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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| EDA2R | 60401 | Ectodysplasin A2 receptor | X | XEDAR; EDAA2R; EDA-A2R; TNFRSF27 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20501644 | 2009 | Cell line : - Source : ATCC. Sample Type : - No. of Sample : - Stage : - | Recombinant Fc-EDA-A2 and Fc-FASL, Cell culture and transfections, qRT-PCR, Western blotting | Down-regulation | - | Extracellular NH(2) terminus of XEDAR protein was cleaved by a metalloproteinase and released into culture media. The remaining COOH-terminal membrane-anchored fragment was rapidly degraded through the ubiquitin-proteasome pathway.
XEDAR as a direct p53 target that was frequently downregulated in colorectal cancer tissues due to its epigenetic alterations or through the p53 gene mutations. HEK293, HEK293T, U373MG, H1299, NCI-H716, and NHDF cell lines were used. |
| 19543321 | 2009 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 12 Stage : - | Genome-wide expression profile. | Methylation | - | Promoter hypermethylation of the XEDAR gene was detected in 20 of 20 colorectal cancer cell lines and in 6 of 12 colorectal cancer tissues respectively. XEDAR is a putative tumor suppressor that could prevent malignant transformation and tumor progression by regulating apoptosis and anoikis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Tumor necrosis factor receptor superfamily |
| Description | EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that are encoded by the anhidrotic ectodermal dysplasia (EDA) gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. The protein encoded by this gene specifically binds to EDA-A2 isoform. This protein is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, May 2011] |
| Chromosome | X |
| Location | Xq12 |
| Start | 66594384 |
| End | 66639298 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 44915 |
| OMIM ID | 300276 |
| HGNC ID | HGNC:17756 |
| Unigene ID | Hs.302017 |
| Ensembl ID | ENSG00000131080 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011531001.1 |
|---|---|
| Exon | join(1..98,23269..23365,34073..34251,34793..34878, 36502..36666,39204..39260,39433..39825,41206..44915) | mRNA Sequence | Download Select all |
| Length | 4363 |
CDS Information
| Location | join(23279..23365,34073..34251,34793..34878,36502..36575, 41206..41292) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_001186616.1 |
|---|---|
| Protein Name | Ectodysplasin A2 receptor |
| Molecular Wt. (Da) | 32598 |
| Protein Sequence | Download Select all |
| Length | 297 |
| Uniprot ID | Q14192 |
| Ensembl Protein ID | ENSP00000322909 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
No STRING Network could be found.
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cytokine-cytokine receptor interaction | hsa04060 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd15838 | 3-118 | TNFRSF27 |
| cl22855 | 3-118 | TNFRSF superfamily |
| cd13418 | 2-118 | TNFRSF19 |
| cd00185 | 17-108 | TNFRSF |
| cd13419 | 15-108 | TNFRSF19L |
| cd13421 | Feb-91 | TNFRSF_EDAR |
| cd15834 | 3-113 | TNFRSF1A_teleost |
| cd15835 | 8-118 | TNFRSF1B_teleost |
| cd10575 | 13-119 | TNFRSF6B |
| cd13424 | 16-84 | TNFRSF9_teleost |
| cd10578 | 3-107 | TNFRSF3 |
| cd13408 | Mar-84 | TNFRSF7 |
| cd13416 | Feb-83 | TNFRSF16 |
| cd13410 | 41-90 | TNFRSF9 |
| cd10576 | 18-113 | TNFRSF1A |
| cd13412 | 13-83 | TNFRSF11B_teleost |
| cd13416 | 13-109 | TNFRSF16 |
| cd15839 | 3-110 | TNFRSF_viral |
| cd10577 | 3-119 | TNFRSF1B |
| cd13406 | Jan-85 | TNFRSF4 |
| pfam00020 | 44-83 | TNFR_c6 |
| smart00208 | 44-83 | TNFR |
| cd10577 | Feb-88 | TNFRSF1B |
| pfam00020 | 31-Mar | TNFR_c6 |
| cd10581 | 14-91 | TNFRSF11B |
Ontology Information
| HPRD ID | 4014 |
|---|---|
| Molecular Class | Cell surface receptor |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219); Regulation of biological process (GO:0050789) |
Drug Information
No matching records could be found.