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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PTPRZ1 5803 protein tyrosine phosphatase, receptor-type, Z polypeptide 1  7PTP18, RPTPB, phosphacan 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23096495   2013Cell line : -

Source : -

Sample Type : -

No. of Sample : 133 CRC patients

Stage : -

Methyl specific PCR and Illumina 27K microarray Hypermethylation-PTPR family has an important role in the etiology of CRC.

The analysis of promoter methylation using an Illumina 27K microarray revealed four protein tyrosine phosphatases PTPRM, PTPRT, PTPRR and PTPRZ1 as being hypermethylated with p-value 0.2 and P = 0.05.


Gene Details



Chromosome 7 - NC_000007.14 (121873105..122062036)

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Gene Type protein coding
Gene Family Protein tyrosine phosphatases / Class I Cys-based PTPs : Transmembrane receptor-like, "Fibronectin type III domain containing"
Description This gene encodes a member of the receptor protein tyrosine phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.  
Chromosome 7
Location 7q31.3
Start 121873105  
End 122062036  
Strand +  
Gene Sequence

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Length 188932  
OMIM ID 176891   
HGNC ID HGNC:9685   
Unigene ID Hs.489824   
Ensembl ID ENSG00000106278   
PharmGKB ID -   

mRNA Information


mRNA ID NM_002851.2
Exon join(1..453,55052..55117,94847..95026,99437..99588, 103069..103164,103681..103747,110561..110718, 110863..111013,123278..123462,124776..124902, 131510..131556,137230..140785,146020..146164, 155448..155539,158370..158455,160991..161011, 161178..161274,163496..163578,165651..165785, 166350..166484,167712..167875,169504..169639, 171318..171464,178324..178417,178762..178835, 180806..180934,181837..181983,185696..185838, 186649..186784,187976..188932)  
mRNA Sequence

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Length 5589  



CDS Information


   
Location join(396..453,55052..55117,94847..95026,99437..99588, 103069..103164,103681..103747,110561..110718, 110863..111013,123278..123462,124776..124902, 131510..131556,137230..140785,146020..146164, 155448..155539,158370..158455,160991..161011, 161178..161274,163496..163578,165651..165785, 166350..166484,167712..167875,169504..169639, 171318..171464,178324.
CDS Sequence

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CCDS ID CCDS34740.1



Protein Information


      
Protein IDNP_001193767.1
Protein Nameprotein tyrosine phosphatase, receptor-type, Z polypeptide 1
Molecular Wt. (Da)160755
Protein Sequence

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Length 1455  
Uniprot IDP34932
Ensembl Protein ID ENSP00000302961  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation2285

Enzyme Information


   
EC3.1.3.48
Nameprotein-tyrosine-phosphatase
phosphotyrosine phosphatase
phosphoprotein phosphatase (phosphotyrosine)
phosphotyrosine histone phosphatase
protein phosphotyrosine phosphatase
tyrosylprotein phosphatase
phosphotyrosine protein phosphatase
phosphotyrosylprotein phosphatase
tyrosine O-phosphate phosphatase
PPT-phosphatase
PTPase
[phosphotyrosine]protein phosphatase
PTP-phosphatase
ClassHydrolases; Acting on ester bonds; Phosphoric-monoester hydrolases
Sysnameprotein-tyrosine-phosphate phosphohydrolase  
Substrateprotein tyrosine phosphate [CPD:C01167]; H2O  
Productprotein tyrosine [CPD:C00585]; phosphate  
Reaction (IUBMB)



PPi Information


(Click to view network : Source STRING)      View   

                                                                           
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
119ADD237NP_001608.1in vivo16105548   
1499CTNNB1286NP_001895.1in vivo10706604   
2909GRLF15592NP_004482.4in vitro16513268   
4192MDK1200NP_002382.1in vitro;in vivo10212223   
5764PTN1199NP_002816.1in vitro;in vivo1   070   660   416   814   770   


Pathway Information


      
Pathway Name Pathway ID
Epithelial cell signaling in Helicobacter pylori infection hsa05120


Structure Information


PDB ID3JXF
Resolution2
MethodX-RAY DIFFRACTION
Chains A, B  
Molecule Receptor-type tyrosine-protein phosphatase zeta  
Model View



Domain Information




ID Location Description
cd000471752-1991  PTPc
cl214831752-1991  PTPc superfamily
cd0312245-298  alpha_CARP_receptor_like
cl0001245-298  alpha_CA superfamily
cd000472050-2280  PTPc
cl214832050-2280  PTPc superfamily
cd00063313-406  FN3
cl21522313-406  FN3 superfamily
smart0105738-295  Carb_anhydrase
cd0032660-297  alpha_CA
cd0312346-300  alpha_CA_VI_IX_XII_XIV
cd0312646-300  alpha_CA_XII_XIV
cd0311759-298  alpha_CA_IV_XV_like
pfam0019456-300  Carb_anhydrase
cd0315045-300  alpha_CA_IX
cd0312545-300  alpha_CA_VI
smart000121891-1991  PTPc_DSPc
smart004041891-1991  PTPc_motif
cd0311938-300  alpha_CA_I_II_III_XIII
cd0311860-300  alpha_CA_V
cd0312445-263  alpha_CA_prokaryotic_like
cd0314960-300  alpha_CA_VII
cd0312149-296  alpha_CARP_X_XI_like
cd0312049-289  alpha_CARP_VIII
COG333838-271  Cah
smart004042182-2281  PTPc_motif
smart000122182-2281  PTPc_DSPc
pfam00041313-401  fn3
smart00060313-395  FN3
PLN022021-263  PLN02202
smart001951927-1971  DSPc
smart001941716-1991  PTPc
smart001942022-2280  PTPc
pfam001021750-1991  Y_phosphatase
pfam001022048-2281  Y_phosphatase
COG55991711-1991  COG5599
PHA027381722-2001  PHA02738
PHA027471741-1986  PHA02747
PHA027421750-1991  PHA02742
PHA027461741-1994  PHA02746
PHA027472040-2284  PHA02747
PHA027462041-2279  PHA02746
COG55992022-2282  COG5599
PHA027382037-2279  PHA02738
PHA027401744-2001  PHA02740
PHA027422023-2286  PHA02742
PLN0217949-253  PLN02179
PHA027402045-2284  PHA02740
COG24531898-1986  CDC14


Ontology Information


   
HPRD ID2770
Molecular ClassReceptor tyrosine phosphatase
Molecular FunctionChaperone activity (GO:0003754)
Biological ProcessProtein metabolism (GO:0019538)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO