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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PTPRZ1 | 5803 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1  | 7 | PTP18, RPTPB, phosphacan  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23096495    | 2013 | Cell line : - Source : - Sample Type : - No. of Sample : 133 CRC patients Stage : - | Methyl specific PCR and Illumina 27K microarray | Hypermethylation | - | PTPR family has an important role in the etiology of CRC. The analysis of promoter methylation using an Illumina 27K microarray revealed four protein tyrosine phosphatases PTPRM, PTPRT, PTPRR and PTPRZ1 as being hypermethylated with p-value 0.2 and P = 0.05. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Protein tyrosine phosphatases / Class I Cys-based PTPs : Transmembrane receptor-like, "Fibronectin type III domain containing" |
| Description | This gene encodes a member of the receptor protein tyrosine phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.   |
| Chromosome | 7 |
| Location | 7q31.3 |
| Start | 121873105   |
| End | 122062036   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 188932   |
| OMIM ID | 176891    |
| HGNC ID | HGNC:9685    |
| Unigene ID | Hs.489824    |
| Ensembl ID | ENSG00000106278    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_002851.2 |
|---|---|
| Exon | join(1..453,55052..55117,94847..95026,99437..99588, 103069..103164,103681..103747,110561..110718, 110863..111013,123278..123462,124776..124902, 131510..131556,137230..140785,146020..146164, 155448..155539,158370..158455,160991..161011, 161178..161274,163496..163578,165651..165785, 166350..166484,167712..167875,169504..169639, 171318..171464,178324..178417,178762..178835, 180806..180934,181837..181983,185696..185838, 186649..186784,187976..188932)   | mRNA Sequence |    Download   Select all |
| Length | 5589   |
CDS Information
| Location | join(396..453,55052..55117,94847..95026,99437..99588, 103069..103164,103681..103747,110561..110718, 110863..111013,123278..123462,124776..124902, 131510..131556,137230..140785,146020..146164, 155448..155539,158370..158455,160991..161011, 161178..161274,163496..163578,165651..165785, 166350..166484,167712..167875,169504..169639, 171318..171464,178324. |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS34740.1 |    
Protein Information
| Protein ID | NP_001193767.1 |
|---|---|
| Protein Name | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 |
| Molecular Wt. (Da) | 160755 |
| Protein Sequence |    Download   Select all |
| Length | 1455   |
| Uniprot ID | P34932 |    
| Ensembl Protein ID | ENSP00000302961   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 2285 |
Enzyme Information
| EC | 3.1.3.48 |    
|---|---|
| Name | protein-tyrosine-phosphatase phosphotyrosine phosphatase phosphoprotein phosphatase (phosphotyrosine) phosphotyrosine histone phosphatase protein phosphotyrosine phosphatase tyrosylprotein phosphatase phosphotyrosine protein phosphatase phosphotyrosylprotein phosphatase tyrosine O-phosphate phosphatase PPT-phosphatase PTPase [phosphotyrosine]protein phosphatase PTP-phosphatase |
| Class | Hydrolases; Acting on ester bonds; Phosphoric-monoester hydrolases |
| Sysname | protein-tyrosine-phosphate phosphohydrolase   |
| Substrate | protein tyrosine phosphate [CPD:C01167]; H2O   |
| Product | protein tyrosine [CPD:C00585]; phosphate   |
| Reaction (IUBMB) | ![]() |
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 119 |    ADD2 |    37 |    NP_001608.1 |    in vivo |    16105548    |
| 1499 |    CTNNB1 |    286 |    NP_001895.1 |    in vivo |    10706604    |
| 2909 |    GRLF1 |    5592 |    NP_004482.4 |    in vitro |    16513268    |
| 4192 |    MDK |    1200 |    NP_002382.1 |    in vitro;in vivo |    10212223    |
| 5764 |    PTN |    1199 |    NP_002816.1 |    in vitro;in vivo |    1   070   660   416   814   770    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Epithelial cell signaling in Helicobacter pylori infection |    hsa05120 |    
Structure Information
| PDB ID | 3JXF |
|---|---|
| Resolution | 2 |
| Method | X-RAY DIFFRACTION |
| Chains | A, B   |
| Molecule | Receptor-type tyrosine-protein phosphatase zeta   |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00047 | 1752-1991  | PTPc |
| cl21483 | 1752-1991  | PTPc superfamily |
| cd03122 | 45-298  | alpha_CARP_receptor_like |
| cl00012 | 45-298  | alpha_CA superfamily |
| cd00047 | 2050-2280  | PTPc |
| cl21483 | 2050-2280  | PTPc superfamily |
| cd00063 | 313-406  | FN3 |
| cl21522 | 313-406  | FN3 superfamily |
| smart01057 | 38-295  | Carb_anhydrase |
| cd00326 | 60-297  | alpha_CA |
| cd03123 | 46-300  | alpha_CA_VI_IX_XII_XIV |
| cd03126 | 46-300  | alpha_CA_XII_XIV |
| cd03117 | 59-298  | alpha_CA_IV_XV_like |
| pfam00194 | 56-300  | Carb_anhydrase |
| cd03150 | 45-300  | alpha_CA_IX |
| cd03125 | 45-300  | alpha_CA_VI |
| smart00012 | 1891-1991  | PTPc_DSPc |
| smart00404 | 1891-1991  | PTPc_motif |
| cd03119 | 38-300  | alpha_CA_I_II_III_XIII |
| cd03118 | 60-300  | alpha_CA_V |
| cd03124 | 45-263  | alpha_CA_prokaryotic_like |
| cd03149 | 60-300  | alpha_CA_VII |
| cd03121 | 49-296  | alpha_CARP_X_XI_like |
| cd03120 | 49-289  | alpha_CARP_VIII |
| COG3338 | 38-271  | Cah |
| smart00404 | 2182-2281  | PTPc_motif |
| smart00012 | 2182-2281  | PTPc_DSPc |
| pfam00041 | 313-401  | fn3 |
| smart00060 | 313-395  | FN3 |
| PLN02202 | 1-263  | PLN02202 |
| smart00195 | 1927-1971  | DSPc |
| smart00194 | 1716-1991  | PTPc |
| smart00194 | 2022-2280  | PTPc |
| pfam00102 | 1750-1991  | Y_phosphatase |
| pfam00102 | 2048-2281  | Y_phosphatase |
| COG5599 | 1711-1991  | COG5599 |
| PHA02738 | 1722-2001  | PHA02738 |
| PHA02747 | 1741-1986  | PHA02747 |
| PHA02742 | 1750-1991  | PHA02742 |
| PHA02746 | 1741-1994  | PHA02746 |
| PHA02747 | 2040-2284  | PHA02747 |
| PHA02746 | 2041-2279  | PHA02746 |
| COG5599 | 2022-2282  | COG5599 |
| PHA02738 | 2037-2279  | PHA02738 |
| PHA02740 | 1744-2001  | PHA02740 |
| PHA02742 | 2023-2286  | PHA02742 |
| PLN02179 | 49-253  | PLN02179 |
| PHA02740 | 2045-2284  | PHA02740 |
| COG2453 | 1898-1986  | CDC14 |
Ontology Information
| HPRD ID | 2770 |    
|---|---|
| Molecular Class | Receptor tyrosine phosphatase |
| Molecular Function | Chaperone activity (GO:0003754) |
| Biological Process | Protein metabolism (GO:0019538)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    

