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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PTPN11 5781 protein tyrosine phosphatase, non-receptor type 11  12BPTP3, SH-PTP2, SHP-2, PTP2C, SHP2 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24439672   2014Cell line : -

Source : 682 patients from Shanghai, China (training cohort) and validated in 343 patients from Guangzhou, China (validation cohort).

Sample Type : Population based case control study and CRC tumor

No. of Sample : 343

Stage : -

Western blotting,real time RT-PCR,ImmunohistochemistryDown-regulation--

24173294   2014Cell line : SW480, SW620, CACO2, HCT116, HT29

Source : The first affiliated hospital of Nanjing Medical University (Nanjing, China).

Sample Type : Paraffin-embedded tissues and groups of frozen tissues.

No. of Sample : 232

Stage : TNM Stage I-IV

 ImmunohistochemistryUp-regulation--


Gene Details



NC_000012.11 (112856536..112947717)

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Gene Type protein coding
Gene Family Protein tyrosine phosphatases / Class I Cys-based PTPs : Non-receptor, "SH2 domain containing"
Description The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]  
Chromosome 12
Location 12q24.1
Start 112856536  
End 112947717  
Strand +  
Gene Sequence

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Length 91182  
OMIM ID 176876   
HGNC ID HGNC:9644   
Unigene ID Hs.506852   
Ensembl ID ENSG00000179295   
PharmGKB ID PA33986   

mRNA Information


mRNA ID ?NM_002834.3
Exon complement(<1..107)  
mRNA Sequence

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Length 1276  



CDS Information


   
Location345..1211
CDS Sequence

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CCDS ID CCDS58280.1



Protein Information


      
Protein IDNP_002825.3
Protein Nameprotein tyrosine phosphatase, non-receptor type 11
Molecular Wt. (Da)214324
Protein Sequence

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Length 597  
Uniprot IDO76061
Ensembl Protein ID ENSP00000265087  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation580
YPhosphorylation542
SPhosphorylation576
SPhosphorylation576
SPhosphorylation576
YPhosphorylation62
YPhosphorylation63;-
SPhosphorylation558
TAcetylation2
SPhosphorylation591
KAcetylation280
KAcetylation198
YPhosphorylation66
YPhosphorylation279

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
392ARHGAP14108NP_004299.1in vitro1   516   989   815   588   980   
613BCR1044NP_004318.3in vivo12115002   
624BDKRB2213NP_000614.1in vivo12177051   
634CEACAM1191NP_001703.2in vitro986   784   812   108   545   
847CAT282NP_001743.1in vitro15556604   
867CBL1320NP_005179.2in vivo11157475   
945CD331165NP_001763.3in vitro10206955   
1147CHUK2811NP_001269.3in vivo11136824   
1439CSF2RB739NP_000386.1in vitro;in vivo91   620   899   254   654   
1441CSF3R737NP_724781.1in vivo9824671   
1493CTLA4474NP_005205.2in vitro;in vivo8638161   
1956EGFR579NP_005219.2in vitro;in vivo7   673   163   112   231   550   000   000   000   000   000   
2057EPOR587NP_000112.1in vivo8639815   
2185PTK2B3131NP_004094.3in vitro;in vivo10880513   
2206MS4A2915NP_000130.1in vitro9379041   
2534FYN655NP_002028.1in vitro10212213   
2549GAB15116NP_997006.1yeast 2-hybrid1   194   058   110   068   650   000   000   000   000   000   000   000   000   
2885GRB2150NP_002077.1in vivo8   041   791   125   314   300   000   000   
3192HNRNPU4185NP_114032.2in vitro8943344   
3454IFNAR1126NP_000620.2in vitro;in vivo9029147   
3459IFNGR1127NP_000407.1in vitro10022928   
3480IGF1R932NP_000866.1in vitro;in vivo7642582   
3566IL4R990NP_000409.1in vitro;in vivo11714803   
3572IL6ST2824NP_002175.2in vitro;in vivo91   959   771   094   628   000   000   000   
3643INSR975NP_000199.2in vitro;in vivo74   939   468   135   823   
3667IRS1943NP_005535.1in vitro;in vivo850   528   297   569   387   000   000   
3716JAK1992NP_002218.2in vivo89   953   991   240   376   800   000   000   
3717JAK2993NP_004963.1in vivo755   960   389   126   468   000   000   
3815KIT1287NP_000213.1in vitro;in vivo75   233   819   528   781   
3821KLRC11192NP_002250.1in vitro;in vivo9485206   
3932LCK1080NP_005347.3in vitro10617656   
3977LIFR1048NP_002301.1in vitro;in vivo10800945   
4233MET1280NP_001120972.1in vivo8662733   
4914NTRK11869NP_002520.2in vitro9282923   
4915NTRK22712NP_006171.2in vitro10386953   
5156PDGFRA1429NP_006197.1in vitro;in vivo8943348   
5159PDGFRB1423NP_002600.1in vitro;in vivo7   691   811   126   814   920   000   000   
5175PECAM11425NP_000433.3in vitro;in vivo9054388   
5294PIK3CG3135NP_002640.2in vivo10386953   
5295PIK3R11381NP_852664.1in vivo9918857   
5335PLCG11398NP_002651.2in vitro15563458   
5595MAPK33479NP_002737.2in vitro8197172   
5618PRLR1457NP_000940.1in vitro1   099   194   914   522   990   
5777PTPN61475NP_536859.1in vivo8541543   
5979RET1266NP_066124.1in vitro12959980   
6401SELE566NP_000441.2in vitro11602579   
6654SOS11681NP_005624.2in vivo9344843   
6772STAT12777NP_009330.1in vitro;in vivo12270932   
6774STAT326NP_644805.1in vivo11594781   
6776STAT5A3301NP_003143.2in vitro;in vivo120   606   511   223   745   000   000   000   
6777STAT5B5037NP_036580.2in vitro10617656   
7010TEK2571NP_000450.2in vitro;in vivo;yeast 2-hybrid10521483   
9019MPZL15086NP_003944.1in vitro;in vivo97   926   371   068   152   200   000   000   
9021SOCS35006NP_003946.3in vitro12403768   
9846GAB25866NP_036428.1in vitro;in vivo112   876   101   006   865   000   000   000   
9961MVP5475NP_059447.2in vitro1   513   303   715   588   980   
10253SPRY23916NP_005833.1in vitro15031289   
10818FRS26372NP_006645.3in vitro;in vivo963   278   111   447   289   
29990PILRB8382AAG17224.1in vitro;in vivo1   032   704   911   812   650   
57292KIR2DL5A5603NP_065396.1in vitro15187115   
140885SIRPA3912NP_542970.1in vitro8943344   


Pathway Information


                                                                              
Pathway Name Pathway ID
Adipocytokine signaling pathway hsa04920
Chronic myeloid leukemia hsa05220
Epithelial cell signaling in Helicobacter pylori infection hsa05120
Herpes simplex infection hsa05168
Insulin resistance hsa04931
Jak-STAT signaling pathway hsa04630
Leukocyte transendothelial migration hsa04670
Natural killer cell mediated cytotoxicity hsa04650
Neurotrophin signaling pathway hsa04722
Phospholipase D signaling pathway hsa04072
Proteoglycans in cancer hsa05205
Ras signaling pathway hsa04014
Renal cell carcinoma hsa05211


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00047276-523  PTPc
cl21483276-523  PTPc superfamily
cd103405-103  SH2_N-SH2_SHP_like
cl152555-103  SH2 superfamily
cd09931111-218  SH2_C-SH2_SHP_like
cl15255111-218  SH2 superfamily
smart00012418-522  PTPc_DSPc
smart00404418-522  PTPc_motif
pfam00017Jun-81  SH2
cd10340111-217  SH2_N-SH2_SHP_like
pfam00017112-197  SH2
smart00252110-201  SH2
smart00252Jun-84  SH2
cd00173111-197  SH2
cd00173May-81  SH2
cd09933109-200  SH2_Src_family
cd09937111-200  SH2_csk_like
cd10354Jun-81  SH2_Cterm_RasGAP
cd099323-103  SH2_C-SH2_PLC_gamma_like
cd09941112-201  SH2_Grb2_like
cd10354112-197  SH2_Cterm_RasGAP
cd09941Jun-85  SH2_Grb2_like
cd10341109-202  SH2_N-SH2_PLC_gamma_like
cd09943Jun-82  SH2_Nck_family
cd099356-101  SH2_ABL
cd09933Jun-84  SH2_Src_family
cd09935112-210  SH2_ABL
cd09932109-217  SH2_C-SH2_PLC_gamma_like
cd10347110-197  SH2_Nterm_shark_like
cd10408112-216  SH2_Nck1
cd099385-103  SH2_N-SH2_Zap70_Syk_like
cd10409112-216  SH2_Nck2
cd10361108-200  SH2_Fps_family
cd10355Jan-81  SH2_DAPP1_BAM32_like
cd09943112-202  SH2_Nck_family
cd10370109-201  SH2_Src_Src42
cd10409Jun-81  SH2_Nck2
cd1035390-197  SH2_Nterm_RasGAP
cd10341Jun-85  SH2_N-SH2_PLC_gamma_like
cd10347May-81  SH2_Nterm_shark_like
cd09937May-81  SH2_csk_like
cd10371110-199  SH2_Src_Blk
cd10362109-197  SH2_Src_Lck
cd09944Mar-88  SH2_Grb7_family
cd10408Jun-81  SH2_Nck1
cd10355112-203  SH2_DAPP1_BAM32_like
cd09944109-200  SH2_Grb7_family
cd103436-102  SH2_SHIP
cd10363109-199  SH2_Src_HCK
cd09940May-90  SH2_Vav_family
cd103703-101  SH2_Src_Src42
cd10418109-197  SH2_Src_Fyn_isoform_a_like
cd104066-101  SH2_Vav2
cd09945112-202  SH2_SHB_SHD_SHE_SHF_like
cd09926112-198  SH2_CRK_like
cd09925110-215  SH2_SHC
cd10414Mar-88  SH2_Grb14
cd10367109-197  SH2_Src_Fgr
cd09934112-215  SH2_Tec_family
cd10346112-202  SH2_SH2B_family
cd10337Jun-96  SH2_BCAR3
cd09929112-203  SH2_BLNK_SLP-76
cd10360Jun-81  SH2_Srm
cd10337109-219  SH2_BCAR3
cd10368109-197  SH2_Src_Fyn
cd099346-101  SH2_Tec_family
cd099304-103  SH2_cSH2_p85_like
cd10348Jun-82  SH2_Cterm_shark_like
cd10414109-200  SH2_Grb14
cd10348112-197  SH2_Cterm_shark_like
cd10364109-199  SH2_Src_Lyn
cd10365109-200  SH2_Src_Src
cd10362Jun-81  SH2_Src_Lck
cd10369109-200  SH2_Src_Frk
cd10417111-208  SH2_SH2D7
cd10352Jul-83  SH2_a2chimerin_b2chimerin
cd10344101-197  SH2_SLAP
cd10399110-218  SH2_Tec_Bmx
cd10343112-216  SH2_SHIP
cd09945Jun-81  SH2_SHB_SHD_SHE_SHF_like
cd10384115-197  SH2_SOCS3
cd10407Feb-90  SH2_Vav3
cd10353May-81  SH2_Nterm_RasGAP
cd10356Mar-78  SH2_ShkA_ShkC
cd10351Jun-83  SH2_SH2D4B
cd10405Jun-84  SH2_Vav1
cd10349111-197  SH2_SH2D2A_SH2D7
cd103926-102  SH2_SHF
cd10413109-200  SH2_Grb7
cd09938111-217  SH2_N-SH2_Zap70_Syk_like
cd10390112-202  SH2_SHD
cd099426-102  SH2_nSH2_p85_like
cd09929Jan-84  SH2_BLNK_SLP-76
cd103906-102  SH2_SHD
cd10402Jun-80  SH2_C-SH2_Zap70
cd103976-104  SH2_Tec_Btk
cd10419110-199  SH2_Src_Fyn_isoform_b_like
cd09930112-210  SH2_cSH2_p85_like
cd10405112-212  SH2_Vav1
cd10366109-200  SH2_Src_Yes
cd09923112-198  SH2_SOCS_family
cd103966-104  SH2_Tec_Itk
cd103633-101  SH2_Src_HCK
cd10367Mar-83  SH2_Src_Fgr
cd10392112-202  SH2_SHF
cd10415Mar-88  SH2_Grb10
cd10350108-212  SH2_SH2D4A
cd10371May-81  SH2_Src_Blk
cd10352113-194  SH2_a2chimerin_b2chimerin
cd10388Jun-84  SH2_SOCS7
cd10369Jun-81  SH2_Src_Frk
cd10344May-83  SH2_SLAP
cd09940111-211  SH2_Vav_family
cd10398112-216  SH2_Tec_Txk
cd10412112-202  SH2_SH2B3
cd10418Mar-83  SH2_Src_Fyn_isoform_a_like
cd10350Jun-83  SH2_SH2D4A
cd10413Mar-88  SH2_Grb7
cd103896-102  SH2_SHB
cd10357Jan-57  SH2_ShkD_ShkE
cd09925Jun-86  SH2_SHC
cd10410107-202  SH2_SH2B1
cd10349May-81  SH2_SH2D2A_SH2D7
cd10365Mar-95  SH2_Src_Src
cd10402112-215  SH2_C-SH2_Zap70
cd10361Jun-85  SH2_Fps_family
cd09942112-211  SH2_nSH2_p85_like
cd104007-102  SH2_SAP1a
cd10401112-201  SH2_C-SH2_Syk_like
cd10417May-83  SH2_SH2D7
cd10364Mar-81  SH2_Src_Lyn
cd10411112-202  SH2_SH2B2
cd10368Mar-83  SH2_Src_Fyn
cd10358109-215  SH2_PTK6_Brk
cd10400113-151  SH2_SAP1a
cd10387Jun-82  SH2_SOCS6
cd10397112-218  SH2_Tec_Btk
cd103986-102  SH2_Tec_Txk
cd10401Jun-81  SH2_C-SH2_Syk_like
cd10384Nov-82  SH2_SOCS3
cd10351112-211  SH2_SH2D4B
cd10415109-200  SH2_Grb10
cd10406106-206  SH2_Vav2
cd10396112-200  SH2_Tec_Itk
cd09926Jun-85  SH2_CRK_like
cd10360112-197  SH2_Srm
cd10345Jun-80  SH2_C-SH2_Zap70_Syk_like
cd10419Apr-83  SH2_Src_Fyn_isoform_b_like
cd09946112-202  SH2_HSH2_like
cd10388112-195  SH2_SOCS7
cd09923Jun-82  SH2_SOCS_family
cd10407106-212  SH2_Vav3
cd10356109-150  SH2_ShkA_ShkC
cd10346Jun-56  SH2_SH2B_family
cd09927Feb-46  SH2_Tensin_like
cd10383106-197  SH2_SOCS2
cd09927108-196  SH2_Tensin_like
cd10416108-202  SH2_SH2D2A
cd10366Mar-84  SH2_Src_Yes
cd10412Jan-59  SH2_SH2B3
cd09946Jun-81  SH2_HSH2_like
cd10342112-151  SH2_SAP1
cd103426-102  SH2_SAP1
cd10411Jun-84  SH2_SH2B2
cd10389112-197  SH2_SHB
cd10358Mar-81  SH2_PTK6_Brk
cd10416Feb-84  SH2_SH2D2A
cd09919110-170  SH2_STAT_family
cd10382115-203  SH2_SOCS1
cd103916-102  SH2_SHE
cd10718Jun-82  SH2_CIS
cd103996-103  SH2_Tec_Bmx
cd1038213-83  SH2_SOCS1
cd10391112-197  SH2_SHE
smart00195439-473  DSPc
cd10345112-198  SH2_C-SH2_Zap70_Syk_like
smart00194246-524  PTPc
pfam00102273-523  Y_phosphatase
COG5599242-525  COG5599
PHA02742227-525  PHA02742
PHA02738229-527  PHA02738
PHA02746234-526  PHA02746
PHA02747269-535  PHA02747
PHA02740324-527  PHA02740
COG2453427-542  CDC14


Ontology Information


   
HPRD ID4678
Molecular ClassTyrosine phosphatase
Molecular FunctionReceptor activity (GO:0004872)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO