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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
RALB 5899 V-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)  2- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21715253   2011Cell line : -

Source : Gene Ontology database

Sample Type : -

No. of Sample : -

Stage : -

Soft agar colony size and formation frequency,Immunoblotting.Unknown--

18006783   2007Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Cluster and pathway analyses were done using GeneSpring software and Gene Ontology database.Up-regulation-Clusters of expression showed different expression in the transformed cells that revert to normal after treatment; they included Ras/Erk/Ral-B, Jagged2/Notch, calcineurin, lysyl-oxidase.

Cluster and pathway analyses were done using GeneSpring software and Gene Ontology database.

22790202   2012Cell line : -

Source : ATCC

Sample Type : -

No. of Sample : -

Stage : -

real time RT-PCR and western blotting, immunohistochemistryUp-regulation--


Gene Details



Chromosome: 2; NC_000002.11 (121010414..121052286)

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Gene Type protein coding
Gene Family -
Description This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq, Jul 2008]  
Chromosome 2
Location 2q14.2
Start 120240070  
End 120294711  
Strand +  
Gene Sequence

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Length 54642  
OMIM ID 179551   
HGNC ID HGNC:9840   
Unigene ID Hs.469820    
Ensembl ID ENSG00000144118   
PharmGKB ID -   

mRNA Information


mRNA ID XM_005263724.1
Exon join(1..56,38549..38709,45805..46013,49511..49688, 53072..54642)  
mRNA Sequence

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Length 2275  



CDS Information


   
Locationjoin(38..56,38546..38709,45805..46013,49511..49688, 53072..53191)
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDNP_002872.1
Protein NameV-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)
Molecular Wt. (Da)23277
Protein Sequence

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Length 206  
Uniprot IDP21291
Ensembl Protein ID ENSP00000345079  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


   
EC3.6.5.2
Namesmall monomeric GTPase
ClassHydrolases; Acting on acid anhydrides; Acting on GTP to facilitate cellular and subcellular movement
SysnameGTP phosphohydrolase (cell-regulating)  
SubstrateGTP [CPD:C00044]; H2O  
ProductGDP [CPD:C00035]; phosphate  
Reaction (IUBMB)



PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
801CALM1241NP_008819.1in vitro;in vivo;yeast 2-hybrid12034722   


Pathway Information


                              
Pathway Name Pathway ID
Pancreatic cancer hsa05212
Pathways in cancer hsa05200
Phospholipase D signaling pathway hsa04072
Rap1 signaling pathway hsa04015
Ras signaling pathway hsa04014


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0413915-178  RalA_RalB
cl2145515-178  P-loop_NTPase superfamily
smart0017315-177  RAS
smart0001015-177  small_GTPase
cd0087616-176  Ras
cd0413815-177  H_N_K_Ras_like
cd0414515-177  M_R_Ras_like
cd0417715-177  RSR1
cd0414416-180  Ras2
cd0417515-176  Rap1
cd0413615-176  Rap_like
cd0417615-176  Rap2
cd0414115-181  Rit_Rin_Ric
cd0015416-172  Rab
smart0017516-176  RAB
cd0413716-176  RheB
cd0414616-177  RERG_RasL11_like
cd0186814-176  Rab11_like
cd0412316-176  Rab21
cd0186713-179  Rab8_Rab10_Rab13_like
cd0414315-172  Rhes_like
cd0414816-185  RGK
cd0186016-176  Rab5_related
cd0414716-177  Ras_dva
cd0186914-179  Rab1_Ypt1
cd0186115-169  Rab6
cd0186614-179  Rab2
cd0414015-173  ARHI_like
cd0186216-174  Rab7
cd0186316-176  Rab18
cd0411915-176  RJL
cd0186414-176  Rab19
cd0015716-174  Rho
smart0017417-169  RHO
cd0411316-176  Rab4
cd0411116-179  Rab39
cd0412016-181  Rab12
cd0412216-176  Rab14
cd041168-176  Rab9
cd0411014-204  Rab35
cd0412714-167  Rab27A
cd0088220-174  Ras_like_GTPase
cd0186514-169  Rab3
cd0411716-179  Rab15
cd0411414-176  Rab30
cd0410616-169  Rab23_like
cd0411215-179  Rab26
cd0413016-169  Wrch_1
cd0410916-183  Rab28
cd0414216-182  RRP22
cd0411516-173  Rab33B_Rab33A
cd0413216-169  Rho4_like
cd0410716-204  Rab32_Rab38
cd0087716-174  Ran
cd0187116-176  Rac1_like
cd0412916-169  Rho2
cd0187016-169  RhoA_like
cd0187416-169  Cdc42
cd0413316-169  Rop_like
cd0413516-169  Tc10
cd0187516-176  RhoG
cd0411816-169  Rab24
cd0410116-174  RabL4
cd0412114-174  Rab40
cd0412416-175  RabL2
pfam0847716-131  Miro
cd0413116-169  Rnd
cd0189316-170  Miro1
cd0410815-170  Rab36_Rab34
cd0413416-174  Rho3
cd0412616-204  Rab20
cd0991416-167  RocCOR
cd0417216-164  Rnd3_RhoE_Rho8
cd041749-161  Rnd1_Rho6
cd0417316-185  Rnd2_Rho7
cd0410316-176  Centaurin_gamma
cd0412816-172  Spg1
cd0415919-168  Arl10_like
COG222916-173  Srp102
cd0415315-153  Arl5_Arl8
cd0087816-169  Arf_Arl
cd0187316-174  RhoBTB
cd0088020-169  Era_like
cd0415213-142  Arl4_Arl7
cd01887116-167  IF2_eIF5B
cd0416068-139  Arfrp1
cd01854114-168  YjeQ_EngC
smart0017716-134  ARF
cd0189790-168  NOG
cd01895103-169  EngA2
cd0189219-139  Miro2
pfam0002516-134  Arf
pfam0782634-131  IMP_cyclohyd
cl0133034-131  IMP_cyclohyd superfamily
cd0415616-146  ARLTS1
cd0416490-167  trmE
pfam0007116-177  Ras
PTZ0036915-177  PTZ00369
COG110016-186  Gem1
PLN031186-176  PLN03118
PLN0310814-179  PLN03108
PLN0311014-176  PLN03110
TIGR0023116-169  small_GTP
PTZ0013216-176  PTZ00132
PLN0307116-176  PLN03071
PTZ0009935-169  PTZ00099
smart0017620-176  RAN
COG116016-182  Der
COG116290-168  RsgA
COG048615-167  MnmE
PRK00093103-182  PRK00093
TIGR0391889-168  GTP_HydF
PRK12298122-186  obgE
TIGR0045015-132  mnmE_trmE_thdF
COG115990-184  Era
PRK0529155-179  trmE
PRK00098114-168  PRK00098
TIGR03594103-169  GTPase_EngA


Ontology Information


   
HPRD ID412
Molecular ClassUnknown
Molecular FunctionExtracellular matrix structural constituent (GO:0005201)
Biological ProcessCell growth and/or maintenance (GO:0008151)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO