000112.1	in vivo	8639815
2185	PTK2B	3131	NP_004094.3	in vitro;in vivo	10880513
2206	MS4A2	915	NP_000130.1	in vitro	9379041
2534	FYN	655	NP_002028.1	in vitro	10212213
2549	GAB1	5116	NP_997006.1	yeast 2-hybrid	1   194   058   110   068   650   000   000   000   000   000   000   000   000
2885	GRB2	150	NP_002077.1	in vivo	8   041   791   125   314   300   000   000
3192	HNRNPU	4185	NP_114032.2	in vitro	8943344
3454	IFNAR1	126	NP_000620.2	in vitro;in vivo	9029147
3459	IFNGR1	127	NP_000407.1	in vitro	10022928
3480	IGF1R	932	NP_000866.1	in vitro;in vivo	7642582
3566	IL4R	990	NP_000409.1	in vitro;in vivo	11714803
3572	IL6ST	2824	NP_002175.2	in vitro;in vivo	91   959   771   094   628   000   000   000
3643	INSR	975	NP_000199.2	in vitro;in vivo	74   939   468   135   823
3667	IRS1	943	NP_005535.1	in vitro;in vivo	850   528   297   569   387   000   000
3716	JAK1	992	NP_002218.2	in vivo	89   953   991   240   376   800   000   000
3717	JAK2	993	NP_004963.1	in vivo	755   960   389   126   468   000   000
3815	KIT	1287	NP_000213.1	in vitro;in vivo	75   233   819   528   781
3821	KLRC1	1192	NP_002250.1	in vitro;in vivo	9485206
3932	LCK	1080	NP_005347.3	in vitro	10617656
3977	LIFR	1048	NP_002301.1	in vitro;in vivo	10800945
4233	MET	1280	NP_001120972.1	in vivo	8662733
4914	NTRK1	1869	NP_002520.2	in vitro	9282923
4915	NTRK2	2712	NP_006171.2	in vitro	10386953
5156	PDGFRA	1429	NP_006197.1	in vitro;in vivo	8943348
5159	PDGFRB	1423	NP_002600.1	in vitro;in vivo	7   691   811   126   814   920   000   000
5175	PECAM1	1425	NP_000433.3	in vitro;in vivo	9054388
5294	PIK3CG	3135	NP_002640.2	in vivo	10386953
5295	PIK3R1	1381	NP_852664.1	in vivo	9918857
5335	PLCG1	1398	NP_002651.2	in vitro	15563458
5595	MAPK3	3479	NP_002737.2	in vitro	8197172
5618	PRLR	1457	NP_000940.1	in vitro	1   099   194   914   522   990
5777	PTPN6	1475	NP_536859.1	in vivo	8541543
5979	RET	1266	NP_066124.1	in vitro	12959980
6401	SELE	566	NP_000441.2	in vitro	11602579
6654	SOS1	1681	NP_005624.2	in vivo	9344843
6772	STAT1	2777	NP_009330.1	in vitro;in vivo	12270932
6774	STAT3	26	NP_644805.1	in vivo	11594781
6776	STAT5A	3301	NP_003143.2	in vitro;in vivo	120   606   511   223   745   000   000   000
6777	STAT5B	5037	NP_036580.2	in vitro	10617656
7010	TEK	2571	NP_000450.2	in vitro;in vivo;yeast 2-hybrid	10521483
9019	MPZL1	5086	NP_003944.1	in vitro;in vivo	97   926   371   068   152   200   000   000
9021	SOCS3	5006	NP_003946.3	in vitro	12403768
9846	GAB2	5866	NP_036428.1	in vitro;in vivo	112   876   101   006   865   000   000   000
9961	MVP	5475	NP_059447.2	in vitro	1   513   303   715   588   980
10253	SPRY2	3916	NP_005833.1	in vitro	15031289
10818	FRS2	6372	NP_006645.3	in vitro;in vivo	963   278   111   447   289
29990	PILRB	8382	AAG17224.1	in vitro;in vivo	1   032   704   911   812   650
57292	KIR2DL5A	5603	NP_065396.1	in vitro	15187115
140885	SIRPA	3912	NP_542970.1	in vitro	8943344

Pathway Information

                                                                              

Pathway Name	Pathway ID
Adipocytokine signaling pathway	hsa04920
Chronic myeloid leukemia	hsa05220
Epithelial cell signaling in Helicobacter pylori infection	hsa05120
Herpes simplex infection	hsa05168
Insulin resistance	hsa04931
Jak-STAT signaling pathway	hsa04630
Leukocyte transendothelial migration	hsa04670
Natural killer cell mediated cytotoxicity	hsa04650
Neurotrophin signaling pathway	hsa04722
Phospholipase D signaling pathway	hsa04072
Proteoglycans in cancer	hsa05205
Ras signaling pathway	hsa04014
Renal cell carcinoma	hsa05211

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd00047	276-523	PTPc
cl21483	276-523	PTPc superfamily
cd10340	5-103	SH2_N-SH2_SHP_like
cl15255	5-103	SH2 superfamily
cd09931	111-218	SH2_C-SH2_SHP_like
cl15255	111-218	SH2 superfamily
smart00012	418-522	PTPc_DSPc
smart00404	418-522	PTPc_motif
pfam00017	Jun-81	SH2
cd10340	111-217	SH2_N-SH2_SHP_like
pfam00017	112-197	SH2
smart00252	110-201	SH2
smart00252	Jun-84	SH2
cd00173	111-197	SH2
cd00173	May-81	SH2
cd09933	109-200	SH2_Src_family
cd09937	111-200	SH2_csk_like
cd10354	Jun-81	SH2_Cterm_RasGAP
cd09932	3-103	SH2_C-SH2_PLC_gamma_like
cd09941	112-201	SH2_Grb2_like
cd10354	112-197	SH2_Cterm_RasGAP
cd09941	Jun-85	SH2_Grb2_like
cd10341	109-202	SH2_N-SH2_PLC_gamma_like
cd09943	Jun-82	SH2_Nck_family
cd09935	6-101	SH2_ABL
cd09933	Jun-84	SH2_Src_family
cd09935	112-210	SH2_ABL
cd09932	109-217	SH2_C-SH2_PLC_gamma_like
cd10347	110-197	SH2_Nterm_shark_like
cd10408	112-216	SH2_Nck1
cd09938	5-103	SH2_N-SH2_Zap70_Syk_like
cd10409	112-216	SH2_Nck2
cd10361	108-200	SH2_Fps_family
cd10355	Jan-81	SH2_DAPP1_BAM32_like
cd09943	112-202	SH2_Nck_family
cd10370	109-201	SH2_Src_Src42
cd10409	Jun-81	SH2_Nck2
cd10353	90-197	SH2_Nterm_RasGAP
cd10341	Jun-85	SH2_N-SH2_PLC_gamma_like
cd10347	May-81	SH2_Nterm_shark_like
cd09937	May-81	SH2_csk_like
cd10371	110-199	SH2_Src_Blk
cd10362	109-197	SH2_Src_Lck
cd09944	Mar-88	SH2_Grb7_family
cd10408	Jun-81	SH2_Nck1
cd10355	112-203	SH2_DAPP1_BAM32_like
cd09944	109-200	SH2_Grb7_family
cd10343	6-102	SH2_SHIP
cd10363	109-199	SH2_Src_HCK
cd09940	May-90	SH2_Vav_family
cd10370	3-101	SH2_Src_Src42
cd10418	109-197	SH2_Src_Fyn_isoform_a_like
cd10406	6-101	SH2_Vav2
cd09945	112-202	SH2_SHB_SHD_SHE_SHF_like
cd09926	112-198	SH2_CRK_like
cd09925	110-215	SH2_SHC
cd10414	Mar-88	SH2_Grb14
cd10367	109-197	SH2_Src_Fgr
cd09934	112-215	SH2_Tec_family
cd10346	112-202	SH2_SH2B_family
cd10337	Jun-96	SH2_BCAR3
cd09929	112-203	SH2_BLNK_SLP-76
cd10360	Jun-81	SH2_Srm
cd10337	109-219	SH2_BCAR3
cd10368	109-197	SH2_Src_Fyn
cd09934	6-101	SH2_Tec_family
cd09930	4-103	SH2_cSH2_p85_like
cd10348	Jun-82	SH2_Cterm_shark_like
cd10414	109-200	SH2_Grb14
cd10348	112-197	SH2_Cterm_shark_like
cd10364	109-199	SH2_Src_Lyn
cd10365	109-200	SH2_Src_Src
cd10362	Jun-81	SH2_Src_Lck
cd10369	109-200	SH2_Src_Frk
cd10417	111-208	SH2_SH2D7
cd10352	Jul-83	SH2_a2chimerin_b2chimerin
cd10344	101-197	SH2_SLAP
cd10399	110-218	SH2_Tec_Bmx
cd10343	112-216	SH2_SHIP
cd09945	Jun-81	SH2_SHB_SHD_SHE_SHF_like
cd10384	115-197	SH2_SOCS3
cd10407	Feb-90	SH2_Vav3
cd10353	May-81	SH2_Nterm_RasGAP
cd10356	Mar-78	SH2_ShkA_ShkC
cd10351	Jun-83	SH2_SH2D4B
cd10405	Jun-84	SH2_Vav1
cd10349	111-197	SH2_SH2D2A_SH2D7
cd10392	6-102	SH2_SHF
cd10413	109-200	SH2_Grb7
cd09938	111-217	SH2_N-SH2_Zap70_Syk_like
cd10390	112-202	SH2_SHD
cd09942	6-102	SH2_nSH2_p85_like
cd09929	Jan-84	SH2_BLNK_SLP-76
cd10390	6-102	SH2_SHD
cd10402	Jun-80	SH2_C-SH2_Zap70
cd10397	6-104	SH2_Tec_Btk
cd10419	110-199	SH2_Src_Fyn_isoform_b_like
cd09930	112-210	SH2_cSH2_p85_like
cd10405	112-212	SH2_Vav1
cd10366	109-200	SH2_Src_Yes
cd09923	112-198	SH2_SOCS_family
cd10396	6-104	SH2_Tec_Itk
cd10363	3-101	SH2_Src_HCK
cd10367	Mar-83	SH2_Src_Fgr
cd10392	112-202	SH2_SHF
cd10415	Mar-88	SH2_Grb10
cd10350	108-212	SH2_SH2D4A
cd10371	May-81	SH2_Src_Blk
cd10352	113-194	SH2_a2chimerin_b2chimerin
cd10388	Jun-84	SH2_SOCS7
cd10369	Jun-81	SH2_Src_Frk
cd10344	May-83	SH2_SLAP
cd09940	111-211	SH2_Vav_family
cd10398	112-216	SH2_Tec_Txk
cd10412	112-202	SH2_SH2B3
cd10418	Mar-83	SH2_Src_Fyn_isoform_a_like
cd10350	Jun-83	SH2_SH2D4A
cd10413	Mar-88	SH2_Grb7
cd10389	6-102	SH2_SHB
cd10357	Jan-57	SH2_ShkD_ShkE
cd09925	Jun-86	SH2_SHC
cd10410	107-202	SH2_SH2B1
cd10349	May-81	SH2_SH2D2A_SH2D7
cd10365	Mar-95	SH2_Src_Src
cd10402	112-215	SH2_C-SH2_Zap70
cd10361	Jun-85	SH2_Fps_family
cd09942	112-211	SH2_nSH2_p85_like
cd10400	7-102	SH2_SAP1a
cd10401	112-201	SH2_C-SH2_Syk_like
cd10417	May-83	SH2_SH2D7
cd10364	Mar-81	SH2_Src_Lyn
cd10411	112-202	SH2_SH2B2
cd10368	Mar-83	SH2_Src_Fyn
cd10358	109-215	SH2_PTK6_Brk
cd10400	113-151	SH2_SAP1a
cd10387	Jun-82	SH2_SOCS6
cd10397	112-218	SH2_Tec_Btk
cd10398	6-102	SH2_Tec_Txk
cd10401	Jun-81	SH2_C-SH2_Syk_like
cd10384	Nov-82	SH2_SOCS3
cd10351	112-211	SH2_SH2D4B
cd10415	109-200	SH2_Grb10
cd10406	106-206	SH2_Vav2
cd10396	112-200	SH2_Tec_Itk
cd09926	Jun-85	SH2_CRK_like
cd10360	112-197	SH2_Srm
cd10345	Jun-80	SH2_C-SH2_Zap70_Syk_like
cd10419	Apr-83	SH2_Src_Fyn_isoform_b_like
cd09946	112-202	SH2_HSH2_like
cd10388	112-195	SH2_SOCS7
cd09923	Jun-82	SH2_SOCS_family
cd10407	106-212	SH2_Vav3
cd10356	109-150	SH2_ShkA_ShkC
cd10346	Jun-56	SH2_SH2B_family
cd09927	Feb-46	SH2_Tensin_like
cd10383	106-197	SH2_SOCS2
cd09927	108-196	SH2_Tensin_like
cd10416	108-202	SH2_SH2D2A
cd10366	Mar-84	SH2_Src_Yes
cd10412	Jan-59	SH2_SH2B3
cd09946	Jun-81	SH2_HSH2_like
cd10342	112-151	SH2_SAP1
cd10342	6-102	SH2_SAP1
cd10411	Jun-84	SH2_SH2B2
cd10389	112-197	SH2_SHB
cd10358	Mar-81	SH2_PTK6_Brk
cd10416	Feb-84	SH2_SH2D2A
cd09919	110-170	SH2_STAT_family
cd10382	115-203	SH2_SOCS1
cd10391	6-102	SH2_SHE
cd10718	Jun-82	SH2_CIS
cd10399	6-103	SH2_Tec_Bmx
cd10382	13-83	SH2_SOCS1
cd10391	112-197	SH2_SHE
smart00195	439-473	DSPc
cd10345	112-198	SH2_C-SH2_Zap70_Syk_like
smart00194	246-524	PTPc
pfam00102	273-523	Y_phosphatase
COG5599	242-525	COG5599
PHA02742	227-525	PHA02742
PHA02738	229-527	PHA02738
PHA02746	234-526	PHA02746
PHA02747	269-535	PHA02747
PHA02740	324-527	PHA02740
COG2453	427-542	CDC14

Ontology Information

   

HPRD ID	4678
Molecular Class	Tyrosine phosphatase
Molecular Function	Receptor activity (GO:0004872)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

View SNP Geneview Report